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1. 发明申请

US20060199855A1 Process for producing atorvastatin hemicalcium 失效
标题翻译：生产阿托伐他汀半钙的方法
公开(公告)号：US20060199855A1
公开(公告)日：2006-09-07
申请号：US11197413
申请日：2005-08-05
申请人： K.S. Keshava Murthy , Yajun Zhao , Daqing Che , Bhaskar Reddy Guntoori , Sammy Chris Duncan , Stephen Horne
发明人： K.S. Keshava Murthy , Yajun Zhao , Daqing Che , Bhaskar Reddy Guntoori , Sammy Chris Duncan , Stephen Horne
IPC分类号： A61K31/401 , C07D207/34
CPC分类号： C07D207/34 , C07D405/06 , Y02P20/55
摘要： A process is provided for preparing pharmaceutical grade atorvastatin hemicalcium salt comprising: (a) deesterifying, wherein R is an ester protecting group to (b) extracting R(R*,R*)-3 into an organic solvent or mixture of solvents, (c) adding a base of formula NR1R2R3 wherein R1, R2 and R3 are independently selected from H, substituted or non-substituted C1 to C7 alkyl, C6 to C9 aryl, C8 to C10 aralkyl or aminoalkyl to form atorvastatin base salt, (d) isolating by precipitation of the above atorvastatin base salt and purifying when necessary,
摘要翻译：提供用于制备药物级阿托伐他汀半钙盐的方法，其包括：（a）脱酯化，其中R是酯保护基团，以（b）将R（R *，R *） - 3提取到有机溶剂或溶剂混合物中 c）加入式NR 1 R 2 R 3 R 3的碱，其中R 1，R 2， R 3和R 3独立地选自H，取代或未取代的C 1 -C 7烷基，C 6至C 9芳基，C 8至C 10芳烷基或氨基烷基以形成阿托伐他汀碱盐，（d）通过上述阿托伐他汀碱盐的沉淀分离，必要时进行纯化，

2. 发明申请

US20050203302A1 Preparation of atorvastatin 失效
标题翻译：阿托伐他汀的制备
公开(公告)号：US20050203302A1
公开(公告)日：2005-09-15
申请号：US10800741
申请日：2004-03-16
申请人： Bhaskar Guntoori , Daqing Che , Fan Wang , Yajun Zhao , K.S. Murthy , Stephen Horne
发明人： Bhaskar Guntoori , Daqing Che , Fan Wang , Yajun Zhao , K.S. Murthy , Stephen Horne
IPC分类号： C07D207/34 , C07D207/416 , C07D27/36
CPC分类号： C07D207/416 , C07D207/34
摘要： A process for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, tert-butylester comprising: (a) reduction of 5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-oxo-1-pentanoic acid, (R)-2-hydroxy-1,2,2-triphenylethyl ester; (b) hydrolysis of (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid, (R)-2-hydroxy-1,2,2-triphenylethyl ester using an alkali base in a solvent to form the acid; (c) alkylation of the acid forming (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, tert-butylester.
摘要翻译：制备（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] 包括：（a）还原5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] -3-氧代-1-戊酸，（R）-2-羟基-1,2,2-三苯乙基酯; （b）（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] -3-羟基-1-戊酸，（R）-2-羟基-1,2,2-三苯基乙基酯，使用碱在溶剂中形成酸; （c）酸形成（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1 - 基] -5-羟基-3-氧代-1-庚酸叔丁酯。

3. 发明申请

US20060153005A1 Determination of anisotropic physical characteristics in and around reservoirs 审中-公开
标题翻译：储层周围各向异性物理特征的确定
公开(公告)号：US20060153005A1
公开(公告)日：2006-07-13
申请号：US11180956
申请日：2005-07-13
申请人： Jorg Herwanger , Stephen Horne
发明人： Jorg Herwanger , Stephen Horne
IPC分类号： G01V1/28
CPC分类号： G01V1/30 , E21B41/0064 , G01V2210/63 , Y02C10/14
摘要： A method and apparatus for use in estimating stress fields in a geological formation are disclosed. The method includes ascertaining a perturbation of stress in the triaxial stress state in a reservoir and in a surrounding rock mass over time; and determining the change in a seismic attribute resulting from the perturbation in the stress. The apparatus includes a program storage medium encoded with instructions that, when executed by a computing device, perform such a method or a computing system programmed to perform such a method.
摘要翻译：公开了一种用于估算地质构造中的应力场的方法和装置。该方法包括确定储层和周围岩体随时间的三轴应力状态下的应力扰动; 并确定由压力扰动产生的地震属性的变化。该装置包括编码有指令的程序存储介质，该指令在由计算设备执行时执行编程为执行这种方法的这种方法或计算系统。

