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1. 发明授权

US5741243A Method of altering composition of nutritional product during enteral tube feeding 失效
公开(公告)号：US5741243A
公开(公告)日：1998-04-21
申请号：US673941
申请日：1996-07-01
申请人： Ronita Kay Geckle , Terrence Bruce Mazer , Joseph Edward Walton , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Mark Anthony McCamish , Robert Louis Joseph , William Guy Pierson
发明人： Ronita Kay Geckle , Terrence Bruce Mazer , Joseph Edward Walton , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Mark Anthony McCamish , Robert Louis Joseph , William Guy Pierson
IPC分类号： A61J15/00 , A61K9/22 , A61M5/00 , A61M5/14 , A61M31/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. During enteral tube feeding the nutritional product passes through a formulation chamber, e.g., a drip chamber, having located therein at least one controlled release dosage form unit containing at least one beneficial agent. The beneficial agent may be selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, and any such together with a physiologically acceptable marker dye in controlled release dosage form and/or the same or different additional beneficial agent not in controlled release dosage form. Controlled release dosage forms may be of a conventional sustained release type or an osmotically driven delivery device.

2. 发明授权

US5738651A Apparatus for altering composition of nutritional product during enteral tube feeding 失效
公开(公告)号：US5738651A
公开(公告)日：1998-04-14
申请号：US673449
申请日：1996-06-28
申请人： Joseph Edward Walton , Terrence Bruce Mazer , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Mark Anthony McCamish , Robert Louis Joseph , William Guy Pierson
发明人： Joseph Edward Walton , Terrence Bruce Mazer , Ronita Kay Geckle , Carl Joseph Piontek , Susan Beth Duel , Andre Daab-Krzykowski , Mark Anthony McCamish , Robert Louis Joseph , William Guy Pierson
IPC分类号： A61J15/00 , A61M5/00 , A61M5/14 , A61M31/00 , A61M37/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： An apparatus is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply thereof, such as a hangable container, to a feeding tube delivering the liquid enteral nutritional product to the gastrointestinal tract of a patient. The apparatus has at least one formulation chamber, such as a drip chamber, with at least one controlled release dosage form unit in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving type material, or a quantity of fine hollow permeable fibers located therein. The controlled release dosage form unit or units contain at least one beneficial agent selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, to any of which a physiologically acceptable marker dye in controlled release dosage form and/or the same or different beneficial agent not in controlled release dosage form may be added. A liquid nutritional product flows through the formulation chamber during enteral tube feeding of a patient.

3. 发明授权

US07278975B2 Method and apparatus for detecting a tremor induced in a subject 有权
标题翻译：用于检测受试者中诱发的震颤的方法和装置
公开(公告)号：US07278975B2
公开(公告)日：2007-10-09
申请号：US10462336
申请日：2003-06-16
申请人： Mark Anthony McCamish , Robert Rex Rice
发明人： Mark Anthony McCamish , Robert Rex Rice
IPC分类号： A61B5/103 , A61B5/117
CPC分类号： A61B5/1101
摘要： A method and apparatus are provided for detecting tremors induced in a subject that are indicative of stress, emotion, fatigue, deception or other similar psychological states. The apparatus includes a signal source for directly applying an excitation signal having a predefined amplitude and frequency to the subject so as to induce the tremor. The apparatus also includes a Doppler system for irradiating the subject with electromagnetic radiation and for detecting the electromagnetic radiation returning from the subject following modulation by the induced tremor. The Doppler system also analyzes the returning electromagnetic radiation to determine at least one of an amplitude of the induced tremor and a phase shift of the induced tremor relative to the excitation signal provided by the signal source. The amplitude and/or phase shift of the modulated electromagnetic radiation provide information regarding the stress, emotion, fatigue, deception or other similar psychological states of the subject.
摘要翻译：提供了一种用于检测在受试者中诱发的指示压力，情绪，疲劳，欺骗或其他类似心理状态的震颤的方法和装置。该装置包括用于将具有预定义的振幅和频率的激励信号直接施加到受试者以引起震颤的信号源。该装置还包括用于用电磁辐射照射受试者的多普勒系统，并且用于检测由被诱导的震颤调节后从受检者返回的电磁辐射。多普勒系统还分析返回的电磁辐射以确定诱发震颤的幅度和诱发震颤相对于由信号源提供的激励信号的相移中的至少一个。调制的电磁辐射的振幅和/或相移提供关于受试者的压力，情绪，疲劳，欺骗或其他类似心理状态的信息。

