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1. 发明申请

US20060116673A1 Ablation instrument and method 审中-公开
标题翻译：消融仪和方法
公开(公告)号：US20060116673A1
公开(公告)日：2006-06-01
申请号：US11336214
申请日：2006-01-20
申请人： Jules Gauthier , Dany Berube , Hiep Nguyen
发明人： Jules Gauthier , Dany Berube , Hiep Nguyen
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B18/1492 , A61B18/18 , A61B2018/1807 , A61B2018/1861
摘要： A flexible microwave antenna assembly for a surgical ablation instrument is capable of conforming to a tissue surface for ablation thereof. The ablation instrument includes a transmission line having a proximal portion suitable for connection to an electromagnetic energy source, and includes a flexible antenna coupled to the transmission line for radially generating an electric field sufficiently strong to cause tissue ablation. A flexible shield device is coupled to the antenna to substantially shield a surrounding area of the antenna from the electric field radially generated therefrom while permitting a majority of the field to be directed generally in a predetermined direction. A flexible insulator is disposed between the shield device and the antenna to define a window portion enabling the transmission of the directed electric field in the predetermined direction. The antenna, the shield device and the insulator are formed for selective manipulative bending thereof, as a unit, into contact positions that generally conform the window portion to the biological tissue surface to be ablated.
摘要翻译：用于外科消融器械的柔性微波天线组件能够符合组织表面以用于其消融。消融仪器包括具有适于连接到电磁能源的近端部分的传输线，并且包括耦合到传输线的柔性天线，用于径向产生足够强的电场以引起组织消融。柔性屏蔽装置耦合到天线，以基本上屏蔽天线的周围区域与从其径向产生的电场，同时允许大部分区域通常沿预定方向定向。柔性绝缘体设置在屏蔽装置和天线之间以限定能够沿预定方向传输定向电场的窗口部分。形成天线，屏蔽装置和绝缘体，用于将其作为一个单元选择性地操作弯曲成通常使窗口部分与要烧蚀的生物组织表面一致的接触位置。

2. 发明授权

US07301131B2 Microwave ablation instrument with flexible antenna assembly and method 失效
标题翻译：微波消融仪具有柔性天线组件及方法
公开(公告)号：US07301131B2
公开(公告)日：2007-11-27
申请号：US11356917
申请日：2006-02-16
申请人： Jules Gauthier , Dany Berube , Hiep Nguyen
发明人： Jules Gauthier , Dany Berube , Hiep Nguyen
IPC分类号： H05B6/64 , A61N1/00
CPC分类号： A61B18/1815 , A61B18/1492 , A61B18/18 , A61B2018/1807 , A61B2018/1861
摘要： A flexible microwave antenna assembly for a surgical ablation instrument capable of conforming to a tissue surface for ablation thereof. The ablation instrument includes a transmission line having a proximal portion suitable for connection to an electromagnetic energy source. The antenna assembly includes a flexible antenna coupled to the transmission line for radially generating an electric field sufficiently strong to cause tissue ablation. A flexible shield device is coupled to the antenna to substantially shield a surrounding area of the antenna from the electric field radially generated therefrom while permitting a majority of the field to be directed generally in a predetermined direction. A flexible insulator is disposed between the shield device and the antenna which defines a window portion enabling the transmission of the directed electric field in the predetermined direction. The antenna, the shield device and the insulator are formed for selective manipulative bending thereof, as a unit, to one of a plurality of contact positions to generally conform the window portion to the biological tissue surface to be ablated.
摘要翻译：一种用于外科消融器械的柔性微波天线组件，其能够符合组织表面以用于其消融。消融器具包括具有适于连接到电磁能源的近端部分的传输线。天线组件包括耦合到传输线的柔性天线，用于径向地产生足够强的电场以引起组织消融。柔性屏蔽装置耦合到天线，以基本上屏蔽天线的周围区域与从其径向产生的电场，同时允许大部分区域通常沿预定方向定向。柔性绝缘体设置在屏蔽装置和天线之间，该天线限定能够沿着预定方向传输定向电场的窗口部分。形成天线，屏蔽装置和绝缘体，用于将其作为一个单元选择性操作地弯曲成多个接触位置中的一个，以将窗口部分大体上与待烧蚀的生物组织表面相一致。

