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1. 发明授权

US06610660B1 O2-arylated or O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and O2-substituted 1-[(2-carboxylato) pyrrolidin-1-yl] diazen-1-ium-1,2-diolates 有权
标题翻译： O-芳基化或O-糖基化的1-取代的二氮-1-烯-1,2-二醇酯和O 2取代的1 - [（2-羧基）吡咯烷-1-基]二氮-1- ium -1,2-二醇酯
公开(公告)号：US06610660B1
公开(公告)日：2003-08-26
申请号：US09254301
申请日：1999-05-03
申请人： Joseph E. Saavedra , Larry K. Keefer , Aloka Srinivasan , William G. Rice , Xinhua Ji , Christian Bogdan
发明人： Joseph E. Saavedra , Larry K. Keefer , Aloka Srinivasan , William G. Rice , Xinhua Ji , Christian Bogdan
IPC分类号： C07D29522
CPC分类号： C07D213/64 , C07C291/08 , C07D207/16 , C07D239/34 , C07D295/30 , C07H19/06 , C07H19/16
摘要： Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.
摘要翻译：二氮烯鎓二硫醇盐，其中N1位被无机或有机部分取代，并且O-氧与取代或未取代的芳族基团结合。还提供了O-糖基化的1-取代的二氮嗪-1-铋-1,2-二醇酯（O 2 - 糖基化的二氮烯鎓二醇酯）和O 2取代的1 - [（2-羧基）吡咯烷-1-基]二氮-1- 1,2-二醇化物（1 - [（2-羧基）吡咯烷-1-基]二氮烯鎓二硫醇盐）。相对于中性至酸性溶液中的一氧化氮的水解产生，氧芳基二氮烯鎓二硫醇盐是稳定的，并在碱性或亲核环境或微环境中产生一氧化氮。还提供了包含这些化合物的药物组合物和使用这些化合物的方法的组合物。

2. 发明授权

US06911433B2 O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates 有权
标题翻译： O-糖基化的1-取代的二氮嗪-1- ium -1,2-二醇酯
公开(公告)号：US06911433B2
公开(公告)日：2005-06-28
申请号：US10337495
申请日：2003-01-07
申请人： Joseph E. Saavedra , Larry K. Keefer , Aloka Srinivasan , Christian Bogdan , William G. Rice , Xinhua Ji
发明人： Joseph E. Saavedra , Larry K. Keefer , Aloka Srinivasan , Christian Bogdan , William G. Rice , Xinhua Ji
IPC分类号： A61K31/655 , A61K31/726 , A61K31/785 , A61P35/00 , C07C291/08 , C07D207/16 , C07D213/64 , C07D239/34 , C07D295/28 , C07H19/06 , C07H19/16 , C07H13/00 , A61K31/7028
CPC分类号： C07D213/64 , C07C291/08 , C07D207/16 , C07D239/34 , C07D295/30 , C07H19/06 , C07H19/16
摘要： Provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) having the formula: in which R is a saccharide, which is attached to the O2 of the compound by the anomeric carbon of a pyranose ring or a furanose ring.
摘要翻译：提供具有下式的O 2 O-糖基化的1-取代的二氮-1-烯-2,2-二醇酯（O 2 O 2 - 糖基化的二氮烯鎓二醇二醇），其中R是糖类，其通过吡喃糖环或呋喃糖环的异头碳连接到化合物的O 2上。

3. 发明授权

US08510721B2 Dynamic calculation of sample profile reports 有权
标题翻译：动态计算样本资料报告
公开(公告)号：US08510721B2
公开(公告)日：2013-08-13
申请号：US12868495
申请日：2010-08-25
申请人： Alexander Dadiomov , Mayank Agarwal , Xinhua Ji
发明人： Alexander Dadiomov , Mayank Agarwal , Xinhua Ji
IPC分类号： G06F9/44
CPC分类号： G06F11/3612 , G06F11/3419 , G06F11/3466 , G06F2201/865
摘要： The construction or use of a hierarchical time tree that represents an execution time of a program. To construct the hierarchical time tree, the time frame corresponding to the root node is the execution time during which the plurality of call stack samples were gathered from the program. Beginning at the root node, and proceeding recursively, each node is then populated in a manner that all of the call stacks for a given time period need not be accessed in order to provide a report regarding the given time period.
摘要翻译：构建或使用代表程序执行时间的分层时间树。为了构建分层时间树，与根节点对应的时间帧是从节目收集多个呼叫堆栈样本的执行时间。从根节点开始，并递归进行，然后以不必访问给定时间段内的所有呼叫栈的方式填充每个节点，以便提供关于给定时间段的报告。

