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    • 6. 发明申请
    • Treated Three-Dimensional Apertured Liners
    • 处理的三维有孔衬里
    • US20150038933A1
    • 2015-02-05
    • US13955148
    • 2013-07-31
    • Kimberly-Clark Worldwide, Inc.
    • Virginia Lee DayFrank Paul AbutoSridhar Ranganathan
    • A61F13/512A61L15/48A61F13/51
    • A61F13/512A61F13/51113A61F13/52A61F2013/51366A61L15/42A61L15/48Y10T428/24273
    • A bodyside liner material for use in disposable absorbent personal care products has an average material plane and includes a plurality of raised areas extending in a z-direction from the average material plane; a plurality of apertures through the liner material; a hydrophobic treatment agent disposed on the raised areas; and a plurality of land areas disposed between the raised areas, wherein the land areas are hydrophilic. The bodyside liner material can also include a plurality of raised areas extending in a z-direction from the average material plane; a plurality of depressed areas alternating with the plurality of raised areas, wherein the depressed areas extend in the opposite z-direction from the average material plane, and wherein the depressed areas are hydrophilic; a plurality of apertures through the liner material, wherein the apertures are disposed only in the depressions; and a hydrophobic treatment agent disposed on the raised areas.
    • 用于一次性吸收性个人护理产品的体侧内衬材料具有平均材料平面,并且包括从平均材料平面沿z方向延伸的多个凸起区域; 通过衬垫材料的多个孔; 设置在凸起区域上的疏水性处理剂; 以及设置在所述凸起区域之间的多个陆地区域,其中所述陆地区域是亲水的。 身体内衬材料还可以包括从平均材料平面沿z方向延伸的多个凸起区域; 多个凹陷区域与所述多个凸起区域交替,其中所述凹陷区域在与所述平均材料平面相反的z方向上延伸,并且其中所述凹陷区域是亲水的; 穿过所述衬里材料的多个孔,其中所述孔仅设置在所述凹陷中; 以及设置在凸起区域上的疏水性处理剂。
    • 10. 发明申请
    • Microneedles With Improved Open Channel Cross-Sectional Geometries
    • 具有改进的开放通道横截面几何的微针
    • US20160106965A1
    • 2016-04-21
    • US14787044
    • 2014-05-20
    • KIMBERLY-CLARK WORLDWIDE, INC.
    • Andrew BakerRussell F. RossSridhar Ranganathan
    • A61M37/00
    • A61M37/0015A61M2037/0023A61M2037/003A61M2037/0038
    • In one aspect a drug delivery device may include a reservoir containing a liquid drug formulation and a microneedle assembly in fluid communication with the reservoir. The microneedle assembly may include a plurality of microneedles, with each microneedle defining an open channel for receiving a drug formulation. The open channel may have a normalized hydraulic radius ranging from about 0.1 to about 0.8. The open channel may also have a liquid-to-solid interfacial energy and a liquid-to-vapor interfacial energy when a fixed volume of the drug formulation is received therein. In addition, the drug formulation and a cross-sectional geometry of the open channel may be selected and configured such that the liquid-to-solid energy exceeds the liquid-to-vapor energy as the length of the fixed volume of drug formulation is increased within the open channel.
    • 在一个方面,药物递送装置可以包括容纳液体药物制剂和与储存器流体连通的微针组件的储存器。 微针组件可以包括多个微针,每个微针限定用于接收药物制剂的开放通道。 开放通道可以具有约0.1至约0.8的归一化液压半径。 当容纳固定体积的药物制剂时,开放通道也可具有液体 - 固体的界面能量和液体至蒸汽的界面能量。 此外,可以选择和构造药物制剂和开放通道的横截面几何形状,使得当药物制剂的固定体积的长度增加时,液体 - 固体能量超过液体至蒸气能量 在开放的渠道内。