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1. 发明申请

US20050090748A1 Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
标题翻译：将物质或器械急性或慢性传播至血管外治疗部位的方法和装置
公开(公告)号：US20050090748A1
公开(公告)日：2005-04-28
申请号：US10458153
申请日：2003-06-10
申请人： Joshua Makower , Theodore Lamson , J. Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
发明人： Joshua Makower , Theodore Lamson , J. Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
IPC分类号： A61M31/00 , A61B17/00 , A61B17/12 , A61B18/24 , A61M5/14 , A61M25/00 , A61M25/01 , A61M25/06 , A61B8/14
CPC分类号： A61M25/065 , A61B17/00491 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2018/00392 , A61M25/0069 , A61M25/0084 , A61M25/0102 , A61M2025/018
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).
摘要翻译：用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品从目标网站。或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

2. 发明申请

US20080058759A1 Devices, Systems and Methods for Acute or Chronic Delivery of Substances or Apparatus to Extravascular Treatment Sites 审中-公开
公开(公告)号：US20080058759A1
公开(公告)日：2008-03-06
申请号：US11927874
申请日：2007-10-30
申请人： Joshua Makower , Theodore Lamson , J. Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
发明人： Joshua Makower , Theodore Lamson , J. Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
IPC分类号： A61M31/00 , A61M25/00 , A61M25/02 , A61M25/098
CPC分类号： A61M25/0108 , A61B6/12 , A61M5/007 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2210/12
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

3. 发明申请

US20080051756A1 Devices, Systems and Methods for Acute or Chronic Delivery of Substances or Apparatus to Extravascular Treatment Sites 有权
标题翻译：用于急性或慢性输送物质或装置用于血管外治疗部位的装置，系统和方法
公开(公告)号：US20080051756A1
公开(公告)日：2008-02-28
申请号：US11927888
申请日：2007-10-30
申请人： Joshua Makower , Theodore Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
发明人： Joshua Makower , Theodore Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
IPC分类号： A61M5/178 , A61M31/00
CPC分类号： A61M25/0108 , A61B6/12 , A61M5/007 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2210/12
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).
摘要翻译：用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品从目标网站。或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注入物质期间和之后用于闭塞静脉或小静脉的腔，使得该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

4. 发明授权

US08672920B2 Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
标题翻译：用于急性或慢性传播物质或器械至血管外治疗部位的装置，系统和方法
公开(公告)号：US08672920B2
公开(公告)日：2014-03-18
申请号：US11927888
申请日：2007-10-30
申请人： Joshua Makower , Theodore Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
发明人： Joshua Makower , Theodore Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
IPC分类号： A61M31/00
CPC分类号： A61M25/0108 , A61B6/12 , A61M5/007 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2210/12
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessel lumens. A penetrating catheter is inserted into a blood vessel lumen and a penetrator is advanced from the catheter in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the delivery catheter may remain in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member may be advanced into a vein or venule and used to occlude the lumen of the vein or venule during and after injection of a substance such that the substance will not be carried away by normal venous blood flow.
摘要翻译：用于将物质或设备运送到位于血管内腔外的靶位置的方法和装置。将穿透性导管插入血管内腔中，并且穿透器沿导向器朝向目标部位的方向前进。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，输送导管可以保持在适当位置以便从目标部位慢慢或连续地输送物质到和/或获得信息或样品。或者，具有闭塞构件的输送导管可以推入静脉或小静脉中，并用于在注射物质期间和之后闭塞静脉或小静脉的内腔，使得物质不会被正常的静脉血流带走。

5. 发明授权

US08090430B2 Methods and apparatus for acute or chronic delivery or substances or apparatus to extravascular treatment sites 有权
标题翻译：用于急性或慢性传播的方法和装置或血管外治疗部位的物质或装置
公开(公告)号：US08090430B2
公开(公告)日：2012-01-03
申请号：US12567915
申请日：2009-09-28
申请人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese, III , David Tholfsen
发明人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese, III , David Tholfsen
IPC分类号： A61B6/00
CPC分类号： A61M25/065 , A61B17/00491 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2018/00392 , A61M25/0069 , A61M25/0084 , A61M25/0102 , A61M2025/018
摘要： Methods and apparatus for delivery of substances or apparatus to target sites within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site.
摘要翻译：用于将物质或装置输送到人或动物患者体内靶向部位的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管沿目标部位的方向前进。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。

6. 发明授权

US08956408B2 Lens delivery system 有权
标题翻译：镜头投放系统
公开(公告)号：US08956408B2
公开(公告)日：2015-02-17
申请号：US12178565
申请日：2008-07-23
申请人： Terah Whiting Smiley , John A. Scholl , David John Smith , Russell J. Redmond , Derek L. Moran , Barry Cheskin , John Reggie , Gregory Vinton Matthews , Claudio Argento
发明人： Terah Whiting Smiley , John A. Scholl , David John Smith , Russell J. Redmond , Derek L. Moran , Barry Cheskin , John Reggie , Gregory Vinton Matthews , Claudio Argento
IPC分类号： A61F2/16 , A61F9/00
CPC分类号： A61F2/1675 , A61F2/1678
摘要： Delivery devices for delivering an ophthalmic device into an eye. In some embodiments the delivery devices are adapted to deliver an intraocular lens into an eye.
摘要翻译：用于将眼科装置输送到眼睛中的输送装置。在一些实施例中，递送装置适于将眼内透镜输送到眼睛中。

