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1. 发明授权

US09474800B2 Expression vector encoding alphavirus replicase and the use thereof as immunological adjuvant 有权
标题翻译：编码甲病毒复制酶的表达载体及其作为免疫佐剂的用途
公开(公告)号：US09474800B2
公开(公告)日：2016-10-25
申请号：US12993987
申请日：2009-05-22
申请人： Kaja Kiiver , Rein Sikut , Urve Toots , Tarmo Mölder , Andres Männik , Mart Ustav , Katrin Kaldma
发明人： Kaja Kiiver , Rein Sikut , Urve Toots , Tarmo Mölder , Andres Männik , Mart Ustav , Katrin Kaldma
IPC分类号： A61K39/00 , A61K48/00 , A61K39/39 , C07K14/005 , C12N7/00 , C12N9/12
CPC分类号： A61K39/39 , A61K2039/53 , A61K2039/55516 , C07K14/005 , C07K2319/09 , C12N7/00 , C12N9/127 , C12N2710/20022 , C12N2770/36122
摘要： The present invention relates to an alphaviral replicase, especially Semliki Forest Virus replicase, or an expression vector encoding an alphaviral replicase, said alphaviral replicase comprising RNA dependent RNA polymerase activity, for use as an immune system modulating adjuvant. The alphaviral replicase may be used in the combination with a vaccine providing an adjuvant function therein, which when present therein will generate an additional boost to the immune response in the subject to whom this combination is administered as compared to when the vaccine alone is administered to a subject in need thereof. The aim of the present invention is to provide an efficient and easy to administer, species-independent adjuvant which will provide advantages to the adjuvants used together with vaccines today.
摘要翻译：本发明涉及甲病毒复制酶，特别是Semliki森林病毒复制酶，或编码甲病毒复制酶的表达载体，所述表达载体包含RNA依赖性RNA聚合酶活性，用作免疫系统调节佐剂。甲病毒复制酶可以与提供其中的佐剂功能的疫苗组合使用，当其中存在时，其将在给予该组合的受试者中产生额外的促进作用，与将单独的疫苗施用于有需要的科目。本发明的目的是提供一种有效和易于施用的与物种无关的佐剂，其将为今天与疫苗一起使用的佐剂提供优点。

2. 发明申请

US20110171255A1 EXPRESSION VECTOR ENCODING ALPHAVIRUS REPLICASE AND THE USE THEREOF AS IMMUNOLOGICAL ADJUVANT 有权
标题翻译：表达载体编码ALPHAVIRUS REPLICASE及其作为免疫调节剂的用途
公开(公告)号：US20110171255A1
公开(公告)日：2011-07-14
申请号：US12993987
申请日：2009-05-22
申请人： Kaja Kiiver , Rein Sikut , Urve Toots , Tarmo Mölder , Andres Männik , Mart Ustav , Katrin Kaldma
发明人： Kaja Kiiver , Rein Sikut , Urve Toots , Tarmo Mölder , Andres Männik , Mart Ustav , Katrin Kaldma
IPC分类号： A61K39/12 , A61K47/42 , A61P31/18 , A61P35/00 , A61P31/04 , A61K39/00 , C12N15/63 , A61K31/7088
CPC分类号： A61K39/39 , A61K2039/53 , A61K2039/55516 , C07K14/005 , C07K2319/09 , C12N7/00 , C12N9/127 , C12N2710/20022 , C12N2770/36122
摘要： The present invention relates to an alphaviral replicase, especially Semliki Forest Virus replicase, or an expression vector encoding an alphaviral replicase, said alphaviral replicase comprising RNA dependent RNA polymerase activity, for use as an immune system modulating adjuvant. The alphaviral replicase may be used in the combination with a vaccine providing an adjuvant function therein, which when present therein will generate an additional boost to the immune response in the subject to whom this combination is administered as compared to when the vaccine alone is administered to a subject in need thereof. The aim of the present invention is to provide an efficient and easy to administer, species-independent adjuvant which will provide advantages to the adjuvants used together with vaccines today.
摘要翻译：本发明涉及甲病毒复制酶，特别是Semliki森林病毒复制酶，或编码甲病毒复制酶的表达载体，所述表达载体包含RNA依赖性RNA聚合酶活性，用作免疫系统调节佐剂。甲病毒复制酶可以与提供其中的佐剂功能的疫苗组合使用，当其中存在时，其将在给予该组合的受试者中产生额外的促进作用，与将单独的疫苗施用于有需要的科目。本发明的目的是提供一种有效和易于施用的与物种无关的佐剂，其将为今天与疫苗一起使用的佐剂提供优点。