3. 发明申请

US20060138122A1 Microwave ablation instrument with flexible antenna assembly and method 失效
公开(公告)号：US20060138122A1
公开(公告)日：2006-06-29
申请号：US11356917
申请日：2006-02-16
申请人： Jules Gauthier , Dany Berube , Hiep Nguyen
发明人： Jules Gauthier , Dany Berube , Hiep Nguyen
IPC分类号： H05B3/16
CPC分类号： A61B18/1815 , A61B18/1492 , A61B18/18 , A61B2018/1807 , A61B2018/1861
摘要： A flexible microwave antenna assembly for a surgical ablation instrument capable of conforming to a tissue surface for ablation thereof. The ablation instrument includes a transmission line having a proximal portion suitable for connection to an electromagnetic energy source. The antenna assembly includes a flexible antenna coupled to the transmission line for radially generating an electric field sufficiently strong to cause tissue ablation. A flexible shield device is coupled to the antenna to substantially shield a surrounding area of the antenna from the electric field radially generated therefrom while permitting a majority of the field to be directed generally in a predetermined direction. A flexible insulator is disposed between the shield device and the antenna which defines a window portion enabling the transmission of the directed electric field in the predetermined direction. The antenna, the shield device and the insulator are formed for selective manipulative bending thereof, as a unit, to one of a plurality of contact positions to generally conform the window portion to the biological tissue surface to be ablated.

4. 发明授权

US07033352B1 Flexible ablation instrument 失效
标题翻译：柔性消融仪
公开(公告)号：US07033352B1
公开(公告)日：2006-04-25
申请号：US09484548
申请日：2000-01-18
申请人： Jules Gauthier , Dany Berube , Hiep Nguyen
发明人： Jules Gauthier , Dany Berube , Hiep Nguyen
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B18/1492 , A61B18/18 , A61B2018/1807 , A61B2018/1861
摘要： A flexible microwave antenna assembly for a surgical ablation instrument capable of conforming to a tissue surface for ablation thereof. The ablation instrument includes a transmission line having a proximal portion suitable for connection to an electromagnetic energy source. The antenna assembly includes a flexible antenna coupled to the transmission line for radially generating an electric field sufficiently strong to cause tissue ablation. A flexible shield device is coupled to the antenna to substantially shield a surrounding area of the antenna from the electric field radially generated therefrom while permitting a majority of the field to be directed generally in a predetermined direction. A flexible insulator is disposed between the shield device and the antenna which defines a window portion enabling the transmission of the directed electric field in the predetermined direction. The antenna, the shield device and the insulator are formed for selective manipulative bending thereof, as a unit, to one of a plurality of contact positions to generally conform the window portion to the biological tissue surface to be ablated.
摘要翻译：一种用于外科消融器械的柔性微波天线组件，其能够符合组织表面以用于其消融。消融器具包括具有适于连接到电磁能源的近端部分的传输线。天线组件包括耦合到传输线的柔性天线，用于径向地产生足够强的电场以引起组织消融。柔性屏蔽装置耦合到天线，以基本上屏蔽天线的周围区域与从其径向产生的电场，同时允许大部分区域通常沿预定方向定向。柔性绝缘体设置在屏蔽装置和天线之间，该天线限定能够沿着预定方向传输定向电场的窗口部分。形成天线，屏蔽装置和绝缘体，用于将其作为一个单元选择性操作地弯曲成多个接触位置中的一个，以将窗口部分大体上与待烧蚀的生物组织表面相一致。

5. 发明申请

US20080071259A1 MICROWAVE ABLATION INSTRUMENT WITH FLEXIBLE ANTENNA ASSEMBLY 审中-公开
标题翻译：具有柔性天线组件的微波雷达仪器
公开(公告)号：US20080071259A1
公开(公告)日：2008-03-20
申请号：US11945072
申请日：2007-11-26
申请人： Jules Gauthier , Dany Berube , Hiep Nguyen
发明人： Jules Gauthier , Dany Berube , Hiep Nguyen
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B18/1492 , A61B18/18 , A61B2018/1807 , A61B2018/1861
摘要： A flexible microwave antenna assembly for a surgical ablation instrument capable of conforming to a tissue surface for ablation thereof. The ablation instrument includes a transmission line having a proximal portion suitable for connection to an electromagnetic energy source. The antenna assembly includes a flexible antenna coupled to the transmission line for radially generating an electric field sufficiently strong to cause tissue ablation. A flexible shield device is coupled to the antenna to substantially shield a surrounding area of the antenna from the electric field radially generated therefrom while permitting a majority of the field to be directed generally in a predetermined direction. A flexible insulator is disposed between the shield device and the antenna which defines a window portion enabling the transmission of the directed electric field in the predetermined direction. The antenna, the shield device and the insulator are formed for selective manipulative bending thereof, as a unit, to one of a plurality of contact positions to generally conform the window portion to the biological tissue surface to be ablated.
摘要翻译：一种用于外科消融器械的柔性微波天线组件，其能够符合组织表面以用于其消融。消融器具包括具有适于连接到电磁能源的近端部分的传输线。天线组件包括耦合到传输线的柔性天线，用于径向地产生足够强的电场以引起组织消融。柔性屏蔽装置耦合到天线，以基本上屏蔽天线的周围区域与从其径向产生的电场，同时允许大部分区域通常沿预定方向定向。柔性绝缘体设置在屏蔽装置和天线之间，该天线限定能够沿着预定方向传输定向电场的窗口部分。形成天线，屏蔽装置和绝缘体，用于将其作为一个单元选择性操作地弯曲成多个接触位置中的一个，以将窗口部分大体上与待烧蚀的生物组织表面相一致。