7. 发明申请

US20060154204A1 Dental implants with improved loading properties 审中-公开
标题翻译：具有改善负荷特性的牙种植体
公开(公告)号：US20060154204A1
公开(公告)日：2006-07-13
申请号：US11035312
申请日：2005-01-12
申请人： John Reggie
发明人： John Reggie
IPC分类号： A61C8/00
CPC分类号： A61C8/0031 , A61C8/001
摘要： A dental prosthetic comprising an elongate threaded implant adapted to be secured within the trabecular region of a maxilla or mandible. An abutment is secured to the elongate threaded implant and adapted to receive a crown. The abutment and elongate threaded implant extend generally along a common longitudinal axis. A generally flat surface is secured to a region where the abutment meets the implant and extends generally perpendicular to the axis of the abutment and implant. The generally flat surface is shaped to engage the cortical region of the maxilla or mandible, and thereby minimize micromotion and allow for osseointegration despite immediate installation of a crown and immediate mechanical loading. Methods for implanting dental prosthetics are also described.
摘要翻译：包括细长螺纹植入物的牙修复物，其适于固定在上颌骨或下颌骨的小梁区域内。基座固定到细长螺纹植入物并适于接纳冠部。基座和细长螺纹植入件大致沿共同的纵向轴线延伸。大致平坦的表面被固定到邻接部位与植入物相交的区域，并且大致垂直于基台和植入物的轴线延伸。大致平坦的表面被成形为接合上颌骨或下颌骨的皮质区域，从而尽可能地减小微运动并且允许骨整合，尽管立即安装冠部并且立即机械加载。还描述了用于植入牙修复体的方法。

8. 发明申请

US20090030425A1 Lens Delivery System 有权
标题翻译：镜头投放系统
公开(公告)号：US20090030425A1
公开(公告)日：2009-01-29
申请号：US12178565
申请日：2008-07-23
申请人： Terah Whiting Smiley , John A. Scholl , David John Smith , Russell J. Redmond , Derek L. Moran , Barry Cheskin , John Reggie , Gregory Vinton Matthews , Claudio Argento
发明人： Terah Whiting Smiley , John A. Scholl , David John Smith , Russell J. Redmond , Derek L. Moran , Barry Cheskin , John Reggie , Gregory Vinton Matthews , Claudio Argento
IPC分类号： A61F9/007
CPC分类号： A61F2/1675 , A61F2/1678
摘要： Delivery devices for delivering an ophthalmic device into an eye. In some embodiments the delivery devices are adapted to deliver an intraocular lens into an eye.
摘要翻译：用于将眼科装置输送到眼睛中的输送装置。在一些实施例中，递送装置适于将眼内透镜输送到眼睛中。

9. 发明申请

US20060154205A1 Dental implants with improved loading properties 审中-公开
标题翻译：具有改善负荷特性的牙种植体
公开(公告)号：US20060154205A1
公开(公告)日：2006-07-13
申请号：US11328815
申请日：2006-01-09
申请人： John Reggie
发明人： John Reggie
IPC分类号： A61C8/00
CPC分类号： A61C8/0031 , A61C8/001
摘要： A dental prosthetic includes an elongate threaded implant adapted to be secured within the trabecular region of a maxilla or mandible. An abutment having a first region adapted to receive a crown and a second region adapted for coupling to the elongate threaded implant is secured to the elongate threaded implant. The abutment and elongate threaded implant extend generally along a common longitudinal axis. A compliant brace is adapted for placement between the first region of the abutment and the elongate threaded implant. The compliant brace includes first, second, and third elongate extensions capable of engaging the cortical region of the maxilla or mandible, thereby minimizing micromotion and allowing for osseointegration despite immediate installation of a crown and immediate mechanical loading. The dental prosthetic may also include an adaptor for coupling the elongate threaded implant and the abutment. Methods for implanting dental prosthetics are also described.
摘要翻译：牙科假体包括细长的螺纹植入物，其适于固定在上颌骨或下颌骨的小梁区域内。具有适于容纳冠部的第一区域和适于联接到细长螺纹植入物的第二区域的邻接件固定到细长螺纹植入物。基座和细长螺纹植入件大致沿共同的纵向轴线延伸。柔性支架适于放置在基台的第一区域和细长螺纹植入物之间。顺应性支架包括能够接合上颌骨或下颌骨的皮质区域的第一，第二和第三细长延伸部分，从而尽可能减小微动作并允许骨整合，尽管立即安装牙冠并立即机械加载。牙修复体还可以包括用于联接细长螺纹植入物和邻接物的适配器。还描述了用于植入牙修复体的方法。

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