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1. 发明授权

US08747845B2 Methods of treatment by administering antibodies that bind colony stimulating factor 1 receptor (CSF1R) 有权
标题翻译：通过施用结合集落刺激因子1受体（CSF1R）的抗体进行治疗的方法
公开(公告)号：US08747845B2
公开(公告)日：2014-06-10
申请号：US13464503
申请日：2012-05-04
申请人： Justin Wong , Maximiliano Vasquez
发明人： Justin Wong , Maximiliano Vasquez
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/2866 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/11 , C12N15/63
摘要： Antibodies that bind CSF1R are provided. Antibody heavy chains and light chains that are capable of forming antibodies that bind CSF1R are also provided. Polynucleotides encoding antibodies to CSF1R are provided. Polynucleotides encoding antibody heavy chains and lights chains are also provided. Methods of treatment using antibodies to CSF1R are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis, bone loss, and multiple sclerosis.
摘要翻译：提供了结合CSF1R的抗体。还提供能够形成结合CSF1R的抗体的抗体重链和轻链。提供编码CSF1R抗体的多核苷酸。还提供了编码抗体重链和灯链的多核苷酸。提供使用抗CSF1R抗体的方法。这些方法包括但不限于治疗类风湿性关节炎，骨丢失和多发性硬化症的方法。

2. 发明申请

US20110274683A1 Antibodies That Bind CSF1R 有权
标题翻译：绑定CSF1R的抗体
公开(公告)号：US20110274683A1
公开(公告)日：2011-11-10
申请号：US13100990
申请日：2011-05-04
申请人： Justin Wong , Maximiliano Vasquez
发明人： Justin Wong , Maximiliano Vasquez
IPC分类号： A61K39/395 , A61P19/02 , C12N5/0786 , C12N1/15 , C12N1/19 , A61P35/00 , C07K16/28 , C07H21/04 , A61P35/02 , A61P25/00 , A61P19/00 , C12N5/10 , C12N5/02
CPC分类号： C07K16/2866 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/11 , C12N15/63
摘要： Antibodies that bind CSF1R are provided. Antibody heavy chains and light chains that are capable of forming antibodies that bind CSF1R are also provided. Polynucleotides encoding antibodies to CSF1R are provided. Polynucleotides encoding antibody heavy chains and lights chains are also provided. Methods of treatment using antibodies to CSF1R are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis, bone loss, and multiple sclerosis.
摘要翻译：提供了结合CSF1R的抗体。还提供能够形成结合CSF1R的抗体的抗体重链和轻链。提供编码CSF1R抗体的多核苷酸。还提供了编码抗体重链和灯链的多核苷酸。提供使用抗CSF1R抗体的方法。这些方法包括但不限于治疗类风湿性关节炎，骨丢失和多发性硬化症的方法。

3. 发明申请

US20120219524A1 ANTIBODIES THAT BIND COLONY STIMULATING FACTOR 1 RECEPTOR (CSF1R) 有权
标题翻译：结核分枝杆菌刺激因子1受体（CSF1R）的抗体
公开(公告)号：US20120219524A1
公开(公告)日：2012-08-30
申请号：US13464503
申请日：2012-05-04
申请人： Justin Wong , Maximiliano Vasquez
发明人： Justin Wong , Maximiliano Vasquez
IPC分类号： A61K38/21 , A61P25/00 , A61P35/02 , A61P19/08 , A61P35/00 , A61P19/10 , A61K39/395 , A61P19/02
CPC分类号： C07K16/2866 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/11 , C12N15/63
摘要： Antibodies that bind CSF1R are provided. Antibody heavy chains and light chains that are capable of forming antibodies that bind CSF1R are also provided. Polynucleotides encoding antibodies to CSF1R are provided. Polynucleotides encoding antibody heavy chains and lights chains are also provided. Methods of treatment using antibodies to CSF1R are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis, bone loss, and multiple sclerosis.
摘要翻译：提供了结合CSF1R的抗体。还提供能够形成结合CSF1R的抗体的抗体重链和轻链。提供编码CSF1R抗体的多核苷酸。还提供了编码抗体重链和灯链的多核苷酸。提供使用抗CSF1R抗体的方法。这些方法包括但不限于治疗类风湿性关节炎，骨丢失和多发性硬化症的方法。

