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1. 发明授权

US08220642B2 Polysulfone-based blood treatment membrane and method of producing the same 有权
标题翻译：聚砜类血液处理膜及其制造方法
公开(公告)号：US08220642B2
公开(公告)日：2012-07-17
申请号：US12601543
申请日：2008-05-26
申请人： Junya Satoh , Takahiro Ichi , Shunji Maniwa
发明人： Junya Satoh , Takahiro Ichi , Shunji Maniwa
IPC分类号： B01D69/00 , B01D69/02 , B01D67/00
CPC分类号： B01D71/68 , A61L33/068 , B01D67/0011 , B01D69/141 , B01D2325/00 , B01D2325/24 , C08L81/06
摘要： A polysulfone-based blood treatment membrane that exhibits excellent antioxidant properties, excellent long-term storage stability, and a practical strength, and ensures high productivity, a polysulfone-based blood treatment membrane that exhibits excellent antioxidant properties and long-term storage stability, rarely allows endotoxins to enter a treatment liquid, exhibits a practical strength, and ensures high productivity, and a method of producing the same. A polysulfone-based blood treatment membrane includes a polysulfone-based resin, a hydrophilic polymer, and a lipophilic antioxidant, the membrane containing the lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane, and the total amount of the lipophilic antioxidant present on the surface of the membrane being 4 to 25 mg per gram of the membrane. Another polysulfone-based blood treatment membrane contains a lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane, wherein the inner surface of the membrane has a TOF-SIMS normalized peak intensity of the lipophilic antioxidant of 1.8.times.10.sup.-4 or more, and the outer surface of the membrane has a TOF-SIMS normalized peak intensity of the lipophilic antioxidant of 2.4.times.10.sup.-4 or more. A method of producing a polysulfone-based blood treatment membrane that includes a polysulfone-based resin, a hydrophilic polymer, and a lipophilic antioxidant includes producing a membrane intermediate that contains the lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane intermediate, and heating the membrane intermediate at 100 to 180.degree. C. for 0.1 to 360 minutes in a dry state.
摘要翻译：一种聚砜系血液处理膜，其表现出优异的抗氧化性能，优异的长期保存稳定性和实用强度，并且确保高生产率，表现出优异的抗氧化性能和长期保存稳定性的聚砜系血液处理膜，很少允许内毒素进入处理液，具有实用的强度，并且确保高生产率及其制备方法。基于聚砜的血液处理膜包括聚砜系树脂，亲水性聚合物和亲脂性抗氧化剂，每克膜含有30〜76mg的亲脂性抗氧化剂的膜和亲脂性的总量存在于膜表面的抗氧化剂每克膜为4至25mg。

