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1. 发明申请

US20060062851A1 Delivery device containing venlafaxine and memantine and methods of use thereof 审中-公开
标题翻译：含有文拉法辛和美金刚的递送装置及其使用方法
公开(公告)号：US20060062851A1
公开(公告)日：2006-03-23
申请号：US11159410
申请日：2005-06-22
申请人： Juan Vergez , Joaquina Faour , Marcelo Ricci , Ana Pastini
发明人： Juan Vergez , Joaquina Faour , Marcelo Ricci , Ana Pastini
IPC分类号： A61K9/24
CPC分类号： A61K45/06 , A61K9/0004 , A61K9/209
摘要： The present invention provides an osmotic device containing controlled release venlafaxine in the core in combination with an anti-Alzheimer's or an anti-Parkinson's drug in a rapid release external coat. Memantine is used as an anti-Alzheimer's drug or an anti-Parkinson's drug. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. One embodiment of the osmotic device includes an external coat that has been spray-coated rather than compression-coated onto the device. The device is useful for the treatment of depression in Alzheimer's disease and/or Parkinson's disease patients. The device and method can also be used to treat or ameliorate other symptoms associated with Alzheimer's disease, Parkinson's disease or any other neurological disorder. Other dosage forms that provide a controlled, sustained or extended release of venlafaxine in combination with a rapid or immediate release of memantine are useful in the invention.
摘要翻译：本发明提供一种渗透装置，其包含与快速释放外涂层中的抗阿尔茨海默氏病或抗帕金森氏药物组合的核心中的文拉法而控制释放。美金刚被用作抗阿尔茨海默病药物或抗帕金森氏药物。本发明的具体实施方案提供具有预定释放特征的渗透装置。渗透装置的一个实施例包括已经被喷涂而不是被压缩涂覆到该装置上的外部涂层。该装置可用于治疗阿尔茨海默病和/或帕金森病患者的抑郁症。该装置和方法还可用于治疗或改善与阿尔茨海默病，帕金森病或任何其他神经障碍相关的其它症状。提供文拉法辛与美金刚的快速或立即释放相结合的受控，持续或延长释放的其它剂型在本发明中是有用的。

2. 发明申请

US20050163851A1 Osmotic device containing a venlafaxine salt and a salt having an ion in common 有权
标题翻译：渗透装置含有文拉法辛盐和具有共同离子的盐
公开(公告)号：US20050163851A1
公开(公告)日：2005-07-28
申请号：US11010829
申请日：2004-12-13
申请人： Ethel Feleder , Glenn Meyer , Marcelo Ricci , Joaquina Faour , Ana Pastini , Marcelo Befumo
发明人： Ethel Feleder , Glenn Meyer , Marcelo Ricci , Joaquina Faour , Ana Pastini , Marcelo Befumo
IPC分类号： A61K9/00 , A61K9/24 , A61K31/13 , A61K31/137 , A61K31/277
CPC分类号： A61K9/0004 , A61K31/13 , A61K31/137 , A61K31/277
摘要： The osmotic devices of the present invention include a single core comprising a salt of a drug and an osmotic salt, wherein the drug salt and the osmotic salt have a common ion. The release rate of the active drug is reduced, and the release profile of the active drug is modified, from a first order release profile to a zero order, pseudo-zero order, or sigmoidal release profile, by increasing the amount of the sodium chloride in the core of the device. In one embodiment the sodium chloride is used to modify a controlled release profile to a delayed and controlled release profile.
摘要翻译：本发明的渗透装置包括包含药物和渗透盐的盐的单核心，其中药物盐和渗透盐具有共同的离子。活性药物的释放速率降低，并且通过增加氯化钠的量，将活性药物的释放曲线从一级释放曲线修改为零级，伪零级或S形释放曲线在设备的核心。在一个实施方案中，氯化钠用于将受控释放曲线修饰为延迟和控制释放曲线。

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