4. 发明授权

US07223736B2 Composition for the prevention and treatment of cachexia 有权
标题翻译：用于预防和治疗恶病质的组合物
公开(公告)号：US07223736B2
公开(公告)日：2007-05-29
申请号：US10784451
申请日：2004-02-23
申请人： Bonnie Chandler Abbruzzese , Mark Anthony McCamish , Frederick Oliver Cope , Stephen Joseph DeMichele
发明人： Bonnie Chandler Abbruzzese , Mark Anthony McCamish , Frederick Oliver Cope , Stephen Joseph DeMichele
IPC分类号： A23J3/16 , A61K38/17
CPC分类号： A61K9/0029 , A23L33/12 , A23L33/16 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K31/202 , A61K31/70 , A61K47/12 , A61K47/183 , Y10S426/80 , Y10S426/801 , A23V2250/187 , A23V2250/1868 , A23V2250/708 , A23V2250/712 , A23V2250/1626 , A23V2250/5046 , A23V2250/211 , A23V2200/30 , A23V2200/308 , A23V2200/02
摘要： The present invention relates to methods and nutritional compositions for the prevention and treatment of cachexia and anorexia. The methods of the invention comprise administering a composition comprising effective amounts of ω-3 fatty acids such as alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid or mixtures thereof; of branched-chain amino acids valine, leucine, isoleucine or mixtures thereof; with or without reduced levels of tryptophan and 5-hydroxytryptophan; and of antioxidant system selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, or mixtures thereof.
摘要翻译：本发明涉及用于预防和治疗恶病质和厌食症的方法和营养组合物。本发明的方法包括施用包含有效量的ω-3脂肪酸如α-亚麻酸，十八碳四烯酸，二十碳五烯酸，二十二碳五烯酸，二十二碳六烯酸或其混合物的组合物; 的支链氨基酸缬氨酸，亮氨酸，异亮氨酸或其混合物; 具有或不具有降低水平的色氨酸和5-羟色氨酸; 以及选自包含β-胡萝卜素，维生素C，维生素E，硒或其混合物的组的抗氧化剂系统。

5. 发明授权

US06326355B1 Method for the prevention and treatment of cachexia and anorexia 有权
标题翻译：预防和治疗恶病质和厌食症的方法
公开(公告)号：US06326355B1
公开(公告)日：2001-12-04
申请号：US09479550
申请日：2000-01-07
申请人： Bonnie Chandler Abbruzzese , Mark Anthony McCamish , Frederick Oliver Cope , Stephen Joseph Demichele
发明人： Bonnie Chandler Abbruzzese , Mark Anthony McCamish , Frederick Oliver Cope , Stephen Joseph Demichele
IPC分类号： A23J316
CPC分类号： A61K9/0029 , A23L33/12 , A23L33/16 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K31/202 , A61K31/70 , A61K47/12 , A61K47/183 , Y10S426/80 , Y10S426/801 , A23V2250/187 , A23V2250/1868 , A23V2250/708 , A23V2250/712 , A23V2250/1626 , A23V2250/5046 , A23V2250/211 , A23V2200/30 , A23V2200/308 , A23V2200/02
摘要： The present invention relates to methods and nutritional compositions for the prevention and treatment of cachexia and anorexia. The methods of the invention comprise administering a composition comprising effective amounts of &ohgr;-3 fatty acids such as alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid or mixtures thereof, of branched-chain amino acids valine, leucine, isoleucine or mixtures thereof; with or without reduced levels of tryptophan and 5-hydroxytryptophan; and of antioxidant system selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, or mixtures thereof.
摘要翻译：本发明涉及用于预防和治疗恶病质和厌食症的方法和营养组合物。本发明的方法包括施用包含有效量的ω-3脂肪酸如α-亚麻酸，十八碳四烯酸，二十碳五烯酸，二十二碳五烯酸，二十二碳六烯酸或其混合物的支链氨基酸缬氨酸，亮氨酸，异亮氨酸或其混合物; 具有或不具有降低水平的色氨酸和5-羟色氨酸; 以及选自包含β-胡萝卜素，维生素C，维生素E，硒或其混合物的组的抗氧化剂系统。

