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1. 发明授权

US08909337B2 System to treat AV-conducted ventricular tachyarrhythmia 有权
标题翻译：系统治疗AV进行性室性快速性心律失常
公开(公告)号：US08909337B2
公开(公告)日：2014-12-09
申请号：US13473774
申请日：2012-05-17
申请人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
发明人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
IPC分类号： A61N1/365 , A61N1/368 , A61N1/362 , A61N1/36 , A61N1/39 , A61B5/0464 , A61N1/05
CPC分类号： A61N1/36114 , A61B5/0464 , A61N1/0587 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3962 , A61N2001/0585
摘要： Various aspects of the present subject matter provide devices and methods to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments of the method, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面提供了治疗AV进行性室性快速性心律失常（AVCVT）的装置和方法。根据该方法的各种实施例，感测到AVCVT，当检测到AVCVT以阻止AV传导时刺激IVC-LA脂肪垫，并且在IVC-LA脂肪垫被刺激的同时提供心动过缓支持起搏。本文提供了其它方面和实施例。

2. 发明授权

US08190257B2 System to treat AV-conducted ventricular tachyarrhythmia 有权
标题翻译：系统治疗AV进行性室性快速性心律失常
公开(公告)号：US08190257B2
公开(公告)日：2012-05-29
申请号：US12473783
申请日：2009-05-28
申请人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
发明人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61B5/0464 , A61N1/0587 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3962 , A61N2001/0585
摘要： Various aspects of the present subject matter provide devices and methods to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments of the method, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面提供了治疗AV进行性室性快速性心律失常（AVCVT）的装置和方法。根据该方法的各种实施例，感测到AVCVT，当检测到AVCVT以阻止AV传导时刺激IVC-LA脂肪垫，并且在IVC-LA脂肪垫被刺激的同时提供心动过缓支持起搏。本文提供了其它方面和实施例。

3. 发明申请

US20100286741A1 CARDIAC RHYTHM MANAGEMENT DEVICE WITH NEURAL SENSOR 审中-公开
标题翻译： CARDIAC RHYTHM管理设备与神经传感器
公开(公告)号：US20100286741A1
公开(公告)日：2010-11-11
申请号：US12840449
申请日：2010-07-21
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36117
摘要： Various aspects of the present subject matter relate to a device. In various embodiments, the device comprises at least one port adapted to connect at least one lead, a CRM functions module connected to the port and adapted to provide at least one CRM function using the lead, a neural function module, and a controller connected to the CRM functions module and the neural function module. The at least one CRM function includes a function to provide an electrical signal to the lead to capture cardiac tissue. The neural function module includes a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The controller is adapted to implement a CRM therapy based on the signal indicative of the nerve traffic. Other aspects are provided herein.
摘要翻译：本主题的各个方面涉及一种装置。在各种实施例中，该装置包括适于连接至少一个引线，连接到端口的CRM功能模块和适于使用引线提供至少一个CRM功能的至少一个端口，神经功能模块和连接到 CRM功能模块和神经功能模块。所述至少一个CRM功能包括向导线提供电信号以捕获心脏组织的功能。所述神经功能模块包括连接到所述端口的信号处理模块，并适于接收并处理来自所述导线的神经交通信号并将其处理成指示神经流量的信号。控制器适于基于指示神经流量的信号来实施CRM治疗。本文提供了其他方面。

4. 发明授权

US09409025B2 Cardiac rhythm management device with neural sensor 有权
公开(公告)号：US09409025B2
公开(公告)日：2016-08-09
申请号：US12840449
申请日：2010-07-21
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36117
摘要： Various aspects of the present subject matter relate to a device. In various embodiments, the device comprises at least one port adapted to connect at least one lead, a CRM functions module connected to the port and adapted to provide at least one CRM function using the lead, a neural function module, and a controller connected to the CRM functions module and the neural function module. The at least one CRM function includes a function to provide an electrical signal to the lead to capture cardiac tissue. The neural function module includes a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The controller is adapted to implement a CRM therapy based on the signal indicative of the nerve traffic. Other aspects are provided herein.

