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    • 7. 发明授权
    • Method of selective esterification
    • 选择性酯化方法
    • US07368593B1
    • 2008-05-06
    • US10920514
    • 2004-08-18
    • Ramanujam PrasadJeffrey P. ConradThaddeus J. Ilg
    • Ramanujam PrasadJeffrey P. ConradThaddeus J. Ilg
    • C07C69/88
    • C07C67/11C07C69/732
    • A method of preparing a compound of formula I wherein R is a hydrocarbon and n is an integer from 1 to 5, including the steps of: contacting a compound of formula II with a compound selected from the group consisting of amines, and carbonates, bicarbonates, and hydroxides of alkali metals, and combinations thereof, in a solvent to produce a salt of a compound of formula II; treating the salt of the compound of formula II in a polar, aprotic solvent with an organic halide having a formula R—X, wherein X is selected from chlorine, bromine, iodine, and combinations thereof, to produce an ester of formula I; isolating a reaction product including the ester of formula I from the solvent by precipitation or solvent extraction; and purifying the compound of formula I, is disclosed.
    • 一种制备式I化合物的方法,其中R是烃,n是1至5的整数,包括以下步骤:使式II化合物与选自胺和碳酸酯,碳酸氢盐的化合物接触 ,和碱金属的氢氧化物及其组合在溶剂中以产生式II化合物的盐; 在极性非质子溶剂中用具有式R-X的有机卤化物处理式II化合物的盐,其中X选自氯,溴,碘及其组合,得到式I的酯; 通过沉淀或溶剂萃取从溶剂中分离包括式I的酯的反应产物; 并公开了式I化合物的纯化。