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1. 发明授权

US06350589B1 Compositions of highly-purified natural mixtures of type I interferon derived from leukocytes and methods 失效
标题翻译：来自白细胞的I型干扰素的高度纯化天然混合物的组合物和方法
公开(公告)号：US06350589B1
公开(公告)日：2002-02-26
申请号：US09224895
申请日：1998-12-31
申请人： Joseph P. Morris , Duy Nguyen , James Kappelman , Michael D. Potter , Mead M. McCabe , Reza Ziai , Stephen B. Feldman , Hipolito Hartman
发明人： Joseph P. Morris , Duy Nguyen , James Kappelman , Michael D. Potter , Mead M. McCabe , Reza Ziai , Stephen B. Feldman , Hipolito Hartman
IPC分类号： C12P100
CPC分类号： C07K14/56 , A61K38/00
摘要： This invention relates to methods for isolating highly-purified mixtures of natural type I interferons from white blood cells. The invention also relates to highly-purified mixtures of natural type I interferons which resemble natural type I interferon in that it includes 9 subtypes, i.e., alpha-1, alpha-2, alpha-5, alpha-7, alpha-8, alpha-10, alpha-14, alpha-21 and omega, giving rise to possibly 20 molecular species, including alpha-1a, alpha-1new, alpha-2a, alpha-2b, alpha-2c, alpha-5, alpha-5LG, alpha-7, alpha-8a, alpha-8c, alpha-10a, alpha-14a, alpha14-b, alpha 14-c, alpha-14LG, alpha-21a, alpha-21b, alpha-21c, omega and omega LG.
摘要翻译：本发明涉及从白细胞分离天然I型干扰素的高度纯化混合物的方法。本发明还涉及类似于天然I型干扰素的天然I型干扰素的高度纯化的混合物，因为它包括9种亚型，即α-1，α-2，α-5，α-7，α-8，α -10，α-14，α-21和ω，产生可能20个分子物质，包括α-1a，α-1新，α-2a，α-2b，α-2c，α-5，α-5LG， α-7，α-8a，α-8c，α-10a，α-14a，α14-b，α14-c，α-14LG，α-21a，α-21b，α-21c，ω和ω-LG。

2. 发明授权

US06433144B1 Compositions of highly-purified natural mixtures of type I Interferon derived from leukocytes and methods 失效
标题翻译：来自白细胞的I型干扰素的高度纯化天然混合物的组合物和方法
公开(公告)号：US06433144B1
公开(公告)日：2002-08-13
申请号：US09229039
申请日：1999-01-12
申请人： Joseph P. Morris , Duy Nguyen , James Kappelman , Michael D. Potter , Mead M. McCabe , Reza Ziai , Stephen Feldman , Hipolito Hartman
发明人： Joseph P. Morris , Duy Nguyen , James Kappelman , Michael D. Potter , Mead M. McCabe , Reza Ziai , Stephen Feldman , Hipolito Hartman
IPC分类号： C07K1700
CPC分类号： C07K14/56 , A61K38/00
摘要： This invention relates to methods for isolating highly purified mixtures of natural Type I interferon from white blood cells. The invention also relates to highly-purified mixtures of Type I interferon which resemble natural Type I interferon in that the highly purified mixtures of natural Type I interferon includes at least 9 subtypes, i.e., alpha-1, alpha-2, alpha-5, alpha-7, alpha-8, alpha-10, alpha-14, alpha-21 and omega, giving rise to at least 16, and possibly 20 or more molecular species, including alpha-1a, alpha-1new, alpha-2a, alpha-2b, alpha-2c, alpha-5, alpha-5LG, alpha-7, alpha-8a, alpha-8c, alpha-10a, alpha-14a, alphal4-b, alpha 14-c, alpha-14LG, alpha-21a, alpha-21b, alpha-21c, omega and omega LG.
摘要翻译：本发明涉及从白细胞中分离出高度纯化的天然I型干扰素混合物的方法。本发明还涉及类似于天然I型干扰素的I型干扰素的高度纯化的混合物，因为天然I型干扰素的高度纯化的混合物包括至少9种亚型，即α-1，α-2，α-5， α-7，α-8，α-10，α-14，α-21和ω，产生至少16种，并且可能有20种或更多种分子物质，包括α-1a，α-1新，α-2a， α-2b，α-2c，α-5，α-5LG，α-7，α-8a，α-8c，α-10a，α-14a，alphal4-b，α14-c，α-14LG， -21a，α-21b，α-21c，ω和ωLG。

