专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5462704A Method for preparing a porous polyurethane vascular graft prosthesis 失效
标题翻译：多孔聚氨酯血管移植假体的制备方法
公开(公告)号：US5462704A
公开(公告)日：1995-10-31
申请号：US233455
申请日：1994-04-26
申请人： Jui-Hsiang Chen , Jeng Wei , Andrew T. Hu , Yu-Der Lee , Ru-Fong Laiw , Muh-Lan Chen , Chung-Yi Chang , Fan-Yen Lee , Shu-Fang Jiang
发明人： Jui-Hsiang Chen , Jeng Wei , Andrew T. Hu , Yu-Der Lee , Ru-Fong Laiw , Muh-Lan Chen , Chung-Yi Chang , Fan-Yen Lee , Shu-Fang Jiang
IPC分类号： A61L27/18 , C08J9/28 , B29C67/20
CPC分类号： C08J9/28 , A61L27/18 , C08J2375/04
摘要： A porous polyurethane tube suitable for use as a vascular graft prosthesis is prepared by placing solvent type polyurethane resin coated mandrel in a static coagulant consisting of water, ethanol and optionally aprotic solvent within 30 seconds immediately after the coating step, separating the tube by placing the mandrel in a swelling agent containing at least 90 percent by weight of ethanol and rinsing with a solution containing at least 80 percent by weight ethanol.
摘要翻译：适合用作血管移植假体的多孔聚氨酯管通过将溶剂型聚氨酯树脂涂布的心轴放置在由水，乙醇和任选的非质子溶剂组成的静态凝结剂中，立即在涂布步骤之后立即在30秒内将其放置在包含至少90重量％乙醇的溶胀剂中的心轴，并用含有至少80重量％乙醇的溶液冲洗。

2. 发明申请

US20080182776A1 Drug-loaded poly (alkyl-cyanoacrylate) nanoparticles and process foe the preparation thereof 有权
标题翻译：药物负载聚（烷基 - 氰基丙烯酸酯）纳米颗粒及其制备方法
公开(公告)号：US20080182776A1
公开(公告)日：2008-07-31
申请号：US11700226
申请日：2007-01-31
申请人： Yu-Der Lee , Chi-Yu Huang , Chih-Ming Chen
发明人： Yu-Der Lee , Chi-Yu Huang , Chih-Ming Chen
IPC分类号： A61K31/711 , A61K38/02 , A61K47/14 , A61K31/167 , A61K31/37
CPC分类号： A61K9/5138 , A61K9/1075 , A61K9/5192 , A61K31/167 , A61K31/37 , A61K31/711
摘要： A process for preparing the drug-loaded cyanoacrylate nanoparticles is described. The cyanoacrylate nanoparticles which effectively deliver biological and therapeutic agents are synthesized by miniemulsion polymerization with surfactant, pluronic F127 or F68. Before initiation of polymerization, active agents with particularly highly hydrophobicity are dissolved in cyanoacrylate monomer. Compared with the drug-loaded polyalkylcyanoacrylate nanoparticles produced by emulsion polymerization, those produced by miniemulsion polymerization possess higher loading and encapsulation efficiencies. While the content of dissolved agents increases, furthermore, the loading and encapsulation efficiencies increase concurrently.
摘要翻译：描述了制备负载药物的氰基丙烯酸酯纳米颗粒的方法。通过与表面活性剂pluronic F127或F68的细乳液聚合合成有效递送生物和治疗剂的氰基丙烯酸酯纳米粒子。在聚合开始之前，具有特别高度疏水性的活性剂溶解在氰基丙烯酸酯单体中。与通过乳液聚合制备的载药聚氰基丙烯酸甲酯纳米颗粒相比，通过细乳液聚合制备的纳米颗粒具有更高的负载和包封效率。而溶解剂的含量增加，此外，负载和封装效率同时增加。

