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1. 发明授权

US07724037B2 Apparatus and methods for self-biasing differential signaling circuitry having multimode output configurations for low voltage applications 有权
标题翻译：具有用于低电压应用的多模输出配置的用于自偏压差动信号电路的装置和方法
公开(公告)号：US07724037B2
公开(公告)日：2010-05-25
申请号：US12352916
申请日：2009-01-13
申请人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard W. Fung
发明人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard W. Fung
IPC分类号： H03K19/094
CPC分类号： H03K17/302 , H03K17/04106
摘要： The present disclosure relates to a differential signaling circuit including differential signaling circuitry having at least one output and one input, that can operate in multiple mode of operations while using a single, low voltage supply source. Two or more switches are included and configured to selectively couple a supply voltage to the output dependent on a mode of operation of the differential signaling circuitry. The circuit also includes a switch control biasing circuit operatively coupled to at least one of the switches and to the output of the differential signaling circuitry. The switch control biasing circuit provides a switch control biasing voltage to control a state of the switch based on a voltage level of the output. Further, a bulk biasing circuit is included and operatively coupled to the switch. The bulk biasing circuit selectively provides a bulk biasing voltage to the switch based on the voltage level of the output.
摘要翻译：本公开涉及一种差分信号电路，其包括具有至少一个输出和一个输入的差分信号电路，其可以在使用单个低电压电源时在多种操作模式下操作。两个或更多个开关被包括并配置成根据差分信号电路的操作模式选择性地将电源电压耦合到输出。电路还包括可操作地耦合到至少一个开关和差分信号电路的输出的开关控制偏置电路。开关控制偏置电路提供开关控制偏置电压，以基于输出的电压电平来控制开关的状态。此外，体积偏置电路被包括并且可操作地耦合到开关。体积偏置电路基于输出的电压电平选择性地向开关提供体积偏置电压。

2. 发明申请

US20090115457A1 Apparatus and Methods for Self-Biasing Differential Signaling Circuitry Having Multimode Output Configurations for Low Voltage Applications 有权
标题翻译：具有用于低电压应用的多模输出配置的自偏压差分信号电路的装置和方法
公开(公告)号：US20090115457A1
公开(公告)日：2009-05-07
申请号：US12352916
申请日：2009-01-13
申请人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard W. Fung
发明人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard W. Fung
IPC分类号： H03K19/20
CPC分类号： H03K17/302 , H03K17/04106
摘要： The present disclosure relates to a differential signaling circuit including differential signaling circuitry having at least one output and one input, that can operate in multiple mode of operations while using a single, low voltage supply source. Two or more switches are included and configured to selectively couple a supply voltage to the output dependent on a mode of operation of the differential signaling circuitry. The circuit also includes a switch control biasing circuit operatively coupled to at least one of the switches and to the output of the differential signaling circuitry. The switch control biasing circuit provides a switch control biasing voltage to control a state of the switch based on a voltage level of the output. Further, a bulk biasing circuit is included and operatively coupled to the switch. The bulk biasing circuit selectively provides a bulk biasing voltage to the switch based on the voltage level of the output.
摘要翻译：本公开涉及一种差分信号电路，其包括具有至少一个输出和一个输入的差分信号电路，其可以在使用单个低电压电源时在多种操作模式下操作。两个或更多个开关被包括并且被配置为根据差分信号电路的操作模式来选择性地将电源电压耦合到输出。电路还包括可操作地耦合到至少一个开关和差分信号电路的输出的开关控制偏置电路。开关控制偏置电路提供开关控制偏置电压，以基于输出的电压电平来控制开关的状态。此外，体积偏置电路被包括并且可操作地耦合到开关。体积偏置电路基于输出的电压电平选择性地向开关提供体积偏置电压。

3. 发明授权

US07495477B2 Apparatus and methods for self-biasing differential signaling circuitry having multimode output configurations for low voltage applications 有权
标题翻译：具有用于低电压应用的多模输出配置的用于自偏压差动信号电路的装置和方法
公开(公告)号：US07495477B2
公开(公告)日：2009-02-24
申请号：US11830897
申请日：2007-07-31
申请人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard W. Fung
发明人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard W. Fung
IPC分类号： H03K19/094
CPC分类号： H03K17/302 , H03K17/04106
摘要： The present disclosure relates to a differential signaling circuit including differential signaling circuitry having at least one output and one input, that can operate in multiple mode of operations while using a single, low voltage supply source. Two or more switches are included and configured to selectively couple a supply voltage to the output dependent on a mode of operation of the differential signaling circuitry. The circuit also includes a switch control biasing circuit operatively coupled to at least one of the switches and to the output of the differential signaling circuitry. The switch control biasing circuit provides a switch control biasing voltage to control a state of the switch based on a voltage level of the output. Further, a bulk biasing circuit is included and operatively coupled to the switch. The bulk biasing circuit selectively provides a bulk biasing voltage to the switch based on the voltage level of the output.
摘要翻译：本公开涉及一种差分信号电路，其包括具有至少一个输出和一个输入的差分信号电路，其可以在使用单个低电压电源时在多种操作模式下操作。两个或更多个开关被包括并配置成根据差分信号电路的操作模式选择性地将电源电压耦合到输出。电路还包括可操作地耦合到开关中的至少一个和差分信号电路的输出的开关控制偏置电路。开关控制偏置电路提供开关控制偏置电压，以基于输出的电压电平来控制开关的状态。此外，体积偏置电路被包括并且可操作地耦合到开关。体积偏置电路基于输出的电压电平选择性地向开关提供体积偏置电压。

