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1. 发明申请

US20070254876A1 Glucuronate salt of a piperazine compound 有权
标题翻译：哌嗪化合物的葡糖醛酸盐
公开(公告)号：US20070254876A1
公开(公告)日：2007-11-01
申请号：US11519756
申请日：2006-09-12
申请人： Subodh Deshmukh , Kadum Ali , Christopher Diorio , Eric Ehrnsperger , Mahdi Fawzi , Syed Shah , Mahmoud Mirmehrabi
发明人： Subodh Deshmukh , Kadum Ali , Christopher Diorio , Eric Ehrnsperger , Mahdi Fawzi , Syed Shah , Mahmoud Mirmehrabi
IPC分类号： A61K31/536 , A61P1/00 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/30 , C07D498/04
CPC分类号： C07D413/12
摘要： The present invention provides a salt form, and compositions thereof, useful as a modulator of one or more GPCRs and which exhibits desirable characteristics for the same. The present invention also provides methods for preparing said salt form.
摘要翻译：本发明提供盐形式及其组合物，其可用作一种或多种GPCR的调节剂，并且其表现出所需特性。本发明还提供了制备所述盐形式的方法。

2. 发明申请

US20070060580A1 Salicylate and gentisate salts of a piperazine compound 有权
标题翻译：哌嗪化合物的水杨酸盐和龙胆酸盐
公开(公告)号：US20070060580A1
公开(公告)日：2007-03-15
申请号：US11519738
申请日：2006-09-12
申请人： Subodh Deshmukh , Kadum Ali , Christopher Diorio , Wendy Dulin , Eric Ehrnsperger , Mahdi Fawzi , Syed Shah
发明人： Subodh Deshmukh , Kadum Ali , Christopher Diorio , Wendy Dulin , Eric Ehrnsperger , Mahdi Fawzi , Syed Shah
IPC分类号： A61K31/538 , C07D413/14
CPC分类号： C07C65/10 , C07C65/05 , C07D413/12
摘要： The present invention provides salt forms, and compositions thereof, useful as modulators of one or more GPCRs and which exhibit desirable characteristics for the same.
摘要翻译：本发明提供盐形式及其组合物，其可用作一种或多种GPCR的调节剂，并且其表现出对其的期望特性。

3. 发明申请

US20070059366A1 Sustained-release formulation and uses thereof 有权
标题翻译：持续释放制剂及其用途
公开(公告)号：US20070059366A1
公开(公告)日：2007-03-15
申请号：US11519763
申请日：2006-09-12
申请人： Kadum Ali , Christopher Diorio , Eric Ehrnsperger , Mahdi Fawzi , Syed Shah
发明人： Kadum Ali , Christopher Diorio , Eric Ehrnsperger , Mahdi Fawzi , Syed Shah
IPC分类号： A61K9/22 , A61K31/70
CPC分类号： A61K9/2054 , A61K9/2886 , A61K9/5073 , A61K31/538 , A61K31/70
摘要： The present invention provides sustained-release formulations useful and methods for using the same.
摘要翻译：本发明提供了有用的缓释制剂及其使用方法。

4. 发明申请

US20070048374A1 Bazedoxifene acetate formulations 有权
标题翻译：乙酸巴西多昔芬配方
公开(公告)号：US20070048374A1
公开(公告)日：2007-03-01
申请号：US11508801
申请日：2006-08-23
申请人： Syed Shah , Christopher Diorio , Eric Ehrnsperger , Kadum Ali
发明人： Syed Shah , Christopher Diorio , Eric Ehrnsperger , Kadum Ali
IPC分类号： A61K9/20 , A61K31/55
CPC分类号： A61K9/2095 , A61K31/404 , A61K31/55
摘要： The present invention is directed to formulations of bazedoxifene acetate that have reduced polymorph conversion, compositions containing the same, preparations thereof, and uses thereof.
摘要翻译：本发明涉及具有降低的多晶型转化率的巴西多昔芬乙酸酯的制剂，含有它们的组合物，其制备方法及其用途。

