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1. 发明申请

US20110098317A1 USE OF UNSATURATED SPHINGOSINE COMPOUNDS AS CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER 有权
标题翻译：使用不饱和化合物作为治疗癌症的化学治疗剂
公开(公告)号：US20110098317A1
公开(公告)日：2011-04-28
申请号：US12747253
申请日：2008-12-12
申请人： Julie D. Saba , Henrik Fyrst , Robert Bittman
发明人： Julie D. Saba , Henrik Fyrst , Robert Bittman
IPC分类号： A61K31/133 , C12N5/09 , A61K31/436 , A61K31/35 , A61P35/00
CPC分类号： C07C215/24 , A61K8/68 , A61K31/133 , A61K31/352 , A61K31/436 , A61K31/5377 , Y02A50/402 , Y02A50/481
摘要： The present invention is directed to unsaturated sphingosine compounds which are useful as therapeutic agents for the treatment of cancer and for the treatment of other diseases including diabetes and infection with intracellular bacteria. This invention is also directed to methods of using the compounds and pharmaceutical compositions comprising the compounds in treating these diseases.
摘要翻译：本发明涉及可用作治疗癌症和治疗其它疾病（包括糖尿病和细胞内细菌感染）的治疗剂的不饱和鞘氨醇化合物。本发明还涉及使用包含该化合物的化合物和药物组合物来治疗这些疾病的方法。

2. 发明授权

US08741967B2 Use of unsaturated sphingosine compounds as chemotherapeutic agents for the treatment of cancer 有权
标题翻译：使用不饱和鞘氨醇化合物作为治疗癌症的化学治疗剂
公开(公告)号：US08741967B2
公开(公告)日：2014-06-03
申请号：US12747253
申请日：2008-12-12
申请人： Julie D. Saba , Henrik Fyrst , Robert Bittman
发明人： Julie D. Saba , Henrik Fyrst , Robert Bittman
IPC分类号： A61K8/68 , A61K31/133
CPC分类号： C07C215/24 , A61K8/68 , A61K31/133 , A61K31/352 , A61K31/436 , A61K31/5377 , Y02A50/402 , Y02A50/481
摘要： The present invention is directed to unsaturated sphingosine compounds which are useful as therapeutic agents for the treatment of cancer and for the treatment of other diseases including diabetes and infection with intracellular bacteria. This invention is also directed to methods of using the compounds and pharmaceutical compositions comprising the compounds in treating these diseases.
摘要翻译：本发明涉及可用作治疗癌症和治疗其它疾病（包括糖尿病和细胞内细菌感染）的治疗剂的不饱和鞘氨醇化合物。本发明还涉及使用包含该化合物的化合物和药物组合物来治疗这些疾病的方法。

3. 发明授权

US06830881B2 Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor 有权
标题翻译：鞘氨醇-1-磷酸裂解酶多肽，多核苷酸和调节剂及其用途的方法
公开(公告)号：US06830881B2
公开(公告)日：2004-12-14
申请号：US10053510
申请日：2002-01-17
申请人： Julie D. Saba , Henrik Fyrst
发明人： Julie D. Saba , Henrik Fyrst
IPC分类号： C12N988
CPC分类号： G01N33/5085 , A01K2217/05 , A01K2217/075 , C12N9/88 , G01N2405/08
摘要： Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.
摘要翻译：提供用于诊断和治疗癌症的组合物，方法和试剂盒。治疗组合物可以包含调节鞘氨醇-1-磷酸裂解酶（SPL）的表达或活性的试剂。这种组合物可以施用于患有癌症的哺乳动物。诊断方法和试剂盒可以使用适合于检测内源性SPL变化的试剂。这些方法和试剂盒可用于检测癌症的存在或评价已知疾病的预后。还提供了SPL多肽，多核苷酸和抗体。

