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1. 发明授权

US08620428B2 Electrical inibition of the phrenic nerve during cardiac pacing 有权
标题翻译：心脏起搏期间膈神经的电吸收
公开(公告)号：US08620428B2
公开(公告)日：2013-12-31
申请号：US12963399
申请日：2010-12-08
申请人： Juan Gabriel Hincapie Ordonez , Holly Rockweiler
发明人： Juan Gabriel Hincapie Ordonez , Holly Rockweiler
IPC分类号： A61N1/00
CPC分类号： A61N1/365 , A61B5/0205 , A61B5/04001 , A61B5/0809 , A61B5/0816 , A61B5/1107 , A61B5/113 , A61B5/4041 , A61N1/3601 , A61N1/36167 , A61N1/3627 , A61N1/3712
摘要： According to various method embodiments for pacing a heart and avoiding unwanted stimulation of a phrenic nerve during cardiac pacing, a desired pacing time for delivering a cardiac pace is determined, and a desired nerve traffic inhibition time to inhibit nerve traffic in the phrenic nerve is determined using the desired pace time. The cardiac pace is delivered at the desired pacing time and nerve traffic in the phrenic nerve is inhibited at the desired nerve traffic inhibition time.
摘要翻译：根据用于在心脏起搏期间起搏心脏并避免膈神经的不期望的刺激的各种方法实施例，确定用于递送心脏步速的期望的起搏时间，并且确定抑制膈神经中的神经交通的期望的神经交通抑制时间使用所需的步行时间。心跳速度在所需的起搏时间输送，膈神经的神经交通在所需神经阻滞时间被抑制。

2. 发明申请

US20110152956A1 ELECTRICAL INIBITION OF THE PHRENIC NERVE DURING CARDIAC PACING 有权
标题翻译：心脏神经痛的电刺激
公开(公告)号：US20110152956A1
公开(公告)日：2011-06-23
申请号：US12963399
申请日：2010-12-08
申请人： Juan Gabriel Hincapie Ordonez , Holly Rockweiler
发明人： Juan Gabriel Hincapie Ordonez , Holly Rockweiler
IPC分类号： A61N1/00
CPC分类号： A61N1/365 , A61B5/0205 , A61B5/04001 , A61B5/0809 , A61B5/0816 , A61B5/1107 , A61B5/113 , A61B5/4041 , A61N1/3601 , A61N1/36167 , A61N1/3627 , A61N1/3712
摘要： According to various method embodiments for pacing a heart and avoiding unwanted stimulation of a phrenic nerve during cardiac pacing, a desired pacing time for delivering a cardiac pace is determined, and a desired nerve traffic inhibition time to inhibit nerve traffic in the phrenic nerve is determined using the desired pace time. The cardiac pace is delivered at the desired pacing time and nerve traffic in the phrenic nerve is inhibited at the desired nerve traffic inhibition time.
摘要翻译：根据用于在心脏起搏期间起搏心脏并避免膈神经的不期望的刺激的各种方法实施例，确定用于递送心脏步速的期望的起搏时间，并且确定抑制膈神经中的神经交通的期望的神经交通抑制时间使用所需的步行时间。心跳速度在所需的起搏时间输送，膈神经的神经交通在所需神经阻滞时间被抑制。

3. 发明授权

US08972022B2 Methods and apparatus for controlling neurostimulation using evoked responses 有权
标题翻译：使用诱发反应控制神经刺激的方法和装置
公开(公告)号：US08972022B2
公开(公告)日：2015-03-03
申请号：US13156879
申请日：2011-06-09
申请人： Juan Gabriel Hincapie Ordonez , David J. Ternes , Jason J. Hamann , Stephen Ruble
发明人： Juan Gabriel Hincapie Ordonez , David J. Ternes , Jason J. Hamann , Stephen Ruble
IPC分类号： A61N1/00 , A61B5/04 , A61N1/36 , A61B5/00
CPC分类号： A61N1/36139 , A61B5/04001 , A61B5/4041 , A61B5/4047 , A61B5/4058 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36135 , A61N1/36167
摘要： A neurostimulation system provides for capture verification and stimulation intensity adjustment to ensure effectiveness of vagus nerve stimulation in modulating one or more target functions in a patient. In various embodiments, stimulation is applied to the vagus nerve, and evoked responses are detected to verify that the stimulation captures the vagus nerve and to adjust one or more stimulation parameters that control the stimulation intensity.
摘要翻译：神经刺激系统提供捕获验证和刺激强度调节，以确保迷走神经刺激在调节患者体内的一个或多个目标功能方面的有效性。在各种实施例中，对迷走神经施加刺激，并且检测诱发反应以验证刺激捕获迷走神经并调节控制刺激强度的一个或多个刺激参数。

