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1. 发明申请

US20060167280A1 Method for purifying simvastatin 审中-公开
标题翻译：辛伐他汀纯化方法
公开(公告)号：US20060167280A1
公开(公告)日：2006-07-27
申请号：US10503769
申请日：2003-02-06
申请人： Jung Kim , Tae Kang , Eui Park , Dong Cho , Hyeung Baek
发明人： Jung Kim , Tae Kang , Eui Park , Dong Cho , Hyeung Baek
IPC分类号： C07D309/30
CPC分类号： C07D309/30
摘要： The present invention relates to a purification method of simvastatin crystal, more particularly to a method of effectively removing impurities contained in crude simvastatin obtained by a conventional synthetic method of simvastatin while minimizing loss of effective components to obtain high-quality simvastatin with good yield.
摘要翻译：本发明涉及辛伐他汀晶体的纯化方法，更具体地说，涉及一种有效去除通过常规的辛伐他汀合成方法获得的粗辛辛伐他汀所含杂质的方法，同时使有效成分的损失最小化，以获得高质量的辛伐他汀。

2. 发明申请

US20070275082A1 Preparation Method for Sustained Release Microspheres Using a Dual-Feed Nozzle 审中-公开
标题翻译：使用双进料喷嘴的持续释放微球的制备方法
公开(公告)号：US20070275082A1
公开(公告)日：2007-11-29
申请号：US10570564
申请日：2004-09-03
申请人： Hee Lee , Sung Kim , Jung Kim , Young Jung , Jung Kim , Ho Choi , Seung Chang , Kee Park
发明人： Hee Lee , Sung Kim , Jung Kim , Young Jung , Jung Kim , Ho Choi , Seung Chang , Kee Park
IPC分类号： A61K38/09 , A61K9/16
CPC分类号： A61K9/1647 , A61K9/1682 , A61K9/1694 , A61K38/09
摘要： Disclosed is a method of preparing sustained release microspheres by spray-drying liquids with different compositions for preparation the sustained release microspheres through an ultrasonic dual-feed nozzle. Unlike conventional methods of preparing sustained release microspheres by spray-drying a single liquid containing a biodegradable polymer, a drug, an additive and a solvent through a single-feed nozzle, the present method is characterized by simultaneously spray-drying two liquids with different compositions for preparation of the sustained release microspheres respectively through internal and external channels of an ultrasonic dual-feed nozzle to coat sprayed droplets through the internal channel with other sprayed droplets through the external channel. The present method is effective in achieving a low initial release and a desired continuous release.
摘要翻译：公开了一种通过喷雾干燥具有不同组成的液体制备缓释微球的方法，用于通过超声波双重给料喷嘴制备缓释微球。与通过单一进料喷嘴喷雾干燥含有可生物降解的聚合物，药物，添加剂和溶剂的单一液体制备缓释微球体的常规方法不同，本方法的特征在于同时喷雾干燥具有不同组成的两种液体分别通过超声双馈喷嘴的内部和外部通道制备缓释微球，通过内部通道将喷雾的液滴通过外部通道与其他喷雾液滴一起涂覆。本发明的方法在实现低的初始释放和期望的连续释放方面是有效的。

3. 发明申请

US20060092825A1 OFDM transmission apparatus and method having minimal transmission delay 有权
标题翻译： OFDM发送装置和方法具有最小的传输延迟
公开(公告)号：US20060092825A1
公开(公告)日：2006-05-04
申请号：US11115585
申请日：2005-04-26
申请人： Jung Kim , Jae Lee , Jung Kim
发明人： Jung Kim , Jae Lee , Jung Kim
IPC分类号： H04J11/00
CPC分类号： H04L25/03866 , H04L1/0059 , H04L1/0071 , H04L27/2601
摘要： An OFDM transmission apparatus having minimal transmission delay comprises a training symbol storage and generation unit, a delay unit and a controller. The training symbol storage and generation unit stores training symbols for the preamble, and outputs the stored training symbols when a training symbol output request signal is received. The delay unit receives data for the signal field from the MAC layer, delays the received data by the data processing time of the scrambler, and outputs the delayed data to the convolution encoder. The controller outputs the training symbol output request signal, requesting the preamble of the frame, to the training symbol storage and generation unit when a frame transmission request is received from the MAC layer, and outputs a data request signal, requesting the signal field and the data field, to the MAC layer in consideration of total data processing time (TPROCESS).
摘要翻译：具有最小传输延迟的OFDM发送装置包括训练符号存储和生成单元，延迟单元和控制器。训练符号存储和生成单元存储用于前导码的训练符号，并且当接收到训练符号输出请求信号时，输出存储的训练符号。延迟单元接收来自MAC层的信号字段的数据，将接收的数据延迟加扰器的数据处理时间，并将延迟的数据输出到卷积编码器。当从MAC层接收到帧发送请求时，控制器向训练符号存储和生成单元输出请求帧的前导码的训练符号输出请求信号，并输出请求信号字段和数据字段，考虑总数据处理时间（T＆lt; PROCESS＆lt; / SUB＆gt;）到MAC层。

