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1. 发明申请

US20120070853A1 YKL-40 AS A MARKER FOR GASTROINTESTINAL CANCERS 失效
标题翻译： YKL-40作为胃肠癌标志物
公开(公告)号：US20120070853A1
公开(公告)日：2012-03-22
申请号：US13063402
申请日：2009-09-14
申请人： Julia Sidenius Johansen , Nicolai Aagaard Schultz , Benny Vittrup Jensen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
发明人： Julia Sidenius Johansen , Nicolai Aagaard Schultz , Benny Vittrup Jensen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N33/57446 , G01N2800/52
摘要： The present invention relates to gastrointestinal cancers and methods for selecting a treatment for said gastrointestinal cancer in a subject. The present invention further relates to a methods of diagnosing the presence of and/or classifying the severity of a gastrointestinal cancer; together with methods for determining the effect of a therapy administered and/or the prognosis for a subject suffering from a gastrointestinal cancer, before, during or after administering the treatment. For all the methods applies that a determined level of YKL-40 above one or more reference levels indicates the treatment, the severity of the disease, the effect of the treatment and/or the prognosis of the subject. The reference level is typically a level obtained from healthy individuals or a level previously obtained from the same subject. The subject may suffer from any one or more gastrointestinal cancers, such as upper gastrointestinal cancers, and metastatic colorectal cancer. The present invention further relates to a kit and a device that may be used in the method of the present invention.
摘要翻译：本发明涉及胃肠癌和用于选择受治疗者中所述胃肠癌的治疗的方法。本发明还涉及诊断胃肠癌的严重性的存在和/或分类的方法; 以及在施用治疗之前，期间或之后确定施用治疗的效果和/或患有胃肠癌患者的预后的方法。所有方法都适用于高于一个或多个参考水平的确定水平的YKL-40表示治疗，疾病的严重程度，治疗的效果和/或预后。参考水平通常是从健康个体获得的水平或以前从相同受试者获得的水平。受试者可能患有任何一种或多种胃肠癌，例如上消化道癌和转移性结肠直肠癌。本发明还涉及可用于本发明方法的试剂盒和装置。

2. 发明授权

US08580520B2 YKL-40 as a marker for gastrointestinal cancers 失效
标题翻译： YKL-40作为胃肠癌的标志物
公开(公告)号：US08580520B2
公开(公告)日：2013-11-12
申请号：US13063402
申请日：2009-09-14
申请人： Julia Sidenius Johansen , Nicolai Aagaard Schultz , Benny Vittrup Jensen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
发明人： Julia Sidenius Johansen , Nicolai Aagaard Schultz , Benny Vittrup Jensen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
IPC分类号： G01N33/53
CPC分类号： G01N33/57419 , G01N33/57446 , G01N2800/52
摘要： The present invention relates to gastrointestinal cancers and methods for selecting a treatment for said gastrointestinal cancer in a subject. The present invention further relates to a methods of diagnosing the presence of and/or classifying the severity of a gastrointestinal cancer; together with methods for determining the effect of a therapy administered and/or the prognosis for a subject suffering from a gastrointestinal cancer, before, during or after administering the treatment. For all the methods applies that a determined level of YKL-40 above one or more reference levels indicates the treatment, the severity of the disease, the effect of the treatment and/or the prognosis of the subject. The reference level is typically a level obtained from healthy individuals or a level previously obtained from the same subject. The subject may suffer from any one or more gastrointestinal cancers, such as upper gastrointestinal cancers, and metastatic colorectal cancer. The present invention further relates to a kit and a device that may be used in the method of the present invention.
摘要翻译：本发明涉及胃肠癌和用于选择受治疗者中所述胃肠癌的治疗的方法。本发明还涉及诊断胃肠癌的严重性的存在和/或分类的方法; 以及在施用治疗之前，期间或之后确定施用治疗的效果和/或患有胃肠癌患者的预后的方法。所有方法都适用于高于一个或多个参考水平的确定水平的YKL-40表示治疗，疾病的严重程度，治疗的效果和/或预后。参考水平通常是从健康个体获得的水平或以前从相同受试者获得的水平。受试者可能患有任何一种或多种胃肠癌，例如上消化道癌和转移性结肠直肠癌。本发明还涉及可用于本发明方法的试剂盒和装置。