4. 发明申请

US20120137308A1 ADAPTIVE TREE STRUCTURE FOR VISUALIZING DATA 有权
标题翻译：用于可视化数据的自适应树结构
公开(公告)号：US20120137308A1
公开(公告)日：2012-05-31
申请号：US12956127
申请日：2010-11-30
申请人： Mayank Agarwal , Alexander Dadiomov , Xinhua Ji
发明人： Mayank Agarwal , Alexander Dadiomov , Xinhua Ji
IPC分类号： G06F9/46
CPC分类号： G06F9/542 , G06F17/30994
摘要： One or more systems and/or techniques for generating an adaptive tree structure for storing event data based upon data density of events are disclosed. In particular, the adaptive tree structure may comprise one or more levels of nodes, where a level may correspond to a resolution of events. Nodes may correspond to particular time spans over which event data was recorded. A node may be designated as a raw node comprising raw events or a summary node comprising summary events based upon the number of events occurring within a time span covered by the node.
摘要翻译：公开了一种或多种用于基于事件的数据密度生成用于存储事件数据的自适应树结构的系统和/或技术。特别地，自适应树结构可以包括一个或多个节点级别，其中级别可以对应于事件的分辨率。节点可以对应于记录事件数据的特定时间跨度。可以将节点指定为包括原始事件的原始节点或基于在该节点覆盖的时间范围内发生的事件的数量的包含摘要事件的摘要节点。

5. 发明授权

US09146836B2 Linking diagnostic visualizations to application code 有权
标题翻译：将诊断可视化链接到应用程序代码
公开(公告)号：US09146836B2
公开(公告)日：2015-09-29
申请号：US13324488
申请日：2011-12-13
申请人： James Rapp , Daniel Griffing , Alexander Dadiomov , Matthew Jacobs , Ben Nesson , Drake A. Campbell , Mayank Agarwal , Paulo Cesar Sales Janotti , Xinhua Ji , Eric Ledoux , Alexey Kamenev , Jared Robert Van Leeuwen
发明人： James Rapp , Daniel Griffing , Alexander Dadiomov , Matthew Jacobs , Ben Nesson , Drake A. Campbell , Mayank Agarwal , Paulo Cesar Sales Janotti , Xinhua Ji , Eric Ledoux , Alexey Kamenev , Jared Robert Van Leeuwen
IPC分类号： G06F9/44 , G06F11/36 , G06F11/32
CPC分类号： G06F11/3664 , G06F11/321 , G06F11/323
摘要： The present invention extends to methods, systems, and computer program products for linking diagnostic visualizations to regions of application code. Diagnostic visualizations emitted during execution of an application are displayed. The diagnostic visualizations partially represent the abstract objective of the application (e.g., as envisioned by a developer). Diagnostic data for at least one of a plurality of components is displayed. The diagnostic data indicates the performance of the at least one of the plurality of components during execution of the application. The displayed one or more diagnostic visualizations and the displayed diagnostic data is correlated to link the one or more diagnostic visualizations to the at least one of the plurality of components. Linking the one or more diagnostic visualizations to the at least one of the plurality of components can better indicate how the application's behavior reconciles the abstract objective.
摘要翻译：本发明扩展到用于将诊断可视化连接到应用代码区域的方法，系统和计算机程序产品。显示在执行应用程序期间发出的诊断可视化。诊断可视化部分地表示应用程序的抽象目标（例如，如开发者所设想的）。显示多个组件中的至少一个的诊断数据。诊断数据指示在执行应用期间多个组件中的至少一个的性能。将所显示的一个或多个诊断可视化和所显示的诊断数据相关联以将所述一个或多个诊断可视化链接到所述多个组件中的至少一个。将一个或多个诊断可视化链接到多个组件中的至少一个组件可以更好地指示应用程序的行为如何协调抽象目标。