4. 发明授权

US08206715B2 Antibodies that bind colony stimulating factor 1 receptor (CSF1R) 有权
标题翻译：结合集落刺激因子1受体（CSF1R）的抗体
公开(公告)号：US08206715B2
公开(公告)日：2012-06-26
申请号：US13100990
申请日：2011-05-04
申请人： Justin Wong , Maximiliano Vasquez
发明人： Justin Wong , Maximiliano Vasquez
IPC分类号： A61K39/395 , C07K16/00 , C12P21/08
CPC分类号： C07K16/2866 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/11 , C12N15/63
摘要： Antibodies that bind CSF1R are provided. Antibody heavy chains and light chains that are capable of forming antibodies that bind CSF1R are also provided. Polynucleotides encoding antibodies to CSF1R are provided. Polynucleotides encoding antibody heavy chains and lights chains are also provided. Methods of treatment using antibodies to CSF1R are provided. Such methods include, but are not limited to, methods of treating rheumatoid arthritis, bone loss, and multiple sclerosis.
摘要翻译：提供了结合CSF1R的抗体。还提供能够形成结合CSF1R的抗体的抗体重链和轻链。提供编码CSF1R抗体的多核苷酸。还提供了编码抗体重链和灯链的多核苷酸。提供使用抗CSF1R抗体的方法。这些方法包括但不限于治疗类风湿性关节炎，骨丢失和多发性硬化症的方法。

5. 发明授权

US08877688B2 Rationally designed, synthetic antibody libraries and uses therefor 有权
标题翻译：合理设计的合成抗体文库及其用途
公开(公告)号：US08877688B2
公开(公告)日：2014-11-04
申请号：US12404059
申请日：2009-03-13
申请人： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
发明人： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
IPC分类号： C40B40/08
CPC分类号： C12N15/1093 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
摘要翻译：本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。图书馆旨在反映人类免疫系统自然产生的免疫缺陷病毒库，具有或不具有衍生自其他物种的DH区段，并且基于通过检查可公开获得的抗体序列数据库而得出的合理设计。

6. 发明授权

US08691730B2 Rationally designed, synthetic antibody libraries and uses therefor 有权
标题翻译：合理设计的合成抗体文库及其用途
公开(公告)号：US08691730B2
公开(公告)日：2014-04-08
申请号：US12210072
申请日：2008-09-12
申请人： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
发明人： Maximiliano Vasquez , Michael Feldhaus , Tillman U. Gerngross , K. Dane Wittrup
IPC分类号： C40B40/08
CPC分类号： C07K16/18 , C07K16/005 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/10
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
摘要翻译：本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。这些图书馆旨在反映由人类免疫系统自然产生的免疫缺陷文库，并且基于通过检查公开可得到的人抗体序列数据库的合理设计。

7. 发明申请

US20110158986A1 HUMANIZED ANTIBODIES THAT SEQUESTER AMYLOID BETA PEPTIDE 有权
标题翻译：氨基酸肽序列的人类抗体
公开(公告)号：US20110158986A1
公开(公告)日：2011-06-30
申请号：US12976282
申请日：2010-12-22
申请人： David M. Holtzman , Ronald DeMattos , Kelly R. Bales , Steven M. Paul , Naoya Tsurushita , Maximiliano Vasquez
发明人： David M. Holtzman , Ronald DeMattos , Kelly R. Bales , Steven M. Paul , Naoya Tsurushita , Maximiliano Vasquez
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/63 , C12N5/10 , A61P25/00 , A61P25/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble Aβ peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13-28 of the amyloid beta peptide Aβ.
摘要翻译：描述了以预防和治疗形成淀粉样斑块为特征的病症的治疗方法。该方法采用螯合可溶性A＆Bgr的人源化抗体来自人类生物流体的肽或其优选特异性结合淀粉样蛋白β肽A＆bgr的第13-28位含有的表位。