4. 发明申请

US20080064065A1 NON-ACTIVATED POLYPEPTIDES HAVING A FUNCTION OF TISSUE REGENERATION AND METHOD FOR PREPARING THE SAME 有权
标题翻译：具有组织再生功能的非活性多聚体及其制备方法
公开(公告)号：US20080064065A1
公开(公告)日：2008-03-13
申请号：US11781243
申请日：2007-07-21
申请人： Jung Kim , Jung Kim , Tae Kim , Jong Lee , Jong Yook
发明人： Jung Kim , Jung Kim , Tae Kim , Jong Lee , Jong Yook
IPC分类号： C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C07K14/51 , C07K2319/10 , C07K2319/21 , C12N15/62
摘要： Non-activated tissue-regeneration polypeptides (TRPs) and their preparation methods are disclosed. The TRPs include: a protein transduction domain (PTD) making the polypeptides to permeate a cell membrane without cell membrane receptors; a furin activation domain (FAD) which has at least one proprotein convertase cleavage site and which can be cleaved by the proprotein convertase and activate a tissue regeneration domain (TRD) in cells; and a tissue regeneration domain (TRD) which can be activated by the proprotein convertase cleavage of the FAD to stimulate the growth or formation of tissues or to induce the regeneration of tissues. The TRPs can be mass-produced by cultured bacteria, such as recombinant E. coli, are in a non-activated state before in vivo administration, and their separation, purification, handling, storage and administration are simple and convenient. The in vivo administration of the TRPs is useful to stimulate the formation or regeneration of tissues, such as bones or cartilages, or to improve the fibrosis and cirrhosis of organs, such as kidneys, liver, lungs and heart by pharmacological mechanisms completely different from those of prior rhBMPs or TGF-β proteins.
摘要翻译：公开了非活化组织再生多肽（TRP）及其制备方法。 TRP包括：蛋白转导结构域（PTD），其使多肽渗透到没有细胞膜受体的细胞膜上; 具有至少一个蛋白质转换酶切割位点的弗林蛋白酶激活结构域（FAD），其可被前蛋白转化酶切割并激活细胞中的组织再生结构域（TRD）; 和组织再生结构域（TRD），其可以通过FAD的蛋白质转化酶切割来激活以刺激组织的生长或形成或诱导组织的再生。 TRP可以通过培养的细菌如重组大肠杆菌大量生产，在体内给药之前处于非活化状态，其分离，纯化，处理，储存和给药简单方便。 TRP的体内施用可用于刺激组织如骨骼或软骨的形成或再生，或通过与这些完全不同的药理学机制来改善器官（例如肾，肝，肺和心脏）的纤维化和肝硬化。的先前的rhBMP或TGF-β蛋白。