4. 发明申请

US20060017387A1 Inductively-driven plasma light source 审中-公开
标题翻译：电感驱动等离子光源
公开(公告)号：US20060017387A1
公开(公告)日：2006-01-26
申请号：US11176015
申请日：2005-07-07
申请人： Donald Smith , Stephen Horne , Matthew Besen , Paul Blackborow
发明人： Donald Smith , Stephen Horne , Matthew Besen , Paul Blackborow
IPC分类号： H01J7/24 , H05B31/26
CPC分类号： H05G2/001
摘要： An apparatus for producing light includes a chamber that has a plasma discharge region and that contains an ionizable medium. The apparatus also includes a magnetic core that surrounds a portion of the plasma discharge region. The apparatus also includes a pulse power system for providing at least one pulse of energy to the magnetic core for delivering power to a plasma formed in the plasma discharge region. The plasma has a localized high intensity zone.
摘要翻译：一种用于制造光的装置包括具有等离子体放电区域并且包含可电离介质的室。该装置还包括围绕等离子体放电区域的一部分的磁芯。该装置还包括脉冲功率系统，用于向磁芯提供至少一个能量脉冲以将功率传递到等离子体放电区域中形成的等离子体。等离子体具有局部高强度区域。

5. 发明申请

US20050277651A1 Preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride (ziprasidone hydrochloride) 失效
标题翻译：制备无水形式的5- [2- [4-（1,2-苯并异噻唑-3-基）-1-哌嗪基]乙基] -6-氯-1,3-二氢-2H-吲哚-2-酮盐酸盐（齐拉西酮盐酸盐）
公开(公告)号：US20050277651A1
公开(公告)日：2005-12-15
申请号：US10928139
申请日：2004-08-30
申请人： Carlos Zetina-Rocha , Allan Rey , Stephen Horne
发明人： Carlos Zetina-Rocha , Allan Rey , Stephen Horne
IPC分类号： A61K31/496 , C07D417/04 , C07D417/12 , C07D417/14
CPC分类号： C07D417/12
摘要： The present invention relates to new and useful processes for the preparation of the anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride.
摘要翻译：本发明涉及制备无水形式的5- [2- [4-（1,2-苯并异噻唑-3-基）-1-哌嗪基]乙基] -6-氯-1,1- 3-二氢-2H-吲哚-2-酮盐酸盐。

6. 发明申请

US20050033476A1 Method of processing geophysical data 失效
标题翻译：地球物理数据处理方法
公开(公告)号：US20050033476A1
公开(公告)日：2005-02-10
申请号：US10484469
申请日：2002-07-17
申请人： Stephen Horne , Richard Bale
发明人： Stephen Horne , Richard Bale
IPC分类号： G01V1/00 , G01V1/30 , G05B19/04
CPC分类号： G01V1/30
摘要： A method of processing geophysical data comprises determining the azimuth of a mirror symmetry plane within the earth from the geophysical data that comprises sets of geophysical data acquired with different source-receiver azimuths. The data are processed to determine attributes of the geophysical data that are azimuth-dependent. One azimuth-dependent attribute of the geophysical data is selected, and a value of the source-receiver azimuth about which the selected attribute exhibits mirror symmetry is determined. This locates a mirror symmetry plane within the earth. The azimuth which the selected attribute exhibits mirror symmetry may be determined by generating an objective function indicative of the difference between the actual value of an attribute at one azimuth and the value predicted for that attribute at that azimuth using a trial estimate of the azimuth of a mirror symmetry plane, and finding the azimuth of a mirror symmetry plane that minimises the objective function.
摘要翻译：处理地球物理数据的方法包括从地球物理数据确定地球内的镜面对称平面的方位角，该地球物理数据包括用不同的源 - 接收机方位获得的地球物理数据集。处理数据以确定与方位角相关的地球物理数据的属性。选择地球物理数据的一个与方位角相关的属性，并且确定所选择的属性呈现出镜像对称性的源 - 接收机方位角的值。这在地球内定位了镜面对称平面。所选择的属性具有镜像对称性的方位角可以通过生成指示在一个方位角处的属性的实际值与在该方位角为该属性预测的值之间的差异的目标函数来确定，其中使用方位角的试验估计镜像对称平面，并找到最小化目标函数的镜像对称平面的方位角。

7. 发明授权

US5633386A Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof 失效
标题翻译：用于制造氟康唑的商业方法和可用于其制造的中间体
公开(公告)号：US5633386A
公开(公告)日：1997-05-27
申请号：US470636
申请日：1995-06-06
申请人： Keshava Murthy , Gamini Weeratunga , Derek J. Norris , Stephen Horne , Derrick L. J. Clive
发明人： Keshava Murthy , Gamini Weeratunga , Derek J. Norris , Stephen Horne , Derrick L. J. Clive
IPC分类号： C07D249/08 , C07D521/00 , C07D403/10
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56
摘要： A process for making Fluconazole is provided comprising carrying out the following scheme of reaction: ##STR1##
摘要翻译：提供制备氟康唑的方法，包括进行以下反应方案： + TR