4. 发明授权

US07253663B2 Apparatus and methods for self-biasing differential signaling circuitry having multimode output configurations for low voltage applications 有权
标题翻译：具有用于低电压应用的多模输出配置的用于自偏压差动信号电路的装置和方法
公开(公告)号：US07253663B2
公开(公告)日：2007-08-07
申请号：US11160243
申请日：2005-06-15
申请人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard W Fung
发明人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard W Fung
IPC分类号： H03K19/094
CPC分类号： H03K17/302 , H03K17/04106
摘要： The present disclosure relates to a differential signaling circuit including differential signaling circuitry having at least one output and one input, that can operate in multiple mode of operations while using a single, low voltage supply source. Two or more switches are included and configured to selectively couple a supply voltage to the output dependent on a mode of operation of the differential signaling circuitry. The circuit also includes a switch control biasing circuit operatively coupled to at least one of the switches and to the output of the differential signaling circuitry. The switch control biasing circuit provides a switch control biasing voltage to control a state of the switch based on a voltage level of the output. Further, a bulk biasing circuit is included and operatively coupled to the switch. The bulk biasing circuit selectively provides a bulk biasing voltage to the switch based on the voltage level of the output.
摘要翻译：本公开涉及一种差分信号电路，其包括具有至少一个输出和一个输入的差分信号电路，其可以在使用单个低电压电源时在多种操作模式下操作。两个或更多个开关被包括并配置成根据差分信号电路的操作模式选择性地将电源电压耦合到输出。电路还包括可操作地耦合到至少一个开关和差分信号电路的输出的开关控制偏置电路。开关控制偏置电路提供开关控制偏置电压，以基于输出的电压电平来控制开关的状态。此外，体积偏置电路被包括并且可操作地耦合到开关。体积偏置电路基于输出的电压电平选择性地向开关提供体积偏置电压。

5. 发明申请

US20070268043A1 APPARATUS AND METHODS FOR SELF-BIASING DIFFERENTIAL SIGNALING CIRCUITRY HAVING MULTIMODE OUTPUT CONFIGURATIONS FOR LOW VOLTAGE APPLICATIONS 有权
标题翻译：用于自偏置具有用于低电压应用的多模输出配置的差分信号电路的装置和方法
公开(公告)号：US20070268043A1
公开(公告)日：2007-11-22
申请号：US11830897
申请日：2007-07-31
申请人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard Fung
发明人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard Fung
IPC分类号： H03K19/20 , H03K19/094
CPC分类号： H03K17/302 , H03K17/04106
摘要： The present disclosure relates to a differential signaling circuit including differential signaling circuitry having at least one output and one input, that can operate in multiple mode of operations while using a single, low voltage supply source. Two or more switches are included and configured to selectively couple a supply voltage to the output dependent on a mode of operation of the differential signaling circuitry. The circuit also includes a switch control biasing circuit operatively coupled to at least one of the switches and to the output of the differential signaling circuitry. The switch control biasing circuit provides a switch control biasing voltage to control a state of the switch based on a voltage level of the output. Further, a bulk biasing circuit is included and operatively coupled to the switch. The bulk biasing circuit selectively provides a bulk biasing voltage to the switch based on the voltage level of the output.
摘要翻译：本公开涉及一种差分信号电路，其包括具有至少一个输出和一个输入的差分信号电路，其可以在使用单个低电压电源时在多种操作模式下操作。两个或更多个开关被包括并配置成根据差分信号电路的操作模式选择性地将电源电压耦合到输出。电路还包括可操作地耦合到至少一个开关和差分信号电路的输出的开关控制偏置电路。开关控制偏置电路提供开关控制偏置电压，以基于输出的电压电平来控制开关的状态。此外，体积偏置电路被包括并且可操作地耦合到开关。体积偏置电路基于输出的电压电平选择性地向开关提供体积偏置电压。

