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    • 2. 发明申请
    • Heteroaryl fused azapolycyclic compounds
    • 杂芳基稠合的氮杂多环化合物
    • US20050020830A1
    • 2005-01-27
    • US10889395
    • 2004-07-12
    • Martin AllenJotham CoeSpiros LirasChristopher O'DonnellBrian O'Neill
    • Martin AllenJotham CoeSpiros LirasChristopher O'DonnellBrian O'Neill
    • A61P25/34C07D471/08C07D498/08C07D487/14
    • C07D471/08
    • The present invention provides a compound having the structure of formula I: wherein R1 is hydrogen, (C1-C6) alkyl, unconjugated (C3-C6) alkenyl, benzyl, YC(═O)(C1-C6) alkyl or —CH2CH2—O—(C1-C4) alkyl; X is CH2 or CH2CH2; Y is (C2-C6) alkylene; Z is (CH2)m, CF2, or C(═O), where m is 0, 1 or 2; R2 and R3 are selected independently from hydrogen, halogen, —(C1-C6) alkyl optionally substituted with from 1 to 7 halogen atoms, and —O(C1-C6) alkyl optionally substituted with from 1 to 7 halogen atoms, or R2 and R3 each together with the atom to which it is connected independently form C(═O), S→O, S(═O)2, or N→O; and is a 5- to 7-membered monocyclic heteroaryl group selected from pyridinyl, pyridone, pyridazinyl, imidazolyl, pyrimidinyl, pyrazolyl, triazolyl, pyrazinyl, furyl, thienyl, isoxazolyl, thiazolyl, oxazolyl, isothiazolyl, pyrrolyl, cinnolinyl, triazinyl, oxadiazolyl, thiadiazolyl and furazanyl groups.
    • 本发明提供具有式I结构的化合物:其中R 1是氢,(C 1 -C 6)烷基,未结合的(C 3 -C 6)烯基,苄基,YC(= O)(C 1 -C 6)烷基或 -CH 2 CH 2 -O-(C 1 -C 4)烷基; X是CH 2或CH 2 CH 2; Y是(C 2 -C 6)亚烷基; Z是(CH 2)m,CF 2或C(= O),其中m是0,1或2; R 2和R 3独立地选自氢,卤素,任选被1至7个卤素原子取代的 - (C 1 -C 6)烷基和任选被1至7个取代的-O(C 1 -C 6)烷基 卤素原子或R 2和R 3各自与其连接的原子一起独立地形成C(= O),S-> O,S(= O)2或N-> O; 吡啶基,吡唑基,三唑基,吡嗪基,呋喃基,噻吩基,异恶唑基,噻唑基,恶唑基,异噻唑基,吡咯基,噌啉基,三嗪基,恶二唑基, 噻二唑基和呋咱基。
    • 6. 发明申请
    • SYSTEMS AND METHODS FOR DATA COMPRESSION
    • 用于数据压缩的系统和方法
    • US20120056763A1
    • 2012-03-08
    • US12877673
    • 2010-09-08
    • GIOVANNI MOTTAMarko SlyzLashawn McgheeSait Can SaydagBrian O'Neill
    • GIOVANNI MOTTAMarko SlyzLashawn McgheeSait Can SaydagBrian O'Neill
    • H03M7/30
    • H03M7/40
    • In one embodiment, an initial series of bytes are scanned to determine a frequency of occurrence within the initial series of bytes for a plurality of byte strings. A data structure is generated containing the plurality of byte strings and count values representing a frequency of occurrence for the plurality of byte strings in the initial series of bytes. A most common byte string of the plurality of byte strings in the initial series of bytes is determined from the count values. Each instance of the most common byte string in the initial series of bytes is replaced with a first substitute byte string to form a revised series of bytes. A most common byte string in the revised series of bytes is determined from the data structure without resetting the count values associated with at least some of the plurality of byte strings.
