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1. 发明授权

US06899107B2 Osteoinduction of cortical bone allografts by coating with biopolymers seeded with recipient periosteal bone cells 失效
标题翻译：通过用接受者骨膜骨细胞接种的生物聚合物涂覆皮质骨同种异体移植物的骨诱导
公开(公告)号：US06899107B2
公开(公告)日：2005-05-31
申请号：US10330568
申请日：2002-12-27
申请人： Kai-Uwe Lewandrowski , Shrikar Bondre , Debra J. Trantolo , Maurice V. Cattaneo , Joseph D. Gresser , Donald L. Wise
发明人： Kai-Uwe Lewandrowski , Shrikar Bondre , Debra J. Trantolo , Maurice V. Cattaneo , Joseph D. Gresser , Donald L. Wise
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/28 , A61F2/30 , A61F2/46 , A61L27/34 , A61L27/36 , A61L27/38 , A61B19/00
CPC分类号： A61L27/3804 , A61F2/0077 , A61F2/06 , A61F2/30767 , A61F2002/2835 , A61F2002/30062 , A61F2002/30064 , A61F2002/4648 , A61F2210/0004 , A61F2310/00353 , A61L27/34 , A61L27/3608 , A61L27/3625 , A61L27/365 , A61L27/3847 , A61L27/3895 , A61L2430/02 , A61L27/58 , A61L27/56 , A61L27/38 , C08L67/04 , C08L73/02 , C08L77/00 , C08L67/00
摘要： A method by which immune responses to cortical bone grafts and other substrates (e.g., cement, IPN, etc.) can be minimized and at the same time graft osteoinductive potential can be improved, and improved graft substrate materials are disclosed. The method of the invention provides new types of bone grafts that incorporate into host bone more thoroughly and more rapidly, eliminating long-term complications, such as fracture, non-union, infection, and rejection. In the method of the invention, bone grafts or other substrates are modified to have an osteoinductive surface modification that the recipient's body will accept as its own tissue type and therefore will not reject or otherwise cause to fail. The osteoinductive surface modification comprises a biopolymer matrix coating that is seeded with periosteal cells that have been previously harvested either from the graft recipient or from an allogenic or xenogenic donor source.
摘要翻译：可以将对皮质骨移植物和其他底物（例如水泥，IPN等）的免疫应答最小化并且同时可以改善移植骨骼骨诱导电位的方法，并且公开改进的移植物基质材料。本发明的方法提供了更全面和更快速地掺入宿主骨的新型骨移植物，消除了长期的并发症，例如骨折，非联合，感染和排斥。在本发明的方法中，骨移植物或其他底物被修饰为具有骨诱导性表面修饰，受体的身体将被接受为其自身的组织类型，因此不会拒绝或以其他方式导致失败。骨诱导性表面改性包括生物聚合物基质涂层，其接种已经从移植受体或从同种异体或异种供体来源收获的骨膜细胞。