6. 发明申请

US20060284649A1 APPARATUS AND METHODS FOR SELF-BIASING DIFFERENTIAL SIGNALING CIRCUITRY HAVING MULTIMODE OUTPUT CONFIGURATIONS FOR LOW VOLTAGE APPLICATIONS 有权
标题翻译：用于自偏置具有用于低电压应用的多模输出配置的差分信号电路的装置和方法
公开(公告)号：US20060284649A1
公开(公告)日：2006-12-21
申请号：US11160243
申请日：2005-06-15
申请人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard Fung
发明人： Junho Cho , Nancy Chan , Ramesh Senthinathan , Stephen Yue , Richard Fung
IPC分类号： H03K19/094
CPC分类号： H03K17/302 , H03K17/04106
摘要： The present disclosure relates to a differential signaling circuit including differential signaling circuitry having at least one output and one input, that can operate in multiple mode of operations while using a single, low voltage supply source. Two or more switches are included and configured to selectively couple a supply voltage to the output dependent on a mode of operation of the differential signaling circuitry. The circuit also includes a switch control biasing circuit operatively coupled to at least one of the switches and to the output of the differential signaling circuitry. The switch control biasing circuit provides a switch control biasing voltage to control a state of the switch based on a voltage level of the output. Further, a bulk biasing circuit is included and operatively coupled to the switch. The bulk biasing circuit selectively provides a bulk biasing voltage to the switch based on the voltage level of the output.
摘要翻译：本公开涉及一种差分信号电路，其包括具有至少一个输出和一个输入的差分信号电路，其可以在使用单个低电压电源时在多种操作模式下操作。两个或更多个开关被包括并配置成根据差分信号电路的操作模式选择性地将电源电压耦合到输出。电路还包括可操作地耦合到至少一个开关和差分信号电路的输出的开关控制偏置电路。开关控制偏置电路提供开关控制偏置电压，以基于输出的电压电平来控制开关的状态。此外，体积偏置电路被包括并且可操作地耦合到开关。体积偏置电路基于输出的电压电平选择性地向开关提供体积偏置电压。

7. 发明授权

US08999965B2 Anthraquinone based near IR emitting compounds and uses thereof 有权
标题翻译：基于蒽醌的近红外发射化合物及其用途
公开(公告)号：US08999965B2
公开(公告)日：2015-04-07
申请号：US13126234
申请日：2009-10-20
申请人： Stephen Yue , Shih-Jung Huang , Jolene Bradford
发明人： Stephen Yue , Shih-Jung Huang , Jolene Bradford
IPC分类号： A61K31/33 , C12Q1/68 , C09B1/516 , G01N21/64
CPC分类号： G01N33/52 , C07C225/36 , C07C237/10 , C07C2603/24 , C07D205/04 , C07D213/36 , C07D233/61 , C07D249/04 , C07D295/13 , C07D295/192 , C07H21/04 , C09B1/5165 , C12Q1/6816 , C12Q1/6841 , G01N21/6428 , G01N2021/6441
摘要： Disclosed are near IR emitting fluorescent compounds; methods of making and kits containing the described compounds; and their use in fluorescence-based detection of biological materials.
摘要翻译：近红外发射荧光化合物; 制备方法和含有所述化合物的试剂盒; 以及它们在荧光检测生物材料中的应用。

8. 发明授权

US08669374B2 Functionalized cyanine dyes (PEG) 有权
标题翻译：官能化花青染料（PEG）
公开(公告)号：US08669374B2
公开(公告)日：2014-03-11
申请号：US13218395
申请日：2011-08-25
申请人： Gene Shen , Stephen Yue
发明人： Gene Shen , Stephen Yue
IPC分类号： C07D209/02 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6869 , C07D209/14 , C07D401/14 , C07D405/14 , C07H19/10 , C07K5/0815 , C07K5/1019 , C09B23/0025 , C09B23/0033 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/164 , C12Q1/6844 , C12Q1/6876 , G01N33/52 , G01N33/582 , G01N2333/9126
摘要： The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.
摘要翻译：本发明提供了一种新颖的花青染料，其可用连接体部分官能化，这些连接部分有助于它们与增加水溶性的其它物质和取代基结合，并优化染料的光学性质。还提供了染料的缀合物，使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。

9. 发明授权

US08569506B2 Modified carbocyanine dyes and their conjugates 有权
公开(公告)号：US08569506B2
公开(公告)日：2013-10-29
申请号：US13556643
申请日：2012-07-24
申请人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
发明人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
IPC分类号： C07D215/00
CPC分类号： G01N1/30 , A61K41/0057 , C07C66/02 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/24 , C07D209/54 , C07D209/60 , C07D209/96 , C07D401/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04 , C07K1/13 , C09B23/02 , C09B23/06 , C09B23/083 , C09B23/107 , C12Q1/6825 , C40B70/00 , G01N31/22 , G01N33/533 , G01N33/535 , G01N33/58 , G01N33/581 , G01N33/582 , G01N2001/302 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

10. 发明授权

US08470529B2 Methine-substituted cyanine dye compounds 有权
公开(公告)号：US08470529B2
公开(公告)日：2013-06-25
申请号：US12851030
申请日：2010-08-05
申请人： Jason Dallwig , David Hagen , Ching-Ying Cheung , Gerald Thomas , Stephen Yue
发明人： Jason Dallwig , David Hagen , Ching-Ying Cheung , Gerald Thomas , Stephen Yue
IPC分类号： A61K31/4709 , C07D215/12 , C12Q1/68
CPC分类号： C09B23/164 , C07D277/64 , C07D417/06 , C09B23/0008 , C09B23/04 , C09B23/06 , C09B23/107 , C12Q1/6806 , C12Q1/6876 , C12Q2600/16 , G01N33/5308 , Y10T436/143333
摘要： Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.

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