3. 发明授权

US06358455B1 Process for preparing a laminated composite of condensation type silicone rubber and polyurethane by induce surface reconstruction 有权
标题翻译：通过诱导表面重建制备缩合型硅橡胶和聚氨酯的层压复合材料的方法
公开(公告)号：US06358455B1
公开(公告)日：2002-03-19
申请号：US09450359
申请日：1999-11-29
申请人： Ming-Fu Tsai , Yu-Der Lee , Yong-Chien Ling , Wen-Hsiung Ku , Chang-Hao Tai
发明人： Ming-Fu Tsai , Yu-Der Lee , Yong-Chien Ling , Wen-Hsiung Ku , Chang-Hao Tai
IPC分类号： B29C4102
CPC分类号： C08J7/047 , B29C35/02 , B29C39/025 , B29C67/246 , B29K2075/00 , B29K2083/00 , B32B27/28 , B32B27/40 , B32B2038/0076 , C08J2383/04 , C08J2475/00
摘要： Induced surface reconstruction of silicone rubber by blending silicone gel reactants with a modified and curing with a mold having high critical surface tension was used to improve the adhesion of chemically inert silicone rubber to polyurethane. The modifier has the following formula wherein m=25˜50; R1, R2, R3, R4, R11 and R12 independently are alkyl; R′ is R or OR, wherein R is a polymer backbone having a molecular weight of 1000˜20000. The mold is formed with a material having a critical surface tension greater than that of a polymer having a repeating unit of said R.
摘要翻译：通过将具有高临界表面张力的模具改性和固化的硅胶凝胶反应物引入硅橡胶的表面重构来改善化学惰性硅橡胶与聚氨酯的粘附性。改性剂具有以下形式：m = 25〜50; R1，R2，R3，R4，R11和R12独立地是烷基; R'是R或OR，其中R是分子量为1000〜20000的聚合物主链。模具由具有大于具有所述R的重复单元的聚合物的临界表面张力的材料形成。

4. 发明申请

US20100203150A1 Novel amphiphilic copolymers and fabrication method thereof 审中-公开
标题翻译：新型两亲性共聚物及其制造方法
公开(公告)号：US20100203150A1
公开(公告)日：2010-08-12
申请号：US12320843
申请日：2009-02-06
申请人： Yu-Der Lee , Kuo-Yung Chang , Chia-Chun Lin
发明人： Yu-Der Lee , Kuo-Yung Chang , Chia-Chun Lin
IPC分类号： A61K9/14 , A61K31/7072
CPC分类号： A61K9/1075 , A61K31/00
摘要： The present invention discloses a comb-like amphiphilic copolymer comprising a hydrophilic segment and a hydrophobic segment. It also discloses a novel fabrication method for synthesizing said amphiphilic copolymers. A novel initiator comprising a drug molecule, e.g. 5′-DFUR, bonded to one or two macromolecules of a hydrophobic polymer is provided. A spherical micelle with core-shell structure is formed by self-aggregation of said amphiphilic copolymer. It discloses a micelle-like nanoparticle comprising one or more said amphiphilic copolymers. The nanoparticles contain said drug molecules innately with no need to encapsulate the desired drug into the nanoparticles. The nanoparticles can serve as micellar drug carriers for delivering the drug. A nanocarrier comprising said nanoparticle and an active water-insoluble substance, e.g. SN-38, Camptothecin, encapsulated in the nanoparticle is also disclosed. The nanocarriers can serve as a means of cocktail therapy to deliver a mixture of two kinds of drugs to affected parts.
摘要翻译：本发明公开了一种包含亲水链段和疏水片段的梳状两亲性共聚物。它还公开了一种用于合成所述两亲性共聚物的新型制备方法。包含药物分子的新型引发剂。提供了与一个或两个大分子的疏水性聚合物键合的5'-DFUR。通过所述两亲共聚物的自聚集形成具有核 - 壳结构的球形胶束。它公开了包含一种或多种所述两亲性共聚物的胶束样纳米颗粒。纳米颗粒本身含有所述药物分子，而不需要将所需药物包封到纳米颗粒中。纳米颗粒可以用作用于递送药物的胶束药物载体。包含所述纳米颗粒和活性水不溶性物质的纳米载体，例如。还公开了包封在纳米颗粒中的喜树碱SN-38。纳米载体可以作为鸡尾酒疗法的一种手段，将两种药物的混合物递送到受影响的部位。

5. 发明授权

US08679539B2 Drug-loaded poly (alkyl-cyanoacrylate) nanoparticles and process for the preparation thereof 有权
标题翻译：载药聚（烷基 - 氰基丙烯酸酯）纳米颗粒及其制备方法
公开(公告)号：US08679539B2
公开(公告)日：2014-03-25
申请号：US11700226
申请日：2007-01-31
申请人： Yu-Der Lee , Chi-Yu Huang , Chih-Ming Chen
发明人： Yu-Der Lee , Chi-Yu Huang , Chih-Ming Chen
IPC分类号： A61K9/14
CPC分类号： A61K9/5138 , A61K9/1075 , A61K9/5192 , A61K31/167 , A61K31/37 , A61K31/711
摘要： A process for preparing the drug-loaded cyanoacrylate nanoparticles is described. The cyanoacrylate nanoparticles which effectively deliver biological and therapeutic agents are synthesized by miniemulsion polymerization with surfactant, pluronic F127 or F68. Before initiation of polymerization, active agents with particularly highly hydrophobicity are dissolved in cyanoacrylate monomer. Compared with the drug-loaded polyalkylcyanoacrylate nanoparticles produced by emulsion polymerization, those produced by miniemulsion polymerization possess higher loading and encapsulation efficiencies. While the content of dissolved agents increases, furthermore, the loading and encapsulation efficiencies increase concurrently.
摘要翻译：描述了制备负载药物的氰基丙烯酸酯纳米颗粒的方法。通过与表面活性剂pluronic F127或F68的细乳液聚合合成有效递送生物和治疗剂的氰基丙烯酸酯纳米粒子。在聚合开始之前，具有特别高度疏水性的活性剂溶解在氰基丙烯酸酯单体中。与通过乳液聚合制备的载药聚氰基丙烯酸甲酯纳米颗粒相比，通过细乳液聚合制备的纳米颗粒具有更高的负载和包封效率。而溶解剂的含量增加，此外，负载和封装效率同时增加。