5. 发明申请

US20050227966A1 Bazedoxifene acetate formulations 审中-公开
标题翻译：乙酸巴西多昔芬配方
公开(公告)号：US20050227966A1
公开(公告)日：2005-10-13
申请号：US11100693
申请日：2005-04-07
申请人： Syed Shah , Kadum Ali , Christian Ofslager , Mahdi Fawzi
发明人： Syed Shah , Kadum Ali , Christian Ofslager , Mahdi Fawzi
IPC分类号： A61K9/14 , A61K9/16 , A61K31/00 , A61K31/55
CPC分类号： A61K9/146 , A61K9/1635 , A61K9/1641 , A61K31/55
摘要： The present invention is directed to solid dispersions of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
摘要翻译：本发明涉及醋酸巴西多昔芬，含有它们的组合物，其制备方法及其用途的固体分散体。

6. 发明申请

US20050227964A1 Bazedoxifene ascorbate 失效
标题翻译：巴西多昔芬抗坏血酸
公开(公告)号：US20050227964A1
公开(公告)日：2005-10-13
申请号：US11100902
申请日：2005-04-07
申请人： Mahdi Fawzi , Kadum Ali , Syed Shah
发明人： Mahdi Fawzi , Kadum Ali , Syed Shah
IPC分类号： A61K31/55 , C07D209/12 , C07D43/02
CPC分类号： C07D209/12
摘要： The present invention is directed to bazedoxifene ascorbate, compositions containing the same, dispersions thereof, preparations thereof, and uses thereof.
摘要翻译：本发明涉及抗坏血酸巴西多昔芬，含有它们的组合物，其分散体，制剂及其用途。

7. 发明申请

US20070015824A1 Serotonin and norepinephrine reuptake inhibitor and uses thereof 失效
标题翻译： 5-羟色胺和去甲肾上腺素再摄取抑制剂及其应用
公开(公告)号：US20070015824A1
公开(公告)日：2007-01-18
申请号：US11486336
申请日：2006-07-13
申请人： Syed Shah , Mahdi Fawzi , Eric Ehrnsperger , Panolil Raveendranath
发明人： Syed Shah , Mahdi Fawzi , Eric Ehrnsperger , Panolil Raveendranath
IPC分类号： A61K31/35 , C07D309/10 , A61K9/48 , A61K9/20
CPC分类号： C07D309/10 , A61K9/20 , A61K9/48
摘要： Selective dual serotonin and norepinephrine reuptake inhibitors are provided. These compounds have a lower side-effect profile and are useful in compositions and products for use in treatment of a variety of conditions including depression, fibromyalgia, anxiety, panic disorder, agoraphobia, post traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, Gilles de la Tourette Syndrome, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction, borderline personality disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, pain, Shy Drager syndrome, Raynaud's syndrome, Parkinson's Disease, and epilepsy.
摘要翻译：提供选择性双重5-羟色胺和去甲肾上腺素再摄取抑制剂。这些化合物具有较低的副作用特征，并且可用于治疗各种病症的组合物和产品，包括抑郁症，纤维肌痛，焦虑症，惊恐障碍，广场恐怖症，创伤后应激障碍，经前期焦虑障碍，注意力缺陷障碍，强迫症，社会焦虑症，广泛性焦虑症，自闭症，精神分裂症，肥胖症，神经性厌食症，神经性贪食症，杜氏综合征，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍，边缘性人格障碍，纤维肌痛综合征，糖尿病性神经病变疼痛，慢性疲劳综合征，疼痛，Shie Drager综合征，雷诺综合征，帕金森病和癫痫。

8. 发明申请

US20070015791A1 Serotonin and norepinephrine reuptake inhibitors and uses thereof 失效
标题翻译： 5-羟色胺和去甲肾上腺素再摄取抑制剂及其用途
公开(公告)号：US20070015791A1
公开(公告)日：2007-01-18
申请号：US11485693
申请日：2006-07-13
申请人： Syed Shah , Mahdi Fawzi , Panolil Raveendranath , Eric Ehrnsperger
发明人： Syed Shah , Mahdi Fawzi , Panolil Raveendranath , Eric Ehrnsperger
IPC分类号： A61K31/445 , C07D211/44
CPC分类号： C07D211/44
摘要： Selective dual serotonin and norepinephrine reuptake inhibitors are provided. These compounds have a lower side-effect profile and are useful in compositions and products for use in treatment of a variety of conditions including depression, fibromyalgia, anxiety, panic disorder, agorophobia, post traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, Gilles de la Tourette Syndrome, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction, borderline personality disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, pain, Shy Drager syndrome, Raynaud's syndrome, Parkinson's Disease, and epilepsy.
摘要翻译：提供选择性双重5-羟色胺和去甲肾上腺素再摄取抑制剂。这些化合物具有较低的副作用特征，并且可用于治疗各种病症的组合物和产品，包括抑郁症，纤维肌痛，焦虑症，惊恐障碍，广泛性恐惧症，创伤后应激障碍，经前焦虑障碍，注意力缺陷障碍，强迫症，社会焦虑症，广泛性焦虑症，自闭症，精神分裂症，肥胖症，神经性厌食症，神经性贪食症，杜氏综合征，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍，边缘性人格障碍，纤维肌痛综合征，糖尿病性神经病变疼痛，慢性疲劳综合征，疼痛，Shie Drager综合征，雷诺综合征，帕金森病和癫痫。

