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1. 发明授权

US4415738A Process for the production thiazolines-(3) 失效
标题翻译：生产噻唑啉的方法 - （3）
公开(公告)号：US4415738A
公开(公告)日：1983-11-15
申请号：US281858
申请日：1981-07-09
申请人： Jurgen Martens , Paul Scherberich , Horst Bethge , Axel Kleemann
发明人： Jurgen Martens , Paul Scherberich , Horst Bethge , Axel Kleemann
IPC分类号： C07D277/10 , C07D277/60 , C07D277/08
CPC分类号： C07D277/60 , C07D277/10
摘要： There are produced thiazoline-(3) compounds which optionally are substituted or unsubstituted in the 2 and/or 5 positions by reaction of oxo compounds with a metal sulfides, ammonia and oxo compounds which are substituted by halogen in the position adjacent to the oxo group. In this process a mixture of oxo compounds, metal sulfides and ammonia is present and the halogen substituted oxo compound is introduced into the mixture. By using in this manner of mixing, high yields are obtained in a relatively short period of time.
摘要翻译：产生噻唑啉 - （3）化合物，其任选在2和/或5位上被取代或未取代，其中氧代化合物与金属硫化物，氨和氧代化合物的反应，所述卤代化合物在与氧代基相邻的位置被卤素取代。在该方法中，存在氧化合物，金属硫化物和氨的混合物，并将卤素取代的氧代化合物引入混合物中。通过以这种混合方式使用，在相对短的时间内获得高产率。

2. 发明授权

US4469876A Process for the production of L-proline 失效
标题翻译：生产L-脯氨酸的方法
公开(公告)号：US4469876A
公开(公告)日：1984-09-04
申请号：US418841
申请日：1982-09-16
申请人： Karlheinz Drauz , Axel Kleemann , Jurgen Martens , Paul Scherberich , Franz Effenberger
发明人： Karlheinz Drauz , Axel Kleemann , Jurgen Martens , Paul Scherberich , Franz Effenberger
IPC分类号： C07D207/16 , C07D207/22 , C07D207/12
CPC分类号： C07D207/16 , C07D207/22
摘要： L-proline is produced from the methyl or ethyl ester of L-pyroglutamic acid by reacting this with at least twice the molar amount of phosgene to form the corresponding 1-chlorocarbonyl-5,5-dichloroproline ester, producing the corresponding 2-chloro-1-chlorocarbonyl-pyrrolin-(2)-carboxylic acid ester-(5) therefrom by splitting off hydrogen chloride, catalytically hydrogenating the pyrrolin-(2) compound to the corresponding N-chlorocarbonyl-proline ester and hydrolyzing the latter with acid to form L-proline.
摘要翻译：通过将其与至少两倍摩尔量的光气反应形成相应的1-氯羰基-5,5-二氯脯氨酸酯，由L-焦谷氨酸的甲酯或乙酯制备L-脯氨酸，产生相应的2-氯 - 通过分离氯化氢，将吡咯啉 - （2）化合物催化氢化成相应的N-氯羰基 - 脯氨酸酯并用酸水解后者形成1-氯羰基 - 吡咯啉 - （2） - 羧酸酯 - （5） L-脯氨酸。

3. 发明授权

US4345072A Process for the production of 5-arylidene hydantoins (B) 失效
标题翻译：生产5-亚芳基乙内酰脲（B）的方法
公开(公告)号：US4345072A
公开(公告)日：1982-08-17
申请号：US251540
申请日：1981-04-06
申请人： Axel Kleemann , Theodor Lussling , Wolf Pfeifer , Paul Scherberich
发明人： Axel Kleemann , Theodor Lussling , Wolf Pfeifer , Paul Scherberich
IPC分类号： C07D233/96 , C07D233/72 , C07D233/76
CPC分类号： C07D233/96
摘要： 5-Arylidene hydantoins are produced by condensation of an aromatic aldehyde with hydantoin in the presence of at least one ammonium salt of an aliphatic or aromatic carboxylic acid. The desired 5-arylidene hydantoins are obtained in high yields.
摘要翻译： 5-亚芳基乙内酰脲通过芳族醛与乙内酰脲在至少一种脂族或芳族羧酸的铵盐的存在下缩合来制备。以高产率获得所需的5-亚芳基乙内酰脲。

