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1. 发明申请

US20060270709A1 Dihydropyridine compounds and compositions for headaches 审中-公开
标题翻译：二氢吡啶化合物和组合物用于头痛
公开(公告)号：US20060270709A1
公开(公告)日：2006-11-30
申请号：US11396555
申请日：2006-04-04
申请人： Julian Gray , Yoshiharu Yamanishi , Nobuyuki Mori , Scott Fields
发明人： Julian Gray , Yoshiharu Yamanishi , Nobuyuki Mori , Scott Fields
IPC分类号： A61K31/445 , A61K31/444
CPC分类号： A61K31/4412 , A61K31/444 , A61K31/445 , A61K2300/00
摘要： The invention provides methods for treating and/or preventing cognitive impairments, dementia, or neurodegenerative diseases and disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis) in patients by administering therapeutically effective amounts of an AMPA receptor antagonist (e.g., 1,2-dihydropyridine compounds) and therapeutically effective amounts of nootropics (e.g., cholinesterase inhibitors) to patients. The invention also provides combinations, commercial packages, and pharmaceutical compositions comprising therapeutically effective amounts of AMPA receptor antagonists (e.g., 1,2-dihydropyridine compounds) and therapeutically effective amounts nootropics (e.g., cholinesterase inhibitors). The 1,2-dihydropyridine compound may be, for example, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one. The cholinesterase inhibitor may be, for example, donepezil.
摘要翻译：本发明提供了通过施用治疗有效量的AMPA受体拮抗剂（例如，治疗和/或预防）的方法来治疗和/或预防患者的认知障碍，痴呆或神经变性疾病和障碍（例如，阿尔茨海默氏病，帕金森病，亨廷顿舞蹈病，肌萎缩性侧索硬化），1,2-二氢吡啶化合物）和治疗有效量的益智酸（例如胆碱酯酶抑制剂）给患者。本发明还提供了包含治疗有效量的AMPA受体拮抗剂（例如1,2-二氢吡啶化合物）和治疗有效量的精神病药（例如胆碱酯酶抑制剂）的组合，商业包装和药物组合物。 1,2-二氢吡啶化合物可以是例如3-（2-氰基苯基）-5-（2-吡啶基）-1-苯基-1,2-二氢吡啶-2-酮。胆碱酯酶抑制剂可以是例如多奈哌齐。

2. 发明申请

US20090131480A1 Dihydropyridine Compounds for Neurodegenerative Diseases and Dementia 审中-公开
标题翻译：二氢吡啶化合物用于神经退行性疾病和痴呆
公开(公告)号：US20090131480A1
公开(公告)日：2009-05-21
申请号：US11887729
申请日：2006-04-04
申请人： Julian A. Gray , Yoshiharu Yamanishi , Julian A. Gray , Yoshiharu Yamanishi , Nobuyuki Mori , Scott Fields
发明人： Julian A. Gray , Yoshiharu Yamanishi , Julian A. Gray , Yoshiharu Yamanishi , Nobuyuki Mori , Scott Fields
IPC分类号： A61K31/444 , A61P25/28
CPC分类号： A61K31/4412 , A61K31/444 , A61K31/445 , A61K2300/00
摘要： The invention provides methods for treating and/or preventing cognitive impairments, dementia, or neurodegenerative diseases and disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis) in patients by administering therapeutically effective amounts of an AMPA receptor antagonist (e.g., 1,2-dihydropyridine compounds) and therapeutically effective amounts of nootropics (e.g., cholinesterase inhibitors) to patients. The invention also provides combinations, commercial packages, and pharmaceutical compositions comprising therapeutically effective amounts of AMPA receptor antagonists (e.g., 1,2-dihydropyridine compounds) and therapeutically effective amounts nootropics (e.g., cholinesterase inhibitors). The 1,2-dihydropyridine compound may be, for example, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one. The cholinesterase inhibitor may be, for example, donepezil.
摘要翻译：本发明提供了通过施用治疗有效量的AMPA受体拮抗剂（例如，治疗和/或预防）的方法来治疗和/或预防患者的认知障碍，痴呆或神经变性疾病和障碍（例如，阿尔茨海默氏病，帕金森病，亨廷顿舞蹈病，肌萎缩性侧索硬化），1,2-二氢吡啶化合物）和治疗有效量的益智酸（例如胆碱酯酶抑制剂）给患者。本发明还提供了包含治疗有效量的AMPA受体拮抗剂（例如1,2-二氢吡啶化合物）和治疗有效量的精神病药（例如胆碱酯酶抑制剂）的组合，商业包装和药物组合物。 1,2-二氢吡啶化合物可以是例如3-（2-氰基苯基）-5-（2-吡啶基）-1-苯基-1,2-二氢吡啶-2-酮。胆碱酯酶抑制剂可以是例如多奈哌齐。