6. 发明申请

US20080138418A1 Nanoparticles composed of alkyl-cyanoacrylate polymers 审中-公开
标题翻译：由氰基丙烯酸烷基酯聚合物组成的纳米颗粒
公开(公告)号：US20080138418A1
公开(公告)日：2008-06-12
申请号：US11634908
申请日：2006-12-07
申请人： Yu-Der Lee , Chi-Yu Huang
发明人： Yu-Der Lee , Chi-Yu Huang
IPC分类号： A61K9/14 , A61K47/14
CPC分类号： A61K9/5138
摘要： The role of nanoparticle composition as biodegradable carriers for variously therapeutical drugs is disclosed. Nanoparticles are synthesized by anion emulsion polymerization of two alkyl-cyanoacrylate monomers with adjusted content ratio. By modulating the compositions, particle size, hydrophobicity and degradation rate of the copolymers is controlled. Hence, to encapsulate wide range of therapeutical drugs, poly(alkyl cyanoacrylate) nanoparticles with feasible compositions are applied individually. The copolymer nanoparticles produced by n-butyl cyanoactylate (BCA) and 2-octyl cyanoacrylate (OCA), for example, were used therein. The nanoparticles composed of poly[(n-butyl cyanoacrylate)-co-(2-octyl cyanoacrylate)] and poly(2-octyl cyanoacrylate) might be adequate for therapeutical administration.
摘要翻译：公开了纳米颗粒组合物作为用于各种治疗药物的生物可降解载体的作用。通过阴离子乳液聚合两种具有调节含量的氰基丙烯酸烷基酯单体合成纳米颗粒。通过调节组合物，控制共聚物的粒度，疏水性和降解速率。因此，为了封装广泛的治疗药物，单独使用具有可行组合物的聚（氰基丙烯酸烷基酯）纳米颗粒。使用例如由氰基丙烯酸正丁酯（BCA）和2-辛基氰基丙烯酸酯（OCA）制备的共聚物纳米粒子。由[（氰基丙烯酸正丁酯） - 共 - （2-辛基氰基丙烯酸酯）]和聚（2-辛基氰基丙烯酸酯）组成的纳米颗粒可能适合治疗。

7. 发明授权

US06290892B1 Process for preparing a laminated composite of addition type silicone rubber and polyurethane by induce surface reconstruction 失效
标题翻译：通过诱导表面重建制备加成型硅橡胶和聚氨酯的叠层复合材料的方法
公开(公告)号：US06290892B1
公开(公告)日：2001-09-18
申请号：US09450355
申请日：1999-11-29
申请人： Ming-Fu Tsai , Yu-Der Lee , Yong Chien Ling , Wen-Hsiung Ku , Yuan-Chyi Lin
发明人： Ming-Fu Tsai , Yu-Der Lee , Yong Chien Ling , Wen-Hsiung Ku , Yuan-Chyi Lin
IPC分类号： B29C4102
CPC分类号： B32B27/08 , B29C37/0078 , B29C41/22 , B29C2791/001 , B29K2075/00 , B29K2083/00 , B29K2105/0005 , B32B27/40 , C08G18/69 , C08J5/12
摘要： Induced surface reconstruction of silicone rubber by blending silicone gel reactants of addition type with a modifier and curing with a mold having a high critical surface tension was used to improve the adhesion of chemically inert silicone rubber to polyurethane. The modifier has the following formula wherein m=25˜50; R1, R2, R3, and R4 independently are alkyl; R′ is R or OR, wherein R is a polymer backbone having a molecular weight of 1000˜20000. The mold is formed with a material having a critical surface tension greater than that of a polymer having a repeating unit of said R.
摘要翻译：通过将添加类型的有机硅凝胶反应物与改性剂混合并用具有高临界表面张力的模具进行固化来改善硅橡胶的表面重构，以改善化学惰性硅橡胶与聚氨酯的粘合性。改性剂具有以下形式：m = 25〜50; R1，R2，R3和R4独立地是烷基; R'是R或OR，其中R是分子量为1000〜20000的聚合物主链。模具由具有大于具有所述R的重复单元的聚合物的临界表面张力的材料形成。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式