9. 发明申请

US20070015828A1 Highly selective serotonin and norepinephrine dual reuptake inhibitor and use thereof 审中-公开
标题翻译：高选择性5-羟色胺和去甲肾上腺素双重摄取抑制剂及其用途
公开(公告)号：US20070015828A1
公开(公告)日：2007-01-18
申请号：US11485663
申请日：2006-07-13
申请人： Syed Shah , Eric Ehrnsperger , Richard Saunders , Mahdi Fawzi , Rocco Galante , Garth Whiteside
发明人： Syed Shah , Eric Ehrnsperger , Richard Saunders , Mahdi Fawzi , Rocco Galante , Garth Whiteside
IPC分类号： A61K31/277 , A61K31/137
CPC分类号： C07C215/64 , C07B2200/13 , C07C217/52 , C07C2601/14
摘要： Highly selective dual serotonin and norepinephrine reuptake inhibitors are provided. These compounds have a lower side-effect profile and are useful in compositions and products for use in treatment of a variety of conditions including depression, fibromyalgia, anxiety, panic disorder, agorophobia, post traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, Gilles de la Tourette Syndrome, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction, borderline personality disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, pain, visceral pain, Shy Drager syndrome, Raynaud's syndrome, Parkinson's Disease, and epilepsy.
摘要翻译：提供了高选择性双重5-羟色胺和去甲肾上腺素再摄取抑制剂。这些化合物具有较低的副作用特征，并且可用于治疗各种病症的组合物和产品，包括抑郁症，纤维肌痛，焦虑症，惊恐障碍，广泛性恐惧症，创伤后应激障碍，经前焦虑障碍，注意力缺陷障碍，强迫症，社会焦虑症，广泛性焦虑症，自闭症，精神分裂症，肥胖症，神经性厌食症，神经性贪食症，杜氏综合征，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍，边缘性人格障碍，纤维肌痛综合征，糖尿病性神经病变疼痛，慢性疲劳综合征，疼痛，内脏痛，Shie Drager综合征，雷诺综合征，帕金森病和癫痫。

10. 发明申请

US20060223791A1 O-desmethylvenlafaxine and bazedoxifene combination product and uses thereof 审中-公开
标题翻译： O-去甲基文拉法辛和巴多昔芬组合产品及其用途
公开(公告)号：US20060223791A1
公开(公告)日：2006-10-05
申请号：US11386420
申请日：2006-03-22
申请人： Syed Shah , Mahdi Fawzi , Christopher Diorio
发明人： Syed Shah , Mahdi Fawzi , Christopher Diorio
IPC分类号： A61K31/55 , A61K31/205
CPC分类号： C07C215/64 , A61K9/146 , A61K9/1652 , A61K9/209 , A61K9/5047 , A61K9/5084 , A61K31/137 , A61K31/205 , A61K31/55 , A61K45/06 , C07D209/12 , C07D403/12 , A61K2300/00
摘要： A combination product containing at least two active compounds, O-desmethylvenlafaxine or a pharmaceutically acceptable salt thereof and bazedoxifene or a pharmaceutically acceptable salt thereof is described. Also described are methods of making and using this combination product to treat a variety of conditions associated with low circulating estrogen levels or low estrogen receptor activity.
摘要翻译：描述了含有至少两种活性化合物O-去甲基文拉法新或其药学上可接受的盐和巴西多昔芬或其药学上可接受的盐的组合产品。还描述了制备和使用该组合产品以治疗与低循环雌激素水平或低雌激素受体活性相关的各种病症的方法。

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