2. 发明授权

US06551355B1 Tissue transplant coated with biocompatible biodegradable polymer 失效
标题翻译：用生物相容性生物降解聚合物涂覆的组织移植物
公开(公告)号：US06551355B1
公开(公告)日：2003-04-22
申请号：US09133945
申请日：1998-08-14
申请人： Kai-Uwe Lewandrowski , Shrikar Bondre , Debra J. Trantolo , Maurice V. Cattaneo , Joseph D. Gresser , Donald L. Wise
发明人： Kai-Uwe Lewandrowski , Shrikar Bondre , Debra J. Trantolo , Maurice V. Cattaneo , Joseph D. Gresser , Donald L. Wise
IPC分类号： A61F228
CPC分类号： A61L27/3804 , A61F2/0077 , A61F2/06 , A61F2/30767 , A61F2002/2835 , A61F2002/30062 , A61F2002/30064 , A61F2002/4648 , A61F2210/0004 , A61F2310/00353 , A61L27/34 , A61L27/3608 , A61L27/3625 , A61L27/365 , A61L27/3847 , A61L27/3895 , A61L2430/02 , A61L27/58 , A61L27/56 , A61L27/38 , C08L67/04 , C08L73/02 , C08L77/00 , C08L67/00
摘要： A method by which immune responses to cortical bone grafts and other substrates (e.g., cement, IPN, etc.) can be minimized and at the same time graft osteoinductive potential can be improved, and improved graft substrate materials are disclosed. The method of the invention provides new types of bone grafts that incorporate into host bone more thoroughly and more rapidly, eliminating long-term complications, such as fracture, non-union, infection, and rejection. In the method of the invention, bone grafts or other substrates are modified to have an osteoinductive surface modification that the recipient's body will accept as its own tissue type and therefore will not reject or otherwise cause to fail. The osteoinductive surface modification comprises a biopolymer matrix coating that is seeded with periosteal cells that have been previously harvested either from the graft recipient or from an allogenic or xenogenic donor source.
摘要翻译：可以将对皮质骨移植物和其他底物（例如水泥，IPN等）的免疫应答最小化并且同时可以改善移植骨骼骨诱导电位的方法，并且公开改进的移植物基质材料。本发明的方法提供了更全面和更快速地掺入宿主骨的新型骨移植物，消除了长期的并发症，例如骨折，非联合，感染和排斥。在本发明的方法中，骨移植物或其他底物被修饰为具有骨诱导性表面修饰，受体的身体将被接受为其自身的组织类型，因此不会拒绝或以其他方式导致失败。骨诱导性表面改性包括生物聚合物基质涂层，其接种已经从移植受体或从同种异体或异种供体来源收获的骨膜细胞。

3. 发明授权

US07077866B2 Resorbable interbody spinal fusion devices 失效
标题翻译：可再生体内脊柱融合装置
公开(公告)号：US07077866B2
公开(公告)日：2006-07-18
申请号：US09785593
申请日：2001-02-16
申请人： Joseph D. Gresser , Debra J. Trantolo , Robert S. Langer , Kai-Uwe Lewandrowski , Alexander M. Klibanov , Donald L. Wise
发明人： Joseph D. Gresser , Debra J. Trantolo , Robert S. Langer , Kai-Uwe Lewandrowski , Alexander M. Klibanov , Donald L. Wise
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61F2/30965 , A61F2/442 , A61F2002/2835 , A61F2002/30062 , A61F2002/30112 , A61F2002/30133 , A61F2002/30153 , A61F2002/30179 , A61F2002/30217 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30868 , A61F2002/30904 , A61F2002/30957 , A61F2210/0004 , A61F2230/0004 , A61F2230/0015 , A61F2230/0019 , A61F2230/0058 , A61F2230/0067 , Y10S623/926
摘要： A resorbable interbody fusion device for use in spinal fixation is disclosed. The device is composed of 25–100% bioresorbable or resorbable material. The interbody fusion device of the invention can be in any convenient form, such as a wedge, screw or cage. Preferably, the resorbable device of the invention is in the shape of a tapered wedge or cone, which further desirably incorporates structural features such as serrations or threads better to anchor the device in the adjoining vertebrae. The preferred device further comprises a plurality of peripheral voids and more desirably a central void space therein, which may desirably be filled with a grafting material for facilitating bony development and/or spinal fusion, such as an autologous grafting material. As the preferred material from which the resorbable interbody fusion device is manufactured is most likely to be a polymer that can produce acidic products upon hydrolytic degradation, the device preferably further includes a neutralization compound, or buffer, in sufficiently high concentration to decrease the rate of pH change as the device degrades, in order to prevent sterile abscess formation caused by the accumulation of unbuffered acidic products in the area of the implant.
摘要翻译：公开了一种用于脊柱固定的可再吸收体内融合装置。该装置由25-100％的生物可吸收或可再吸收材料组成。本发明的体内融合装置可以是任何方便的形式，例如楔形物，螺钉或笼子。优选地，本发明的可再吸收装置是锥形楔形或锥形的形状，其进一步期望地包括诸如锯齿或线的结构特征，以更好地将装置锚定在相邻的椎骨中。优选的装置还包括多个周边空隙，并且更期望地为其中的中心空隙空间，其可期望地填充有用于促进骨发育和/或脊柱融合的接枝材料，例如自体移植材料。作为制造可再吸收的体内融合装置的优选材料最可能是在水解降解时可以产生酸性产物的聚合物，该装置优选还包含足够高浓度的中和化合物或缓冲剂，以降低 pH值随器械降解而改变，以防止在植入物区域积聚无缓冲酸性产物引起的无菌性脓肿形成。