4. 发明申请

US20120271382A1 SYSTEMS AND METHODS TO ACCOUNT FOR NECK MOVEMENT DURING NERVE STIMULATION 有权
标题翻译：神经刺激期间用于NECK运动的系统和方法
公开(公告)号：US20120271382A1
公开(公告)日：2012-10-25
申请号：US13453279
申请日：2012-04-23
申请人： Shantha Arcot-Krishnamurthy , Stephen Ruble , Jason J. Hamann , Juan Gabriel Hincapie Ordonez , David J. Ternes
发明人： Shantha Arcot-Krishnamurthy , Stephen Ruble , Jason J. Hamann , Juan Gabriel Hincapie Ordonez , David J. Ternes
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/36053 , A61N1/3611 , A61N1/36132 , A61N1/36135
摘要： Some embodiments provide a method, comprising performing a neural stimulation test routine for stimulating a neural target in a cervical region of a patient, wherein for each of a plurality of head positions, performing the neural stimulation test routine includes testing a plurality of electrode configurations. The method further comprises recording threshold data for each of the tested electrode configurations for the plurality of head positions, and recommending an electrode configuration based on the recorded threshold data.
摘要翻译：一些实施例提供了一种方法，包括执行用于刺激患者的子宫颈区域中的神经靶标的神经刺激测试程序，其中对于多个头部位置中的每一个，执行神经刺激测试程序包括测试多个电极配置。该方法还包括记录针对多个头部位置的每个测试电极配置的阈值数据，以及基于记录的阈值数据推荐电极配置。

5. 发明申请

US20120095530A1 METHOD AND APPARATUS FOR CONTROLLING NEUROSTIMULATION ACCORDING TO PHYSICAL STATE 有权
标题翻译：用于根据物理状态控制神经元的方法和装置
公开(公告)号：US20120095530A1
公开(公告)日：2012-04-19
申请号：US13272786
申请日：2011-10-13
申请人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
发明人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/372
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36135
摘要： A neurostimulation system senses a signal indicative of a patient's physical state such as posture and/or activity level. In various embodiments, a stored value for each of stimulation parameters controlling delivery of neurostimulation is selected according to the patient's physical state. In various embodiments, values of the stimulation parameters are approximately optimized for each of a number of different physical states, and are stored for later selection.
摘要翻译：神经刺激系统感测指示患者的身体状态（例如姿势和/或活动水平）的信号。在各种实施例中，根据患者的身体状态选择控制神经刺激传递的每个刺激参数的存储值。在各种实施例中，刺激参数的值针对多个不同物理状态中的每一个近似优化，并且被存储以供稍后选择。

6. 发明授权

US08594805B2 Systems to detect vagus capture 有权
标题翻译：用于检测迷走神经捕获的系统
公开(公告)号：US08594805B2
公开(公告)日：2013-11-26
申请号：US13586432
申请日：2012-08-15
申请人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
发明人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
IPC分类号： A61N1/00
CPC分类号： A61B5/0492 , A61B5/0488 , A61B5/4035 , A61N1/0556 , A61N1/36053 , A61N1/36114
摘要： Some embodiments provide a system for delivering neurostimulation. Some system embodiments comprise a lead configured to be implanted in the body, a stimulation output circuit configured to deliver neurostimulation pulses to the vagus nerve through the lead, an EMG sensing circuit configured to use the lead to sense EMG signals from laryngeal muscle activity, and an evoked muscular response detection circuit configured to use the EMG signals sensed by the EMG sensing circuit to detect evoked laryngeal muscle activity evoked by the neurostimulation pulse.
摘要翻译：一些实施例提供用于递送神经刺激的系统。一些系统实施例包括被配置为植入体内的引线，刺激输出电路，其经配置以通过引线将神经刺激脉冲输送到迷走神经; EMG感测电路，被配置为使用引线来感测来自喉部肌肉活动的EMG信号;以及诱发肌肉反应检测电路，被配置为使用由EMG感测电路感测的EMG信号来检测由神经刺激脉冲诱发的诱发喉部肌肉活动。

