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1. 发明申请

US20100093976A1 USE OF INTERLEUKIN-11 AS THERAPEUTIC AGENT FOR HEART DISEASE 有权
标题翻译：使用作为心脏病的治疗药物的白细胞介素-11
公开(公告)号：US20100093976A1
公开(公告)日：2010-04-15
申请号：US12312077
申请日：2007-10-24
申请人： Junichi Azuma , Yasushi Fujio , Ryusuke Kimura , Makiko Maeda , Atsushi Arita , Masanori Obana , Takashi Ito , Tsuyoshi Fukuda
发明人： Junichi Azuma , Yasushi Fujio , Ryusuke Kimura , Makiko Maeda , Atsushi Arita , Masanori Obana , Takashi Ito , Tsuyoshi Fukuda
IPC分类号： C07K14/54
CPC分类号： A61K38/2073
摘要： The present invention demonstrates the myocardial protective effects of interleukin 11 in vivo, and provides preventive, therapeutic, or other types of drugs for heart disease using interleukin 11 as the active ingredient. The present invention, by utilizing the myocardial protective effects of interleukin 11, can suppress the progress of myocardial injury, prevent the onset of heart failure, or suppress the progress of heart failure.
摘要翻译：本发明证实白细胞介素11在体内的心肌保护作用，并且使用白细胞介素11作为活性成分提供用于心脏病的预防，治疗或其它类型的药物。本发明利用白细胞介素11的心肌保护作用可以抑制心肌损伤的进展，防止心力衰竭的发生，抑制心力衰竭的进展。

2. 发明授权

US08361966B2 Use of interleukin-11 as therapeutic agent for heart disease 有权
标题翻译：使用白细胞介素-11作为心脏病的治疗剂
公开(公告)号：US08361966B2
公开(公告)日：2013-01-29
申请号：US12312077
申请日：2007-10-24
申请人： Junichi Azuma , Yasushi Fujio , Ryusuke Kimura , Makiko Maeda , Atsushi Arita , Masanori Obana , Takashi Ito , Tsuyoshi Fukuda
发明人： Junichi Azuma , Yasushi Fujio , Ryusuke Kimura , Makiko Maeda , Atsushi Arita , Masanori Obana , Takashi Ito , Tsuyoshi Fukuda
IPC分类号： A61K38/20 , C07K14/54
CPC分类号： A61K38/2073
摘要： The present invention demonstrates the myocardial protective effects of interleukin 11 in vivo, and provides preventive, therapeutic, or other types of drugs for heart disease using interleukin 11 as the active ingredient. The present invention, by utilizing the myocardial protective effects of interleukin 11, can suppress the progress of myocardial injury, prevent the onset of heart failure, or suppress the progress of heart failure.
摘要翻译：本发明证实白细胞介素11在体内的心肌保护作用，并且使用白细胞介素11作为活性成分提供用于心脏病的预防，治疗或其它类型的药物。本发明利用白细胞介素11的心肌保护作用可以抑制心肌损伤的进展，防止心力衰竭的发生，抑制心力衰竭的进展。

3. 发明申请

US20100003681A1 GENE POLYMORPHISM USEFUL FOR ASSISTANCE/THERAPY FOR SMOKING CESSATION 审中-公开
标题翻译：基因多态性有助于帮助/治疗吸烟
公开(公告)号：US20100003681A1
公开(公告)日：2010-01-07
申请号：US12310114
申请日：2007-08-09
申请人： Junichi Azuma , Yasushi Fujio , Chieko Taniguchi , Tsuyoshi Fukuda , Makiko Maeda , Tomoko Kubota , Etsuko Tange , Risa Ueki
发明人： Junichi Azuma , Yasushi Fujio , Chieko Taniguchi , Tsuyoshi Fukuda , Makiko Maeda , Tomoko Kubota , Etsuko Tange , Risa Ueki
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/156 , G01N2800/307
摘要： Disclosed is a method for determination of a smoking trend in a subject which is useful for the assistance or therapy for smoking cessation, which comprises the steps of detecting one or more polymorphisms occurring on one or more genes selected from the genes (1) to (3) or a genome or in the neighborhood of the genes or the genome and determining the smoking trend based on the results of the detection: (1) nicotinic acetylcholine receptor β2 subunit (CHRNB2) gene; (2) serotonin transporter (SLC6A4(5HTT)) gene; and (3) nicotinic acetylcholine receptor α4 subunit (CHRNA4) gene.
摘要翻译：公开了一种用于确定受试者的吸烟趋势的方法，其用于戒烟的辅助或治疗，其包括以下步骤：检测在一个或多个基因上发生的多态性，所述一个或多个基因选自基因（1）至（ 3）或基因组或基因或基因组附近，并根据检测结果确定吸烟趋势：（1）烟碱乙酰胆碱受体β2亚基（CHRNB2）基因; （2）5-羟色胺转运蛋白（SLC6A4（5HTT））基因; 和（3）烟碱乙酰胆碱受体α4亚基（CHRNA4）基因。