4. 发明授权

US06241771B1 Resorbable interbody spinal fusion devices 失效
公开(公告)号：US06241771B1
公开(公告)日：2001-06-05
申请号：US09131716
申请日：1998-08-10
申请人： Joseph D. Gresser , Debra J. Trantolo , Robert S. Langer , Kai-Uwe Lewandrowski , Alexander M. Klibanov , Donald L. Wise
发明人： Joseph D. Gresser , Debra J. Trantolo , Robert S. Langer , Kai-Uwe Lewandrowski , Alexander M. Klibanov , Donald L. Wise
IPC分类号： A61F244
CPC分类号： A61F2/4455 , A61F2/30965 , A61F2/442 , A61F2002/2835 , A61F2002/30062 , A61F2002/30112 , A61F2002/30133 , A61F2002/30153 , A61F2002/30179 , A61F2002/30217 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30868 , A61F2002/30904 , A61F2002/30957 , A61F2210/0004 , A61F2230/0004 , A61F2230/0015 , A61F2230/0019 , A61F2230/0058 , A61F2230/0067 , Y10S623/926
摘要： A resorbable interbody fusion device for use in spinal fixation is disclosed. The device is composed of 25-100% bioresorbable or resorbable material. The interbody fusion device of the invention can be in any convenient form, such as a wedge, screw or cage. Preferably, the resorbable device of the invention is in the shape of a tapered wedge or cone, which further desirably incorporates structural features such as serrations or threads better to anchor the device in the adjoining vertebrae. The preferred device further comprises a plurality of peripheral voids and more desirably a central void space therein, which may desirably be filled with a grafting material for facilitating bony development and/or spinal fusion, such as an autologous grafting material. As the preferred material from which the resorbable interbody fusion device is manufactured is most likely to be a polymer that can produce acidic products upon hydrolytic degradation, the device preferably further includes a neutralization compound, or buffer, in sufficiently high concentration to decrease the rate of pH change as the device degrades, in order to prevent sterile abscess formation caused by the accumulation of unbuffered acidic products in the area of the implant.

5. 发明授权

US06548002B2 Method of making a biodegradable interbody spinal fusion devices 失效
标题翻译：制造可生物降解的椎体间融合器的方法
公开(公告)号：US06548002B2
公开(公告)日：2003-04-15
申请号：US09905620
申请日：2001-07-13
申请人： Joseph D. Gresser , Debra J. Trantolo , Robert S. Langer , Kai-Uwe Lewandrowski , Alexander M. Klibanov , Donald L. Wise
发明人： Joseph D. Gresser , Debra J. Trantolo , Robert S. Langer , Kai-Uwe Lewandrowski , Alexander M. Klibanov , Donald L. Wise
IPC分类号： B29C3910
CPC分类号： A61F2/4455 , A61F2/30965 , A61F2/442 , A61F2002/2835 , A61F2002/30062 , A61F2002/30112 , A61F2002/30133 , A61F2002/30153 , A61F2002/30179 , A61F2002/30217 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30868 , A61F2002/30904 , A61F2002/30957 , A61F2210/0004 , A61F2230/0004 , A61F2230/0015 , A61F2230/0019 , A61F2230/0058 , A61F2230/0067 , Y10S623/926
摘要： A resorbable interbody fusion device for use in spinal fixation is disclosed. The device is composed of 25-100% bioresorbable or resorbable material. The interbody fusion device of the invention can be in any convenient form, such as a wedge, screw or cage. Preferably, the resorbable device of the invention is in the shape of a tapered wedge or cone, which further desirably incorporates structural features such as serrations or threads better to anchor the device in the adjoining vertebrae. The preferred device further comprises a plurality of peripheral voids and more desirably a central void space therein, which may desirably be filled with a grafting material for facilitating bony development and/or spinal fusion, such as an autologous grafting material. As the preferred material from which the resorbable interbody fusion device is manufactured is most likely to be a polymer that can produce acidic products upon hydrolytic degradation, the device preferably further includes a neutralization compound, or buffer, in sufficiently high concentration to decrease the rate of pH change as the device degrades, in order to prevent sterile abscess formation caused by the accumulation of unbuffered acidic products in the area of the implant.
摘要翻译：公开了一种用于脊柱固定的可再吸收体内融合装置。该装置由25-100％的生物可吸收或可再吸收材料组成。本发明的体内融合装置可以是任何方便的形式，例如楔形物，螺钉或笼子。优选地，本发明的可再吸收装置是锥形楔形或锥形的形状，其进一步期望地包括诸如锯齿或线的结构特征，以更好地将装置锚定在相邻的椎骨中。优选的装置还包括多个周边空隙，并且更期望地为其中的中心空隙空间，其可期望地填充有用于促进骨发育和/或脊柱融合的接枝材料，例如自体移植材料。作为制造可再吸收的体内融合装置的优选材料最可能是在水解降解时可以产生酸性产物的聚合物，该装置优选还包含足够高浓度的中和化合物或缓冲剂，以降低 pH值随器械降解而改变，以防止在植入物区域积聚无缓冲酸性产物引起的无菌性脓肿形成。