7. 发明申请

US20130041269A1 METHOD AND APPARATUS FOR DETERMINATION OF PHYSIOLOGICAL PARAMETERS USING CERVICAL IMPEDANCE 有权
标题翻译：用于确定使用阻塞的生理参数的方法和装置
公开(公告)号：US20130041269A1
公开(公告)日：2013-02-14
申请号：US13568887
申请日：2012-08-07
申请人： Jeffrey E. Stahmann , David J. Ternes , Barun Maskara , Shantha Arcot-Krishnamurthy , Juan Gabriel Hincapie Ordonez , Scott Vanderlinde
发明人： Jeffrey E. Stahmann , David J. Ternes , Barun Maskara , Shantha Arcot-Krishnamurthy , Juan Gabriel Hincapie Ordonez , Scott Vanderlinde
IPC分类号： A61B5/0205 , A61N1/36 , A61B5/08 , A61B5/11 , A61B5/024 , A61B5/05 , A61B5/021
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/0215 , A61B5/0295 , A61B5/0535 , A61B5/1076 , A61B5/4836 , A61B5/686 , A61B5/6876 , A61B5/6877 , A61B5/7203 , A61B5/7275
摘要： Implanted electrodes can be used to deliver electrical stimulation signals to areas near blood vessels, nerves, or other internal body locations. In an example, an electrode can be implanted in a cervical location and can be used to measure dimensional changes in an artery using impedance plethysmography. Measured artery dimensional changes can be used to determine one or more physiological parameters associated with a patient's health status, such as pulse transit time, relative pulse pressure, or aterial compliance, among others. These parameters can be used to monitor a patient health status or to modulate a patient's therapy, among other uses. In some examples, an electrode configured to deliver an electrostimulation signal to nerve tissue can be used to provide non-neurostimulating electrical stimulation plethysmography signals near a blood vessel.
摘要翻译：可以使用植入电极将电刺激信号传送到血管，神经或其他内部身体位置附近的区域。在一个实例中，电极可以植入颈部位置，并可用于使用阻抗体积描记法测量动脉的尺寸变化。测量的动脉尺寸变化可以用于确定与患者的健康状况相关联的一个或多个生理参数，例如脉搏传播时间，相对脉压或全身依从性等。这些参数可用于监测患者的健康状况或调节患者的治疗以及其他用途。在一些示例中，可以使用构造成将神经刺激信号传递给神经组织的电极，以在血管附近提供非神经刺激电刺激体积描记信号。

8. 发明申请

US20120065702A1 AUTOMATIC SELECTION OF LEAD CONFIGURATION FOR A NEURAL STIMULATION LEAD 有权
标题翻译：自动选择神经刺激引线的引导配置
公开(公告)号：US20120065702A1
公开(公告)日：2012-03-15
申请号：US13220423
申请日：2011-08-29
申请人： Shantha Arcot-Krishnamurthy , David J. Ternes , Jason Hamann , Juan Gabriel Hincapie Ordonez , Stephen Ruble
发明人： Shantha Arcot-Krishnamurthy , David J. Ternes , Jason Hamann , Juan Gabriel Hincapie Ordonez , Stephen Ruble
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36128 , A61N1/36146 , A61N1/36185 , A61N1/37235 , A61N1/37288
摘要： A neurostimulation system includes a neural stimulation lead having a proximal portion and a distal portion and including a plurality of electrodes along the distal portion. The plurality of electrodes are configured for positioning proximate a portion of the autonomic nervous system. A neural stimulation circuit, coupled to the plurality of electrodes, delivers neural stimulation pulses to the plurality of electrodes. A processor and controller is configured to control the neural stimulation circuit to deliver first neural stimulation pulses to each of a plurality of electrode configurations. Each electrode configuration includes one or more of the plurality of electrodes. The processor and controller is further configured to receive information related to motor fiber activity that is induced in response to delivery of the first neural stimulation pulses to each of the plurality of electrode configurations and to identify the electrode configurations that induce the motor fiber activity.
摘要翻译：神经刺激系统包括神经刺激引线，其具有近端部分和远端部分，并且沿着远端部分包括多个电极。多个电极被配置用于定位在自主神经系统的一部分附近。耦合到多个电极的神经刺激电路将神经刺激脉冲传送到多个电极。处理器和控制器被配置为控制神经刺激电路将第一神经刺激脉冲传送到多个电极配置中的每一个。每个电极配置包括多个电极中的一个或多个。所述处理器和控制器进一步被配置为接收与响应于所述第一神经刺激脉冲传送到所述多个电极配置中的每一个而被诱发的电动机纤维活动相关的信息，并且识别诱导所述电机纤维活性的电极配置。