3. 发明授权

US07521182B2 Selection system containing non-antibiotic resistance selection marker 有权
标题翻译：选择系统含有非抗生素抗性选择标记
公开(公告)号：US07521182B2
公开(公告)日：2009-04-21
申请号：US10531870
申请日：2004-09-15
申请人： Tanel Tenson , Silja Laht , Maarja Ado-Jaan , Andres Männik , Urve Toots , Mart Ustav
发明人： Tanel Tenson , Silja Laht , Maarja Ado-Jaan , Andres Männik , Urve Toots , Mart Ustav
IPC分类号： C12Q1/02 , C12N1/20 , C12N1/21 , C12N15/70
CPC分类号： C12N9/90 , A61K2039/53
摘要： A selection system free of antibiotic resistance genes, which is based on the use of an araD gene as a selection marker carried on a vector which is inserted in a bacterial strain deficient of the araD gene. The araD gene from E. coli encodes the L-ribulose-5-phosphate-4-epimerase. A method of selecting the cells transformed with a plasmid, which contains the araD gene. The non-antibiotic selection marker makes the system suitable for producing therapeutics. The araD gene is not essential for growth of the host but manipulation of it affects the growth under certain selective conditions. Deletion of araD leads to accumulation of substance which is toxic to the host but not to humans. The araD gene is relatively small and therefore a small plasmid may be constructed, which requires less energy for replication, and leads to increased growth rate and yield.
摘要翻译：一种没有抗生素抗性基因的选择系统，其基于使用araD基因作为选择标记，其携带在插入araD基因缺陷的细菌菌株中的载体上。来自大肠杆菌的araD基因编码L-核酮糖-5-磷酸-4-差向异构酶。选择用含有araD基因的质粒转化的细胞的方法。非抗生素选择标记使该系统适合于生产治疗。 araD基因对于宿主的生长不是必需的，但是它的操作影响在某些选择性条件下的生长。删除araD会导致对宿主有毒的物质的积累，但不会对人体产生毒性。 araD基因相对较小，因此可以构建小质粒，其需要较少的复制能量，并且导致增加的生长速率和产率。

4. 发明授权

US07498314B2 Expression vectors and uses thereof 有权
标题翻译：表达载体及其用途
公开(公告)号：US07498314B2
公开(公告)日：2009-03-03
申请号：US10138098
申请日：2002-05-03
申请人： Kai Krohn , Vesna Blazevic , Marja Tähtinen , Mart Ustav , Urve Toots , Andres Männik , Annamari Ranki , Ene Ustav
发明人： Kai Krohn , Vesna Blazevic , Marja Tähtinen , Mart Ustav , Urve Toots , Andres Männik , Annamari Ranki , Ene Ustav
IPC分类号： A61K48/00 , A61K31/711 , C07H21/04 , C12N5/10 , C12N1/21 , C12P21/00
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/53 , C12N15/85 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to novel vectors, to DNA vaccines and gene therapeutics containing said vectors, to methods for the preparation of the vectors and DNA vaccines and gene therapeutics, and to therapeutic uses of said vectors. More specifically, the present invention relates to novel vectors comprising an expression cassette of a gene of a nuclear-anchoring protein, which contains a DNA binding domain capable of binding to a specific DNA sequence and a functional domain capable of binding to a nuclear component and a multimerized DNA sequence forming a binding site for the nuclear-anchoring protein, and optionally an expression cassette of a gene, genes or a DNA sequence or DNA sequences of interest. The present invention further relates to DNA vaccines and gene therapeutics containing the novel vectors, to methods for the preparation of the novel vectors and the DNA vaccines and gene therapeutics.
摘要翻译：本发明涉及新型载体，DNA疫苗和含有所述载体的基因治疗剂，用于制备载体和DNA疫苗和基因治疗剂的方法以及所述载体的治疗用途。更具体地，本发明涉及包含核锚定蛋白的基因的表达盒的新载体，其包含能够结合特定DNA序列的DNA结合结构域和能够结合核成分的功能结构域，形成核 - 锚定蛋白的结合位点的多聚DNA序列，以及任选的基因的表达盒，感兴趣的DNA序列或DNA序列。本发明还涉及含有新载体的DNA疫苗和基因治疗剂，用于制备新载体和DNA疫苗和基因治疗剂的方法。

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