6. 发明授权

US5817328A Material for buffered resorbable internal fixation devices and method for making same 失效
标题翻译：缓冲可吸收内固定装置的材料及其制造方法
公开(公告)号：US5817328A
公开(公告)日：1998-10-06
申请号：US626521
申请日：1996-04-03
申请人： Joseph D. Gresser , Debra J. Trantolo , Robert Langer , Alexander M. Klibanov , Donald L. Wise
发明人： Joseph D. Gresser , Debra J. Trantolo , Robert Langer , Alexander M. Klibanov , Donald L. Wise
IPC分类号： A61K47/30 , A61F2/02 , A61K9/16 , A61K9/20 , A61K47/32 , A61K47/34 , A61L27/14 , A61L27/18 , A61L27/58
CPC分类号： A61L27/58 , A61K9/1611 , A61K9/1617 , A61K9/1647 , A61K9/2009 , A61K9/2027 , A61K9/204 , A61L27/18 , A61F2210/0004
摘要： A bioerodible implantable material, comprising a bioerodible polymer that produces acidic products upon hydrolytic degradation, and a buffering compound that buffers the acidic products and maintains the local pH within a desired range. The buffer compound acts to reduce the inflammatory foreign body response generated by the acidic products and reduces the sterile abscess condition that occurs at the site of the bioerodible implant materials of the prior art. Materials made according to the invention may be used for internal fixation devices (IFDs) for bone repair.
摘要翻译：生物可蚀刻可植入材料，其包括在水解降解时产生酸性产物的生物可腐蚀聚合物，以及缓冲化合物，其缓冲酸性产物并将局部pH保持在所需范围内。缓冲剂化合物用于减少由酸性产物产生的炎症异物反应并降低在现有技术的生物可蚀解植入材料的位置发生的无菌脓肿状况。根据本发明制备的材料可用于骨修复的内固定装置（IFD）。

