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1. 发明授权

US4990455A Novel human TNF polypeptide mutants and DNA's encoding said mutants 失效
标题翻译：新型人TNF多肽突变体和DNA编码所述突变体
公开(公告)号：US4990455A
公开(公告)日：1991-02-05
申请号：US64609
申请日：1987-06-22
申请人： Junichi Yamagishi , Hitoshi Kawashima , Ryuji Furuta , Hirotada Kotani , Katuhisa Nakata
发明人： Junichi Yamagishi , Hitoshi Kawashima , Ryuji Furuta , Hirotada Kotani , Katuhisa Nakata
IPC分类号： C12N15/28 , A61K38/00 , C07K14/525
CPC分类号： C07K14/525 , A61K38/00
摘要： A human TNF polypeptide mutant having an amino acid sequence of modified human TNF polypeptide, a DNA having a base sequence encoding the above human TNF polypeptide mutant and a method of producing the above human TNF polypeptide mutant by culturing a host transformed with a vector having inserted therein the above DNA. The above human TNF polypeptide mutant is soluble and has antitumor activity.
摘要翻译：具有修饰的人TNF多肽的氨基酸序列的人TNF多肽突变体，具有编码上述人TNF多肽突变体的碱基序列的DNA和通过培养用插入的载体转化的宿主来生产上述人TNF多肽突变体的方法其中含有上述DNA。上述人TNF多肽突变体是可溶的并具有抗肿瘤活性。

2. 发明授权

US5290917A Modified polypeptides of IL-1.alpha. 失效
标题翻译： IL-1α的修饰多肽
公开(公告)号：US5290917A
公开(公告)日：1994-03-01
申请号：US681077
申请日：1991-04-05
申请人： Michiko Yamayoshi , Hitoshi Kawashima , Junichi Yamagishi , Hirotada Kotani , Ryuji Furuta , Toshikazu Fukui
发明人： Michiko Yamayoshi , Hitoshi Kawashima , Junichi Yamagishi , Hirotada Kotani , Ryuji Furuta , Toshikazu Fukui
IPC分类号： A61K38/00 , C07K14/545 , C07K13/00
CPC分类号： C07K14/545 , A61K38/00 , Y10S930/141
摘要： Novel polypeptides having a modified amino acid sequence of human interleukin 1.alpha. polypeptides in which a certain amino acid residue(s) in said amino acid sequence is(are) exchanged for other amino acid residue(s). Said polypeptides having no capacity of induction of production of prostaglandin E.sub.2 while maintaining other biological activities of human interleukin 1 such as activation of lymphocyte and being expected to be useful as a medicament.
摘要翻译：具有人白细胞介素1α多肽的修饰的氨基酸序列的新型多肽，其中所述氨基酸序列中的某些氨基酸残基被交换为其它氨基酸残基。所述多肽不具有诱导前列腺素E2产生的能力，同时保持人白细胞介素1的其它生物学活性，例如淋巴细胞的活化并预期可用作药物。

3. 发明授权

US5401643A Method of preparing an active human neutrophil chemotactic factor polypeptide 失效
标题翻译：制备活性人嗜中性粒细胞趋化因子多肽的方法
公开(公告)号：US5401643A
公开(公告)日：1995-03-28
申请号：US855471
申请日：1992-03-23
申请人： Masaaki Yamada , Ryuji Furuta , Junichi Yamagishi , Kouji Matsushima
发明人： Masaaki Yamada , Ryuji Furuta , Junichi Yamagishi , Kouji Matsushima
IPC分类号： C12N15/09 , C07K1/14 , C07K1/22 , C07K14/00 , C07K14/52 , C07K14/54 , C12N15/12 , C12P21/00 , C12P21/02 , C12R1/19 , C12N7/00 , C12N15/00 , C12P19/34
CPC分类号： C07K14/5421
摘要： A simple and efficient method of preparing active recombinant human neutrophil chemotactic factor. The human neutrophil chemotactic factor (NCF) is solubilized from a transformant cell homogenate using urea or guanidine hydrochloride. The polypeptide is further purified from the solution using conventional protocols such as CM-Sepharose CL-6B, HW-55 column, etc.. By using this method, large amounts of active human NCF can be recovered and purified.
摘要翻译：一种简单有效的制备活性重组人嗜中性粒细胞趋化因子的方法。使用尿素或盐酸胍从转化细胞匀浆中溶解人嗜中性粒细胞趋化因子（NCF）。使用常规方案如CM-Sepharose CL-6B，HW-55柱等，从溶液中进一步纯化多肽。通过使用该方法，可以回收和纯化大量的活性人类NCF。