6. 发明授权

US08595750B2 Adaptive tree structure for visualizing data 有权
标题翻译：用于可视化数据的自适应树结构
公开(公告)号：US08595750B2
公开(公告)日：2013-11-26
申请号：US12956127
申请日：2010-11-30
申请人： Mayank Agarwal , Alexander Dadiomov , Xinhua Ji
发明人： Mayank Agarwal , Alexander Dadiomov , Xinhua Ji
IPC分类号： G06F9/46
CPC分类号： G06F9/542 , G06F17/30994
摘要： One or more systems and/or techniques for generating an adaptive tree structure for storing event data based upon data density of events are disclosed. In particular, the adaptive tree structure may comprise one or more levels of nodes, where a level may correspond to a resolution of events. Nodes may correspond to particular time spans over which event data was recorded. A node may be designated as a raw node comprising raw events or a summary node comprising summary events based upon the number of events occurring within a time span covered by the node.
摘要翻译：公开了一种或多种用于基于事件的数据密度生成用于存储事件数据的自适应树结构的系统和/或技术。特别地，自适应树结构可以包括一个或多个节点级别，其中级别可以对应于事件的分辨率。节点可以对应于记录事件数据的特定时间跨度。可以将节点指定为包括原始事件的原始节点或基于在该节点覆盖的时间范围内发生的事件的数量的包含摘要事件的摘要节点。

7. 发明授权

US08490058B2 Time-based navigation within resource utilization data 有权
标题翻译：资源利用率数据中的基于时间的导航
公开(公告)号：US08490058B2
公开(公告)日：2013-07-16
申请号：US13324444
申请日：2011-12-13
申请人： James Rapp , Daniel Griffing , Alexander Dadiomov , Matthew Jacobs , Hazim Shafi , Ryan Nowak , Ben Nesson , Drake A. Campbell , Mayank Agarwal , Paulo Cesar Sales Janotti , Xinhua Ji , George Essex Englebeck , Vikram Bapat
发明人： James Rapp , Daniel Griffing , Alexander Dadiomov , Matthew Jacobs , Hazim Shafi , Ryan Nowak , Ben Nesson , Drake A. Campbell , Mayank Agarwal , Paulo Cesar Sales Janotti , Xinhua Ji , George Essex Englebeck , Vikram Bapat
IPC分类号： G06F9/44 , G06F11/00
CPC分类号： G06F11/3664 , G06F11/3017 , G06F11/323 , G06F11/3409
摘要： The present invention extends to methods, systems, and computer program products for time-based navigation within resource utilization data. A computer system is configured to present resource utilization data representing performance of computer resources. The resource utilization data is displayed on a diagnostic data trace during the execution of the application. The user can select a desired time range and the resource utilization data within the time range will be displayed at other traces. The diagnostic data trace is still presented so that the user can understand the relation between the selected time range and the overall time length. Further, the user can modify the selected time range by change the extents of the selected time range using resizing tool. The resource utilization data within the modified selected time range, similarly, is also displayed along with the diagnostic data trace.
摘要翻译：本发明扩展到资源利用数据内的时间导航的方法，系统和计算机程序产品。计算机系统被配置为呈现表示计算机资源的性能的资源利用率数据。在执行应用程序期间，资源利用率数据显示在诊断数据跟踪上。用户可以选择期望的时间范围，并且时间范围内的资源利用率数据将显示在其他轨迹上。仍然呈现诊断数据跟踪，以便用户可以了解所选时间范围与总时间长度之间的关系。此外，用户可以通过使用调整大小工具来改变所选择的时间范围的范围来修改所选择的时间范围。修改的选定时间范围内的资源利用率数据也与诊断数据跟踪一起显示。