3. 发明申请

US20070292418A1 Compositions and methods for immunotherapy 审中-公开
标题翻译：组合物和免疫治疗方法
公开(公告)号：US20070292418A1
公开(公告)日：2007-12-20
申请号：US11605557
申请日：2006-11-28
申请人： Scott Fields , Lynn Hawkins , Sally Ishizaka , Daniel Rossignol
发明人： Scott Fields , Lynn Hawkins , Sally Ishizaka , Daniel Rossignol
IPC分类号： A61K39/395 , A61P43/00
CPC分类号： A61K39/0008 , A61K39/0011 , A61K2039/55511 , A61K2039/55522
摘要： The invention relates to immunotherapeutic compounds, compositions that include such compounds, and methods of using the compounds, for example, to treat an individual having, at risk for, or previously treated for a cancer.
摘要翻译：本发明涉及免疫治疗化合物，包括这些化合物的组合物，以及使用该化合物的方法，例如，治疗患有癌症的风险或预先治疗的个体。

4. 发明授权

US08603482B2 Compositions and methods for cancer immunotherapy 有权
标题翻译：癌症免疫治疗的组成和方法
公开(公告)号：US08603482B2
公开(公告)日：2013-12-10
申请号：US13158786
申请日：2011-06-13
申请人： Daniel P. Rossignol , Sally T. Ishizaka , Lynn D. Hawkins , Scott Fields
发明人： Daniel P. Rossignol , Sally T. Ishizaka , Lynn D. Hawkins , Scott Fields
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/55511
摘要： The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment for cancer, or in post-therapy recovery from cancer or the compounds of the invention can be administered as a prophylactic to a subject individual to prevent or delay the development of cancer.
摘要翻译：本发明涉及免疫治疗化合物以及用于在患有癌症，癌症诊断，癌症治疗或癌症治疗后恢复的危险中的受试个体中刺激免疫应答的方法或本发明的化合物可以是作为对个体进行预防以预防或延缓癌症的发展。

5. 发明申请

US20070020232A1 Compositions and methods for cancer immunotherapy 有权
标题翻译：癌症免疫治疗的组成和方法
公开(公告)号：US20070020232A1
公开(公告)日：2007-01-25
申请号：US11411332
申请日：2006-04-26
申请人： Daniel Rossignol , Sally Ishizaka , Lynn Hawkins , Scott Fields
发明人： Daniel Rossignol , Sally Ishizaka , Lynn Hawkins , Scott Fields
IPC分类号： A61K39/395 , A61K38/08 , A61K38/21 , A61K38/19 , A61K31/522 , A61K31/5383 , A61K31/7076 , A61K31/7072 , A61K31/704 , A61K31/396 , A61K31/395
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/55511
摘要： The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment for cancer, or in post-therapy recovery from cancer or the compounds of the invention can be administered as a prophylactic to a subject individual to prevent or delay the development of cancer.
摘要翻译：本发明涉及免疫治疗化合物以及用于在患有癌症，癌症诊断，癌症治疗或癌症治疗后恢复的危险中的受试个体中刺激免疫应答的方法或本发明的化合物可以是作为对个体进行预防以预防或延缓癌症的发展。

6. 发明申请

US20060089823A1 Methods and systems for modeling stress intensity solutions for integrally stiffened panels 有权
标题翻译：用于整体加强板的应力强度解决方案的建模方法和系统
公开(公告)号：US20060089823A1
公开(公告)日：2006-04-27
申请号：US10974496
申请日：2004-10-26
申请人： Eric Meyer , Scott Fields , Ken Knopp , Jeffrey Sermersheim
发明人： Eric Meyer , Scott Fields , Ken Knopp , Jeffrey Sermersheim
IPC分类号： G06F17/10
CPC分类号： G06F17/5018 , G06F2217/04 , G06F2217/06
摘要： Systems and methods for modeling stress intensity solutions of integrally stiffened panels are disclosed. In one embodiment, a method includes serving a process over the internet. The process includes taking a problem definition, automatically forming a finite element model at least partially based on the problem definition, automatically verifying a suitability condition of the finite element model, automatically solving a computational solution using the finite element model and automatically validating the computational solution. In one aspect, providing a problem definition includes at least one of providing a geometry definition, providing a crack definition, and providing load and constraint definition.
摘要翻译：公开了用于对整体加强板的应力强度解的建模的系统和方法。在一个实施例中，一种方法包括通过因特网服务一个进程。该过程包括进行问题定义，至少部分地基于问题定义自动形成有限元模型，自动验证有限元模型的适用性条件，使用有限元模型自动求解计算解，并自动验证计算解。在一个方面，提供问题定义包括提供几何定义，提供裂缝定义以及提供加载和约束定义中的至少一个。