5. 发明申请

US20070105762A1 Non-activated polypeptides having a function of tissue regeneration and method for preparing the same 审中-公开
标题翻译：具有组织再生功能的非活化多肽及其制备方法
公开(公告)号：US20070105762A1
公开(公告)日：2007-05-10
申请号：US10560329
申请日：2005-11-02
申请人： Jung Kim , Jung Kim , Tae Kim , Jong Lee , Jong Yook
发明人： Jung Kim , Jung Kim , Tae Kim , Jong Lee , Jong Yook
IPC分类号： A61K38/17 , C07K14/475 , C07H21/04 , C12P21/06
CPC分类号： C07K14/51
摘要： Non-activated tissue-regeneration polypeptides (TRPs) and the preparation methods thereof are disclosed. The TRPs contain: a protein transduction domain (PTD) making the polypeptides to permeate a cell membrane without cell membrane receptors; a furin activation domain (FAD) which has at least one proprotein convertase cleavage site and which can be cleaved by the proprotein convertase and activate a tissue regeneration domain (TRD) in cells; and a tissue regeneration domain (TRD) which can be activated by the proprotein convertase cleavage of the FAD to stimulate the growth or formation of tissues or to induce the regeneration of tissues. The TRPs can be practically mass-produced by the culture of bacteria, such as recombinant E. coli, and are in a non-activated state before in vivo administration. Thus, their production cost is only a few tenths of the prior active proteins having uses similar thereto, and processes for their separation, purification, handling, storage and administration are significantly simple and convenient. The in vivo administration of the TRPs can stimulate the formation or regeneration of tissues, such as bones or cartilages, or improve the fibrosis and cirrhosis of organs, such as kidneys, liver, lungs and heart by pharmacological mechanisims completely different from those of prior rhBMPs or TGF-β proteins. Accordingly, the TRPs will be useful as drugs having new mechanisms.
摘要翻译：公开了非活化组织再生多肽（TRP）及其制备方法。 TRP包含：蛋白转导结构域（PTD），其使多肽渗透到没有细胞膜受体的细胞膜上; 具有至少一个蛋白质转换酶切割位点的弗林蛋白酶激活结构域（FAD），其可被前蛋白转化酶切割并激活细胞中的组织再生结构域（TRD）; 和组织再生结构域（TRD），其可以通过FAD的蛋白质转化酶切割来激活以刺激组织的生长或形成或诱导组织的再生。 TRP可以通过细菌的培养物，如重组大肠杆菌，实际上大量生产，并且在体内给药之前处于非活化状态。因此，它们的生产成本只是其相似用途的现有活性蛋白质的十分之一，其分离，纯化，处理，储存和给药的方法显而易见。 TRP的体内施用可以刺激组织如骨骼或软骨的形成或再生，或通过与以前的rhBMP完全不同的药理学机制改善器官（例如肾脏，肝脏，肺和心脏）的纤维化和肝硬化或TGF-β蛋白。因此，TRP将作为具有新机制的药物是有用的。

6. 发明授权

US09131918B2 3-dimensional ultrasound image provision using volume slices in an ultrasound system 有权
标题翻译：在超声系统中使用体积切片的三维超声图像提供
公开(公告)号：US09131918B2
公开(公告)日：2015-09-15
申请号：US12727019
申请日：2010-03-18
申请人： Suk Jin Lee , Jung Kim
发明人： Suk Jin Lee , Jung Kim
IPC分类号： A61B8/00 , A61B8/08 , G01S7/52 , G01S15/89
CPC分类号： A61B8/00 , A61B8/463 , A61B8/483 , G01S7/52073 , G01S7/52074 , G01S15/8993
摘要： Embodiments for providing a plurality of 3-dimensional ultrasound images by using a plurality of volume slices in an ultrasound system are disclosed. The ultrasound system comprises: an ultrasound data acquisition unit configured to transmit and receive ultrasound signals to and from a target object to acquire ultrasound data; a volume data forming unit configured to form volume data by using the ultrasound data; a user input unit for allowing a user to input a user instruction; and a processing unit configured to set a plurality of volume slice regions having different widths in the volume data in response to the user instruction and form a plurality of 3-dimensional ultrasound images by using volume slices defined by the volume slice regions.
摘要翻译：公开了通过在超声系统中使用多个体积片来提供多个3维超声图像的实施例。所述超声波系统包括：超声数据获取单元，被配置为向目标物体发送超声波信号并从目标对象接收超声波信号以获取超声波数据; 体数据形成单元，被配置为通过使用所述超声数据来形成体数据; 用户输入单元，用于允许用户输入用户指令; 以及处理单元，被配置为响应于所述用户指令在所述体数据中设置具有不同宽度的多个体积切片区域，并且通过使用由所述体积切片区域定义的体积切片形成多个3维超声图像。

