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1. 发明授权

US5698535A SIN-1A cyclodextrin inclusion complexes 失效
标题翻译： SIN-1A环糊精包合物
公开(公告)号：US5698535A
公开(公告)日：1997-12-16
申请号：US571853
申请日：1996-04-16
申请人： Joseph Geczy , Andrasne Vikmon , Jozsef Szejtli , Lajos Szente , Julianna Szeman
发明人： Joseph Geczy , Andrasne Vikmon , Jozsef Szejtli , Lajos Szente , Julianna Szeman
IPC分类号： C07D271/04 , A61K9/00 , A61K31/42 , A61K31/4245 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/724 , A61K33/08 , A61K47/40 , A61K47/48 , A61P9/10 , A61P35/00 , A61P43/00 , C08B37/00 , C08B37/16 , A61K31/715 , C07D271/02 , C08B30/18
CPC分类号： B82Y5/00 , A61K31/5375 , A61K47/48969 , C08B37/0015
摘要： New inclusion complexes which are stable in their so-lid state formed of SIN-1A and cyclodextrins or cyclodextrin derivatives and optionally also containing ions as catalyst or stabilizer. The complexes release nitric oxide at room temperature upon dissolving in water or aqueous systems. The ions are preferably carboxylic acid anions such as acetate, formiate, propionate, ascorbinate, tartarate and/or lactate and/or inorganic acid anions such as phosphate, phosphite, borate, carbonate, hydrocarbonate, sulfate, sulfite and/or cations such as alkali and/or ammonium. Pharmaceutical compositions as well as kits containing the complexes. The kits are to be used as NO-liberating standards to release NO in a predictable amount and rate on dissolving in aqueous media. Processes for the preparation of the complexes by subjecting at a suitable pH SIN-1 to the catalytic action of ions to shift the equilibrium towards formation of SIN-1A in the presence of cyclodextrins or cyclodextrin derivatives capable to form inclusion complexes, whereby the SIN-1A formed is immediately complexed and stabilized and isolating in the solid state the obtained new complexes optionally containing ions. A preferred process includes reacting SIN-1 and a cyclodextrin or cyclodextrin derivative in the solid state in the presence of a salt as a catalyst by thoroughly admixing or milling the components together or by freeze drying an aqueous, oxygen-free solution containing the components, followed preferably by "second drying" in vacuo.
摘要翻译： PCT No.PCT / HU95 / 00011 Sec。 371日期1996年04月16日 102（e）日期1996年4月16日PCT提交1995年4月25日PCT公布。 WO95 / 29172 PCT出版物日期1995年11月2日在SIN-1A和环糊精或环糊精衍生物形成的其盖状态下稳定的新包合配合物和任选地还含有离子作为催化剂或稳定剂。当溶解在水或水体系中时，复合物在室温下释放一氧化氮。离子优选为羧酸阴离子，例如乙酸盐，甲酸盐，丙酸盐，抗坏血酸盐，酒石酸盐和/或乳酸盐和/或无机酸阴离子如磷酸盐，亚磷酸盐，硼酸盐，碳酸盐，烃酸盐，硫酸盐，亚硫酸盐和/或阳离子如碱和/或铵。药物组合物以及含有复合物的试剂盒。这些试剂盒应用作NO释放标准，以可预测的量释放NO，并在溶解在含水介质中的速率。通过在合适的pH值SIN-1下，在能够形成包合络合物的环糊精或环糊精衍生物的存在下，使离子的转移平衡转化为SIN-1A的形成，从而制备络合物的方法，由此SIN- 1A立即复合并稳定，并在固态中分离得到的任意含有离子的新配合物。优选的方法包括在盐的存在下，通过将组分完全混合或研磨在一起或通过冷冻干燥含有组分的含水无氧溶液，使SIN-1和环糊精或环糊精衍生物在盐的存在下反应，之后优选在真空中“二次干燥”。