4. 发明授权

US5306627A Process for producing a human neutrophil chemotactic factor peptide and a recombinant expression vector for the said polypeptide 失效
标题翻译：用于产生人嗜中性粒细胞趋化因子肽的方法和用于所述多肽的重组表达载体
公开(公告)号：US5306627A
公开(公告)日：1994-04-26
申请号：US711275
申请日：1991-06-04
申请人： Masaaki Yamada , Ryuji Furuta , Junichi Yamagishi , Kouji Matsushima , Teizo Yoshimura
发明人： Masaaki Yamada , Ryuji Furuta , Junichi Yamagishi , Kouji Matsushima , Teizo Yoshimura
IPC分类号： C12N15/09 , A61K38/00 , C07K1/14 , C07K14/00 , C07K14/52 , C07K14/54 , C12N15/12 , C12P21/02 , C12R1/19 , C12N7/00 , C12N15/00 , C12P19/34
CPC分类号： C07K14/5421 , A61K38/00
摘要： An expression vector in which a DNA encoding a human neutrophil chemotactic factor polypeptide is inserted, a transformant (a host cell transformed with the expression vector), and a process for production of the said polypeptide by using the said transformant.
摘要翻译：插入编码人嗜中性粒细胞趋化因子多肽的DNA的表达载体，转化体（用表达载体转化的宿主细胞）和使用所述转化体生产所述多肽的方法。

5. 发明授权

US07129817B2 Apparatus for controlling articles in custody 失效
标题翻译：用于控制羁押物品的装置
公开(公告)号：US07129817B2
公开(公告)日：2006-10-31
申请号：US10210722
申请日：2002-08-01
申请人： Junichi Yamagishi
发明人： Junichi Yamagishi
IPC分类号： G08B29/00 , G06T1/00
CPC分类号： G07C9/00142 , G05B2219/24162 , G07C9/00158 , G07C9/00563 , G07C9/00912 , G07C2009/00936 , G07C2209/08
摘要： An apparatus for reliably and easily controlling articles in custody, for example articles in a safe, has a storage unit lockable to keep the articles therein and unlockable to allow the articles to be taken out therefrom, an input unit to input biometric information for unlocking the storage unit, a registration unit to register biometric information in advance, a collator to collate the input biometric information with the registered biometric information, a controller to unlock the storage unit if the collation by the collator authenticates the input biometric information, and a recorder to record at least a person related to the authenticated biometric information in response to the unlocking of the storage unit.
摘要翻译：一种用于可靠且容易地控制保管物品的设备，例如保险箱中的物品，具有可锁定的存储单元，用于将物品保持在其中并可解锁以允许物品从中取出;输入单元，用于输入生物识别信息以解锁存储单元，用于预先登记生物特征信息的登记单元，用于将输入的生物体信息与登记的生物体信息进行核对的整理机;控制器，用于如果所述整理机的核对对所述输入的生物体信息进行核对，则将所述存储单元解锁，响应于存储单元的解锁，至少记录与认证的生物特征信息相关的人员。

6. 发明授权

US07077399B2 Chip collecting machine 失效
标题翻译：芯片收集机
公开(公告)号：US07077399B2
公开(公告)日：2006-07-18
申请号：US10195345
申请日：2002-07-15
申请人： Junichi Yamagishi
发明人： Junichi Yamagishi
IPC分类号： A47L9/10
CPC分类号： A47L7/0085 , A47L5/365 , G07D9/00
摘要： A chip collecting machine includes an electric fan for sucking air; a suction chamber formed in a substantially cylindrical suction drum for air suction by the electric fan; a suction hose externally connected to and in communication with the suction chamber; and a dust separating filter supported at the upper end of the suction drum to hang downward in the suction chamber. The dust separating filter is interposed between a discharge opening of the suction hose and the electric fan. A substantially cylindrical collecting case is removably arranged outside the dust separating filter in the suction chamber. The inside of the case communicates with the discharge opening of the suction hose.
摘要翻译：芯片收集机包括用于吸入空气的电风扇; 吸入室，形成在大致圆筒形的吸入鼓中，用于通过电风扇进行吸气; 外部连接到吸入室并与吸入室连通的抽吸软管; 以及支撑在吸鼓的上端的吸尘分离过滤器，以在吸入室内向下悬挂。灰尘分离过滤器介于抽吸软管的排出口和电风扇之间。大致圆筒形收集箱可抽吸地布置在抽吸室内的除尘过滤器的外部。壳体内部与抽吸软管的排放口连通。

7. 发明申请

US20060085260A1 Coupon service system 审中-公开
标题翻译：优惠券服务体系
公开(公告)号：US20060085260A1
公开(公告)日：2006-04-20
申请号：US11255224
申请日：2005-10-19
申请人： Junichi Yamagishi
发明人： Junichi Yamagishi
IPC分类号： G06Q30/00
CPC分类号： G06Q20/20 , G06Q20/327 , G06Q30/02 , G06Q30/0225 , G06Q30/0235
摘要： A coupon service system is capable of reducing time and expenses needed for market research, making a correct and sure marketing plan, and providing customers with services that match their respective needs. The coupon service system includes a store terminal provided with a reader. When a cellular phone is brought into a read area of the reader, the reader reads a coupon stored in the cellular phone and determines whether or not the coupon is valid. If the coupon is valid, the reader provides the user of the cellular phone with a service corresponding to the coupon and transmits data related to the user to a management server. The management server stores the data in a customer database.
摘要翻译：优惠券服务系统能够减少市场研究所需的时间和费用，制定正确和可靠的营销计划，并为客户提供符合其各自需求的服务。优惠券服务系统包括设有阅读器的商店终端。当蜂窝电话被带入读取器的读取区域时，读取器读取存储在蜂窝电话中的优惠券并确定优惠券是否有效。如果优惠券有效，则读者向蜂窝电话的用户提供与优惠券相对应的服务，并将与用户相关的数据发送到管理服务器。管理服务器将数据存储在客户数据库中。