4. 发明申请

US20080248032A1 COMPOSITIONS AND METHODS FOR PROTECTION AGAINST CARDIAC AND/OR CENTRAL NERVOUS SYSTEM TISSUE INJURY BY INHIBITING SPHINGOSINE-1-PHOSPHATE LYASE 审中-公开
标题翻译：用于抑制心肌细胞和/或中枢神经系统组织的组合物和方法通过抑制丝氨酸1-磷酸酶的损伤
公开(公告)号：US20080248032A1
公开(公告)日：2008-10-09
申请号：US11943430
申请日：2007-11-20
申请人： Julie D. Saba
发明人： Julie D. Saba
IPC分类号： A61K31/4164 , A61K39/395 , A61P9/00 , A61K31/7088
CPC分类号： A61K31/4164 , A61K31/7088
摘要： The present invention relates generally to the prevention and/or treatment of cardiac and stroke injury. In particular, the present invention provides compositions and methods for preventing and treating tissue injury in cardiac and stroke settings and injury due to ischemia/reperfusion, hypoxia, cardiotoxicity of certain therapeutic regimens, and other causes, by administering an agent that inhibits sphingosine-1-phosphate lyase (SPL) activity.
摘要翻译：本发明一般涉及心脏和卒中损伤的预防和/或治疗。特别地，本发明提供组合物和方法，用于预防和治疗心脏和中风的组织损伤以及由于缺血/再灌注，缺氧，某些治疗方案的心脏毒性以及其它原因引起的损伤，通过施用抑制鞘氨醇-1 磷酸裂解酶（SPL）活性。

5. 发明申请

US20090202551A1 IMMUNOMODULATION BY ALTERING SPHINGOSINE 1-PHOSPHATE LYASE (SPL) ACTIVITY 有权
标题翻译：通过改变菠萝蛋白酶1-磷酸盐（SPL）活性进行免疫调节
公开(公告)号：US20090202551A1
公开(公告)日：2009-08-13
申请号：US11917029
申请日：2006-06-08
申请人： Julie D. Saba
发明人： Julie D. Saba
IPC分类号： A61K39/395 , A61K31/7105 , A61K31/4415 , A61K31/164 , A61K31/711 , A61K38/45 , A61P37/00
CPC分类号： C12N9/88 , A01K2267/03 , C12N2799/022
摘要： Compositions and methods for modulating immune function are provided based on the unexpected discovery that inhibition of sphingosine-1-phosphate lyase (SPL) activity confers useful immunosuppressive effects, for example to modulate immune function in treatment or prevention of inflammation, transplant graft rejection, autoimmune disease, allergy, or other conditions, including therapeutic alteration of immune system cell survival and/or proliferation. Altering SPL activity by direct or indirect pharmacological intervention, or alternatively by molecular genetic methods to alter SPL expression levels, are also contemplated.
摘要翻译：基于意想不到的发现提供了调节免疫功能的组合物和方法，即鞘氨醇-1-磷酸裂解酶（SPL）活性的抑制赋予有用的免疫抑制作用，例如调节治疗或预防炎症的免疫功能，移植排斥反应，自身免疫疾病，过敏或其他病症，包括免疫系统细胞存活和/或增殖的治疗性改变。也可以通过直接或间接的药理学干预或者通过分子遗传学方法改变SPL表达水平来改变SPL活性。

6. 发明授权

US06569666B1 Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor 有权
公开(公告)号：US06569666B1
公开(公告)日：2003-05-27
申请号：US09356643
申请日：1999-07-19
申请人： Julie D. Saba
发明人： Julie D. Saba
IPC分类号： C12N988
CPC分类号： C12Q1/6886 , A01K2217/05 , A01K2217/075 , C12N9/88 , C12Q2600/136 , Y10S435/81 , Y10S435/975
摘要： Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.

7. 发明授权

US06495359B1 Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor 有权
标题翻译：鞘氨醇-1-磷酸裂解酶多肽，多核苷酸和调节剂及其用途的方法
公开(公告)号：US06495359B1
公开(公告)日：2002-12-17
申请号：US09849180
申请日：2001-05-04
申请人： Julie D. Saba , Jianhui Zhou
发明人： Julie D. Saba , Jianhui Zhou
IPC分类号： C12N988
CPC分类号： C12Q1/6886 , A01K2217/05 , A01K2217/075 , C12N9/88 , C12Q2600/136 , Y10S435/81 , Y10S435/975
摘要： Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.
摘要翻译：提供用于诊断和治疗癌症的组合物，方法和试剂盒。治疗组合物可以包含调节鞘氨醇-1-磷酸裂解酶（SPL）的表达或活性的试剂。这种组合物可以施用于患有癌症的哺乳动物。诊断方法和试剂盒可以使用适合于检测内源性SPL变化的试剂。这些方法和试剂盒可用于检测癌症的存在或评价已知疾病的预后。还提供了SPL多肽，多核苷酸和抗体。