7. 发明授权

US5429822A Biodegradable bursting release system 失效
标题翻译：可生物降解爆破释放系统
公开(公告)号：US5429822A
公开(公告)日：1995-07-04
申请号：US852372
申请日：1992-03-13
申请人： Joseph D. Gresser , Donald L. Wise , Abdul G. Jimoh , Don C. Augenstein , Dean O. Kuethe , Debra J. Trantolo
发明人： Joseph D. Gresser , Donald L. Wise , Abdul G. Jimoh , Don C. Augenstein , Dean O. Kuethe , Debra J. Trantolo
IPC分类号： A61K9/00 , A61F2/00
CPC分类号： A61K9/0024
摘要： A biodegradable polymeric multiphasic release system of one or more biodegradable bursting units capable of delivering biologically active substances in a burst or pulse at predetermined times and a method for constructing those units is disclosed. The individual bursting units of the system may take the form of a biodegradable, membrane coated capsule surrounding a core material which may include an active agent. The membrane ruptures after a predetermined time upon exposure to water or bodily, or other aqueous environmental fluids. The bursting units may be used in any situation in which a controlled pulsed release of an active substance is desired. The predetermined time release of each bursting unit is controlled by the composition of the core material, the initial radius and wall thickness of the membrane and the porosity of the membrane. The core material may also contain a chemical composition which generates gas as fluid is drawn into the bursting unit thus adding an additional design variable for predetermining bursts.
摘要翻译：公开了一种可生物降解的聚合多相释放系统，该系统能够在预定时间内以突发或脉冲递送生物活性物质，以及用于构建这些单元的方法。系统的各个破裂单元可以采用围绕可以包含活性剂的核心材料的可生物降解的膜包膜的形式。暴露于水或身体或其他含水环境液体之后，膜会在预定时间后破裂。爆破单元可以用于需要活性物质的受控脉冲释放的任何情况。每个破裂单元的预定时间释放由芯材料的组成，膜的初始半径和壁厚度以及膜的孔隙度来控制。核心材料还可以包含当流体被拉入破裂单元时产生气体的化学组成，从而为预先确定的脉冲串添加额外的设计变量。

8. 发明授权

US6153664A Bioerodible polymeric semi-interpenetrating network alloys and internal fixation devices made therefrom 有权
标题翻译：生物降解聚合物半互穿网络合金和由其制成的内部固定装置
公开(公告)号：US6153664A
公开(公告)日：2000-11-28
申请号：US168129
申请日：1998-10-07
申请人： Donald L. Wise , Joseph D. Gresser , Debra J. Trantolo , Y. Y. Hsu
发明人： Donald L. Wise , Joseph D. Gresser , Debra J. Trantolo , Y. Y. Hsu
IPC分类号： A61L24/00 , A61B17/00 , A61B17/80 , A61B17/86 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/46 , A61L27/26 , A61L27/48 , A61L27/58 , C08J3/28 , C08L11/00 , C08L67/00 , C08L77/00 , C08L101/16 , C08L67/06 , A61K31/765
CPC分类号： A61L27/58 , A61B17/866 , A61L27/26 , A61L27/48 , A61B17/80 , A61B17/8833 , A61B2017/00004 , A61F2/28 , A61F2002/2817 , A61F2002/30004 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2250/0014 , A61L2430/02 , Y10S525/903
摘要： A bioerodible cement system, which, upon mixing of the system parts, forms a cured bioerodible cement, said system comprising a first part comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation; and a second part comprising a second bioerodible scaffolding polymer which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said cured cement is disclosed. In a preferred embodiment, the second bioerodible polymer comprises polypropylene fumarate (PPF), which is cross-linked during curing, desirably by a vinyl monomer such as vinyl pyrrolidone (VP) to form the biopolymeric scaffolding which provides the cured cement with dimensional and geometric stability.
摘要翻译：生物腐蚀性水泥系统，其在系统部件混合后形成固化的可生物腐蚀的水泥，所述系统包括第一部分，其包含能够在水解降解时产生酸性产物的第一生物可腐蚀聚合物; 以及第二部分，其包含第二生物可蚀解脚手架聚合物，其在交联时提供用于所述固化的水泥的生物聚合物支架或内部增强物。在优选的实施方案中，第二生物可侵蚀聚合物包含聚丙烯富马酸盐（PPF），其在固化期间是交联的，理想地是通过乙烯基单体如乙烯基吡咯烷酮（VP）形成生物聚合物支架，其提供具有尺寸和几何尺寸的固化水泥稳定性。

