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1. 发明申请

US20060009528A1 Cannabinoid receptor ligands 有权
公开(公告)号：US20060009528A1
公开(公告)日：2006-01-12
申请号：US11203946
申请日：2005-08-15
申请人： Joseph Kozlowski , Neng-Yang Shih , Brian Lavey , Razia Rizvi , Bandarpalle Shankar , James Spitler , Ling Tong , Ronald Wolin , Michael Wong
发明人： Joseph Kozlowski , Neng-Yang Shih , Brian Lavey , Razia Rizvi , Bandarpalle Shankar , James Spitler , Ling Tong , Ronald Wolin , Michael Wong
IPC分类号： A61K31/18
CPC分类号： C07D213/70 , C07C31/24 , C07C317/22 , C07C317/32 , C07C317/36 , C07C317/44 , C07C323/41 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D213/71 , C07D213/74 , C07D213/89 , C07D215/36 , C07D233/42 , C07D233/84 , C07D239/38 , C07D307/64 , C07D333/20 , C07D333/34 , C07D333/38
摘要： There are disclosed compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit anti-inflammatory and immunodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds and methods of using the compounds for the treatment of various diseases and conditions.

2. 发明申请

US20070265299A1 Compounds for the treatment of inflammatory disorders 有权
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US20070265299A1
公开(公告)日：2007-11-15
申请号：US11653798
申请日：2007-01-16
申请人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Aneta Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
发明人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Aneta Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
IPC分类号： A61K31/44 , A61K31/4152 , A61K31/4412 , A61K31/4709 , A61K35/00 , A61P11/00 , A61P11/08 , A61P17/06 , A61P3/14 , A61P37/00 , A61P37/08 , A61P9/00 , A61P9/10 , C07D215/06 , C07D233/02 , C07D401/06 , C07D471/02
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPS, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMPS，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症。

3. 发明申请

US20070219218A1 Compounds for the treatment of inflammatory disorders 有权
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US20070219218A1
公开(公告)日：2007-09-20
申请号：US11653676
申请日：2007-01-16
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Aneta Micula , Robert Feltz
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Aneta Micula , Robert Feltz
IPC分类号： A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/4741 , A61K31/4745 , A61K31/4178 , C07D403/14 , C07D491/02 , C07D471/02
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物，酯或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或组合介导的疾病或病症其中。

4. 发明申请

US20070197564A1 Compounds for the treatment of inflammatory disorders 有权
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US20070197564A1
公开(公告)日：2007-08-23
申请号：US11653511
申请日：2007-01-16
申请人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong-Heon Kim
发明人： Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong-Heon Kim
IPC分类号： A61K31/52 , C07D471/02 , A61K31/4745 , A61K31/513 , A61K31/519 , C07D473/02 , C07D487/02
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-α或其组合介导的疾病或病症。

5. 发明申请

US20050282861A1 Cannabinoid receptor ligands 失效
标题翻译：大麻素受体配体
公开(公告)号：US20050282861A1
公开(公告)日：2005-12-22
申请号：US11197979
申请日：2005-08-05
申请人： Richard Friary , Joseph Kozlowski , Bandarpalle Shankar , Michael Wong , Guowei Zhou , Brian Lavey , Neng-Yang Shih , Ling Tong , Lei Chen , Youhen Shu
发明人： Richard Friary , Joseph Kozlowski , Bandarpalle Shankar , Michael Wong , Guowei Zhou , Brian Lavey , Neng-Yang Shih , Ling Tong , Lei Chen , Youhen Shu
IPC分类号： A61K31/445 , A61K31/4535 , A61K31/454 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P27/06 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/08 , C07D211/26 , C07D211/96 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
CPC分类号： C07D401/12 , C07D211/26 , C07D211/96 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： There are disclosed compounds of the formula I: or a pharmaceutically acceptable salt of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds.
摘要翻译：公开了具有抗炎和免疫调节活性的式I化合物或化合物的药学上可接受的盐。还公开了含有所述化合物的药物组合物。

6. 发明申请

US20060205797A1 Compounds for the treatment of inflammatory disorders 有权
标题翻译：用于治疗炎性疾病的化合物
公开(公告)号：US20060205797A1
公开(公告)日：2006-09-14
申请号：US11180863
申请日：2005-07-13
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar
IPC分类号： A61K31/425 , A61K31/4178 , C07D417/02 , C07D403/02
CPC分类号： C07D401/14 , C07D403/06 , C07D409/14 , C07D413/14 , C07D417/14
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF—combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-组合介导的疾病或病症。

7. 发明申请

US20060276506A1 Compounds for the treatment of inflammatory disorders 有权
公开(公告)号：US20060276506A1
公开(公告)日：2006-12-07
申请号：US11333663
申请日：2006-01-17
申请人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Umar Mansoor , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li
发明人： Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Umar Mansoor , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li
IPC分类号： A61K31/4709 , A61K31/4245 , A61K31/4178 , C07D413/14 , C07D403/02
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

