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1. 发明授权

US07129072B1 Crystal of fibroblast growth factor receptor 1 in complex with fibroblast growth factor 有权
标题翻译：成纤维细胞生长因子受体1与成纤维细胞生长因子复合的结晶
公开(公告)号：US07129072B1
公开(公告)日：2006-10-31
申请号：US10049429
申请日：2000-08-30
申请人： Joseph Schlessinger , Stevan R. Hubbard , Moosa Mohammadi , Alexander Plotnikov , Zhongtao Zhang , Xiang-Peng Kong
发明人： Joseph Schlessinger , Stevan R. Hubbard , Moosa Mohammadi , Alexander Plotnikov , Zhongtao Zhang , Xiang-Peng Kong
IPC分类号： C12N9/12
CPC分类号： C07K14/71 , C07K14/50 , C07K2299/00
摘要： The determination and use of three dimensional structures of receptor protein tyrosine kinases and/or their ligands are described. One particular group of such structures includes three dimensional structures of the extracellular domain of RPTKs. The three dimensional structures of RPTKs can faciliate the design and identification of modulators of RPTK function. Other such structures can include of RPTK ligands, such as stem cell factor or a fragment thereof. Modulators of RPTK function can be used to treat diseases that are mediated by inappropriate RPTK activity.
摘要翻译：描述了受体蛋白酪氨酸激酶和/或其配体的三维结构的确定和使用。这种结构的一个特定组包括RPTK的细胞外结构域的三维结构。 RPTK的三维结构可以促进RPTK功能调制器的设计和鉴定。其他这样的结构可以包括RPTK配体，例如干细胞因子或其片段。 RPTK功能的调节剂可用于治疗由不适当RPTK活动介导的疾病。

2. 发明授权

US07121270B1 Spark generation method and ignition system using same 失效
标题翻译：火花生成法和点火系统使用相同
公开(公告)号：US07121270B1
公开(公告)日：2006-10-17
申请号：US11212580
申请日：2005-08-29
申请人： Alexander Plotnikov
发明人： Alexander Plotnikov
IPC分类号： F02P3/04 , F02P3/08
CPC分类号： F02P3/0846 , F02P3/0853 , F02P15/08 , F02P15/10 , F02P15/12
摘要： An ignition system providing power and duration controlled ignition spark, comprises a spark controller, first switching energy accumulator, storage capacitor, and second switching energy accumulator with an ignition coil. The ignition system utilizes dual means of switching energy accumulation, internal energy transfer, and three means of energy release to the ignition spark, working in all possible combinations managed by means of the spark controller depending on engine operating conditions, and provides continuous bipolar ignition spark. Spark profile is regulated by means of control signals (2) and (3) based on their frequency, duty cycle, interrelation, and running time.
摘要翻译：提供动力和持续时间控制的点火火花的点火系统包括火花控制器，第一开关蓄能器，储能电容器和具有点火线圈的第二开关蓄能器。点火系统采用双重方式切换能量积聚，内部能量转移和三种能量释放装置的点火火花，根据发动机工作条件，通过火花控制器管理的所有可能组合工作，并提供连续的双极点火火花。基于它们的频率，占空比，相关性和运行时间，通过控制信号（2）和（3）来调节火花轮廓。

3. 发明申请

US20140066410A1 INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION 审中-公开
标题翻译：作为基因表达调节剂的BROMODOMAINS的抑制剂
公开(公告)号：US20140066410A1
公开(公告)日：2014-03-06
申请号：US14001074
申请日：2012-02-23
申请人： Ming-Ming Zhou , Michael Ohlmeyer , Shiraz Mujtaba , Alexander Plotnikov , David Kastrinsky , Guangtao Zhang
发明人： Ming-Ming Zhou , Michael Ohlmeyer , Shiraz Mujtaba , Alexander Plotnikov , David Kastrinsky , Guangtao Zhang
IPC分类号： C07D213/76 , C07C311/44
CPC分类号： C07D213/76 , A61K31/18 , A61K45/06 , C07C311/44 , A61K2300/00
摘要： This disclosure relates generally to compounds and compositions comprising one or more diphenylethylene, diphenylethylyne, and azobenzene analogs. These compounds are useful for treating diseases associated with NF-kB and p53 activity, such as cancer and inflammatory disease.
摘要翻译：本公开一般涉及包含一种或多种二苯基乙烯，二苯基乙烯基和偶氮苯类似物的化合物和组合物。这些化合物可用于治疗与NF-kB和p53活性相关的疾病，如癌症和炎性疾病。

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