2. 发明申请

US20100133170A1 POLYSULFONE-BASED BLOOD TREATMENT MEMBRANE AND METHOD OF PRODUCING THE SAME 有权
标题翻译：基于聚合物的血液处理膜及其制造方法
公开(公告)号：US20100133170A1
公开(公告)日：2010-06-03
申请号：US12601543
申请日：2008-05-26
申请人： Junya Satoh , Takahiro Ichi , Shunji Maniwa
发明人： Junya Satoh , Takahiro Ichi , Shunji Maniwa
IPC分类号： B01D71/68 , C08J5/00 , B29C47/00 , D04H3/16 , B01D69/08 , B01D67/00 , B01D69/02
CPC分类号： B01D71/68 , A61L33/068 , B01D67/0011 , B01D69/141 , B01D2325/00 , B01D2325/24 , C08L81/06
摘要： A polysulfone-based blood treatment membrane that exhibits excellent antioxidant properties, excellent long-term storage stability, and a practical strength, and ensures high productivity, a polysulfone-based blood treatment membrane that exhibits excellent antioxidant properties and long-term storage stability, rarely allows endotoxins to enter a treatment liquid, exhibits a practical strength, and ensures high productivity, and a method of producing the same. A polysulfone-based blood treatment membrane includes a polysulfone-based resin, a hydrophilic polymer, and a lipophilic antioxidant, the membrane containing the lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane, and the total amount of the lipophilic antioxidant present on the surface of the membrane being 4 to 25 mg per gram of the membrane. Another polysulfone-based blood treatment membrane contains a lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane, wherein the inner surface of the membrane has a TOF-SIMS normalized peak intensity of the lipophilic antioxidant of 1.8×10−4 or more, and the outer surface of the membrane has a TOF-SIMS normalized peak intensity of the lipophilic antioxidant of 2.4×10−4 or more. A method of producing a polysulfone-based blood treatment membrane that includes a polysulfone-based resin, a hydrophilic polymer, and a lipophilic antioxidant includes producing a membrane intermediate that contains the lipophilic antioxidant in an amount of 30 to 76 mg per gram of the membrane intermediate, and heating the membrane intermediate at 100 to 180° C. for 0.1 to 360 minutes in a dry state.
摘要翻译：一种聚砜系血液处理膜，其表现出优异的抗氧化性能，优异的长期保存稳定性和实用强度，并且确保高生产率，表现出优异的抗氧化性能和长期保存稳定性的聚砜系血液处理膜，很少允许内毒素进入处理液，具有实用的强度，并且确保高生产率及其制备方法。基于聚砜的血液处理膜包括聚砜系树脂，亲水性聚合物和亲脂性抗氧化剂，每克膜含有30〜76mg的亲脂性抗氧化剂的膜和亲脂性的总量存在于膜表面的抗氧化剂每克膜为4至25mg。另一种基于聚砜的血液处理膜包含每克膜30至76mg的亲脂性抗氧化剂，其中膜的内表面具有1.8×10-4的亲脂性抗氧化剂的TOF-SIMS归一化峰强度以上，膜的外表面的亲油性抗氧化剂的TOF-SIMS归一化峰强度为2.4×10 -4以上。包含聚砜系树脂，亲水性聚合物和亲脂性抗氧化剂的聚砜系血液处理膜的制造方法包括：制造含有亲油性抗氧化剂的膜中间体，其含量为每克膜30〜76mg 中间体，并在100〜180℃下加热膜中间体0.1〜360分钟。

3. 发明授权

US07441666B2 Process for producing an asymmetric porous film 有权
标题翻译：不对称多孔膜的制造方法
公开(公告)号：US07441666B2
公开(公告)日：2008-10-28
申请号：US10475265
申请日：2002-04-18
申请人： Sung-Teh Kim , Chieko Yamamoto , Toshinori Koizumi , Masatoshi Saitoh , Shunji Maniwa
发明人： Sung-Teh Kim , Chieko Yamamoto , Toshinori Koizumi , Masatoshi Saitoh , Shunji Maniwa
IPC分类号： B01D29/00 , B01D71/68 , B01D71/26 , B01D71/28
CPC分类号： B01D67/0088 , B01D63/021 , B01D67/0011 , B01D67/0093 , B01D69/02 , B01D69/08 , B01D69/12 , B01D71/68 , B01D71/80 , B01D2323/30 , B01D2325/022 , B01D2325/14
摘要： It is intended to provide asymmetric porous films which are usable in blood dialysis, plasma separation, etc. and particularly excellent in the performance of selectively separating (fractionating) plasma protein, show little endogenous coagulation, complement or quinine activily and have an extremely high biocompatibility. Porous films made mainly of a synthetic polymer and having an asymmetric structure wherein, in the sectional structure, a dense layer substantially not charged at least on the outermost surface is provided in the side on which a liquid to be treated is loaded and at least part of the film other than the outermost surface is negatively charged. In the above films, the dense layer non-charged at least on the outermost surface serves as a size barrier while the part of the film other than the outermost surface serves as a charge barrier.
摘要翻译：旨在提供可用于血液透析，血浆分离等的不对称多孔膜，并且特别优选选择性分离（分级）血浆蛋白，活性地显示出少量内源性凝血，补体或奎宁，并且具有极高的生物相容性。主要由合成聚合物制成并具有不对称结构的多孔薄膜，其中在截面结构中，至少在最外表面上基本上未被充填的致密层设置在其上装载待处理液体的一侧，并且至少部分的最外表面以外的膜是带负电荷的。在上述膜中，至少在最外表面上未充电的致密层用作尺寸屏障，而除最外表面之外的膜的部分用作电荷屏障。

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