7. 发明授权

US5854851A System and method for diagnosis of living tissue diseases using digital image processing 失效
标题翻译：使用数字图像处理诊断活组织疾病的系统和方法
公开(公告)号：US5854851A
公开(公告)日：1998-12-29
申请号：US289381
申请日：1994-08-11
申请人： Philippe Bamberger , Isaac Leichter , Scott Fields
发明人： Philippe Bamberger , Isaac Leichter , Scott Fields
IPC分类号： G06T5/40 , G06K9/00
CPC分类号： G06T5/008 , G06T5/40 , G06T2207/30068
摘要： A system and method for diagnosis of living tissue diseases is described. The system includes a computer device for controlling its operation. An operator control device is coupled to the computer device. A viewing screen is coupled to the computer device for displaying digitized images of the living tissue. The operator, using the control device, selects desired portions of the digitized image for further image enhancement according to a desired image enhancement feature selectable from a plurality of image enhancement features. The image enhancement features include any combination of grey scale stretching, contrast enhancement based on logarithmic histogram equalization, spot enhancement and magnification. The system further includes means for visualization and quantification of micro-calcifications, and means for visualization and quantification of mass spiculations.
摘要翻译：描述了用于诊断活组织疾病的系统和方法。该系统包括用于控制其操作的计算机设备。操作员控制装置耦合到计算机装置。观察屏幕耦合到计算机设备，用于显示生物体组织的数字化图像。使用控制装置的操作者根据从多个图像增强特征中可选择的期望图像增强特征来选择数字化图像的期望部分以进一步增强图像。图像增强特征包括基于对数直方图均衡，斑点增强和放大的灰度拉伸，对比度增强的任何组合。该系统还包括用于微钙化的可视化和定量的装置，以及用于大量刺激的可视化和定量的装置。

8. 发明申请

US20080070944A1 Novel methods using aminobenzoic acid compounds 审中-公开
标题翻译：使用氨基苯甲酸化合物的新方法
公开(公告)号：US20080070944A1
公开(公告)日：2008-03-20
申请号：US11902338
申请日：2007-09-20
申请人： Jay Barth , Kathleen Lomax , Scott Fields , Mindell Seidlin
发明人： Jay Barth , Kathleen Lomax , Scott Fields , Mindell Seidlin
IPC分类号： A61K31/439 , A61P3/04
CPC分类号： A61K31/46
摘要： The invention provides safe and effective methods for treating and/or preventing gastrointestinal disorders, psychiatric disorders, learning disabilities, Tourette's syndrome, obesity, epilepsy, post-menopausal syndrome, pre-menstrual syndrome, asthma, laryngitis and/or migraines by administering to a patient in need thereof at least one aminobenzoic acid compound. The aminobenzoic acid compound can optionally be administered in combination with other medications that are useful for the disease being treated.
摘要翻译：本发明提供了安全和有效的治疗和/或预防胃肠道疾病，精神病学，学习障碍，图雷特综合征，肥胖症，癫痫，绝经后综合征，月经前症状，哮喘，喉炎和/或偏头痛的方法，需要患者的至少一种氨基苯甲酸化合物。氨基苯甲酸化合物可任选地与可用于所治疗疾病的其它药物组合施用。

9. 发明申请

US20070048701A1 Math aid 审中-公开
标题翻译：数学辅助
公开(公告)号：US20070048701A1
公开(公告)日：2007-03-01
申请号：US11219080
申请日：2005-09-01
申请人： Scott Fields
发明人： Scott Fields
IPC分类号： G09B23/02 , G09B19/02
CPC分类号： G09B19/02
摘要： A math teaching aid for helping beginning students learn how to count change. The invention includes a number of base units with cylindrical depressions in slots for a flag. A flag which determines the desired amount of change is placed in a flag holder in the base unit. Units representing pennies, nickels, dimes and quarters are then placed in the grooves of the base unit to arrive at the desired amount of change.
摘要翻译：帮助初学者的数学教学帮助学习如何计算变化。本发明包括多个基座单元，其具有用于标志的槽中的圆柱形凹陷。确定所需变化量的标志被放置在基本单元中的标志保持器中。然后将代表便士，镍，骰子和四分之一的单位放置在基本单元的槽中以达到所需的变化量。

10. 发明申请

US20070015789A1 Novel methods using aminobenzoic acid compounds 审中-公开
标题翻译：使用氨基苯甲酸化合物的新方法
公开(公告)号：US20070015789A1
公开(公告)日：2007-01-18
申请号：US11332711
申请日：2006-01-11
申请人： Jay Barth , Kathleen Lomax , Scott Fields , Mindell Seidlin
发明人： Jay Barth , Kathleen Lomax , Scott Fields , Mindell Seidlin
IPC分类号： A61K31/46
CPC分类号： A61K31/46
摘要： The invention provides safe and effective methods for treating and/or preventing gastrointestinal disorders, psychiatric disorders, learning disabilities, Tourette's syndrome, obesity, epilepsy, post-menopausal syndrome, pre-menstrual syndrome, asthma, laryngitis and/or migraines by administering to a patient in need thereof at least one aminobenzoic acid compound. The aminobenzoic acid compound can optionally be administered in combination with other medications that are useful for the disease being treated.
摘要翻译：本发明提供了安全和有效的治疗和/或预防胃肠道疾病，精神病学，学习障碍，图雷特综合征，肥胖症，癫痫，绝经后综合征，月经前症状，哮喘，喉炎和/或偏头痛的方法，需要患者的至少一种氨基苯甲酸化合物。氨基苯甲酸化合物可任选地与可用于所治疗疾病的其它药物组合施用。

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