4. 发明申请

US20090053716A1 METHOD OF DETECTING HUMAN CYTOCHROME P450 (CYP) 2D6 GENE MUTATION 审中-公开
标题翻译：检测人细胞色素P450（CYP）2D6基因突变的方法
公开(公告)号：US20090053716A1
公开(公告)日：2009-02-26
申请号：US12175070
申请日：2008-07-17
申请人： Naoko Nakamura , Tsuyoshi Fukuda , Junichi Azuma , Nobuhiro Gemma
发明人： Naoko Nakamura , Tsuyoshi Fukuda , Junichi Azuma , Nobuhiro Gemma
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/156 , C12Q2600/172
摘要： A defect or multi-existence of a CYP2D6 gene is detected with a primer includes a complementary sequence to a sequence which is common between the CYP2D6 gene and a CYP2D8 gene but different from a CYP2D7 gene and which contains one or more of bases at the 86-, 90- and 93-positions in Exon 9 region of the CYP2D6 gene.
摘要翻译：用引物检测CYP2D6基因的缺陷或多重存在，其包括与CYP2D6基因和CYP2D8基因之间共同但与CYP2D7基因不同但在86位含有一个或多个碱基的序列的互补序列 - ，CYP2D6基因的外显子9区域的90-93位。

5. 发明授权

US4565626A Apparatus for blood treatment by pressing blood into treating material and then drawing it out 失效
标题翻译：用于通过将血液压制成处理材料然后将其拉出来进行血液处理的装置
公开(公告)号：US4565626A
公开(公告)日：1986-01-21
申请号：US557227
申请日：1983-11-30
申请人： Junichi Azuma , Koichi Watanabe , Masatake Hori
发明人： Junichi Azuma , Koichi Watanabe , Masatake Hori
IPC分类号： A61M1/34 , A61M39/22
CPC分类号： A61M1/3472 , A61M1/3427 , A61M1/3475 , A61M39/228
摘要： An apparatus for blood treatment has a housing having a blood inlet for introducing the blood to be treated and a blood outlet for exhausting the treated blood, at least one blood channel within the housing and extending from the inlet to the outlet and being constituted by a plasma-separating membrane capable of allowing the plasma component of blood to permeate therethrough while preventing the blood cells from penetrating therethrough. A blood treating material is packed in the space within the housing around the blood channel. A pump is connected to the inlet for pumping blood into the inlet. A pressure varying mechanism operatively associated with the housing imposes from outside the housing on the space within the housing pressure changes for alternately changing the direction of the pressure difference between the inside of the blood channel and the blood treating material-containing space, so that the plasma component of the blood flow in the blood channel is caused to permeate through the plasma-separating membrane toward the blood treating material to bring the plasma into contact with the blood treating material, and the plasma is thereafter caused to be returned to the blood channel through the plasma-separating membrane.
摘要翻译：用于血液处理的装置具有壳体，其具有用于引入待处理血液的血液入口和用于排出经处理的血液的血液出口，壳体内的至少一个血液通道，并且从入口延伸到出口，并由能够使血液的血浆成分透过的血浆分离膜，同时防止血细胞穿透。血液处理材料被包装在围绕血液通道的壳体内的空间中。泵连接到入口以将血液泵入入口。与壳体可操作地相关联的压力变化机构从壳体外部施加在壳体内的空间中的压力变化，以交替地改变血液通道内部和含血液处理材料的空间之间的压力差的方向，使得导致血液通道中的血流的血浆成分通过血浆分离膜向血液处理材料渗透，使血浆与血液处理材料接触，然后使血浆返回到血液通道通过等离子体分离膜。

6. 发明授权

US4069155A Hemodialysis system 失效
标题翻译：血液透析系统
公开(公告)号：US4069155A
公开(公告)日：1978-01-17
申请号：US692024
申请日：1976-06-01
申请人： Yasuhiro Tsujimoto , Junichi Azuma , Yoshihiko Matsumura , Katsumi Noda
发明人： Yasuhiro Tsujimoto , Junichi Azuma , Yoshihiko Matsumura , Katsumi Noda
IPC分类号： A61M1/14 , A61M1/16 , B01D13/00
CPC分类号： A61M1/1694
摘要： A hemodialysis system for use with any type of dialyzer, such as coil-type, Kiil-type and capillary-type or hollow fiber-type dialyzers, which has a fluid circulation circuit and a bypass circuit short-circuiting the fluid circulation circuit. At one junction between the fluid circulation circuit and the bypass circuit, an ejector is employed. The ejector has a nozzle, a diffuser axially aligned with the nozzle and defining an orifice and a suction chamber communicated with the orifice. During circulation of the dialysate in the circulation circuit and from the nozzle onto the diffuser of the ejector, a negative gauge pressure is developed in the suction chamber so that the dialysate can be drawn through the bypass circuit. The circulation circuit and the bypass circuit have respective coupling assemblies for removable connection with the coil-type dialyzer and with the Kiil-type or capillary-type, or hollow fiber-type, dialyzer.
摘要翻译：一种用于任何类型的透析器的血液透析系统，例如线圈型，Kiil型和毛细管型或中空纤维型透析器，其具有使流体循环回路短路的流体循环回路和旁路回路。在流体循环回路和旁路回路之间的一个连接处，采用喷射器。喷射器具有喷嘴，与喷嘴轴向对准的扩散器，并且限定出孔口和与孔口连通的吸入室。在将透析液循环到循环回路中并从喷嘴循环到喷射器的扩散器上时，在吸入室中产生负表压，使得透析液可以通过旁路回路被抽吸。循环回路和旁路回路具有用于与线圈式透析器和Kiil型或毛细管型或中空纤维型透析器可拆卸连接的各自的联接组件。

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