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1. 发明授权

US09724537B2 Abnormal electrical conduction blocking apparatus using photodynamic therapy (PDT) 有权
公开(公告)号：US09724537B2
公开(公告)日：2017-08-08
申请号：US14591178
申请日：2015-01-07
申请人： Keio University
发明人： Tsunenori Arai , Shuntaro Hosokawa
IPC分类号： A61N5/06 , A61B19/00 , A61B18/24 , A61K31/409 , A61N5/067
CPC分类号： A61N5/062 , A61B18/24 , A61K31/409 , A61N5/0601 , A61N5/0603 , A61N2005/0626 , A61N2005/0644 , A61N2005/0651 , A61N2005/0663 , A61N2005/067
摘要： There are provided an apparatus and a method for blocking abnormal conduction in the cardiac muscle using a photodynamic therapy or for treating arrhythmia. There is provided a catheter ablation apparatus for the treatment of arrhythmia using a photodynamic therapy, comprising a catheter leading a photoradiation unit to an abnormal electrical conduction site or a hyperexcitability occurring site in the cardiac muscle of a test subject in which a photosensitizer is present by administering the photosensitizer beforehand and which causes arrhythmia, means for generating a light ray with which the abnormal electrical conduction site or the hyperexcitability occurring site is irradiated, and means for transmitting the light ray to the abnormal electrical conduction site or the hyperexcitability occurring site, wherein the photosensitizer used is a water-soluble chlorine-based photosensitizer and the light ray used is a light ray having an excitation wavelength equal to that of the photosensitizer.

2. 发明申请

US20140330261A1 CATHETER FOR PERFORMING PHOTODYNAMIC ABLATION OF CARDIAC MUSCLE TISSUE VIA PHOTOCHEMICAL REACTION 审中-公开
标题翻译：用于通过光化学反应进行心脏肌肉组织的光化学吸收的导管
公开(公告)号：US20140330261A1
公开(公告)日：2014-11-06
申请号：US14336076
申请日：2014-07-21
申请人： KEIO UNIVERSITY
发明人： Tsunenori Arai , Arisa Ito
IPC分类号： A61B18/24
CPC分类号： A61B18/24 , A61B2018/00351 , A61B2018/00577 , A61B2018/00839 , A61N5/0601 , A61N5/0603 , A61N5/062
摘要： This invention provides a catheter used for blocking abnormal conduction in the cardiac muscle using photodynamic therapy or treating arrhythmia and a method for evaluating the therapeutic effects of the catheter. The catheter has a structure that freely bends at its end, which is used for performing photodynamic ablation of cardiac muscle tissue via photochemical reactions in the blood vessel or cardiac lumen. The catheter comprises a light-emitting window for applying a light beam transmitted through an optical fiber to a target site of cardiac muscle tissue and at least two electrodes for potential measurement in the periphery of the light-emitting window.
摘要翻译：本发明提供一种用于使用光动力学治疗或治疗心律失常来阻断心肌异常传导的导管和用于评估导管的治疗效果的方法。导管具有在其端部自由弯曲的结构，其用于通过血管或心脏腔中的光化学反应进行心肌组织的光动力消融。导管包括用于将通过光纤传输的光束施加到心脏肌肉组织的靶位点的发光窗口和用于在发光窗口的周边进行电位测量的至少两个电极。

3. 发明申请

US20140214015A1 SYSTEM FOR PREVENTING BLOOD CHARRING AT LASER BEAM EMITTING SITE OF LASER CATHETER 审中-公开
标题翻译：用于防止激光束激光发射场发生血液充血的系统
公开(公告)号：US20140214015A1
公开(公告)日：2014-07-31
申请号：US14243413
申请日：2014-04-02
申请人： KEIO UNIVERSITY
发明人： Tsunenori Arai , Arisa ITO , Mei TAKAHASHI
IPC分类号： A61B18/24
CPC分类号： A61B18/24 , A61B18/245 , A61B2018/00785
摘要： This invention provides a method and a system for preventing charring at a laser beam emitting site during treatment or diagnosis using a laser catheter for applying a laser beam. The method is intended to control laser beam irradiation of an apparatus equipped with a laser catheter comprising a laser beam transmission means and a laser beam emitting site used for diagnosis or treatment with the irradiation of the inside of a blood vessel or heart cavity with a laser beam. The method for controlling laser beam irradiation is intended to prevent blood charring at a laser emission site of an apparatus equipped with a laser catheter, and the method comprises a step of controlling a laser beam output in accordance with temporal changes in the intensity of the diffuse reflected light beam by erythrocytes applied to the inside of a blood vessel or heart cavity.
摘要翻译：本发明提供一种用于在使用激光导管施加激光束的治疗或诊断期间防止激光束发射部位的炭化的方法和系统。该方法旨在控制配备有激光导管的装置的激光束照射，该激光导管包括激光束传输装置和用于诊断或治疗的激光束发射部位，用激光照射血管或心腔内光束。用于控制激光束照射的方法旨在防止装备有激光导管的装置的激光发射部位处的血液烧焦，并且该方法包括根据扩散的强度的时间变化来控制激光束输出的步骤反射光束被红细胞施加到血管或心脏腔内。

4. 发明申请

US20150141902A1 ABNORMAL ELECTRICAL CONDUCTION BLOCKING APPARATUS USING PHOTODYNAMIC THERAPY (PDT) 有权
标题翻译：异常电导阻塞装置使用光电疗法（PDT）
公开(公告)号：US20150141902A1
公开(公告)日：2015-05-21
申请号：US14591178
申请日：2015-01-07
申请人： Keio University
发明人： Tsunenori Arai , Shuntaro Hosokawa
IPC分类号： A61N5/06 , A61K31/409
CPC分类号： A61N5/062 , A61B18/24 , A61K31/409 , A61N5/0601 , A61N5/0603 , A61N2005/0626 , A61N2005/0644 , A61N2005/0651 , A61N2005/0663 , A61N2005/067
摘要： There are provided an apparatus and a method for blocking abnormal conduction in the cardiac muscle using a photodynamic therapy or for treating arrhythmia. There is provided a catheter ablation apparatus for the treatment of arrhythmia using a photodynamic therapy, comprising a catheter leading a photoradiation unit to an abnormal electrical conduction site or a hyperexcitability occurring site in the cardiac muscle of a test subject in which a photosensitizer is present by administering the photosensitizer beforehand and which causes arrhythmia, means for generating a light ray with which the abnormal electrical conduction site or the hyperexcitability occurring site is irradiated, and means for transmitting the light ray to the abnormal electrical conduction site or the hyperexcitability occurring site, wherein the photosensitizer used is a water-soluble chlorine-based photosensitizer and the light ray used is a light ray having an excitation wavelength equal to that of the photosensitizer.
摘要翻译：提供了使用光动力疗法或用于治疗心律失常来阻断心肌异常传导的装置和方法。提供了一种用于使用光动力疗法治疗心律失常的导管消融装置，其包括将导管单元引导到测试对象的心肌中的异常电传导部位或发生心肌中的过度兴奋性发生部位的导管，其中通过以下方式存在光敏剂：预先施用光敏剂并引起心律不齐的手段，用于产生异常导电部位或过度兴奋发生部位的照射用的光线的手段，以及将光线透射到异常导电部位或发生兴奋发生部位的装置，其中，使用的光敏剂是水溶性氯系光敏剂，所使用的光线是具有与光敏剂相同的激发波长的光线。

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