8. 发明授权

US08124111B2 Immunomodulation by altering sphingosine 1-phosphate lyase (SPL) activity 有权
标题翻译：通过改变鞘氨醇1-磷酸裂解酶（SPL）活性进行免疫调节
公开(公告)号：US08124111B2
公开(公告)日：2012-02-28
申请号：US11917029
申请日：2006-06-08
申请人： Julie D. Saba
发明人： Julie D. Saba
IPC分类号： A61K39/00 , C12N9/88
CPC分类号： C12N9/88 , A01K2267/03 , C12N2799/022
摘要： Compositions and methods for modulating immune function are provided based on the unexpected discovery that inhibition of sphingosine-1-phosphate lyase (SPL) activity confers useful immunosuppressive effects, for example to modulate immune function in treatment or prevention of inflammation, transplant graft rejection, autoimmune disease, allergy, or other conditions, including therapeutic alteration of immune system cell survival and/or proliferation. Altering SPL activity by direct or indirect pharmacological intervention, or alternatively by molecular genetic methods to alter SPL expression levels, are also contemplated.
摘要翻译：基于意想不到的发现提供了调节免疫功能的组合物和方法，即鞘氨醇-1-磷酸裂解酶（SPL）活性的抑制赋予有用的免疫抑制作用，例如调节治疗或预防炎症的免疫功能，移植排斥反应，自身免疫疾病，过敏或其他病症，包括免疫系统细胞存活和/或增殖的治疗性改变。也可以通过直接或间接的药理学干预或者通过分子遗传学方法改变SPL表达水平来改变SPL活性。

9. 发明授权

US07973143B2 Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor 有权
标题翻译：鞘氨醇-1-磷酸裂解酶多肽，多核苷酸和调节剂及其用途的方法
公开(公告)号：US07973143B2
公开(公告)日：2011-07-05
申请号：US12341520
申请日：2008-12-22
申请人： Julie D. Saba , Jianhui Zhou
发明人： Julie D. Saba , Jianhui Zhou
IPC分类号： C07K16/40 , C07K16/00 , G01N33/573
CPC分类号： C12Q1/6886 , A01K2217/05 , A01K2217/075 , C12N9/88 , C12Q2600/136 , Y10S435/81 , Y10S435/975
摘要： Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.
摘要翻译：提供用于诊断和治疗癌症的组合物，方法和试剂盒。治疗组合物可以包含调节鞘氨醇-1-磷酸裂解酶（SPL）的表达或活性的试剂。这种组合物可以施用于患有癌症的哺乳动物。诊断方法和试剂盒可以使用适合于检测内源性SPL变化的试剂。这些方法和试剂盒可用于检测癌症的存在或评价已知疾病的预后。还提供了SPL多肽，多核苷酸和抗体。

10. 发明申请

US20090203044A1 SPHINGOSINE-1-PHOSPHATE LYASE POLYPEPTIDES, POLYNUCLEOTIDES AND MODULATING AGENTS AND METHODS OF USE THEREFOR 有权
标题翻译：磷脂酸1-磷酸盐多糖，多核苷酸和调节剂及其使用方法
公开(公告)号：US20090203044A1
公开(公告)日：2009-08-13
申请号：US12341520
申请日：2008-12-22
申请人： Julie D. Saba , Jianhui Zhou
发明人： Julie D. Saba , Jianhui Zhou
IPC分类号： G01N33/573 , C07K16/18
CPC分类号： C12Q1/6886 , A01K2217/05 , A01K2217/075 , C12N9/88 , C12Q2600/136 , Y10S435/81 , Y10S435/975
摘要： Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous SPL. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.
摘要翻译：提供用于诊断和治疗癌症的组合物，方法和试剂盒。治疗组合物可以包含调节鞘氨醇-1-磷酸裂解酶（SPL）的表达或活性的试剂。这种组合物可以施用于患有癌症的哺乳动物。诊断方法和试剂盒可以使用适合于检测内源性SPL变化的试剂。这些方法和试剂盒可用于检测癌症的存在或评价已知疾病的预后。还提供了SPL多肽，多核苷酸和抗体。

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