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1. 发明授权

US5068253A Treatment of a microbial infection with drugs containing para-acetamidobenzoic acid 失效
标题翻译：用含对乙酰氨基苯甲酸的药物治疗微生物感染
公开(公告)号：US5068253A
公开(公告)日：1991-11-26
申请号：US551521
申请日：1990-07-11
申请人： Joseph Kovacs , Henry Masur , Carmen Allegra
发明人： Joseph Kovacs , Henry Masur , Carmen Allegra
IPC分类号： A61K31/195
CPC分类号： A61K31/195
摘要： The present invention relates to a method of treating or preventing a microbial infection, such as Pneumocystis carinii or Toxoplasma gondii, in a patient comprising administering to the patient an antimicrobially effective amount of p-acetamidobenzoic acid or a pharmaceutically acceptable salt thereof so that the microbial infection is inhibited. P-acetamidobenzoic acid or an acceptable salt thereof can be used to treat infections caused by Pneumocystis carinii, Toxoplasma gondii, Plasmodium species and other microorganisms containing the enzyme dihydropteroate synthetase such as most bacteria and some yeasts. The method of the present invention is particularly applicable in situations where the patient is immunosuppressed.
摘要翻译：本发明涉及一种治疗或预防微生物感染的方法，例如卡氏肺囊虫或弓形体弓形虫，包括向患者施用抗微生物有效量的对乙酰氨基苯甲酸或其药学上可接受的盐，使得微生物感染被抑制。对乙酰氨基苯甲酸或其可接受的盐可用于治疗由卡氏肺囊虫，弓形虫，疟原虫物种和含有二氢异戊酸合成酶如大多数细菌和一些酵母的其他微生物引起的感染。本发明的方法特别适用于患者免疫抑制的情况。

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