9. 发明申请

US20120022617A1 MINIMALLY INVASIVE LEAD SYSTEM FOR VAGUS NERVE STIMLATION 有权
标题翻译：用于VAGUS神经刺激的最小入侵引导系统
公开(公告)号：US20120022617A1
公开(公告)日：2012-01-26
申请号：US13186203
申请日：2011-07-19
申请人： Bruce A. Tockman , Juan Gabriel Hincapie Ordonez , Lili Liu
发明人： Bruce A. Tockman , Juan Gabriel Hincapie Ordonez , Lili Liu
IPC分类号： A61N1/372
CPC分类号： A61N1/36114 , A61N1/0556 , A61N1/0558 , A61N1/36185
摘要： A system including two neurostimulation leads can be used for stimulating a select region of a nerve within a nerve bundle. For example, two leads can be used to stimulate a select region of the vagus nerve located within a patient's carotid sheath. The first neurostimulation is positioned within the carotid sheath and the second neurostimulation lead is positioned external to the carotid sheath. Each of the first and second neurostimulation leads includes at least one electrode defining an electrode array about the select region of the nerve. The electrode array, and more particularly, the different possible electrode vector combinations provided by the first and second neurostimulation leads facilitate steering of stimulation current density fields as needed or desired between the electrodes to effectively and efficiently treat a particular medical, psychiatric, or neurological disorder.
摘要翻译：包括两个神经刺激引线的系统可用于刺激神经束内的神经的选择区域。例如，可以使用两个引线来刺激位于患者颈动脉鞘内的迷走神经的选择区域。第一神经刺激位于颈动脉鞘内，第二神经刺激引线位于颈动脉鞘外。第一和第二神经刺激引线中的每一个包括限定围绕神经的选择区域的电极阵列的至少一个电极。电极阵列，更具体地，由第一和第二神经刺激引线提供的不同的可能的电极向量组合有助于在电极之间根据需要或期望的刺激电流密度场的转向，以有效和有效地治疗特定的医学，精神病学或神经障碍。

10. 发明申请

US20110301659A1 VAGUS NERVE STIMULATION WITH TARGET EFFECTS CONTROLLED BY ADJUSTING TEMPORAL PARAMETERS 有权
标题翻译： VAGUS神经刺激与调整时间参数控制的目标效应
公开(公告)号：US20110301659A1
公开(公告)日：2011-12-08
申请号：US13114686
申请日：2011-05-24
申请人： Paul B. Yoo , Warren M. Grill , Juan Gabriel Hincapie Ordonez
发明人： Paul B. Yoo , Warren M. Grill , Juan Gabriel Hincapie Ordonez
IPC分类号： A61N1/362 , A61N1/36
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0488 , A61B5/4029 , A61B5/4035 , A61N1/0556 , A61N1/18 , A61N1/36 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/36167
摘要： One or more temporal stimulation parameters of vagus nerve stimulation (VNS) are selected to substantially modulate one or more target physiological functions without substantially modulating one or more non-target physiological functions. In one embodiment, a stimulation duty cycle is selected such that VNS is delivered to the cervical vagus nerve trunk to modulate a cardiovascular function without causing laryngeal muscle contractions.
摘要翻译：选择迷走神经刺激（VNS）的一个或多个时间刺激参数以基本上调制一个或多个目标生理功能，而基本上不调制一个或多个非目标生理功能。在一个实施例中，选择刺激占空比使得VNS被递送到子宫颈迷走神经干以调节心血管功能而不引起喉部肌肉收缩。

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