3. 发明申请

US20160371725A1 CAMPAIGN OPTIMIZATION SYSTEM 审中-公开
标题翻译：航空优化系统
公开(公告)号：US20160371725A1
公开(公告)日：2016-12-22
申请号：US15186421
申请日：2016-06-17
申请人： Duy Nguyen , Vu Huy Tran
发明人： Duy Nguyen , Vu Huy Tran
IPC分类号： G06Q30/02 , G06F17/30
CPC分类号： G06Q30/0246 , G06F16/9535 , G06F16/957
摘要： A method and apparatuses can include: crawling web sites including an advertiser web site and a publisher website; identifying a resource article from the websites, the resource article including a title, an image, and body content; generating a resource article topic model; identifying a current article being read by a user; generating a current article topic model for the current article; calculating a semantic score by measuring the similarity between the resource article topic model and the current article topic model; calculating a reader score based on a click history of the user and a browsing history of the user; calculating a traffic score based on a demographic relationship between the current article and the resource article; and recommending the resource article to the user based on the semantic score, the reader score, and the traffic score indicating the user will select the resource article.
摘要翻译：方法和装置可以包括：爬行网站，包括广告商网站和发布者网站; 从网站识别资源文章，资源文章包括标题，图像和正文内容; 生成资源文章主题模型; 识别由用户读取的当前文章; 生成当前文章的当前文章主题模型; 通过测量资源文章主题模型与当前文章主题模型的相似性来计算语义分数; 基于用户的点击历史和用户的浏览历史来计算阅读器分数; 根据当前文章和资源文章之间的人口统计关系计算交通分数; 并且基于语义分数，读者得分以及指示用户将选择资源文章的交通分数向用户推荐资源文章。

4. 发明申请

US20140302010A1 SUBSTITUTED BENZIMIDAZOLES 有权
标题翻译：取代苯并咪唑
公开(公告)号：US20140302010A1
公开(公告)日：2014-10-09
申请号：US14008981
申请日：2012-03-28
申请人： Ulrich Klar , Marcus Koppitz , Duy Nguyen , Dirk Kosemund , Roland Neuhaus , Gerhard Siemeister
发明人： Ulrich Klar , Marcus Koppitz , Duy Nguyen , Dirk Kosemund , Roland Neuhaus , Gerhard Siemeister
IPC分类号： C07D235/08 , C07D401/06 , A61K31/4439 , C07D405/12 , A61K45/06 , A61K31/5377 , C07D413/12 , A61K31/422 , C07D403/12 , A61K31/4196 , A61K31/4184 , C07D403/04
CPC分类号： C07D235/08 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , A61K2300/00
摘要： The present invention relates to substituted benzimidazole compounds of general formula (I) in which R3, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译：本发明涉及通式（I）的取代的苯并咪唑化合物，其中R3，R5和A如权利要求中所定义，所述化合物的制备方法，药物组合物和包含所述化合物的组合以及所述化合物的用途用于制造用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物，作为唯一试剂或与其它活性成分组合。

5. 发明申请

US20130195848A1 IMIDAZOPYRAZINES 有权
标题翻译：咪唑并吡嗪
公开(公告)号：US20130195848A1
公开(公告)日：2013-08-01
申请号：US13635734
申请日：2011-03-16
申请人： Ulrich Klar , Marcus Koppitz , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , Stefan Prechtl , Duy Nguyen , William Scott
发明人： Ulrich Klar , Marcus Koppitz , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister , Stefan Prechtl , Duy Nguyen , William Scott
IPC分类号： A61K31/519 , A61K45/06 , C07D487/04
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D487/14
摘要： The present invention relates to imidazopyrazine compounds of general Formula (I): in which X, R1, R2, R3a, R3b, R4a, R4b, R4C, and R4D are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译：本发明涉及通式（I）的咪唑并吡嗪化合物：其中X，R1，R2，R3a，R3b，R4a，R4b，R4C和R4D如说明书和权利要求书中所给出的，涉及制备所述化合物，包含所述化合物的药物组合物和组合，用于制备用于治疗或预防疾病的药物组合物的所述化合物的用途，以及可用于制备所述化合物的中间体化合物。

6. 发明授权

US08182467B2 Deflectable variable radius catheters 有权
标题翻译：可变半径导管
公开(公告)号：US08182467B2
公开(公告)日：2012-05-22
申请号：US12569786
申请日：2009-09-29
申请人： Duy Nguyen , Sheldon Nelson , Elizabeth Nee , Guy P. Vanney
发明人： Duy Nguyen , Sheldon Nelson , Elizabeth Nee , Guy P. Vanney
IPC分类号： A61B5/04 , A61B18/18 , A61M25/00 , A61M31/00 , A61M37/00
CPC分类号： A61M25/0152 , A61M25/0043 , A61M25/0136 , A61M25/0141 , A61M25/0147 , A61M2025/015 , A61M2025/0161 , A61M2025/105
摘要： The invention provides a deflectable catheter capable of forming many variable radius spiral forms from a single, flexible, distal end section. In one aspect, the catheter employs a variable radius control wire to extend or deform a pre-formed loop structure into a three dimensional spiral-like form or geometry. The ability of a single catheter to create a multitude of shapes and sizes allows users to access to a number of anatomical areas without changing the catheter during a procedure or treatment. In another aspect, the invention encompasses methods of producing deflectable variable radius catheters, where two or more regions of the catheter having common control wires are fused or formed onto one another.
摘要翻译：本发明提供了一种能够从单个柔性远端部分形成许多可变半径螺旋形状的可偏转导管。在一个方面，导管使用可变半径控制线来将预成形的环结构延伸或变形为三维螺旋形的形状或几何形状。单个导管创建多种形状和尺寸的能力允许用户在手术或治疗期间不改变导管的情况下进入多个解剖区域。在另一方面，本发明包括生产可偏转可变半径导管的方法，其中具有公共控制线的导管的两个或更多个区域彼此熔合或形成。