4. 发明授权

US4228082A N-Substituted .alpha.-ketocarboxylic acid amides 失效
标题翻译： N-取代的α-酮羧酸酰胺
公开(公告)号：US4228082A
公开(公告)日：1980-10-14
申请号：US56084
申请日：1979-07-09
申请人： Axel Kleemann , Herbert Klenk , Heribert Offermanns , Paul Scherberich , Werner Schwarze
发明人： Axel Kleemann , Herbert Klenk , Heribert Offermanns , Paul Scherberich , Werner Schwarze
IPC分类号： A01N25/00 , A01P3/00 , A01P13/00 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/08 , C07C235/72 , C07D307/54 , C07C103/737 , C07C103/76
CPC分类号： C07D307/54
摘要： Compounds are prepared of the formula ##STR1## where R' is a t-alkyl group having 4 to 18 carbon atoms, preferably t-butyl, t-amyl or t-octyl and R is a straight or branched chain alkyl group with 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms or an alkyl group substituted with one or more phenyl group or a halogen atom, particularly a chlorine atom, or a cycloalkyl group with 3 to 8 carbon atoms, particularly cyclopropyl, which can be substituted by one or more 1 to 3 carbon atom alkyl groups or one or more halogen atoms, preferably chlorine, or phenyl or naphthyl or a five membered heterocyclic group or such phenyl, naphthyl or heterocyclic group substituted by halogen atoms, nitro groups, alkyl or alkoxy with 1 to 5 carbon atoms by condensing in acid medium an acyl cyanide of the formulaR--CO--CN (II)where R is as defined above with either(a) a tertiary alcohol of the formulaHO--R' (III) in which R' is as defined above, or preferably(b) an alkene of the formula ##STR2## where R.sub.1 and R.sub.2 are the same or different and are hydrogen or an alkyl group and wherein R.sub.3 and R.sub.4 are the same or different and wherein the alkyl groups in each case can be 1 to 15 carbon atoms. Some of the compounds are new. They are useful as intermediates for synthesizing herbicides and can be used directly as fungicides.
摘要翻译：化合物由式（I）制备，其中R'是具有4至18个碳原子的叔烷基，优选叔丁基，叔戊基或叔辛基，R是直链或支链烷基具有1至18个碳原子，优选1至10个碳原子的烷基或被一个或多个苯基或卤素原子，特别是氯原子或具有3至8个碳原子的环烷基特别是环丙基取代的烷基，其可以被一个或多个1至3个碳原子的烷基或一个或多个卤素原子，优选氯，或苯基或萘基或五元杂环基或被卤素原子取代的苯基，萘基或杂环基，硝基，烷基或具有1至5个碳原子的烷氧基，通过在酸性介质中缩合式R-CO-CN（II）的酰基氰，其中R如上定义，与（a）式HO-R'（III ），其中R'如上所定义，或优选（b）下式的烯烃（I） V）其中R 1和R 2相同或不同并且是氢或烷基，并且其中R 3和R 4相同或不同，并且其中每种情况下的烷基可以是1至15个碳原子。一些化合物是新的。它们可用作合成除草剂的中间体，可直接用作杀真菌剂。

5. 发明授权

US4254035A Process for the production of 2-acetamidocinnamic acid 失效
标题翻译： 2-乙酰氨基肉桂酸生产方法
公开(公告)号：US4254035A
公开(公告)日：1981-03-03
申请号：US968923
申请日：1978-12-13
申请人： Axel Kleemann , Horst Weigel , Paul Scherberich
发明人： Axel Kleemann , Horst Weigel , Paul Scherberich
IPC分类号： C07C231/02 , C07C67/00 , C07C231/00 , C07C231/14 , C07C233/47 , C07C233/54 , C07D317/44 , C07C101/42
CPC分类号： C07C231/00
摘要： 2-acetamidocinnamic acid and substituted 2-acetamidocinnamic acids are prepared by reacting glycine with an aromtic aldehyde in the presence of acetic anhydride and a tertiary amine and subsequently treating with water.
摘要翻译： 2-乙酰氨基肉桂酸和取代的2-乙酰氨基肉桂酸是通过甘氨酸与芳香醛在乙酸酐和叔胺的存在下反应并随后用水处理来制备的。