    • 在一个实施例中,扫描初始系列字节以确定多个字节串的初始字节序列内的出现频率。 生成包含多个字节串的数据结构和表示初始字节序列中的多个字节串的出现频率的计数值。 从计数值确定初始字节序列中的多个字节串中最常见的字节串。 在初始系列字节中,最常见的字节串的每个实例都被替换为第一个替代字节串,以形成修改后的一系列字节。 在数据结构中确定经修改的字节序列中最常见的字节串,而不重置与至少一些多个字节串相关联的计数值。
    • 8. 发明授权
    • Generation and vending of unique sequence values
    • 独特序列值的生成和售货
    • US08818973B1
    • 2014-08-26
    • US12033847
    • 2008-02-19
    • Brian O'Neill
    • Brian O'Neill
    • G06F17/30
    • G06Q30/06
    • Techniques for generating and vending of unique sequence values are described. Each master of a ring of masters is configured to create and vend the unique sequence values downstream to filling pools for eventual client consumption. When a ring of masters is employed, each master communicates with one another to agree on a current range of values that should next be vended. A master may then vend these values to a layer of one or more filling pools, at least of which includes or has access to persistent and non-persistent storage memories.
    • 描述用于生成和售卖独特序列值的技术。 配置一个主节点的每个主节点,以创建和销售下游的唯一序列值来填充池以最终的客户端消耗。 当一个主人的戒指被使用时,每个主人彼此沟通,就当下的价值范围达成一致。 然后,主人可以将这些值交付到一个或多个填充池的层,其至少包括或者可以访问持久和非持久存储存储器。
    • 9. 发明授权
    • Updating computer files
    • 更新计算机文件
    • US08607218B2
    • 2013-12-10
    • US13260219
    • 2010-02-25
    • Giovanni MottaAshish VarmaBrian O'NeillLaShawn McGhee
    • Giovanni MottaAshish VarmaBrian O'NeillLaShawn McGhee
    • G06F9/44
    • G06F8/65
    • A method of updating computer software includes identifying an orphaned computer file in a second version of computer software, the orphaned computer file having a name that does not correspond to any name of a computer file in a first version of computer software and computing symmetric divergence between the orphaned computer file and each computer file in the first version of computer software. The method also includes choosing a file from the computer files in the first version of computer software that yields a minimum value of symmetric divergence between the file and the orphaned computer file and using the file as a reference file for compressing the orphaned computer file.
    • 更新计算机软件的方法包括在计算机软件的第二版本中识别孤立的计算机文件,所述孤立的计算机文件具有与计算机软件的第一版本中的计算机文件的任何名称不对应的名称,并且计算在第 孤立的计算机文件和计算机软件的第一个版本中的每个计算机文件。 该方法还包括从计算机软件的第一版本中的计算机文件中选择一个文件,该文件产生文件和孤立计算机文件之间的对称分歧的最小值,并使用该文件作为压缩孤立计算机文件的参考文件。
    • 10. 发明授权
    • Systems and methods for data compression
    • 数据压缩的系统和方法
    • US08228216B2
    • 2012-07-24
    • US12877673
    • 2010-09-08
    • Giovanni MottaMarko SlyzLashawn McGheeSait Can SaydagBrian O'Neill
    • Giovanni MottaMarko SlyzLashawn McGheeSait Can SaydagBrian O'Neill
    • H03M7/30
    • H03M7/40
    • In one embodiment, an initial series of bytes are scanned to determine a frequency of occurrence within the initial series of bytes for a plurality of byte strings. A data structure is generated containing the plurality of byte strings and count values representing a frequency of occurrence for the plurality of byte strings in the initial series of bytes. A most common byte string of the plurality of byte strings in the initial series of bytes is determined from the count values. Each instance of the most common byte string in the initial series of bytes is replaced with a first substitute byte string to form a revised series of bytes. A most common byte string in the revised series of bytes is determined from the data structure without resetting the count values associated with at least some of the plurality of byte strings.
    • 在一个实施例中,扫描初始系列字节以确定多个字节串的初始字节序列内的出现频率。 生成包含多个字节串的数据结构和表示初始字节序列中的多个字节串的出现频率的计数值。 从计数值确定初始字节序列中的多个字节串中最常见的字节串。 在初始系列字节中,最常见的字节串的每个实例都被替换为第一个替代字节串,以形成修改后的一系列字节。 在数据结构中确定经修改的字节序列中的最常见的字节串,而不重置与多个字节串中的至少一些相关联的计数值。