3. 发明申请

US20120040354A1 METHODS OF CLASSIFYING THE SEVERITY OF DISEASES OR DISORDERS 审中-公开
标题翻译：分类疾病或疾病严重程度的方法
公开(公告)号：US20120040354A1
公开(公告)日：2012-02-16
申请号：US13063391
申请日：2009-09-14
申请人： Julia Sidenius Johansen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
发明人： Julia Sidenius Johansen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
IPC分类号： C12Q1/68 , C12M1/34 , G01N33/577
CPC分类号： G01N33/57488 , G01N33/57419 , G01N33/6887 , G01N2800/56
摘要： The present invention relates to methods of classifying the severity of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 is compared to one or more reference levels of YKL-40, and the severity of said non-specific disease or disorder is deduced from said comparison. The present invention furthermore relates to a method of classifying the severity of a disease or disorder in a subject, wherein a determined level of YKL-40 is compared to one or more previously determined levels of YKL-40 from the same subject. In both methods, the subject may suffer from a variety of diseases or disorders. In addition the present invention relates to a kit and a device that may be used in the methods of the present invention comprising means for measuring the level of YKL-40 in a sample; and means for comparing the measured level of YKL-40 with one or more reference levels of YKL-40.
摘要翻译：本发明涉及将受试者中非特异性疾病或病症的严重程度分类的方法，其中将确定水平的YKL-40与一个或多个参考水平的YKL-40进行比较，从所述比较中推导出特定的疾病或障碍。本发明还涉及对受试者中疾病或病症的严重程度进行分类的方法，其中将确定水平的YKL-40与来自同一受试者的一种或多种先前确定的YKL-40水平进行比较。在两种方法中，受试者可能患有各种疾病或病症。此外，本发明涉及可用于本发明方法的试剂盒和装置，其包括用于测量样品中YKL-40水平的装置; 以及用于将YKL-40的测量水平与YKL-40的一个或多个参考水平进行比较的装置。

4. 发明申请

US20120040355A1 YKL-40 AS A MARKER FOR SELECTION OF TREATMENT AND MONITORING OF A DISEASE 审中-公开
标题翻译： YKL-40作为选择疾病治疗和监测的标志
公开(公告)号：US20120040355A1
公开(公告)日：2012-02-16
申请号：US13063404
申请日：2009-09-14
申请人： Julia Sidenius Johansen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
发明人： Julia Sidenius Johansen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
IPC分类号： C12Q1/68 , G01N33/577
CPC分类号： G01N33/6887 , G01N33/57419 , G01N33/57488 , G01N2800/52
摘要： The present invention relates to a methods for selecting a treatment for a specific disease or disorder, together with a method of monitoring therapeutic treatment of a specific disease or disorder and a method of determining a prognosis for a subject before, during and after administering a treatment by determining the level of YKL-40 in a sample obtained from the subject and comparing said level with one or more reference levels of YKL-40. The reference level is typically a level obtained from healthy individuals or a level previously obtained from the same subject. The present invention further relates to a kit and a device that may be used in the methods of the present invention.
摘要翻译：本发明涉及用于选择特定疾病或病症的治疗的方法以及监测特定疾病或病症的治疗性治疗的方法以及在施用治疗之前，期间和之后确定受试者的预后的方法通过确定从受试者获得的样品中的YKL-40的水平，并将所述水平与YKL-40的一个或多个参考水平进行比较。参考水平通常是从健康个体获得的水平或以前从相同受试者获得的水平。本发明还涉及可用于本发明方法的试剂盒和装置。