7. 发明授权

US08163739B2 2-arylthiazole-4-carboxamide derivatives, their preparation and use as pharmaceuticals 有权
标题翻译： 2-芳基噻唑-4-甲酰胺衍生物，它们的制备和用作药物
公开(公告)号：US08163739B2
公开(公告)日：2012-04-24
申请号：US12331775
申请日：2008-12-10
申请人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bomer , Judith Guenther
发明人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bomer , Judith Guenther
IPC分类号： A61K31/535 , A61K31/425
CPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D495/04
摘要： The present invention relates to 2-arylthiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof
摘要翻译：本发明涉及式（I）的2-芳基噻唑-4-甲酰胺衍生物，其作为治疗各种病症的药物的用途及其制备方法

8. 发明授权

US07897626B2 2-substituted thiazole-4-carboxamide derivatives, their preparation and use as pharmaceuticals 有权
标题翻译： 2-取代的噻唑-4-甲酰胺衍生物，其制备和用作药物
公开(公告)号：US07897626B2
公开(公告)日：2011-03-01
申请号：US12330696
申请日：2008-12-09
申请人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bömer , Judith Guenther
发明人： Ulrich Bothe , Arne Von Bonin , Duy Nguyen , Ulf Bömer , Judith Guenther
IPC分类号： A61K31/4155 , A61K31/426 , C07D277/24
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention relates to 2-substituted thiazole-4-carboxamide derivatives of the formula (I), the use thereof as medicament for the treatment of various disorders, and processes for the preparation thereof
摘要翻译：本发明涉及式（I）的2-取代噻唑-4-甲酰胺衍生物，其用作治疗各种疾病的药物的用途及其制备方法

9. 发明申请

US20090098189A1 AZAINDOLES AS INHIBITORS OF SOLUBLE ADENYLATE CYCLASE 审中-公开
标题翻译：作为可溶性ADENYLATE CYCLASE的抑制剂
公开(公告)号：US20090098189A1
公开(公告)日：2009-04-16
申请号：US12202744
申请日：2008-09-02
申请人： Bernd BUCHMANN , Michael Haerter , Yolanda Cancho-Grande , Dirk Kosemund , Hartmut Schirok , Duy Nguyen , Martin Fritsch
发明人： Bernd BUCHMANN , Michael Haerter , Yolanda Cancho-Grande , Dirk Kosemund , Hartmut Schirok , Duy Nguyen , Martin Fritsch
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437 , A61P15/16 , A61P15/18 , A61K9/02 , C07D413/14
CPC分类号： C07D471/04
摘要： The present invention relates to azaindoles of general formula I, a method for the production thereof, and to the use thereof for the production of pharmaceutical compositions.
摘要翻译：本发明涉及通式I的氮杂吲哚，其制备方法及其用于制备药物组合物的用途。

10. 发明申请

US20080056987A1 Quinoline derivatives, their preparation, their use, and medicaments comprising them 审中-公开
标题翻译：喹啉衍生物，其制备方法，用途以及包含它们的药物
公开(公告)号：US20080056987A1
公开(公告)日：2008-03-06
申请号：US11765683
申请日：2007-06-20
申请人： Olaf Prien , Knut Eis , Duy Nguyen , Christoph Huwe , Wolfgang Schwede , Judith Guenther , Dieter Zopf
发明人： Olaf Prien , Knut Eis , Duy Nguyen , Christoph Huwe , Wolfgang Schwede , Judith Guenther , Dieter Zopf
IPC分类号： A61K51/00 , A61K31/47 , A61P25/00 , A61P9/00 , C07D295/00 , C12Q1/00 , C12N9/99 , C07D215/00 , A61P43/00 , A61K31/5377
CPC分类号： C07D513/04 , C07D495/04
摘要： The present invention relates to a quinoline derivative having the general formula (A) in which R1, R2, W, X, Y and Z are indicated in the description and the claims, the use of the compounds of the general formula (A) for the treatment of various disorders, and the preparation of compounds of the general formula (A).
摘要翻译：本发明涉及具有通式（A）的喹啉衍生物，其中R 1，R 2，W，X，Y和Z在说明书中表示，权利要求书，通式（A）的化合物用于各种病症的治疗，以及制备通式（A）的化合物。

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