2. 发明授权

US06284746B1 Inclusion complexes of taxol or taxotere or taxus extract formed with cyclodextrins, its preparation and use 失效
标题翻译：含有紫杉醇或泰索帝或紫杉醇提取物的复合物与环糊精形成，其制备和用途
公开(公告)号：US06284746B1
公开(公告)日：2001-09-04
申请号：US08545721
申请日：1995-12-08
申请人： Lajos Szente , József Szejtli , Andrasne Vikmon
发明人： Lajos Szente , József Szejtli , Andrasne Vikmon
IPC分类号： A61K31715
CPC分类号： B82Y5/00 , A61K31/335 , A61K47/6951
摘要： The present invention relates to an active inclusion complex of Taxol, Taxotere or a Taxus extract formed with a cyclodextrin-derivative, a pharmaceutical composition containing the same, a process of preparation and a method of treatment.
摘要翻译：本发明涉及由环糊精衍生物形成的紫杉醇，泰索帝或紫杉属提取物的活性包合物，含有它们的药物组合物，制备方法和治疗方法。

3. 发明申请

US20100260818A1 STABLE MEDICATED CHEWING GUM COMPRISING CYCLODEXTRIN INCLUSION COMPLEX 审中-公开
标题翻译：包含CYCLODEXTRIN包装复合物的稳定的药用茶叶
公开(公告)号：US20100260818A1
公开(公告)日：2010-10-14
申请号：US12668410
申请日：2008-07-11
申请人： Carsten Andersen , My Ly Lao , Julianna Szeman , Lajos Szente
发明人： Carsten Andersen , My Ly Lao , Julianna Szeman , Lajos Szente
IPC分类号： A61K9/68 , A61K31/495 , A61P27/14
CPC分类号： B82Y5/00 , A23G4/12 , A23G4/20 , A61K9/0058 , A61K9/2086 , A61K31/495 , A61K31/496 , A61K47/6951
摘要： The present invention provides stable medicament-containing chewing gum compositions comprising an inclusion complex comprising cyclodextrin and one or more active compound(s) according to formula I, such as cetirizine, and methods for preparing such chewing gum.
摘要翻译：本发明提供了稳定的含药物的口香糖组合物，其包含包含环糊精和一种或多种根据式I的活性化合物的包合物，例如西替利嗪，以及制备这种口香糖的方法。

4. 发明申请

US20080299166A1 NOVEL BIOMATERIALS, THEIR PREPARATION AND USE 审中-公开
标题翻译：新生物材料，其制备和使用
公开(公告)号：US20080299166A1
公开(公告)日：2008-12-04
申请号：US12178934
申请日：2008-07-24
申请人： Lajos Szente , Jozsef Szejtli , Gyorgy L. Kis , Christian Schoch
发明人： Lajos Szente , Jozsef Szejtli , Gyorgy L. Kis , Christian Schoch
IPC分类号： A61K47/30 , A61K47/40 , A61F2/00 , A61K38/02 , A61P17/02 , A61K31/56 , A61K38/43
CPC分类号： A61K9/0024 , A61K9/7015 , A61L27/20 , A61L27/54 , A61L2300/602 , A61L2300/802 , C08L5/16
摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.
摘要翻译：本发明涉及沉淀物形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阴离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤 1.将阴离子聚合物组分和环糊精组分在水性介质中接触，2.向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选到另外包含所述环糊精组分的相应沉淀物。两种类型的沉淀物可任选地包含一种或多种另外的组分。沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。

5. 发明申请

US20100056476A1 PHARMACEUTICAL COMPOSITIONS COMPRISING PERANHYDROCYCLODEXTRIN 审中-公开
标题翻译：药物组合物包含肾上腺皮质激素
公开(公告)号：US20100056476A1
公开(公告)日：2010-03-04
申请号：US12617074
申请日：2009-11-12
申请人： Lajos Szente , Jozsef Szejtli , Laszio Jicsinszky , Georg Ludwig Kis , Christian Scnoch
发明人： Lajos Szente , Jozsef Szejtli , Laszio Jicsinszky , Georg Ludwig Kis , Christian Scnoch
IPC分类号： A61K31/715 , C07H1/00
CPC分类号： A61K9/0048 , A61K47/40
摘要： The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin, a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.
摘要翻译：本发明涉及一种包含环戊二烯环糊精，药物和载体的药物组合物，以使用环戊二烯环糊精作为药物转运增强剂（例如渗透促进剂），以及在制备药物组合物中使用环糊精协同辅助系统。