5. 发明授权

US08697384B2 YKL-40 as a general marker for non-specific disease 失效
标题翻译： YKL-40作为非特异性疾病的一般标志物
公开(公告)号：US08697384B2
公开(公告)日：2014-04-15
申请号：US12812409
申请日：2009-01-22
申请人： Julia Johansen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
发明人： Julia Johansen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
IPC分类号： C12Q1/37
CPC分类号： G01N33/6893 , G01N2400/00 , G01N2800/50
摘要： The present invention relates to methods of diagnosing the presence of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above a reference level indicates the presence of a non-specific disease or disorder. The subject may suffer from a variety of diseases or disorders. The reference level may be a reference level obtained from healthy individuals or it may be a previous measurement obtained from the same subject. The present invention furthermore relates to a method for classifying the severity of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above or below one or more reference levels gives the severity of said non-specific disease or disorder. The present invention further relates to a kit and a device that may be used in the method of the present invention comprising means for measuring the level of YKL-40 in a sample; and means for comparing the measured level of YKL-40 with at least one reference level of YKL-40.
摘要翻译：本发明涉及诊断受试者中非特异性疾病或病症的存在的方法，其中确定的高于参考水平的YKL-40水平表明存在非特异性疾病或病症。受试者可能患有各种疾病或病症。参考水平可以是从健康个体获得的参考水平，或者可以是从相同受试者获得的先前测量值。本发明还涉及用于分类受试者中非特异性疾病或病症的严重性的方法，其中确定的YKL-40水平高于或低于一个或多个参考水平给出所述非特异性疾病的严重性或紊乱。本发明还涉及可用于本发明方法的试剂盒和装置，其包括用于测量样品中YKL-40水平的装置; 以及用于将YKL-40的测量水平与YKL-40的至少一个参考水平进行比较的装置。

6. 发明申请

US20110045518A1 YKL-40 AS A GENERAL MARKER FOR NON-SPECIFIC DISEASE 失效
标题翻译： YKL-40作为非特异性疾病的一般标记
公开(公告)号：US20110045518A1
公开(公告)日：2011-02-24
申请号：US12812409
申请日：2009-01-22
申请人： Julia Johansen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
发明人： Julia Johansen , Stig Bojesen , Børge Grønne Nordestgaard , Hans Jørgen Nielsen , Ib Jarle Christensen
IPC分类号： C12Q1/34 , C12Q1/37 , C12M1/34
CPC分类号： G01N33/6893 , G01N2400/00 , G01N2800/50
摘要： The present invention relates to methods of diagnosing the presence of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above a reference level indicates the presence of a non-specific disease or disorder. The subject may suffer from a variety of diseases or disorders. The reference level may be a reference level obtained from healthy individuals or it may be a previous measurement obtained from the same subject. The present invention furthermore relates to a method for classifying the severity of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above or below one or more reference levels gives the severity of said non-specific disease or disorder. The present invention further relates to a kit and a device that may be used in the method of the present invention comprising means for measuring the level of YKL-40 in a sample; and means for comparing the measured level of YKL-40 with at least one reference level of YKL-40.
摘要翻译：本发明涉及诊断受试者中非特异性疾病或病症的存在的方法，其中确定的高于参考水平的YKL-40水平表明存在非特异性疾病或病症。受试者可能患有各种疾病或病症。参考水平可以是从健康个体获得的参考水平，或者可以是从相同受试者获得的先前测量值。本发明还涉及用于分类受试者中非特异性疾病或病症的严重性的方法，其中确定的YKL-40水平高于或低于一个或多个参考水平给出所述非特异性疾病的严重性或紊乱。本发明还涉及可用于本发明方法的试剂盒和装置，其包括用于测量样品中YKL-40水平的装置; 以及用于将YKL-40的测量水平与YKL-40的至少一个参考水平进行比较的装置。

7. 发明授权

US07807379B2 Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker 失效
标题翻译：基质金属蛋白酶1型（TIMP-1）的组织抑制剂作为癌症标志物
公开(公告)号：US07807379B2
公开(公告)日：2010-10-05
申请号：US11449869
申请日：2006-06-09
申请人： Mads Holten-Andersen , Ross Stephens , Hans Jørgen Nielsen , Ib Jarle Christensen , Nils Brünner
发明人： Mads Holten-Andersen , Ross Stephens , Hans Jørgen Nielsen , Ib Jarle Christensen , Nils Brünner
IPC分类号： G01N33/53
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/57484 , G01N2333/8146 , G01N2333/96494
摘要： The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.
摘要翻译：本发明描述了通过确定表示来自个体的体液样品中的TIMP-1浓度的参数来确定个体是否可能患有癌症的方法。