6. 发明授权

US6077828A Method for the prevention and treatment of cachexia and anorexia 失效
标题翻译：预防和治疗恶病质和厌食症的方法
公开(公告)号：US6077828A
公开(公告)日：2000-06-20
申请号：US842454
申请日：1997-04-24
申请人： Bonnie Chandler Abbruzzese , Mark Anthony McCamish , Frederick Oliver Cope , Stephen Joseph Demichele
发明人： Bonnie Chandler Abbruzzese , Mark Anthony McCamish , Frederick Oliver Cope , Stephen Joseph Demichele
IPC分类号： A61K45/00 , A23L1/29 , A23L1/30 , A23L1/304 , A23L1/305 , A61K31/015 , A61K31/195 , A61K31/20 , A61K31/355 , A61K31/375 , A61K33/04 , A61P3/00 , A61P3/02 , A61P7/00 , A61P35/00 , A61P37/04 , A61P43/00 , A23J3/16 , A61K38/17
CPC分类号： A61K9/0029 , A23L33/12 , A23L33/16 , A23L33/175 , A23L33/40 , A61K31/202 , A61K31/70 , A61K47/12 , A61K47/183 , A23V2002/00 , Y10S426/80 , Y10S426/801
摘要： The present invention relates to methods and nutritional compositions for the prevention and treatment of cachexia and anorexia. The methods of the invention comprise administering a composition comprising effective amounts of .omega.-3 fatty acids such as alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid or mixtures thereof; of branched-chain amino acids valine, leucine, isoleucine or mixtures thereof; with or without reduced levels of tryptophan and 5-hydroxytryptophan; and of antioxidant system selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, or mixtures thereof.
摘要翻译：本发明涉及用于预防和治疗恶病质和厌食症的方法和营养组合物。本发明的方法包括施用包含有效量的ω-3脂肪酸如α-亚麻酸，十八碳四烯酸，二十碳五烯酸，二十二碳五烯酸，二十二碳六烯酸或其混合物的组合物; 的支链氨基酸缬氨酸，亮氨酸，异亮氨酸或其混合物; 具有或不具有降低水平的色氨酸和5-羟色氨酸; 以及选自包含β-胡萝卜素，维生素C，维生素E，硒或其混合物的组的抗氧化剂系统。

7. 发明授权

US06387883B1 Method for the prevention and treatment of cachexia and anorexia 有权
标题翻译：预防和治疗恶病质和厌食症的方法
公开(公告)号：US06387883B1
公开(公告)日：2002-05-14
申请号：US09642630
申请日：2000-08-18
申请人： Bonnie Chandler Abbruzzese , Mark Anthony McCamish , Frederick Oliver Cope , Stephen Joseph DeMichele
发明人： Bonnie Chandler Abbruzzese , Mark Anthony McCamish , Frederick Oliver Cope , Stephen Joseph DeMichele
IPC分类号： A23J316
CPC分类号： A61K9/0029 , A23L33/12 , A23L33/16 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K31/202 , A61K31/70 , A61K47/12 , A61K47/183 , Y10S426/80 , Y10S426/801 , A23V2250/187 , A23V2250/1868 , A23V2250/708 , A23V2250/712 , A23V2250/1626 , A23V2250/5046 , A23V2250/211 , A23V2200/30 , A23V2200/308 , A23V2200/02
摘要： The present invention relates to methods and nutritional compositions for the prevention and treatment of cachexia and anorexia. The methods of the invention comprise administering a composition comprising effective amounts of &ohgr;-3 fatty acids such as alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid or mixtures thereof; of branched-chain amino acids valine, leucine, isoleucine or mixtures thereof; with or without reduced levels of tryptophan and 5-hydroxytryptophan; and of antioxidant system selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, or mixtures thereof.
摘要翻译：本发明涉及用于预防和治疗恶病质和厌食症的方法和营养组合物。本发明的方法包括施用包含有效量的ω-3脂肪酸如α-亚麻酸，十八碳四烯酸，二十碳五烯酸，二十二碳五烯酸，二十二碳六烯酸或其混合物的组合物; 的支链氨基酸缬氨酸，亮氨酸，异亮氨酸或其混合物; 具有或不具有降低水平的色氨酸和5-羟色氨酸; 以及选自包含β-胡萝卜素，维生素C，维生素E，硒或其混合物的组的抗氧化剂系统。

8. 发明授权

US5801198A Retarding neutrophil infiltration ad morphologic reduction in ischemic bowel tissues 失效
标题翻译：阻止缺血性肠组织中性粒细胞浸润形态学减少
公开(公告)号：US5801198A
公开(公告)日：1998-09-01
申请号：US502024
申请日：1995-07-13
申请人： Ronald Thomas Stanko , Robert Harold Miller , Mark Anthony McCamish
发明人： Ronald Thomas Stanko , Robert Harold Miller , Mark Anthony McCamish
IPC分类号： A61K31/19 , A61K31/198 , A61K31/215 , A61P9/00 , A61P9/10 , A61K31/195
CPC分类号： A61K31/19 , A61K31/198
摘要： Treating mammals having ischemic bowel with a therapeutic quantity of pyruvate enterally or parenterally will retard neutrophil infiltration and retain morphology during and following the bowel ischemia. The pyruvate is introduced into the patient enterally or parenterally during the bowel ischemia or the succeeding bowel reperfusion and, preferably, prior to the bowel ischemia. The pyruvate dosage is from 1% to 20% by weight of the patient's caloric intake.
摘要翻译：肠胃肠外用治疗量的丙酮酸处理具有缺血性肠的哺乳动物会阻止嗜中性粒细胞浸润，并在肠缺血期间和之后保留形态。在肠缺血或随后的肠再灌注期间，优选地在肠缺血之前肠内或肠胃外引入丙酮酸盐。丙酮酸剂量为患者热量摄入量的1％至20％。

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