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1. 发明申请

US20100324076A1 Novel sEH Inhibitors and their Use 审中-公开
标题翻译：新型sEH抑制剂及其用途
公开(公告)号：US20100324076A1
公开(公告)日：2010-12-23
申请号：US12864698
申请日：2009-01-30
申请人： Joseph Paul Marino , John Jeffrey McAtee
发明人： Joseph Paul Marino , John Jeffrey McAtee
IPC分类号： A61K31/506 , C07D401/04 , A61P9/12 , A61P9/10 , A61P11/00 , A61P3/10 , A61P5/50 , A61P3/04
CPC分类号： C07D401/04
摘要： The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R5a, R6a, A, B, K, L, M, Y, Z, x, and m are defined herein, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译：本发明涉及新型sEH抑制剂及其在治疗由sEH酶介导的疾病中的用途。具体地，本发明涉及式I化合物：其中R1，R2，R3，R5a，R6a，A，B，K，L，M，Y，Z，x和m如本文所定义，其可接受的盐。本发明的化合物是sEH抑制剂，可用于治疗由sEH酶介导的疾病，例如高血压。因此，本发明进一步涉及包含本发明化合物的药物组合物。本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制sEH和与之相关的病症的治疗方法。

2. 发明申请

US20100069391A1 Novel sEH Inhibitors and Their Use 失效
标题翻译：新型sEH抑制剂及其用途
公开(公告)号：US20100069391A1
公开(公告)日：2010-03-18
申请号：US12513186
申请日：2007-11-02
申请人： Yun Ding , Joseph Paul Marino , Peng Li , Allyn T. Londregan , Barry A. Morgan
发明人： Yun Ding , Joseph Paul Marino , Peng Li , Allyn T. Londregan , Barry A. Morgan
IPC分类号： A61K31/53 , C07D403/04 , A61P11/06
CPC分类号： C07D239/48 , C07D239/50 , C07D251/54 , C07D409/12
摘要： The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme.
摘要翻译：本发明涉及新型sEH抑制剂及其在治疗由sEH酶介导的疾病中的用途。

3. 外观设计

USD662199S1 Mouthpiece 有权
公开(公告)号：USD662199S1
公开(公告)日：2012-06-19
申请号：US29322977
申请日：2008-08-15
申请人： Gregor John McLennan Anderson , Gary Thomas Crosby , Philip William Farr , Joseph Paul Marino , Mark Digby Teucher , James Anthony West
设计人： Gregor John McLennan Anderson , Gary Thomas Crosby , Philip William Farr , Joseph Paul Marino , Mark Digby Teucher , James Anthony West

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