专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4018767A Anti-arrhythmic agents 失效
标题翻译：抗心律失常药
公开(公告)号：US4018767A
公开(公告)日：1977-04-19
申请号：US579763
申请日：1975-05-22
申请人： Joseph Paul Buyniski , Alex Michael Jelenevsky , Ronald Leslie Buchanan
发明人： Joseph Paul Buyniski , Alex Michael Jelenevsky , Ronald Leslie Buchanan
IPC分类号： C07D209/76 , C07D307/93 , C07D413/06 , C07D209/94 , C07D401/06 , C07D403/06
CPC分类号： C07D307/93 , C07D209/76 , Y10S514/821
摘要： A series of 5-endo-(1-naphthoyloxy)-N-[amino-(lower)alkyl]bicyclo[2.2.1]heptane-2,3-di-endo-carboxylic acid imides have been found to possess unique prophylactic and therapeutic activity as anti-arrhythmia agents. An example of such a compound possessing excellent activity is 5-endo-(1-naphthoyloxy)-N-(3-dimethylaminopropyl)bicyclo[2.2.1]heptane-2,3-di-endo-carboxylic acid imide hydrochloride.
摘要翻译：已经发现一系列5-内 - （1-萘氧基）-N- [氨基 - （低级）烷基]双环[2.2.1]庚烷-2,3-二 - 内 - 羧酸酰亚胺具有独特的预防和作为抗心律失常药的治疗活性。具有优异活性的这种化合物的实例是5-内 - （1-萘氧基）-N-（3-二甲基氨基丙基）双环[2.2.1]庚烷-2,3-二 - 内 - 羧酸酰亚胺盐酸盐。

2. 发明授权

US4122273A Bicyclo [2.2.1]-heptane-2,3-di-endo-carboxylic acid imide esters 失效
标题翻译：双环{8 2.2.1 {9-庚烷-2,3-二 - 内 - 羧酸酰亚胺酯
公开(公告)号：US4122273A
公开(公告)日：1978-10-24
申请号：US877521
申请日：1978-02-13
申请人： Ronald Leslie Buchanan , John Theodore Woolever , Alex Michael Jelenevsky
发明人： Ronald Leslie Buchanan , John Theodore Woolever , Alex Michael Jelenevsky
IPC分类号： C07D401/12 , C07D403/12 , C07D409/12 , C07D413/14
CPC分类号： C07D409/12 , C07D401/12 , C07D403/12 , C07D413/14
摘要： A series of 5-endo-(quinoxaline-carbonyloxy)-N[amino-(lower)alkyl]bicyclo[2.2.1]-heptane-2,3-di-endo-carboxylic acid imides has been found to possess excellent prophylactic and therapeutic activity as anti-arrhythmic agents.
摘要翻译：已经发现一系列5-内 - （喹喔啉羰基氧基）-N [氨基 - （低级）烷基]双环[2.2.1] - 庚烷-2,3-二 - 内 - 羧酸酰亚胺具有优异的预防性和作为抗心律失常药的治疗活性。

