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1. 发明授权

US07442694B2 Diazabicyclic compounds useful in the treatment of CNS and other disorders 失效
标题翻译：可用于治疗CNS和其他疾病的二氮杂双环化合物
公开(公告)号：US07442694B2
公开(公告)日：2008-10-28
申请号：US10657738
申请日：2003-09-08
申请人： Jotham W. Coe , Christopher J. O'Donnell , Brian T. O'Neill , Lawrence A. Vincent
发明人： Jotham W. Coe , Christopher J. O'Donnell , Brian T. O'Neill , Lawrence A. Vincent
IPC分类号： C07D487/08 , A61K31/495
CPC分类号： C07D487/08
摘要： The present invention relates to a compounds of formula I: wherein A, B, D, E and F are defined herein; that are useful in treating central nervous system (CNS) diseases, disorders and conditions, such as but not limited to nicotine addiction, schizophrenia, depression, Alzheimer's disease, Parkinson's disease and ADHD. The present invention further comprises pharmaceutical compositions containing such compounds and methods of treatment comprising the use of such compounds.
摘要翻译：本发明涉及式I化合物：其中A，B，D，E和F如本文所定义; 可用于治疗中枢神经系统（CNS）疾病，疾病和病症，例如但不限于尼古丁成瘾，精神分裂症，抑郁症，阿尔茨海默病，帕金森病和ADHD。本发明还包含含有这些化合物的药物组合物和包括使用这些化合物的治疗方法。

2. 发明授权

US07456177B2 Heteroaryl fused azapolycyclic compounds 失效
标题翻译：杂芳基稠合的氮杂多环化合物
公开(公告)号：US07456177B2
公开(公告)日：2008-11-25
申请号：US10889395
申请日：2004-07-12
申请人： Martin P. Allen , Jotham W. Coe , Spiros Liras , Christopher J. O'Donnell , Brian T. O'Neill
发明人： Martin P. Allen , Jotham W. Coe , Spiros Liras , Christopher J. O'Donnell , Brian T. O'Neill
IPC分类号： A61K31/502 , C07D471/02
CPC分类号： C07D471/08
摘要： The present invention provides a compound having the structure of formula I: wherein R1 is hydrogen, (C1–C6) alkyl, unconjugated (C3–C6) alkenyl, benzyl, YC(═O)(C1–C6) alkyl or —CH2CH2—O—(C1–C4) alkyl; X is CH2 or CH2CH2; Y is (C2–C6) alkylene; Z is (CH2)m, CF2, or C(═O), where m is 0, 1 or 2; R2 and R3 are selected independently from hydrogen, halogen, —(C1–C6) alkyl optionally substituted with from 1 to 7 halogen atoms, and —O(C1–C6) alkyl optionally substituted with from 1 to 7 halogen atoms, or R2 and R3 each together with the atom to which it is connected independently form C(═O), S→O, S(═O)2, or N→O; and is a 5- to 7-membered monocyclic heteroaryl group selected from pyridinyl, pyridone, pyridazinyl, imidazolyl, pyrimidinyl, pyrazolyl, triazolyl, pyrazinyl, furyl, thienyl, isoxazolyl, thiazolyl, oxazolyl, isothiazolyl, pyrrolyl, cinnolinyl, triazinyl, oxadiazolyl, thiadiazolyl and furazanyl groups.
摘要翻译：本发明提供具有式I结构的化合物：其中R 1是氢，（C 1 -C 6 -C 6）烷基，未缀合的（C 3 -C 6）烯基，苄基，YC（-O）（C 1 -C 6 - ）烷基或-CH 2 CH 2 -O-（C 1 -C 4 - ）烷基; X是CH 2或CH 2 CH 2 CH 2; Y是（C 2 -C 6 -C 6）亚烷基; Z是（CH 2）2，CH 2或C（-O），其中m是0,1或2; R 2和R 3独立地选自氢，卤素， - （C 1 -C 6 -C 6）烷基或任选被1至7个卤素原子取代的-O（C 1 -C 6 -C 6）烷基，或任选被1至7个卤素原子取代的-O（C 1 -C 6 -C 6）烷基， 2和R 3各自与其连接的原子一起独立地形成C（-O），S-> O，S（-O）2 或N-> O; 吡啶基，吡唑基，三唑基，吡嗪基，呋喃基，噻吩基，异恶唑基，噻唑基，恶唑基，异噻唑基，吡咯基，噌啉基，三嗪基，恶二唑基，噻二唑基和呋咱基。

3. 发明授权

US06881734B2 Pharmaceutical composition for the treatment of CNS and other disorders 失效
标题翻译：用于治疗CNS等疾病的药物组合物
公开(公告)号：US06881734B2
公开(公告)日：2005-04-19
申请号：US10833714
申请日：2004-04-27
申请人： Brian Thomas O'Neill , Jotham Wadsworth Coe , Christopher J. O'Donnell
发明人： Brian Thomas O'Neill , Jotham Wadsworth Coe , Christopher J. O'Donnell
IPC分类号： A61K31/551 , A61K45/00 , A61P1/04 , A61P3/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P21/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , C07D471/08 , C07D519/00
CPC分类号： C07D471/08
摘要： The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant α7 nicotinic receptor agonist.
摘要翻译：本发明涉及一种通过向哺乳动物施用CNS-渗透剂α7烟碱受体激动剂来治疗哺乳动物（包括人）中枢神经系统（CNS）和其它疾病的疾病的方法。它还涉及含有药学上可接受的载体和CNS渗透剂α7烟碱受体激动剂的药物组合物。