7. 发明授权

US08956298B2 Providing an ultrasound spatial compound image in an ultrasound system 有权
标题翻译：在超声系统中提供超声空间复合图像
公开(公告)号：US08956298B2
公开(公告)日：2015-02-17
申请号：US12962289
申请日：2010-12-07
申请人： Suk Jin Lee , Jung Kim
发明人： Suk Jin Lee , Jung Kim
IPC分类号： A61B8/00 , G01S15/89 , A61B8/08 , G06T7/00 , G01S7/52 , A61B8/13
CPC分类号： G01S15/8993 , A61B8/085 , A61B8/13 , A61B8/469 , A61B8/5215 , A61B8/5253 , G01S7/52063 , G01S7/52071 , G01S7/52074 , G06T7/0012
摘要： Embodiments for providing an ultrasound spatial compound image are disclosed. In one embodiment, by way of non-limiting example, an ultrasound system comprises: an ultrasound data acquisition unit configured to transmit and receive ultrasound signals to and from a target object to output first ultrasound data and a plurality of sets of second ultrasound data corresponding to a region of interest (ROI); a user input unit configured to receive input information for defining the ROI; and a processing unit in communication with the ultrasound data acquisition unit and the user input unit, the processing unit being configured to form volume data based on the plurality of sets of second ultrasound data, compare the first ultrasound data with the volume data to detect geometric information therein, form a two-dimensional (2D) ultrasound image based on the first ultrasound data, and a first three-dimensional (3D) ultrasound image and a second 3D ultrasound data based on the volume data in consideration of the geometric information, and perform a spatial compound upon the 2D ultrasound image, the first 3D ultrasound image and the second 3D ultrasound image based on the geometric information to form an ultrasound spatial compound image.
摘要翻译：公开了用于提供超声空间复合图像的实施例。在一个实施例中，作为非限制性示例，超声系统包括：超声数据获取单元，被配置为向目标对象发送和接收超声信号以输出第一超声数据和对应于多个第二超声数据组到感兴趣的区域（ROI）; 用户输入单元，被配置为接收用于定义ROI的输入信息; 以及与所述超声数据获取单元和所述用户输入单元通信的处理单元，所述处理单元被配置为基于所述多组第二超声数据形成体数据，将所述第一超声数据与所述体数据进行比较以检测所述几何信息，基于第一超声数据形成二维（2D）超声图像，以及考虑到几何信息的基于体数据的第一三维（3D）超声图像和第二3D超声数据，以及基于所述几何信息，在所述2D超声图像，所述第一3D超声图像和所述第二3D超声图像上执行空间化合物以形成超声空间复合图像。

8. 发明授权

US07777137B2 Device and method for transmitting shape information of image through tactile sensation using rheological fluid 有权
标题翻译：通过使用流变液的触感传递图像形状信息的装置和方法
公开(公告)号：US07777137B2
公开(公告)日：2010-08-17
申请号：US11702877
申请日：2007-02-05
申请人： Bum Mo Ahn , Ki Uk Kyung , Jung Kim , Dong Soo Kwon
发明人： Bum Mo Ahn , Ki Uk Kyung , Jung Kim , Dong Soo Kwon
IPC分类号： G06F3/046
CPC分类号： G06F3/016 , G09B21/004
摘要： The tactile transmission device includes a plurality of cells arranged at regular intervals, each having a storage space therein. A contact member is installed in each of the cells, an upper portion of the contact member protruding out of the cell. An elastic member is installed in each of the cells, and biases the contact member upwards. A sensor is installed in each of the cells, and measures displacement of the contact member. A magneto-rheological fluid is contained in each of the cells. A coil is installed in each of the cells and generates a magnetic field in the cell. A control means compares a shape information value of the image with a displacement value of the contact member output from the sensor, thus controlling a quantity of current applied to the coil. According to the present invention, the shape information of an image displayed on a screen is corrected to be suitable for a user's characteristics, thus more precisely transmitting the shape information on the screen to the user. Further, a transmission medium for transmitting a tactile sensation to a user has a simple construction, so that miniaturization of the tactile transmission device is very easily realized.
摘要翻译：触觉传输装置包括以规则间隔布置的多个单元，每个单元在其中具有存储空间。接触构件安装在每个单元中，接触构件的上部从单元突出。弹性构件安装在每个单元中，并将接触构件向上偏压。传感器安装在每个单元中，并且测量接触构件的位移。磁流变流体包含在每个电池中。线圈安装在每个电池中，并在电池中产生磁场。控制装置将图像的形状信息值与从传感器输出的接触构件的位移值进行比较，从而控制施加到线圈的电流量。根据本发明，将屏幕上显示的图像的形状信息修正为适合于用户的特性，从而更精确地将画面上的形状信息发送给用户。此外，用于向用户发送触觉的传输介质具有简单的结构，使得触觉传输装置的小型化非常容易实现。