8. 发明申请

US20110060529A1 TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES TYPE-1 (TIMP-1) AS A CANCER MARKER 审中-公开
标题翻译：基质金属蛋白酶1（TIMP-1）作为癌症标记物的组织抑制剂
公开(公告)号：US20110060529A1
公开(公告)日：2011-03-10
申请号：US12871735
申请日：2010-08-30
申请人： Mads Holten-Andersen , Ross W. Stephens , Hans Jørgen Nielsen , Ib Jarle Christensen , Nils Brünner
发明人： Mads Holten-Andersen , Ross W. Stephens , Hans Jørgen Nielsen , Ib Jarle Christensen , Nils Brünner
IPC分类号： G06F19/00 , G01N33/53
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/57484 , G01N2333/8146 , G01N2333/96494
摘要： The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.
摘要翻译：本发明描述了通过确定表示来自个体的体液样品中的TIMP-1浓度的参数来确定个体是否可能患有癌症的方法。

9. 发明授权

US07374886B2 Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker and postoperative marker for minimal residual disease or recurrent disease in patients with a prior history of cancer 失效
标题翻译：基质金属蛋白酶1型（TIMP-1）的组织抑制剂作为癌症标志物，并且具有癌症病史的患者中残留病或复发性疾病的最小残留标志物
公开(公告)号：US07374886B2
公开(公告)日：2008-05-20
申请号：US10117030
申请日：2002-04-08
申请人： Mads Nikolaj Holten-Andersen , Ib Jarle Christensen , Nils Brünner , Hans Jørgen Nielsen
发明人： Mads Nikolaj Holten-Andersen , Ib Jarle Christensen , Nils Brünner , Hans Jørgen Nielsen
IPC分类号： G01N33/53
CPC分类号： G01N33/57484 , G01N33/57415 , G01N33/57419 , G01N2333/8146 , G01N2333/96494
摘要： The present invention describes a method for determining whether an individual is suffering from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.The present invention furthermore describes a method for determining whether an individual is suffering from minimal residual disease or recurrent cancer after being treated for the primary cancer by determining a parameter representing the post-operative TIMP-1 concentration in body fluid samples from the individual. In addition, the invention describes the additive effect of combined post-operative measurements of plasma TIMP-1 and serum CEA.
摘要翻译：本发明描述了通过确定表示来自个体的体液样品中的TIMP-1浓度的参数来确定个体是否患有癌症的方法。本发明还描述了一种用于通过确定表示来自个体的体液样品中的手术后TIMP-1浓度的参数来确定个体是否患有原发性癌症治疗后的最小残留疾病或复发性癌症的方法。此外，本发明描述了血浆TIMP-1和血清CEA组合术后测量的叠加效应。

10. 发明申请

US20110294148A1 TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES TYPE-1 (TIMP-1) AS A CANCER MARKER AND POSTOPERATIVE MARKER FOR MINIMAL RESIDUAL DISEASE OR RECURRENT DISEASE IN PATIENTS WITH A PRIOR HISTORY OF CANCER 审中-公开
标题翻译：作为癌症标志物的基质金属蛋白酶1（TIMP-1）的组织抑制剂和用于癌症以前的病史的患者的最小残留疾病或复发性疾病的手术标记
公开(公告)号：US20110294148A1
公开(公告)日：2011-12-01
申请号：US13198519
申请日：2011-08-04
申请人： Mads Nikolaj Holten-Andersen , Ib Jarle Christensen , Nils Brünner , Hans Jørgen Nielsen
发明人： Mads Nikolaj Holten-Andersen , Ib Jarle Christensen , Nils Brünner , Hans Jørgen Nielsen
IPC分类号： G01N33/566 , G01N27/447 , G06F19/00 , G01N33/559
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/57484 , G01N2333/8146 , G01N2333/96494
摘要： The present invention describes a method for determining whether an individual is suffering from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual. The present invention furthermore describes a method for determining whether an individual is suffering from minimal residual disease or recurrent cancer after being treated for the primary cancer by determining a parameter representing the post-operative TIMP-1 concentration in body fluid samples from the individual. In addition, the invention describes the additive effect of combined post-operative measurements of plasma TIMP-1 and serum CEA.
摘要翻译：本发明描述了通过确定表示来自个体的体液样品中的TIMP-1浓度的参数来确定个体是否患有癌症的方法。本发明还描述了一种用于通过确定表示来自个体的体液样品中的手术后TIMP-1浓度的参数来确定个体在治疗原发性癌症后是否患有最小残留疾病或复发性癌症的方法。此外，本发明描述了血浆TIMP-1和血清CEA组合术后测量的叠加效应。

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