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1. 发明授权

US06296749B1 System and method for chromatography and electrophoresis using circular optical scanning 失效
标题翻译：使用圆形光学扫描进行色谱和电泳的系统和方法
公开(公告)号：US06296749B1
公开(公告)日：2001-10-02
申请号：US09290445
申请日：1999-04-13
申请人： Joseph W. Balch , Laurence R. Brewer , James C. Davidson , Joseph R. Kimbrough
发明人： Joseph W. Balch , Laurence R. Brewer , James C. Davidson , Joseph R. Kimbrough
IPC分类号： G01N2726
CPC分类号： G01N30/74 , G01N27/44721 , G01N27/44791 , G01N30/6082 , G01N30/6095 , G01N2030/386
摘要： A system and method is disclosed for chromatography and electrophoresis using circular optical scanning. One or more rectangular microchannel plates or radial microchannel plates has a set of analysis channels for insertion of molecular samples. One or more scanning devices repeatedly pass over the analysis channels in one direction at a predetermined rotational velocity and with a predetermined rotational radius. The rotational radius may be dynamically varied so as to monitor the molecular sample at various positions along a analysis channel. Sample loading robots may also be used to input molecular samples into the analysis channels. Radial microchannel plates are built from a substrate whose analysis channels are disposed at a non-parallel angle with respect to each other. A first step in the method accesses either a rectangular or radial microchannel plate, having a set of analysis channels, and second step passes a scanning device repeatedly in one direction over the analysis channels. As a third step, the scanning device is passed over the analysis channels at dynamically varying distances from a centerpoint of the scanning device. As a fourth step, molecular samples are loaded into the analysis channels with a robot.
摘要翻译：公开了使用圆形光学扫描的色谱和电泳的系统和方法。一个或多个矩形微通道板或径向微通道板具有用于插入分子样品的一组分析通道。一个或多个扫描装置以预定的旋转速度和预定的旋转半径在一个方向上重复地越过分析通道。旋转半径可以是动态变化的，以便在分析通道的各个位置处监测分子样品。样品加载机器人也可用于将分子样品输入分析通道。径向微通道板由基板构成，其分析通道相对于彼此以非平行的角度设置。该方法的第一步是访问具有一组分析通道的矩形或径向微通道板，并且第二步通过分析通道在一个方向上重复地扫描扫描装置。作为第三步，扫描装置以与扫描装置的中心点动态变化的距离通过分析通道。作为第四步，用机器人将分子样品加载到分析通道中。

2. 发明授权

US06225635B1 System and method for optically locating microchannel positions 失效
标题翻译：用于光学定位微通道位置的系统和方法
公开(公告)号：US06225635B1
公开(公告)日：2001-05-01
申请号：US09131183
申请日：1998-08-07
申请人： Laurence R. Brewer , Joseph Kimbrough , Joseph Balch , J. Courtney Davidson
发明人： Laurence R. Brewer , Joseph Kimbrough , Joseph Balch , J. Courtney Davidson
IPC分类号： G01N27447
CPC分类号： G01N27/44721
摘要： A system and method is disclosed for optically locating a microchannel position. A laser source generates a primary laser beam which is directed at a microchannel plate. The microchannel plates include microchannels at various locations. A back-reflectance beam detector receives a back-reflected beam from the plate. The back-reflected beam is generated when the primary beam reflects off of the plate. A photodiode circuit generates a trigger signal when the back-reflected beam exceeds a predetermined threshold, indicating a presence of the microchannel. The method of the present invention includes the steps of generating a primary beam, directing the primary beam to a plate containing a microchannel, receiving from the plate a back-reflected beam generated in response to the primary beam, and generating a trigger signal when the back-reflected beam exceeds a predetermined threshold which corresponds to a presence of the microchannel.
摘要翻译：公开了用于光学定位微通道位置的系统和方法。激光源产生指向微通道板的主激光束。微通道板包括在各个位置的微通道。后反射光束检测器从板接收反向反射光束。当主光束反射离开板时，产生反射反射光束。当反射光束超过预定阈值时，光电二极管电路产生触发信号，指示存在微通道。本发明的方法包括以下步骤：产生主光束，将主光束引导到包含微通道的光盘;从该光盘接收响应于主光束产生的反射反射光束，并在反向反射光束超过对应于微通道存在的预定阈值。

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