6. 发明授权

US07497858B2 Apparatus and method for assessing transmurality of a tissue ablation 失效
标题翻译：用于评估组织消融的透壁性的装置和方法
公开(公告)号：US07497858B2
公开(公告)日：2009-03-03
申请号：US11682744
申请日：2007-03-06
申请人： Pierre-Antoine Chapelon , Dany Berube , Hiep Nguyen , Faouzi Kallel
发明人： Pierre-Antoine Chapelon , Dany Berube , Hiep Nguyen , Faouzi Kallel
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/00026 , A61B2017/00243 , A61B2018/00351 , A61B2018/00702 , A61B2018/00875
摘要： An instrument assesses the transmurality of an ablation lesion from a first surface of a targeted biological tissue to an opposed second surface thereof. The instrument includes at least a first electrode operably attached to an ablation instrument adapted to engage a tissue first surface, and at least a second electrode adapted to engage a tissue second surface, the at least second electrode positioned generally opposed to the at least first electrode. Alternatively, the at least second electrode may be adapted to be placed within a chamber of an organ. These electrodes facilitate measuring at least one of conduction time, conduction velocity, phase angle, and impedance through at least a portion of the targeted tissue to determine the transmurality of the ablation lesion.
摘要翻译：仪器评估消融病变从目标生物组织的第一表面到其相对的第二表面的透壁性。所述仪器包括至少第一电极，其可操作地附接到适于接合组织第一表面的消融仪器，以及适于接合组织第二表面的至少第二电极，所述至少第二电极与所述至少第一电极大致相对。或者，至少第二电极可以适于放置在器官的腔室内。这些电极有助于测量通过目标组织的至少一部分的导通时间，传导速度，相位角和阻抗中的至少一个，以确定消融损伤的透壁性。

7. 发明授权

US07099717B2 Catheter having improved steering 失效
公开(公告)号：US07099717B2
公开(公告)日：2006-08-29
申请号：US10039887
申请日：2002-01-03
申请人： Robert E. Woodard , Hiep Nguyen , Dany Berube
发明人： Robert E. Woodard , Hiep Nguyen , Dany Berube
IPC分类号： A61B18/18
CPC分类号： A61B18/1492
摘要： A catheter system with an enhanced steering system, allowing for positioning the distal portion of the catheter proximate to a desired biological target tissue site, is provided. The system includes an elongated tubular member having a steerable distal end configured to deflect, or otherwise direct, and properly position at least a portion of the distal end comprising an ablation device during a surgical procedure allowing for the placement of the deflected portion adjacent or proximate to the target tissue surface. The steering system may alternatively be incorporated into a separate guiding catheter as part of the catheter system.