4. 发明申请

US20100035865A1 Sulfonamides and Pharmaceutical Compositions Thereof 审中-公开
标题翻译：磺酰胺及其药物组合物
公开(公告)号：US20100035865A1
公开(公告)日：2010-02-11
申请号：US12527868
申请日：2008-03-26
申请人： Kimberly Gail Estep , Anton F.J. Fliri , Christopher J. O'Donnell
发明人： Kimberly Gail Estep , Anton F.J. Fliri , Christopher J. O'Donnell
IPC分类号： A61K31/451 , C07D211/40 , C07D239/12 , C07D265/10 , C07D319/06 , C07D309/30 , C07D285/16 , C07D279/02 , A61K31/505 , A61K31/535 , A61K31/365 , A61K31/357 , A61K31/549 , A61K31/541 , A61P25/00 , A61P9/00 , A61P25/28 , A61P25/16 , A61P27/02 , A61P21/00 , A61P25/06 , A61P25/22
CPC分类号： C07D211/76 , C07D239/18 , C07D265/10 , C07D279/12 , C07D285/16 , C07D307/32 , C07D319/06 , C07D333/04 , C07D335/02 , C07D409/10
摘要： The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula (I), as defined in the specification. The invention is also directed to compositions containing the compounds of formula (I).
摘要翻译：本发明涉及一类化合物，包括具有如说明书中定义的式（I）结构的化合物的药学上可接受的盐。本发明还涉及含有式（I）化合物的组合物。

5. 发明授权

US06809094B2 Pharmaceutical composition for the treatment of CNS and other disorders 失效
标题翻译：用于治疗CNS等疾病的药物组合物
公开(公告)号：US06809094B2
公开(公告)日：2004-10-26
申请号：US10229447
申请日：2002-08-28
申请人： Brian Thomas O'Neill , Jotham Wadsworth Coe , Christopher J. O'Donnell
发明人： Brian Thomas O'Neill , Jotham Wadsworth Coe , Christopher J. O'Donnell
IPC分类号： C07D47108
CPC分类号： C07D471/08
摘要： The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant &agr;7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant &agr;7 nicotinic receptor agonist.
摘要翻译：本发明涉及一种通过向哺乳动物施用CNS-渗透剂α7烟碱受体激动剂来治疗哺乳动物（包括人）中枢神经系统（CNS）和其它疾病的疾病的方法。它还涉及含有药学上可接受的载体和CNS渗透剂α7烟碱受体激动剂的药物组合物。

6. 发明授权

US06673811B1 1H-pyrrolo [3,2-b] pyridine-3-carboxylic acid amines as GABAA receptor ligands 失效
标题翻译： 1H-吡咯并[3,2-b]吡啶-3-甲酸胺作为GABA A受体配体
公开(公告)号：US06673811B1
公开(公告)日：2004-01-06
申请号：US10299199
申请日：2002-11-19
申请人： George D. Maynard , Manuka Ghosh , Christopher J. O'Donnell
发明人： George D. Maynard , Manuka Ghosh , Christopher J. O'Donnell
IPC分类号： A61K314965
CPC分类号： C07D471/04
摘要： Disclosed are 1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid amides that bind to the benzodiazepine site of GABAA receptors. Such compounds can be used to modulate ligand binding to GABAA receptors in vivo and in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals.
摘要翻译：公开了结合GABA A受体的苯并二氮杂位点的1H-吡咯并[3,2-b]吡啶-3-羧酸酰胺。这些化合物可用于体内和体外调节配体与GABA A受体的结合，并且特别可用于治疗人类，驯养的伴侣动物和家畜中的各种中枢神经系统（CNS）紊乱。

7. 发明授权

US07439236B2 Pharmaceutical composition for the treatment of CNS and other disorders 失效
标题翻译：用于治疗CNS等疾病的药物组合物
公开(公告)号：US07439236B2
公开(公告)日：2008-10-21
申请号：US11559957
申请日：2006-11-15
申请人： Brian Thomas O'Neill , Jotham Wadsworth Coe , Christopher J. O'Donnell
发明人： Brian Thomas O'Neill , Jotham Wadsworth Coe , Christopher J. O'Donnell
IPC分类号： C07D471/08 , A61K31/55 , A61P25/00
CPC分类号： C07D471/08
摘要： The present invention relates to compounds of formula I The substituent designations are as disclosed. At least one of B, Q, D and E is nitrogen. The present invention also provides a method of treating disorders of the Central Nervous System such as schizophrenia and cognitive dysfunction.
摘要翻译：本发明涉及式I化合物。取代基名称如所公开。 B，Q，D和E中的至少一个为氮。本发明还提供了治疗中枢神经系统疾病如精神分裂症和认知功能障碍的方法。

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