9. 发明申请

US20080081081A1 Agastache rugosa extract and composition containing tilianin isolated and purified from said extract having anti-inflammatory activity and anti-atherogenic activity 有权
标题翻译：从所述提取物中分离和纯化的具有抗炎活性和抗动脉粥样硬化活性的提取物的藿香提取物和组合物
公开(公告)号：US20080081081A1
公开(公告)日：2008-04-03
申请号：US11802527
申请日：2007-05-23
申请人： Hyeong Lee , Sei Oh , Kyung Ahn , Soon Choi , Jung Kim , Goo Oh , Jung Hong , Seong Park , Woo Namkung
发明人： Hyeong Lee , Sei Oh , Kyung Ahn , Soon Choi , Jung Kim , Goo Oh , Jung Hong , Seong Park , Woo Namkung
IPC分类号： A61K36/532 , A61P29/00
CPC分类号： A61K36/532 , A23L33/105 , A23L33/11
摘要： This invention includes a composition of Agastache rugosa and tilianin obtained by separation-purification for anti-inflammation and anti-atherosclerosis, and more particularly, an extract of Agastache rugosa and tilianin obtained therefrom by separation-purification which are effective in preventing and treating not only inflammatory diseases but also atherosclerosis related to inflammatory responses and disease in the circulatory system caused by atherosclerosis because they are excellent in inhibiting the activity of complement systems as a factor of inflammatory responses, the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecular-1 (VCAM-1), and the production of nitric oxide (NO). They can also significantly reduce the development of atherosclerosis due to the inflammatory response.
摘要翻译：本发明包括通过用于抗炎和抗动脉粥样硬化的分离纯化获得的藿香粗提物和斜霉素的组合物，更具体地，通过分离纯化从其获得的藿香提取物和斜霉素提取物，其不仅有效预防和治疗炎症性疾病，而且与由动脉粥样硬化引起的循环系统中的炎性反应和疾病有关的动脉粥样硬化，因为它们作为炎症反应因子抑制补体系统的活性，细胞间粘附分子-1（ICAM-1）和血管细胞粘附分子-1（VCAM-1）和一氧化氮（NO）的产生。它们还可以显着减少由于炎症反应引起的动脉粥样硬化的发展。

10. 发明申请

US20080049176A1 THIN FILM TRANSISTOR-ARRAY SUBSTRATE, TRANSFLECTIVE LIQUID CRYSTAL DISPLAY DEVICE WITH THE SAME, AND METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：薄膜晶体管阵列基板，其转移液晶显示装置及其制造方法
公开(公告)号：US20080049176A1
公开(公告)日：2008-02-28
申请号：US11844873
申请日：2007-08-24
申请人： Hyun Kim , Kwan Jung , Hyung Na , Seung Tae , Jung Kim
发明人： Hyun Kim , Kwan Jung , Hyung Na , Seung Tae , Jung Kim
IPC分类号： G02F1/1335 , H01L21/02 , H01L31/0232
CPC分类号： G02F1/133555 , G02F1/133512 , G02F1/13394 , H01L27/12 , H01L27/1288
摘要： A thin film transistor (TFT) array substrate and a transflective LCD device include a gate line and a data line which cross each other; a pixel region which has a transmissive region and a reflective region; a TFT electrically connected to the gate line and the data line; a pixel electrode formed in the pixel region to be electrically connected to the TFT; and a reflective electrode formed in the reflective region, wherein the distance between adjacent pixel electrodes or between the adjacent reflective electrodes with the data line interposed therebetween is in the range of about 3.5 to about 6 μm.
摘要翻译：薄膜晶体管（TFT）阵列基板和透反射LCD装置包括彼此交叉的栅极线和数据线; 具有透射区域和反射区域的像素区域; 电连接到栅极线和数据线的TFT; 形成在与TFT电连接的像素区域中的像素电极; 以及形成在反射区域中的反射电极，其中相邻像素电极之间或相邻的反射电极之间的距离与数据线之间的距离在约3.5至约6μm的范围内。

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