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1. 发明授权

US4377511A Preparation for control of T-system of immunity and method for producing same 失效
标题翻译：免疫T系统的控制准备及其制备方法
公开(公告)号：US4377511A
公开(公告)日：1983-03-22
申请号：US203347
申请日：1980-11-03
申请人： Jury M. Lopukhin , Rem V. Petrov , Vitaly Y. Arion , Jury N. Breusov , Tatyana V. Gladysheva , Irina V. Sanina , Vasily V. Lebedev , Serafima S. Kirzon , Evgeny F. Ivanushkin
发明人： Jury M. Lopukhin , Rem V. Petrov , Vitaly Y. Arion , Jury N. Breusov , Tatyana V. Gladysheva , Irina V. Sanina , Vasily V. Lebedev , Serafima S. Kirzon , Evgeny F. Ivanushkin
IPC分类号： A61K35/24 , A61K35/26 , A61K38/00 , A61K38/22 , A61P7/00 , A61P35/00 , A61P37/00 , C07G7/00 , A61K37/00
CPC分类号： A61K35/26 , Y10S530/837
摘要： The present invention relates to immunopharmacology and, more specifically, to a preparation controlling the T-system of immunity and to a method for producing the same.The preparation controlling the T-system of immunity is characterized by its content as the active principle, peptides with a molecular mass of from 1,500 to 6,000 Dalton having absorption maximum in UV-light at 280 and 275 nm and electrophoretic mobility in a polyacrylamide gel relative to bromophenol blue: 0.062-0.102; 0.156-0.236; 0.354-0.374; 0.382-0.422; 0.432-0.472; 0.485-0.545; 0.850-0.930.The method for producing the preparation according to the present invention comprises homogenization of a tissue of thymus gland in a solution of sodium chloride; the homogenizate is kept for 12-16 hours at a temperature of from 2.degree. to 6.degree. C., the residue is removed, thermolabile proteins are removed from the solution, peptides and proteins are precipitated and then dissolved and peptides are salted-out from the solution successively in three stages, the residue of peptides is removed, ultrafiltered through a membrane with a rated retention limit relative to globular proteins of from 12,000 to 30,000, the ultrafiltrate is gel-chromatographed to isolate peptides with a molecular mass of from 1,500 to 6,000 Dalton, desalted and lyophilized.This preparation is used for the treatment of primary and secondary immunodeficient states, diseases caused by malignant neoplasms, psoriasis and other pathological states.
摘要翻译：本发明涉及免疫药理学，更具体地涉及控制免疫T系统的制剂及其制备方法。控制免疫T系统的制剂的特征在于其作为活性成分的含量，分子量为1,500至6,000道尔顿的肽在280和275nm的紫外光下具有最大吸收和聚丙烯酰胺凝胶相对电泳迁移率至溴酚蓝：0.062-0.102; 0.156-0.236; 0.354-0.374; 0.382-0.422; 0.432-0.472; 0.485-0.545; 0.850-0.930。根据本发明的制备方法包括在氯化钠溶液中均匀化胸腺组织; 匀浆在2℃至6℃的温度下保持12-16小时，除去残余物，从溶液中除去不溶性蛋白质，使肽和蛋白质沉淀，然后溶解，将肽从该溶液依次分三个步骤，除去肽残余物，通过相对于球状蛋白的保留极限为12,000至30,000的膜进行超滤，将超滤液凝胶色谱分离以分离分子量为1,500至 6,000道尔顿，脱盐并冻干。该制剂用于治疗原发性和继发性免疫缺陷状态，由恶性肿瘤引起的疾病，牛皮癣和其他病理状态。

2. 发明授权

US5786334A Hexapeptide having immunostimulatory activity 失效
标题翻译：具有免疫刺激活性的六肽
公开(公告)号：US5786334A
公开(公告)日：1998-07-28
申请号：US143815
申请日：1993-10-27
申请人： Rem V. Petrov , Agusta A. Mikhatlova , Stanklav Jn. Shanurin , Ludmila A. Zakharova , Larissa A. Fonina , Elena A. Kirilina , Sergey A. Gur'yanov
发明人： Rem V. Petrov , Agusta A. Mikhatlova , Stanklav Jn. Shanurin , Ludmila A. Zakharova , Larissa A. Fonina , Elena A. Kirilina , Sergey A. Gur'yanov
IPC分类号： A61K38/00 , A61K39/39 , C07K5/107 , C07K7/06 , C07K14/805 , A61K38/08
CPC分类号： C07K7/06 , A61K39/39 , C07K14/805 , C07K5/1016 , A61K38/00
摘要： The hexapeptide Phe--Leu--Gly--Phe--Pro--Thr, which is derived from a myelopeptide, exhibits immunostimulatory activity when administered to a mammal.
摘要翻译：衍生自骨髓肽的六肽Phe-Leu-Gly-Phe-Pro-Thr在给予哺乳动物时表现出免疫刺激活性。