8. 发明授权

US06865913B2 Locking apparatus 失效
标题翻译：锁定装置
公开(公告)号：US06865913B2
公开(公告)日：2005-03-15
申请号：US10636141
申请日：2003-08-06
申请人： Junichi Yamagishi
发明人： Junichi Yamagishi
IPC分类号： E05B49/00 , E05B35/08 , E05B45/10 , G07C9/00 , E05B13/10
CPC分类号： G07C9/00563 , Y10T70/5832 , Y10T70/7068
摘要： A locking apparatus has a lock driver to electrically lock and unlock a door, a fingerprint read/verify unit to receive a fingerprint from a user, verify the received fingerprint by comparing it with registered fingerprint data) and if the fingerprint verification authenticates the user, enable the lock driver to electrically operate, a key cylinder attached to the door, an interlink linking the key cylinder with the lock driver, and a key to manually operate the lock driver in cooperation with the key cylinder and the interlink.
摘要翻译：锁定装置具有用于电锁和解锁门的锁定驱动器，指纹读取/验证单元以从用户接收指纹，通过与所登记的指纹数据进行比较来验证所接收的指纹），并且如果指纹验证对用户进行认证，使锁定驱动器电动操作，连接到门的钥匙筒，连接钥匙筒与锁定驱动器的相互连接，以及与钥匙筒和连接件协同操作来手动操作锁定驱动器的钥匙。

9. 发明授权

US06732020B2 Accident notification system for vehicle 失效
标题翻译：车辆事故通知系统
公开(公告)号：US06732020B2
公开(公告)日：2004-05-04
申请号：US10143217
申请日：2002-05-09
申请人： Junichi Yamagishi
发明人： Junichi Yamagishi
IPC分类号： B60Q100
CPC分类号： G08G1/205 , B60R2021/0027
摘要： An accident notification system for a vehicle includes a damage predicting system which detects that a vehicle occupant has been injured in an accident involving the vehicle, a vehicle position detecting system which detects the position of the vehicle, and a mobile communication terminal which receives a signal predicting injury to the vehicle occupant from the damage predicting system to generate a calling from the vehicle to a call center. The call center performs a notification to an accident response facility on the basis of the calling and obtains prediction information that the vehicle occupant has been injured from the damage predicting system and vehicle position information detected by the vehicle position detecting system. Accordingly, even when there is no one who notifies an accident response facility of an accident, emergency cleaning-up after an accident and treatment for an injured vehicle occupant can be made.
摘要翻译：车辆的事故通知系统包括：损坏预测系统，其检测到车辆乘客在涉及车辆的事故中受伤;车辆位置检测系统，其检测车辆的位置;以及移动通信终端，其接收信号从损伤预测系统预测车辆乘员的伤害，以产生从车辆到呼叫中心的呼叫。呼叫中心根据呼叫对事故响应设施进行通知，并且从损伤预测系统获得车辆乘员受伤的预测信息和由车辆位置检测系统检测到的车辆位置信息。因此，即使没有人通知事故应急设备，也可以对受伤的车辆乘员进行事故处理后的紧急清理。

10. 发明授权

US5340867A Flame-retardant rubber compositions 失效
标题翻译：阻燃橡胶组合物
公开(公告)号：US5340867A
公开(公告)日：1994-08-23
申请号：US971472
申请日：1992-11-04
申请人： Kazuo Yagawa , Takatsugu Hashimoto , Junichi Yamagishi , Kazuo Hachiya , Satoshi Takezawa
发明人： Kazuo Yagawa , Takatsugu Hashimoto , Junichi Yamagishi , Kazuo Hachiya , Satoshi Takezawa
IPC分类号： C08K3/02 , C08L21/00 , C08K3/22
CPC分类号： C08K3/02 , C08L21/00
摘要： A flame-retardant rubber composition has an oxygen index of 19.8-27.5 and comprises not more than 24% by weight of red phosphorus as a flame retardant based on the rubber composition and a nitrile group-containing elastomer as a flame-retardant polymer component as a part of rubber ingredients constituting the rubber composition. Such flame-retardant rubber compositions are very useful in applications such as industrial goods, tire and the like strongly requiring the fire preventing function.
摘要翻译：阻燃橡胶组合物的氧指数为19.8-27.5，并且包含不超过24重量％的基于橡胶组合物的阻燃剂的红磷和作为阻燃聚合物组分的含腈基弹性体作为阻燃聚合物组分构成橡胶组合物的橡胶成分的一部分。这种阻燃橡胶组合物在诸如强烈要求防火功能的工业品，轮胎等应用中非常有用。

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