5. 发明申请

US20130165998A1 SYSTEM AND METHOD FOR CLOSED-LOOP NEURAL STIMULATION 审中-公开
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US20130165998A1
公开(公告)日：2013-06-27
申请号：US13709271
申请日：2012-12-10
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/36117
摘要： Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.
摘要翻译：各种装置实施例包括脉冲发生器，信号处理模块和控制器。脉冲发生器适于提供在自主神经系统（ANS）内的神经模拟部位应用的神经刺激信号。信号处理模块适于在ANS内的神经感测部位接收和处理感测到的神经流量。控制器连接到脉冲发生器并且适于向脉冲发生器提供神经刺激控制信号以产生神经刺激信号，并且向信号处理模块接收指示所感测的神经流量的反馈控制信号。控制器适于调整神经刺激控制信号以调整神经刺激信号的至少一个参数以收敛于神经感测位置处的期望感测的神经交通。本文提供了其它方面和实施例。

6. 发明授权

US08396560B2 System and method for closed-loop neural stimulation 有权
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US08396560B2
公开(公告)日：2013-03-12
申请号：US10992319
申请日：2004-11-18
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/18
CPC分类号： A61N1/36117 , A61N1/08 , A61N1/36171
摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供了一种装置。在各种实施例中，该装置包括适于连接引线的端口，连接到端口的脉冲发生器，并适于向引线提供神经刺激信号，以及信号处理模块，连接到端口并且适于接收和处理神经交通信号从引导到指示神经交通的信号。该装置包括连接到脉冲发生器和信号处理模块的控制器。控制器适于实现刺激方案，以基于指示神经交通的信号向神经刺激信号提供期望的神经刺激参数。本文提供了其他方面。

7. 发明申请

US20090234408A1 SYSTEM TO TREAT AV-CONDUCTED VENTRICULAR TACHYARRHYTHMIA 有权
标题翻译：系统治疗AV导致的心室TachyarRHYTHMIA
公开(公告)号：US20090234408A1
公开(公告)日：2009-09-17
申请号：US12473783
申请日：2009-05-28
申请人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
发明人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61B5/0464 , A61N1/0587 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3962 , A61N2001/0585
摘要： Various aspects of the present subject matter provide devices and methods to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments of the method, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面提供了治疗AV进行性室性快速性心律失常（AVCVT）的装置和方法。根据该方法的各种实施例，感测到AVCVT，当检测到AVCVT以阻止AV传导时刺激IVC-LA脂肪垫，并且在IVC-LA脂肪垫被刺激的同时提供心动过缓支持起搏。本文提供了其它方面和实施例。

8. 发明申请

US20130190837A1 SYSTEM AND METHOD FOR CLOSED-LOOP NEURAL STIMULATION 审中-公开
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US20130190837A1
公开(公告)日：2013-07-25
申请号：US13792805
申请日：2013-03-11
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/08 , A61N1/36171
摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供了一种装置。在各种实施例中，该装置包括适于连接引线的端口，连接到端口的脉冲发生器，并适于向引线提供神经刺激信号，以及信号处理模块，连接到端口并适于接收和处理神经交通信号从引导到指示神经交通的信号。该装置包括连接到脉冲发生器和信号处理模块的控制器。控制器适于实现刺激方案，以基于指示神经交通的信号向神经刺激信号提供期望的神经刺激参数。本文提供了其他方面。

9. 发明申请

US20120232604A1 SYSTEM TO TREAT AV-CONDUCTED VENTRICULAR TACHYARRHYTHMIA 有权
标题翻译：系统治疗AV导致的心室TachyarRHYTHMIA
公开(公告)号：US20120232604A1
公开(公告)日：2012-09-13
申请号：US13473774
申请日：2012-05-17
申请人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
发明人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/36114 , A61B5/0464 , A61N1/0587 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3962 , A61N2001/0585
摘要： Various aspects of the present subject matter provide devices and methods to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments of the method, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面提供了治疗AV进行性室性快速性心律失常（AVCVT）的装置和方法。根据该方法的各种实施例，感测到AVCVT，当检测到AVCVT以阻止AV传导时刺激IVC-LA脂肪垫，并且在IVC-LA脂肪垫被刺激的同时提供心动过缓支持起搏。本文提供了其它方面和实施例。

10. 发明授权

US08332047B2 System and method for closed-loop neural stimulation 有权
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US08332047B2
公开(公告)日：2012-12-11
申请号：US11280940
申请日：2005-11-16
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36053 , A61N1/36117
摘要： Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.
摘要翻译：各种装置实施例包括脉冲发生器，信号处理模块和控制器。脉冲发生器适于提供在自主神经系统（ANS）内的神经模拟部位应用的神经刺激信号。信号处理模块适于在ANS内的神经感测部位接收和处理感测到的神经流量。控制器连接到脉冲发生器并且适于向脉冲发生器提供神经刺激控制信号以产生神经刺激信号，并且向信号处理模块接收指示所感测的神经流量的反馈控制信号。控制器适于调整神经刺激控制信号以调整神经刺激信号的至少一个参数以收敛于神经感测位置处的期望感测的神经交通。本文提供了其它方面和实施例。

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