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    • 3. 发明申请
    • Recombinant vaccine against bluetongue virus
    • 针对蓝舌病毒的重组疫苗
    • US20070280960A1
    • 2007-12-06
    • US11444698
    • 2006-06-01
    • Jean Christophe Francis AudonnetKemal KaracaJiansheng YaoNigel James MacLachlan
    • Jean Christophe Francis AudonnetKemal KaracaJiansheng YaoNigel James MacLachlan
    • A61K39/12A61K39/275
    • C07K14/005A61K2039/5256C12N15/86C12N2710/24043C12N2720/12122C12N2720/12134G01N33/56983G01N33/6854
    • The present invention relates to an immunogenic or vaccine composition to induce an immune response or protective immune response against Orbiviruses, more specifically bluetongue virus (BTV) in an animal susceptible to BTV infection. The composition may include a pharmaceutically or veterinarily acceptable vehicle or excipient, and a vector. The vector may contain heterologous nucleic acid molecule(s), expresses in vivo in the animal BTV antigen, immunogen or epitope thereof, e.g., BTV VP2; BTV VP2 and VP5; BTV VP2 and VP5 and VP3 and/or VP7. The composition can contain an adjuvant, such as carbomer. Methods for making and using such a composition, including prime-boost regimes and including as to differential diagnosis, are also contemplated. AGACAGTGGTCAATTCCAATGGTACTGTTTGACGATAC
    • 本发明涉及一种免疫原性或疫苗组合物,用于在易感BTV感染的动物中诱导针对罗非鱼病毒的免疫应答或保护性免疫应答,更具体地说是Bluetong病毒(BTV)。 组合物可以包括药学上或兽医学上可接受的载体或赋形剂和载体。 载体可以含有异源核酸分子,在体内在动物BTV抗原,免疫原或其表位例如BTV VP2中表达; BTV VP2和VP5; BTV VP2和VP5以及VP3和/或VP7。 组合物可以含有佐剂,如卡波姆。 还考虑制备和使用这种组合物的方法,包括初始 - 加强方案和包括鉴别诊断。
      AGACAGTGGTCAATTCCAATGGTACTGTTTGACGATAC