6. 发明授权

US4224226A Process for the production of N-substituted .alpha.-ketocarboxylic acid amides 失效
标题翻译：制备N-取代的α-酮羧酸酰胺的方法
公开(公告)号：US4224226A
公开(公告)日：1980-09-23
申请号：US926322
申请日：1978-07-20
申请人： Axel Kleemann , Herbert Klenk , Heribert Offermanns , Paul Scherberich , Werner Schwarze
发明人： Axel Kleemann , Herbert Klenk , Heribert Offermanns , Paul Scherberich , Werner Schwarze
IPC分类号： A01N25/00 , A01P3/00 , A01P13/00 , C07C67/00 , C07C231/00 , C07C231/06 , C07C231/08 , C07C235/72 , C07D307/54 , C07C102/08
CPC分类号： C07D307/54
摘要： Compounds are prepared of the formula ##STR1## where R' is a t-alkyl group having 4 to 18 carbon atoms, preferably t-butyl, t-amyl or t-octyl and R is a straight or branched chain alkyl group with 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms or an alkyl group substituted with one or more phenyl groups or a halogen atom, particularly a chlorine atom, or a cycloalkyl group with 3 to 8 carbon atoms, particularly cyclopropyl, which can be substituted by one or more 1 to 3 carbon atom alkyl groups or one or more halogen atoms, preferably chlorine, or phenyl or naphthyl or a five membered heterocyclic group or such phenyl, naphthyl or heterocyclic group substituted by halogen atoms, nitro groups, alkyl or alkoxy with 1 to 5 carbon atoms by condensing in acid medium an acyl cyanide of the formulaR--CO--CN (II)where R is as defined above with either(a) a tertiary alcohol of the formulaHO--R' (III) in which R' is as defined above, or preferably(b) an alkene of the formula ##STR2## where R.sub.1 and R.sub.2 are the same or different and are hydrogen or an alkyl group and wherein R.sub.3 and R.sub.4 are the same or different and wherein the alkyl groups in each case can be 1 to 15 carbon atoms. Some of the compounds are new. They are useful as intermediates for synthesizing herbicides and can be used directly as fungicides.
摘要翻译：化合物由式（I）制备，其中R'是具有4至18个碳原子的叔烷基，优选叔丁基，叔戊基或叔辛基，R是直链或支链烷基具有1至18个碳原子，优选1至10个碳原子的烷基或被一个或多个苯基或卤素原子，特别是氯原子或具有3至8个碳原子的环烷基，特别是环丙基取代的烷基，其可以被一个或多个1至3个碳原子的烷基或一个或多个卤素原子，优选氯，或苯基或萘基或五元杂环基或被卤素原子取代的苯基，萘基或杂环基，硝基，烷基或具有1至5个碳原子的烷氧基，通过在酸性介质中缩合式R-CO-CN（II）的酰基氰，其中R如上定义，与（a）式HO-R'（III ），其中R'如上所定义，或优选（b）式“IMAGE”（ IV）其中R 1和R 2相同或不同并且是氢或烷基，并且其中R 3和R 4相同或不同，并且其中每种情况下的烷基可以是1至15个碳原子。一些化合物是新的。它们可用作合成除草剂的中间体，可直接用作杀真菌剂。