3. 发明授权

US06469137B1 Myelopeptides and their therapeutic use 失效
标题翻译：骨髓和其治疗用途
公开(公告)号：US06469137B1
公开(公告)日：2002-10-22
申请号：US09341173
申请日：1999-09-07
申请人： Rem V. Petrov , Augusta A. Mikhailova , Larissa A. Fonina , Sergei A. Guriyanov
发明人： Rem V. Petrov , Augusta A. Mikhailova , Larissa A. Fonina , Sergei A. Guriyanov
IPC分类号： C07K706
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1019 , Y02A50/481
摘要： The present invention pertains to peptides comprising 4 to 10 amino acids including X1-Pro, Pro-X2 or X1-Pro-X2, wherein X1 and X2 are independently selected from Lys, Arg, His, Asp, Glu, Asn and Gin, and the other amino acids are independently selected from Gly, Ala, Val, Leu, Ile, Nle, Nva, Pro, Phe, Tyr, Trp, Cys, Met, Ser and Thr. Such peptides, including LVCYPQ (SEQ ID NO: 3), FRPRIMTP (SEQ ID NO: 4), VVYPD (SEQ ID NO: 5) and VDPP (SEQ ID NO: 6), are obtainable from porcine bone marrow cell culture, and have immunostimulating and anti-viral properties.
摘要翻译：本发明涉及包含4-10个氨基酸，包括X1-Pro，Pro-X2或X1-Pro-X2的肽，其中X1和X2独立地选自Lys，Arg，His，Asp，Glu，Asn和Gin，以及其他氨基酸独立地选自Gly，Ala，Val，Leu，Ile，Nle，Nva，Pro，Phe，Tyr，Trp，Cys，Met，Ser和Thr。包括LVCYPQ（SEQ ID NO：3），FRPRIMTP（SEQ ID NO：4），VVYPD（SEQ ID NO：5）和VDPP（SEQ ID NO：6）的这些肽可从猪骨髓细胞培养获得，具有免疫刺激和抗病毒性质。

4. 发明授权

US5811100A Compounds for the prevention and treatment of helmith infections 失效
标题翻译：用于预防和治疗蠕虫感染的化合物
公开(公告)号：US5811100A
公开(公告)日：1998-09-22
申请号：US655282
申请日：1996-05-15
申请人： Emma K. Daugalieva , Arkady V. Nekrasov , Rem V. Petrov , Rakhim M. Khaitov , Ravshan I. Ataullakhanov
发明人： Emma K. Daugalieva , Arkady V. Nekrasov , Rem V. Petrov , Rakhim M. Khaitov , Ravshan I. Ataullakhanov
IPC分类号： A61K45/00 , A61K35/12 , A61K35/56 , A61K39/00 , A61K39/385 , A61K39/39 , A61K47/34 , A61P33/02 , C08F226/06 , C08G73/06 , C12N11/08 , A61K38/00 , C07D243/08
CPC分类号： C08G73/0633 , A61K39/0003 , C12N11/08 , A61K2039/6093
摘要： A compound for protecting a vertebrate against infection by helminths comprising hyaluronidase covalently coupled to an immunostimulating carrier, in preferred form, the immunostimulating carrier to which the hyaluronidase is covalently coupled comprising a copolymer of ethylenepiperazine N-oxide and N-ethylacetylethylenepiperazinium bromide (hereafter referred to as "SYNPOL"), and a process for protecting a vertebrate against infection by helminths comprising administration to the vertebrate of a therapeutically effective amount of a compound comprising hyaluronidase covalently coupled to an immunostimulating carrier, preferably SYNPOL, in preferred form, the compound being administered to the vertebrate in the form of a vaccine.
摘要翻译：用于保护脊椎动物免受蠕虫感染的化合物，其包含透明质酸偶联于免疫刺激载体（优选形式）的免疫刺激载体，所述免疫刺激载体与所述透明质酸酶共价偶联的免疫刺激载体包括乙基哌嗪N-氧化物和N-乙基乙酰基乙基哌嗪鎓溴化物的共聚物（以下称为作为“SYNPOL”）以及保护脊椎动物免受蠕虫感染的方法，包括向脊椎动物施用治疗有效量的包含透明质酸酶的化合物，其共价偶联于免疫刺激载体，优选SYNPOL，优选形式，所施用的化合物以疫苗的形式给脊椎动物。

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