3. 发明授权

US3980668A Anti-arrhythimic 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)alkyl]bicyclo[2,2,1]heptane -2,3-di-endo-carboxylic acid imides 失效
标题翻译：抗心律不齐的5-内 - （3-吲哚羰基氧基）-N- {8氨基 - （低级）烷基{9双环{8,2,1 {9庚烷-2,3-二 - 内 - 羧酸酰亚胺
公开(公告)号：US3980668A
公开(公告)日：1976-09-14
申请号：US594918
申请日：1975-07-10
申请人： Ronald Leslie Buchanan , Alex Michael Jelenevsky
发明人： Ronald Leslie Buchanan , Alex Michael Jelenevsky
IPC分类号： C07D209/42 , A61K31/40 , A61K31/403 , A61K31/404 , A61P9/06 , C07D209/76 , C07D403/12
CPC分类号： C07D403/12 , A61K31/40
摘要： A series of 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)alkyl]bicyclo[2.2.1]heptane-2,3-di-endo-carboxylic acid imides having the formula ##SPC1##Wherein R.sup.1 is H, Cl, Br, F or (lower)alkyl, R.sup.7 is H or methyl, R.sup.2 and R.sup.3 are alike or different and each is H, Cl, Br, F, (lower)alkyl, nitro, CF.sub.3, OH or (lower)alkoxy, n is an integer of 2 to 4 inclusive and R.sup.4 and R.sup.5 are alike or different and each is H, (lower)alkyl or when taken together with the nitrogen a radical of the formula ##SPC2##In which R.sup.6 is (lower)alkyl; or a pharmaceutically acceptable acid addition salt thereof have been found to possess unique prophylactic and therapeutic activity as anti-arrhythmia agents. An example of such a compound possessing excellent activity is 5-endo-(3-indolecarbonyloxy)-N-(3-dimethylaminopropyl)bicyclo-[2.2.1]heptane-2,3-di-endo-carboxylic acid imide hydrochloride.
摘要翻译：具有式WHEREIN R1的一系列5-内 - （3-吲哚羰基氧基）-N- [氨基 - （低级）烷基]双环[2.2.1]庚-3,3-二 - 内 - 羧酸酰亚胺是H ，Cl，Br，F或（低级）烷基，R7是H或甲基，R2和R3是相同或不同的，分别是H，Cl，Br，F，（低级）烷基，硝基，CF3，OH或（低级）烷氧基，n是2〜4的整数，R4和R5相同或不同，各自为H，（低级）烷基，或者当与氮一起时，R 6为（低级）烷基; 或其药学上可接受的酸加成盐已被发现具有独特的预防和治疗活性作为抗心律不齐剂。具有优异活性的这种化合物的实例是5-内 - （3-吲哚羰基氧基）-N-（3-二甲基氨基丙基）双环[2.2.1]庚烷-2,3-二 - 内 - 羧酸酰亚胺盐酸盐。

4. 发明授权

US3980667A Anti-arrhythmic 5-endo-substituted oxy-N-(aminoloweralkyl)bicycle [2.2.2.]o c 失效
标题翻译：抗心律不齐的5-端取代的氧-N-（氨基低级烷基）自行车{8 2.2.2。{9辛烷-2,3-二 - 内 - 羧酸酰亚胺
公开(公告)号：US3980667A
公开(公告)日：1976-09-14
申请号：US555651
申请日：1975-03-05
申请人： Richard Anthony Partyka , Henry Michael Holava , Alex Michael Jelenevsky
发明人： Richard Anthony Partyka , Henry Michael Holava , Alex Michael Jelenevsky
IPC分类号： C07D209/76 , C07D307/77 , C07D209/48
CPC分类号： C07D307/77 , C07D209/76
摘要： Series of 5-endo-benzoyloxy-N-[amino(lower)-alkyl]bicyclo[2.2.2]octane-2,3-di-endo-carboxylic acid imides, 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)alkyl]bicyclo[2.2.2]octane-2,3-di-endo-carboxylic acid imides, 5-endo-n-substituted-carbamoyloxy-N-[amino(lower)alkyl]bicyclo[2.2.2]octane-2,3-di-endo-carboxylic acid imides and 5-endo-(1-naphthoyloxy)-N-[amino(lower)alkyl]bicyclo[2.2.2]octane-2,3-di-endo-carboxylic acid imides have been found to possess unique prophylactic and therapeutic activity as anti-arrhythmia agents. An example of such a compound possessing activity is 5-endo-(3-indolecarbonyloxy)-N-(3-dimethylaminopropyl)bicyclo[2.2.2]octane-2,3-di-endo-carboxylic acid imide hydrochloride of the formula ##SPC1##
摘要翻译： 5-内 - 苯甲酰氧基-N- [氨基（低级） - 烷基]双环[2.2.2]辛烷-2,3-二 - 羧酸酰亚胺系列，5-内 - （3-吲哚羰基氧基）-N - [氨基 - （低级）烷基]双环[2.2.2]辛-2-基-2,3-二 - 内 - 羧酸酰亚胺，5-内 - 取代 - 氨基甲酰氧基-N- [氨基（低级）烷基]双环 [2.2.2]烷-2,3-二 - 内 - 羧酸酰亚胺和5-内 - （1-萘氧基）-N- [氨基（低级）烷基]双环[2.2.2]辛烷-2,3 已经发现二 - 内 - 羧酸酰亚胺作为抗心律失常药具有独特的预防和治疗活性。这种具有活性的化合物的实例是式（I）的5-内 - （3-吲哚羰基氧基）-N-（3-二甲基氨基丙基）双环[2.2.2]咔啉-2,3-二 - 内 - 羧酸酰亚胺盐酸盐

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式