7. 发明授权

US4283337A Process for the purification of tryptophane and derivatives of tryptophane 失效
标题翻译：色氨酸和色氨酸衍生物的纯化方法
公开(公告)号：US4283337A
公开(公告)日：1981-08-11
申请号：US94801
申请日：1979-11-15
申请人： Theodor Lussling , Alfred Maierhofer , Paul Scherberich
发明人： Theodor Lussling , Alfred Maierhofer , Paul Scherberich
IPC分类号： C07D209/20
CPC分类号： C07D209/20
摘要： Tryptophane and tryptophane derivatives are purified by treating them in an inert solvent at a temperature between about 20.degree. C. and the boiling point of the mixture with a salt of dithionous acid. Preferably there is used as solvent a mixture of water and a lower aliphatic carboxylic acid. Normally a single treatment results in a pure, colorless, satisfactory product.
摘要翻译：色氨酸和色氨酸衍生物通过在惰性溶剂中在约20℃和混合物与二硫酸盐的沸点之间的温度下处理来纯化。优选地，作为溶剂使用水和低级脂肪族羧酸的混合物。通常单次处理会产生纯净，无色，令人满意的产品。

8. 发明授权

US4245117A Process for the recovery of pure L-cystine 失效
标题翻译：回收纯L-胱氨酸的方法
公开(公告)号：US4245117A
公开(公告)日：1981-01-13
申请号：US52240
申请日：1979-06-26
申请人： Paul Scherberich
发明人： Paul Scherberich
IPC分类号： C07C319/28 , C07C20060101 , C07C67/00 , C07C313/00 , C07C323/58 , C07C149/247
CPC分类号： C07C227/40
摘要： Pure L-cystine is recovered from a mixture with other aminoacids by fractional crystallization in presence of acids and water from an alcoholic medium.
摘要翻译：存在酸和水从醇介质中通过分级结晶从其它氨基酸的混合物中回收纯L-胱氨酸。

9. 发明授权

US4061674A Process of making penicillamine 失效
标题翻译：制作青霉胺的过程
公开(公告)号：US4061674A
公开(公告)日：1977-12-06
申请号：US657605
申请日：1976-02-12
申请人： Friedrich Asinger , Wolf-Dieter Pfeifer , Heribert Offermanns , Paul Scherberich , Gerd Schreyer
发明人： Friedrich Asinger , Wolf-Dieter Pfeifer , Heribert Offermanns , Paul Scherberich , Gerd Schreyer
IPC分类号： C07D277/06 , C07C99/00
CPC分类号： C07D277/06
摘要： Penicillamine or a homolog thereof is obtained by reacting a 2-disubstituted-5,5-alkyl-thiazolidine nitrile, alkyl having 1 to 6 carbon atoms, with a mineral acid in a two-stage proceeding wherein in the first stage relatively low temperatures and a relatively high concentration of the mineral acid are employed while in the second stage the concentration of the acid is relatively low and the temperatures are relatively high, the term "relatively" referring to the relationship of said two stages of the reaction with mineral acid.
摘要翻译：青霉胺或其同系物是通过2-二取代-5,5-烷基 - 噻唑烷腈，具有1至6个碳原子的烷基与无机酸反应得到的，其中在两阶段进行，其中在第一阶段相对低的温度和使用相对高浓度的无机酸，而在第二阶段酸的浓度相对较低并且温度相对较高，术语“相对”是指反应两个阶段与无机酸的关系。

10. 发明授权

US3954783A Resolution process and salt of protected D-penicillamine and L-pseudonorephedrine 失效
标题翻译：保护D-青霉胺和L-假麻黄碱的分辨过程和盐
公开(公告)号：US3954783A
公开(公告)日：1976-05-04
申请号：US436787
申请日：1974-01-25
申请人： Paul Scherberich
发明人： Paul Scherberich
IPC分类号： C07B31/00 , C07B57/00 , C07C67/00 , C07C313/00 , C07C319/28 , C07C323/58 , C07D277/06
CPC分类号： C07D277/06
摘要： D,L-penicillamine is converted to D-penicillamine with the aid of 1-pseudonorephedrine.
摘要翻译： D，L-青霉胺在1-假麻黄碱的帮助下转化为D-青霉胺。

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