6. 发明授权

US07189798B2 Composition containing mixture of dihydroxybutane sulfonates 有权
标题翻译：含有二羟基丁烷磺酸盐混合物的组合物
公开(公告)号：US07189798B2
公开(公告)日：2007-03-13
申请号：US10601877
申请日：2003-06-24
申请人： Charles M. Buchanan , Steven N. Falling , Juanelle L. Lambert , Shannon E. Large , Jozsef Szejtli , Lajos Szente , Laszlo Jicsinszky
发明人： Charles M. Buchanan , Steven N. Falling , Juanelle L. Lambert , Shannon E. Large , Jozsef Szejtli , Lajos Szente , Laszlo Jicsinszky
IPC分类号： C08G63/688 , C07C309/04 , C07C309/08
CPC分类号： G01N30/482 , B01D15/3833 , B01J20/262 , B01J20/265 , B01J20/285 , B01J20/29 , B01J2220/54 , C07C309/08 , C08B37/0012 , C08B37/0015 , C08G63/6884
摘要： This invention relates to new cyclodextrin derivatives, processes for producing these cyclodextrin derivatives, and inclusion complexes comprised of the new cyclodextrin derivatives and guest molecules, as well as methods of making such materials and related materials and methods of using the same.
摘要翻译：本发明涉及新的环糊精衍生物，制备这些环糊精衍生物的方法，以及由新的环糊精衍生物和客体分子组成的包合配合物，以及制备这些材料的方法及相关材料及其使用方法。

7. 发明授权

US5298496A Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same 失效
标题翻译： 3-吗啉代 - 脱水亚胺或其盐或其互变异构体的包合物，其制备方法和含有它们的药物组合物
公开(公告)号：US5298496A
公开(公告)日：1994-03-29
申请号：US793389
申请日：1992-01-02
申请人： Maaria Vikmon , Jozsef Szejtli , Lajos Szente , Jozsef Gaal , Hermecz: Istvan , Agnes Horvath , Katalin Marmarosi , Gabor Horvath , Iren Munkacsi
发明人： Maaria Vikmon , Jozsef Szejtli , Lajos Szente , Jozsef Gaal , Hermecz: Istvan , Agnes Horvath , Katalin Marmarosi , Gabor Horvath , Iren Munkacsi
IPC分类号： A61K31/41 , A61K31/4245 , A61K31/535 , A61K31/5375 , A61K47/40 , A61K47/48 , A61P9/08 , A61P9/10 , C07D265/28 , C07D271/04 , C07D295/30 , C07D413/04 , C08B37/00 , C08B37/06 , C08B37/16
CPC分类号： C08B37/0015 , C07D271/04 , Y10S514/821 , Y10S514/969
摘要： The invention relates to inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof and pharmaceutical compositions containing the same.The inclusion complex of 3-morpholino-sydnonimine or its salt formed with cyclodextrin derivative is prepared bya) reacting the 3-morpholino-sydnonimine or its salt in an aqueous medium with a cyclodextrin derivative and the complex is isolated from the solution by dehydratation, orb) high energy milling of 3-morpholino-sydnonimine or its salt and a cyclodextrin derivative.
摘要翻译： PCT No.PCT / HU91 / 00013 Sec。 371日期1992年1月2日 102（e）日期1992年1月2日PCT 1991年3月28日PCT。本发明涉及3-吗啉代 - 脱水亚胺或其盐或其互变异构体的包合物，其制备方法和含有它们的药物组合物。由环糊精衍生物形成的3-吗啉代 - 顺式亚胺或其盐的包合络合物是通过以下步骤制备的：a）使3-吗啉代 - 脱水亚胺或其盐在水性介质中与环糊精衍生物反应，并通过脱水从溶液中分离复合物，或b）3-吗啉代 - 二氢亚胺或其盐和环糊精衍生物的高能研磨。