8. 发明授权

US06893436B2 Ablation instrument having a flexible distal portion 失效
标题翻译：消融仪器具有柔性的远端部分
公开(公告)号：US06893436B2
公开(公告)日：2005-05-17
申请号：US10039872
申请日：2002-01-03
申请人： Robert E. Woodard , Hiep Nguyen , Dany Berube
发明人： Robert E. Woodard , Hiep Nguyen , Dany Berube
IPC分类号： A61B17/00 , A61B18/14 , A61B18/18 , A61B19/00
CPC分类号： A61B18/1815 , A61B18/1492 , A61B18/18 , A61B2017/003 , A61B2018/1861 , A61B2090/0454
摘要： An ablation instrument having a flexible portion at or near the distal portion of the instrument, is provided. The instrument includes an elongated tubular member having a steerable distal end configured to deflect, or otherwise direct, and properly position at least a portion of the distal portion, comprising an ablation device, during an ablation procedure. The instrument further includes a deflectable member which cooperates with the steering system allowing for the proper placement of the ablation device adjacent or proximate to the target tissue surface. The steering system may alternatively be incorporated into a separate guiding catheter as part of the catheter system.
摘要翻译：提供了一种在仪器的远端部分或其附近具有柔性部分的消融器械。仪器包括细长的管状构件，其具有可转向的远端，构造成在消融过程期间偏转或以其它方式指导和适当地定位包括消融装置的远侧部分的至少一部分。仪器还包括与转向系统配合的可偏转构件，允许消融装置在目标组织表面附近或邻近处适当放置。转向系统可替代地作为导管系统的一部分并入到单独的引导导管中。

9. 发明申请

US20070149967A1 Apparatus and Method For Assessing Transmurality of a Tissue Ablation 失效
标题翻译：用于评估组织消融的透明度的装置和方法
公开(公告)号：US20070149967A1
公开(公告)日：2007-06-28
申请号：US11682744
申请日：2007-03-06
申请人： Pierre-Antoine Chapelon , Dany Berube , Hiep Nguyen , Faouzi Kallel
发明人： Pierre-Antoine Chapelon , Dany Berube , Hiep Nguyen , Faouzi Kallel
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00026 , A61B2017/00243 , A61B2018/00351 , A61B2018/00702 , A61B2018/00875
摘要： An instrument assesses the transmurality of an ablation lesion from a first surface of a targeted biological tissue to an opposed second surface thereof. The instrument includes at least a first electrode operably attached to an ablation instrument adapted to engage a tissue first surface, and at least a second electrode adapted to engage a tissue second surface, the at least second electrode positioned generally opposed to the at least first electrode. Alternatively, the at least second electrode may be adapted to be placed within a chamber of an organ. These electrodes facilitate measuring at least one of conduction time, conduction velocity, phase angle, and impedance through at least a portion of the targeted tissue to determine the transmurality of the ablation lesion.
摘要翻译：仪器评估消融病变从目标生物组织的第一表面到其相对的第二表面的透壁性。所述仪器包括至少第一电极，其可操作地附接到适于接合组织第一表面的消融仪器，以及适于接合组织第二表面的至少第二电极，所述至少第二电极与所述至少第一电极大致相对。或者，至少第二电极可以适于放置在器官的腔室内。这些电极有助于测量通过目标组织的至少一部分的传导时间，传导速度，相位角和阻抗中的至少一个，以确定消融损伤的透壁性。

10. 发明授权

US07192427B2 Apparatus and method for assessing transmurality of a tissue ablation 失效
标题翻译：用于评估组织消融的透壁性的装置和方法
公开(公告)号：US07192427B2
公开(公告)日：2007-03-20
申请号：US10369887
申请日：2003-02-19
申请人： Pierre-Antoine Chapelon , Dany Berube , Hiep Nguyen , Faouzi Kallel
发明人： Pierre-Antoine Chapelon , Dany Berube , Hiep Nguyen , Faouzi Kallel
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/00026 , A61B2017/00243 , A61B2018/00351 , A61B2018/00702 , A61B2018/00875
摘要： An instrument is provided to assess the transmurality of an ablation lesion from a first surface of a targeted biological tissue to an opposed second surface thereof. The instrument includes at least a first electrode operably attached to an ablation instrument adapted to engage a tissue first surface, and at least a second electrode adapted to engage a tissue second surface, the at least second electrode positioned generally opposed to the at least first electrode. Alternatively, the at least second electrode may be adapted to be placed within a chamber of an organ. These electrodes each measure at least one of conduction time, conduction velocity, phase angle, and impedance through at least a portion of the targeted tissue to determine the transmurality of the ablation lesion.
摘要翻译：提供了一种用于评估消融病变从目标生物组织的第一表面到其相对的第二表面的透壁性的仪器。所述仪器包括至少第一电极，其可操作地附接到适于接合组织第一表面的消融仪器，以及适于接合组织第二表面的至少第二电极，所述至少第二电极与所述至少第一电极大致相对。或者，至少第二电极可以适于放置在器官的腔室内。这些电极各自通过目标组织的至少一部分来测量传导时间，传导速度，相位角和阻抗中的至少一个，以确定消融损伤的透壁性。

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