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1. 发明申请

US20080245787A1 CONTROLLING AND MODERATING MICROWAVE ENERGY IN CONCURRENT MULTIPLE SAMPLE WELL APPLICATIONS 审中-公开
标题翻译：在多种样品中应用微控制器的微控制
公开(公告)号：US20080245787A1
公开(公告)日：2008-10-09
申请号：US11695641
申请日：2007-04-03
申请人： Joseph Lambert , Grace S. Vanier , Jonathan M. Collins , Michael J. Collins
发明人： Joseph Lambert , Grace S. Vanier , Jonathan M. Collins , Michael J. Collins
IPC分类号： H05B6/68
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00689 , B01J2219/00716 , B01L2200/14 , B01L2300/0829 , B01L2300/1838 , B01L2300/1866 , B01L2400/04
摘要： A system for microwave assisted high-throughput chemical processes is disclosed. The system includes a source of microwave radiation, a microwave cavity in communication with the source, and a microtiter plate in the cavity. The microtiter plate is formed of a microwave transparent material and includes a plurality of sample wells. A fluid chamber is defined by the interior of the four walls, the base, the profiles of the wells, and by the top surface of the microtiter plate. A microwave-moderating fluid in the chamber helps produce a more uniform microwave field among the individual wells in the microtiter plate when microwaves are applied in the cavity from the source.
摘要翻译：公开了一种用于微波辅助高通量化学方法的系统。该系统包括微波辐射源，与源极连通的微波空腔和空腔中的微量滴定板。微量滴定板由微波透明材料形成并且包括多个样品孔。流体室由四个壁的内部，基部，孔的轮廓以及微量滴定板的顶表面限定。当微波从源中施加到空腔中时，室中的微波调节流体有助于在微量滴定板中的各个孔中产生更均匀的微波场。

2. 发明授权

US08314208B2 Microwave enhanced N-fmoc deprotection in peptide synthesis 有权
标题翻译：微波增强肽合成中的N-fmoc去保护
公开(公告)号：US08314208B2
公开(公告)日：2012-11-20
申请号：US11351796
申请日：2006-02-10
申请人： Jonathan M. Collins
发明人： Jonathan M. Collins
IPC分类号： A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K1/063 , C07K1/04 , C07K1/045 , C07K1/10
摘要： A method is disclosed for carrying out peptide synthesis comprising deprotecting an Fmoc-protected amino acid with piperazine while applying microwave irradiation to the deprotection reaction.
摘要翻译：公开了一种用于进行肽合成的方法，其包括在将微波照射用于去保护反应的同时用哌嗪去保护Fmoc保护的氨基酸。

3. 发明申请

US20120157563A1 WATER SOLUBLE SOLID PHASE PEPTIDE SYNTHESIS 审中-公开
标题翻译：水溶性固相肽合成
公开(公告)号：US20120157563A1
公开(公告)日：2012-06-21
申请号：US13363650
申请日：2012-02-01
申请人： Jonathan M. Collins
发明人： Jonathan M. Collins
IPC分类号： C07K1/06 , C08J3/28 , C08G65/334
CPC分类号： C07K1/045 , C07K1/063 , Y02P20/55
摘要： A solid phase peptide synthesis method is disclosed. The method includes the steps of deprotecting an amino group in its protected form that is protected with a protecting group that includes an α,β-unsaturated sulfone; washing the deprotected acid in a solvent selected from the group consisting of water, alcohol, and mixtures of water and alcohol; coupling the deprotected acid to a resin-based peptide or a resin-based amino acid; and washing the coupled composition in a solvent selected from the group consisting of water, alcohol, and mixtures of water and alcohol.
摘要翻译：公开了固相肽合成方法。该方法包括以保护基保护的氨基脱保护的步骤，该保护基包括α，β-不饱和砜; 在选自水，醇和水和醇的混合物的溶剂中洗涤去保护的酸; 将去保护的酸偶联到基于树脂的肽或基于树脂的氨基酸上; 并将所述偶联组合物在选自水，醇，以及水和醇的混合物的溶剂中洗涤。

4. 发明申请

US20120041173A1 WATER SOLUBLE SOLID PHASE PEPTIDE SYNTHESIS 审中-公开
标题翻译：水溶性固相肽合成
公开(公告)号：US20120041173A1
公开(公告)日：2012-02-16
申请号：US13209960
申请日：2011-08-15
申请人： Jonathan M. Collins
发明人： Jonathan M. Collins
IPC分类号： C07K1/04 , C07K1/10 , C07K2/00
CPC分类号： C07K1/063 , C07K1/045 , Y02P20/55
摘要： A solid phase peptide synthesis method is disclosed. The method includes the steps of deprotecting an amino group in its protected form that is protected with a protecting group containing a Michael acceptor site composed of an α,β-unsaturated sulfone in a solvent selected from the group consisting of water, alcohol, and mixtures of water and alcohol; washing the deprotected acid in a solvent selected from the group consisting of water, alcohol, and mixtures of water and alcohol; coupling the deprotected acid to a resin-based peptide or a resin-based amino acid in a solvent selected from the group consisting of water, alcohol, and mixtures of water and alcohol; and washing the coupled composition in a solvent selected from the group consisting of water, alcohol, and mixtures of water and alcohol.
摘要翻译：公开了固相肽合成方法。该方法包括以下步骤：将保护形式的氨基脱保护，所述保护基被保护基保护，所述保护基含有由α，β-不饱和砜组成的迈克尔受体位点，所述溶剂选自水，醇和水和酒精的混合物; 在选自水，醇和水和醇的混合物的溶剂中洗涤去保护的酸; 将脱保护的酸与选自水，醇和水和醇的混合物的溶剂中的脱保护酸偶联至基于树脂的肽或树脂基氨基酸; 并将所述偶联组合物在选自水，醇，以及水和醇的混合物的溶剂中洗涤。

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