8. 发明申请

US20120040901A1 NOVEL BIOMATERIALS, THEIR PREPARATION AND USE 审中-公开
标题翻译：新生物材料，其制备和使用
公开(公告)号：US20120040901A1
公开(公告)日：2012-02-16
申请号：US13281033
申请日：2011-10-25
申请人： Lajos Szente , Jozsef Szejtli , György Lajos Kis , Christian Schoch
发明人： Lajos Szente , Jozsef Szejtli , György Lajos Kis , Christian Schoch
IPC分类号： A61K38/22 , C12N9/00 , A61K31/4535 , A23L1/48 , A61K31/568 , A61K31/5575 , A61P43/00 , A01P15/00 , A01N25/00 , A61K31/12
CPC分类号： A61K9/0024 , A61K9/7015 , A61L27/20 , A61L27/54 , A61L2300/602 , A61L2300/802 , C08L5/16
摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.
摘要翻译：本发明涉及沉淀物形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阴离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤 1.将阴离子聚合物组分和环糊精组分在水性介质中接触，2.向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选到另外包含所述环糊精组分的相应沉淀物。两种类型的沉淀物可任选地包含一种或多种另外的组分。沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。

9. 发明授权

US5008386A Methylated cyclodextrin type compounds and process for preparing same 失效
标题翻译：甲基化环糊精型化合物及其制备方法
公开(公告)号：US5008386A
公开(公告)日：1991-04-16
申请号：US256857
申请日：1988-10-12
申请人： Tibor Szabo , Laszlo Institoris , Jozsef Szejtli , Lajos Szente , Ildiko Jodal
发明人： Tibor Szabo , Laszlo Institoris , Jozsef Szejtli , Lajos Szente , Ildiko Jodal
IPC分类号： A61K9/00 , A61K47/40 , A61K47/48 , C08B37/16
CPC分类号： B82Y5/00 , A61K47/40 , A61K47/48969 , A61K9/0019 , C08B37/0012
摘要： The invention relates to novel partially methylated carboxyacyl-cyclodextrins of the general formula (I), ##STR1## wherein A means the cyclodextrin skeleton of the general formula (II) ##STR2## containing the substituents in the position labelled by the wavy line; W stands for an alkylene, alkenylene or arylene group or the substituted derivatives thereof;R means hydrogen, an alkyl, aryl or aralkyl group;m is 6, 7 or 8;n is an integer from 1 to 2m; andp is 2m-n+z, wherein the value of z is from 0 to 3as well as their salts.The novel derivatives induce less haemolytic effect than the cyclodextrin compounds used as starting materials.

10. 发明授权

US4774232A Bile-substituting method of treatment for the promotion of fat digestion 失效
标题翻译：胆汁替代方法，用于促进脂肪消化
公开(公告)号：US4774232A
公开(公告)日：1988-09-27
申请号：US946684
申请日：1986-12-24
申请人： Jozsef Szejtli , Lajos Szente , Katalin Kaloy , Jeno Marton , Andrea Gerloczy
发明人： Jozsef Szejtli , Lajos Szente , Katalin Kaloy , Jeno Marton , Andrea Gerloczy
IPC分类号： A61K31/715 , A61K9/20 , A61K9/28 , A61K9/48 , A61P3/06 , C08B37/16 , A61K31/70
CPC分类号： C08B37/0012
摘要： The invention relates to a method of promoting the fat digestion and absorption, which comprises orally administering to an animal subject a partially methylated-.beta.-cyclodextrin optionally together with pharmaceutically acceptable auxiliary and/or additive materials.
摘要翻译：本发明涉及促进脂肪消化和吸收的方法，其包括向动物受试者口服施用部分甲基化-β-环糊精任选地与药学上可接受的辅助和/或添加剂材料。

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