9. 发明授权

US5512218A Method of making biopolymer-based nonlinear optical materials 失效
标题翻译：制备基于生物聚合物的非线性光学材料的方法
公开(公告)号：US5512218A
公开(公告)日：1996-04-30
申请号：US217312
申请日：1994-03-24
申请人： Joseph D. Gresser , Debra J. Trantolo , Donald L. Wise , Gary E. Wnek
发明人： Joseph D. Gresser , Debra J. Trantolo , Donald L. Wise , Gary E. Wnek
IPC分类号： B29D7/01 , C08G69/10 , G02F1/361 , B29D11/00 , G02F1/37
CPC分类号： C08G69/10 , B29D7/01 , G02F1/3615 , B29K2093/00 , B29K2105/0079
摘要： A biopolymer film and other materials that exhibit nonlinear optical (NLO) properties and a method for making this film. Alignment of biopolymer molecules, which is required for NLO phenomena, is achieved by application of an electric field parallel to the surface of a biopolymer solution as the film is formed. In one embodiment, a solution of poly(.gamma.-benzyl-L-glutamate), PBLG, in methylene chloride is employed. Upon application of an electric field, laminar structures perpendicular to both the field direction and to the film surface are formed. These ordered structures are captured in the film upon evaporation of the biopolymer solvent.
摘要翻译：展示非线性光学（NLO）性质的生物聚合物膜和其它材料以及制备该膜的方法。 NLO现象所需的生物聚合物分子的对准通过在形成膜时施加与生物聚合物溶液的表面平行的电场来实现。在一个实施方案中，使用聚（γ-苄基-L-谷氨酸酯），PBLG在二氯甲烷中的溶液。在施加电场时，形成垂直于场方向和膜表面的层状结构。当生物聚合物溶剂蒸发时，这些有序结构被捕获在膜中。

10. 发明授权

US06419945B1 Buffered resorbable internal fixation devices and methods for making material therefore 有权
标题翻译：因此，缓冲可再吸收的内固定装置和制造材料的方法
公开(公告)号：US06419945B1
公开(公告)日：2002-07-16
申请号：US09166508
申请日：1998-10-05
申请人： Joseph D. Gresser , Debra J. Trantolo , Robert Langer , Alexander M. Klibanov , Donald L. Wise
发明人： Joseph D. Gresser , Debra J. Trantolo , Robert Langer , Alexander M. Klibanov , Donald L. Wise
IPC分类号： A61F202
CPC分类号： A61L27/46 , A61B17/866 , A61B2017/00004 , A61F2/28 , A61F2/2875 , A61F2/30965 , A61F2/442 , A61F2/4455 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/30062 , A61F2002/30133 , A61F2002/30261 , A61F2002/30785 , A61F2002/30789 , A61F2002/30904 , A61F2002/30952 , A61F2002/4475 , A61F2210/0004 , A61F2230/0015 , A61F2230/0082 , A61F2310/00293 , A61K9/1611 , A61K9/1617 , A61K9/1647 , A61K9/2009 , A61K9/2027 , A61K9/204 , A61L27/18 , A61L27/58 , A61L31/127 , A61L31/148 , C08L67/04 , C08L69/00
摘要： An internal fixation device and a bioerodible implantable material useful therefor comprise a bioerodible polymer that produces acidic products or low molecular weight resorbable fragments upon hydrolytic degradation, and a buffering or neutralizing agent in sufficiently high concentration to moderate the rate of change of pH of said bioerodible material during bioerosion. The buffering or neutralizing agent acts to reduce the inflammatory foreign body response generated by the acidic products and reduces the sterile abscess condition that occurs at the site of the bioerodible implant materials of the prior art. Internal fixation devices (IFDs) according to the invention are useful, for example, for the repair, replacement or reconstruction of damaged bone in any area of the body.
摘要翻译：用于其的内部固定装置和生物可蚀解植入材料包括在水解降解时产生酸性产物或低分子量可吸收片段的生物可腐蚀聚合物，以及足够高浓度的缓冲或中和剂，以缓解所述生物可蚀解物的pH变化率生物侵蚀期间的材料。缓冲剂或中和剂用于减少由酸性产物产生的炎症异物反应并降低在现有技术的生物可蚀解植入材料的位置发生的无菌脓肿状况。根据本发明的内部固定装置（IFD）可用于例如身体的任何区域中损伤的骨骼的修复，替换或重建。

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