8. 发明申请

US20060100228A1 Cannabinoid receptor ligands 失效
标题翻译：大麻素受体配体
公开(公告)号：US20060100228A1
公开(公告)日：2006-05-11
申请号：US11157510
申请日：2005-06-21
申请人： Bandarpalle Shankar , Eric Gilbert , Razia Rizvi , Chunli Huang , Joseph Kozlowski , Stuart McCombie , Neng-Yang Shih
发明人： Bandarpalle Shankar , Eric Gilbert , Razia Rizvi , Chunli Huang , Joseph Kozlowski , Stuart McCombie , Neng-Yang Shih
IPC分类号： A61K31/4747 , A61K31/46 , A61K31/405 , C07D455/02 , C07D403/02
CPC分类号： C07D221/20 , C07D209/52 , C07D401/12 , C07D471/08
摘要： Compounds of Formula I: and/or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions containing such compounds exhibit anti-inflammatory and immunomodulatory activity, and can be effective in treating cancer and inflammatory, immunomodulatory or respiratory diseases or conditions.
摘要翻译：式I化合物和/或其药学上可接受的盐，溶剂化物或前药，或含有这些化合物的药物组合物表现出抗炎和免疫调节活性，并且可有效治疗癌症和炎症，免疫调节或呼吸系统疾病或病症。

9. 发明申请

US20070054919A1 Pyrazinyl substituted piperazine-piperidines with CXCR3 antagonist activity 有权
标题翻译：吡嗪基取代的哌嗪 - 哌啶与CXCR3拮抗剂活性
公开(公告)号：US20070054919A1
公开(公告)日：2007-03-08
申请号：US11354138
申请日：2006-02-14
申请人： Stuart Rosenblum , Seong Kim , Qingbei Zeng , Michael Wong , Gopinadhan Anilkumar , Yueheng Jiang , Wensheng Yu , Joseph Kozlowski , Neng-Yang Shih , Bandarpalle Shankar , Brian McGuinness , Guizhen Dong , Lisa Zawacki , Douglas Hobbs , John Baldwin , Yuefei Shao
发明人： Stuart Rosenblum , Seong Kim , Qingbei Zeng , Michael Wong , Gopinadhan Anilkumar , Yueheng Jiang , Wensheng Yu , Joseph Kozlowski , Neng-Yang Shih , Bandarpalle Shankar , Brian McGuinness , Guizhen Dong , Lisa Zawacki , Douglas Hobbs , John Baldwin , Yuefei Shao
IPC分类号： A61K31/497 , C07D403/14
CPC分类号： C07D405/14 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: and the pharmaceutically acceptable salts, solvates and esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物或所述前体药物的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映异构体，立体异构体，旋转异构体，互变异构体或前药，所述化合物具有式1所示的一般结构：及其药学上可接受的盐，溶剂化物和酯。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，疗效治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，牛皮癣），自身免疫性疾病（非限制性的例如，类风湿性关节炎，多发性硬化症），移植排斥反应（非限制性实例包括，同种异体移植排斥反应，异种移植物排斥），感染性疾病（例如结核性麻风病），固定药物爆发，皮肤迟发型超敏反应应答，眼部炎症，I型糖尿病，病毒性脑膜炎和使用式1的化合物的肿瘤。

10. 发明申请

US20070082913A1 Substituted heterocyclic compounds with CXCR3 antagonist activity 有权
标题翻译：取代的具有CXCR3拮抗剂活性的杂环化合物
公开(公告)号：US20070082913A1
公开(公告)日：2007-04-12
申请号：US11545201
申请日：2006-10-10
申请人： Seong Kim , Bandarpalle Shankar , Joseph Kozlowski , Stuart Rosenblum , Neng-Yang Shih
发明人： Seong Kim , Bandarpalle Shankar , Joseph Kozlowski , Stuart Rosenblum , Neng-Yang Shih
IPC分类号： A61K31/497 , A61K31/496 , C07D403/14
CPC分类号： C07D401/14 , C07D401/08 , C07D413/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1: or a pharmaceutically acceptable salt, solvate or ester thereof, wherein the various moieties are defined herein. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g, tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物或所述前体药物的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映异构体，立体异构体，旋转异构体，互变异构体或前药，所述化合物具有式1所示的一般结构：或其药学上可接受的盐，溶剂合物或酯，其中各种部分在本文中定义。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，疗效治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，牛皮癣），自身免疫性疾病（非限制性的例如，类风湿性关节炎，多发性硬化症），移植排斥反应（非限制性实例包括，同种异体移植排斥反应，异种移植物排斥），感染性疾病（例如结核性麻风病），固定药物爆发，皮肤迟发型超敏反应应答，I型糖尿病，病毒性脑膜炎和使用式1的化合物的肿瘤。

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