8. 发明授权

US07545011B2 Semiconductor mount 失效
标题翻译：半导体安装
公开(公告)号：US07545011B2
公开(公告)日：2009-06-09
申请号：US11509944
申请日：2006-08-24
申请人： Stephen Horne , Gary D. Conley
发明人： Stephen Horne , Gary D. Conley
IPC分类号： H01L27/14 , H01L21/00
CPC分类号： H01L31/0508 , H01L31/02008 , H01L31/052 , H01L31/0547 , Y02E10/52
摘要： A mount for a semiconductor device has a first surface with at least one contact region and a second surface. The mount has a substrate to receive the second surface of the semiconductor device and a planar element. The planar element has an aperture sized to surround the semiconductor. A first surface of the planar element is mounted to the substrate and is located to surround the semiconductor device such that the semiconductor device is aligned by the aperture. The mount further has means for mounting the semiconductor device to the substrate in an aligned position. Some embodiments include a method of making and/or using such a mount.
摘要翻译：用于半导体器件的安装件具有至少一个接触区域和第二表面的第一表面。安装座具有用于接收半导体器件的第二表面的基板和平面元件。平面元件具有尺寸设计成围绕半导体的孔径。平面元件的第一表面安装到基板并且被定位成围绕半导体器件，使得半导体器件由孔径对准。该安装件还具有用于将半导体器件以对准位置安装到衬底的装置。一些实施例包括制造和/或使用这种安装件的方法。

9. 发明申请

US20080123313A1 Semiconductor mount 失效
标题翻译：半导体安装
公开(公告)号：US20080123313A1
公开(公告)日：2008-05-29
申请号：US11509944
申请日：2006-08-24
申请人： Stephen Horne , Gary D. Conley
发明人： Stephen Horne , Gary D. Conley
IPC分类号： H05K7/00 , H01L21/50
CPC分类号： H01L31/0508 , H01L31/02008 , H01L31/052 , H01L31/0547 , Y02E10/52
摘要： A mount for a semiconductor device has a first surface with at least one contact region and a second surface. The mount has a substrate to receive the second surface of the semiconductor device and a planar element. The planar element has an aperture sized to surround the semiconductor. A first surface of the planar element is mounted to the substrate and is located to surround the semiconductor device such that the semiconductor device is aligned by the aperture. The mount further has means for mounting the semiconductor device to the substrate in an aligned position. Some embodiments include a method of making and/or using such a mount.
摘要翻译：用于半导体器件的安装件具有至少一个接触区域和第二表面的第一表面。安装座具有用于接收半导体器件的第二表面的基板和平面元件。平面元件具有尺寸设计成围绕半导体的孔径。平面元件的第一表面安装到基板并且被定位成围绕半导体器件，使得半导体器件由孔径对准。该安装件还具有用于将半导体器件以对准位置安装到衬底的装置。一些实施例包括制造和/或使用这种安装件的方法。

10. 发明申请

US20070207990A1 Process for the preparation of phenylcarbamates 失效
标题翻译：苯基氨基甲酸酯的制备方法
公开(公告)号：US20070207990A1
公开(公告)日：2007-09-06
申请号：US11365596
申请日：2006-03-02
申请人： Zhi-Xian Wang , Stephen Horne , K.S. Murthy
发明人： Zhi-Xian Wang , Stephen Horne , K.S. Murthy
IPC分类号： A61K31/553 , A61K31/551 , A61K31/5375 , A61K31/495 , A61K31/445 , A61K31/421 , A61K31/4174 , A61K31/40 , A61K31/397 , A61K31/396 , A61K31/325
CPC分类号： C07C269/04 , C07C271/44
摘要： A process for the preparation of aminoalkyl phenyl carbamate compounds of Formula I, wherein R1 and R2 independently are hydrogen or a C1-6 alkyl; R3 and R4 are the same or different and each is a C1-6 alkyl; or R3 and R4 together with the nitrogen to which they are attached form a cyclic three to eight membered ring, with or without a heteroatom like nitrogen or oxygen; R5 and R6 independently are hydrogen, linear, branched or cyclic C1-6 alkyl; or R5 and R6 together with the nitrogen to which they are attached form a cyclic three to eight membered ring, with or without a heteroatom like nitrogen or oxygen; the carbon centre designated “*” can be racemic or enantiomerically enriched in the (R)— or (S)-configuration; and pharmaceutically acceptable acid addition salts thereof.
摘要翻译：制备式I的氨基烷基苯基氨基甲酸酯化合物的方法，其中R 1和R 2独立地是氢或C 1-6烷基，烷基; R 3和R 4相同或不同，各自为C 1-6烷基; 或R 3和R 4与它们所连接的氮一起形成具有或不具有杂原子如氮或氧的环状三元至八元环; R 5和R 6独立地是氢，直链，支链或环状C 1-6烷基; 或R 5和R 6与它们所连接的氮一起形成具有或不具有杂原子如氮或氧的环状三元至八元环; 指定为“*”的碳中心可以是（R） - 或（S） - 构型的外消旋或对映异构体富集; 及其药学上可接受的酸加成盐。

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