8. 发明授权

US07851600B2 Anti-CCR5 antibody 有权
标题翻译：抗CCR5抗体
公开(公告)号：US07851600B2
公开(公告)日：2010-12-14
申请号：US11581944
申请日：2006-10-16
申请人： William C. Olson , Paul J. Maddon , Naoya Tsurushita , Paul R. Hinton , Maximiliano Vasquez
发明人： William C. Olson , Paul J. Maddon , Naoya Tsurushita , Paul R. Hinton , Maximiliano Vasquez
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The invention is directed an anti-CCR5 antibody which comprises (i) two light chains, each light chain comprising the expression product of a plasmid designated pVK:HuPRO140-VK (ATCC Deposit Designation PTA-4097), and (ii) two heavy chains, each heavy chain comprising an expression product of either a plasmid designated pVg1:HuPRO140 HG2-VH (ATCC Deposit Designation PTA-4098) or a plasmid designated pVg1:HuPRO140 (mutB+D+I)-VH (ATCC Deposit Designation PTA-4099) or a fragment thereof which binds to CCR5 on the surface of a human cell.
摘要翻译：本发明涉及抗CCR5抗体，其包含（i）两条轻链，每条轻链包含命名为pVK：HuPRO140-VK（ATCC保藏号PTA-4097）的质粒的表达产物，和（ii）两条重链每个重链包含称为pVg1：HuPRO140HG2-VH（ATCC保藏号PTA-4098）的质粒或称为pVg1：HuPRO140（mutB + D + I）-VH（ATCC保藏号PTA-4099）的质粒的表达产物）或其与人细胞表面上的CCR5结合的片段。

9. 发明授权

US07771720B2 Humanized PAI-1 antibodies 有权
标题翻译：人源化PAI-1抗体
公开(公告)号：US07771720B2
公开(公告)日：2010-08-10
申请号：US12205760
申请日：2008-09-05
申请人： Donald E. Staunton , Maximiliano Vasquez
发明人： Donald E. Staunton , Maximiliano Vasquez
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/36 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present application relates to compositions of humanized anti-PAI-1 antibodies and antigen-binding fragments thereof which convert PAI-1 to its latent form. One aspect relates to antibodies having one or more modifications in at least one amino acid residue of at least one of the framework regions of the variable heavy chain, the variable light chain or both. Another aspect relates to antibodies which bind and neutralize PAI-1 by converting PAI-1 to its latent form or increasing proteolytic cleavage. Another aspect relates to the use of humanized antibodies which inhibit or neutralize PAI-1 for the detection, diagnosis or treatment of a disease or condition associated with PAI-1 or a combination thereof.
摘要翻译：本申请涉及将PAI-1转化为其潜在形式的人源化抗PAI-1抗体及其抗原结合片段的组合物。一个方面涉及在可变重链，可变轻链或两者的至少一个框架区的至少一个氨基酸残基中具有一个或多个修饰的抗体。另一方面涉及通过将PAI-1转化为其潜在形式或增加蛋白水解切割而结合和中和PAI-1的抗体。另一方面涉及抑制或中和PAI-1用于检测，诊断或治疗与PAI-1或其组合相关的疾病或病症的人源化抗体的用途。

10. 发明申请

US20060251645A1 Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith 失效
标题翻译：与B7-2反应的人源化免疫球蛋白及其治疗方法
公开(公告)号：US20060251645A1
公开(公告)日：2006-11-09
申请号：US11294680
申请日：2005-12-05
申请人： Man Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Celniker , Mary Collins , Samuel Goldman , Gary Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida Veldman
发明人： Man Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Celniker , Mary Collins , Samuel Goldman , Gary Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida Veldman
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/44 , C12N5/06
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/73 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译：本发明涉及包含非人源可变区和人源免疫球蛋白的至少一部分的人源化抗B7-2抗体。本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。

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