8. 发明授权

US09141507B2 Visualization of states of a process 有权
标题翻译：过程状态的可视化
公开(公告)号：US09141507B2
公开(公告)日：2015-09-22
申请号：US12646155
申请日：2009-12-23
申请人： Xinhua Ji , Alexander Dadiomov , Hazim Shafi , Eric Ledoux , William T. Colburn
发明人： Xinhua Ji , Alexander Dadiomov , Hazim Shafi , Eric Ledoux , William T. Colburn
IPC分类号： G06F3/00 , G06F11/32 , G06F3/01 , G06F11/36
CPC分类号： G06F11/323 , G06F11/3664
摘要： A method of providing a visualization of states of a process includes identifying a set of potential states that can occur during the process and a corresponding set of colors, with each color in the set of colors corresponding to one of the potential states. A fixed ordering is established for the set of colors. A timeline graph including a plurality of colored vertical bars is displayed. Each colored vertical bar corresponds to a time interval of the process and includes at least one color selected from the set of colors based on at least one state occurring during the time interval corresponding to the vertical bar. The plurality of colored vertical bars includes a set of multiple-color vertical bars that each include a plurality of colors appearing in a vertical order based on the fixed ordering.
摘要翻译：提供过程状态可视化的方法包括识别可在过程期间发生的一组潜在状态和相应的一组颜色，其中该组颜色中的每种颜色对应于潜在状态之一。为该组颜色建立固定的顺序。显示包括多个彩色垂直条的时间线图。每个彩色垂直条对应于处理的时间间隔，并且基于在对应于垂直条的时间间隔期间发生的至少一个状态，包括从该组颜色中选择的至少一种颜色。多个彩色垂直条包括一组多色垂直条，每一个垂直条都包含基于固定顺序以垂直顺序出现的多种颜色。

9. 发明申请

US20130152052A1 LINKING DIAGNOSTIC VISUALIZATIONS TO APPLICATION CODE 有权
标题翻译：将诊断视觉连接到应用代码
公开(公告)号：US20130152052A1
公开(公告)日：2013-06-13
申请号：US13324488
申请日：2011-12-13
申请人： James Rapp , Daniel Griffing , Alexander Dadiomov , Matthew Jacobs , Ben Nesson , Drake A. Campbell , Mayank Agarwal , Paulo Cesar Sales Janotti , Xinhua Ji , Eric Ledoux , Alexey Kamenev , Jared Robert Van Leeuwen
发明人： James Rapp , Daniel Griffing , Alexander Dadiomov , Matthew Jacobs , Ben Nesson , Drake A. Campbell , Mayank Agarwal , Paulo Cesar Sales Janotti , Xinhua Ji , Eric Ledoux , Alexey Kamenev , Jared Robert Van Leeuwen
IPC分类号： G06F11/36 , G06F3/14
CPC分类号： G06F11/3664 , G06F11/321 , G06F11/323
摘要： The present invention extends to methods, systems, and computer program products for linking diagnostic visualizations to regions of application code. Diagnostic visualizations emitted during execution of an application are displayed. The diagnostic visualizations partially represent the abstract objective of the application (e.g., as envisioned by a developer). Diagnostic data for at least one of a plurality of components is displayed. The diagnostic data indicates the performance of the at least one of the plurality of components during execution of the application. The displayed one or more diagnostic visualizations and the displayed diagnostic data is correlated to link the one or more diagnostic visualizations to the at least one of the plurality of components. Linking the one or more diagnostic visualizations to the at least one of the plurality of components can better indicate how the application's behavior reconciles the abstract objective.
摘要翻译：本发明扩展到用于将诊断可视化连接到应用代码区域的方法，系统和计算机程序产品。显示在执行应用程序期间发出的诊断可视化。诊断可视化部分地表示应用程序的抽象目标（例如，如开发者所设想的）。显示多个组件中的至少一个的诊断数据。诊断数据指示在执行应用期间多个组件中的至少一个的性能。将所显示的一个或多个诊断可视化和所显示的诊断数据相关联以将所述一个或多个诊断可视化链接到所述多个组件中的至少一个。将一个或多个诊断可视化链接到多个组件中的至少一个组件可以更好地指示应用程序的行为如何协调抽象目标。

10. 发明申请

US20130152051A1 TIME-BASED NAVIGATION WITHIN RESOURCE UTILIZATION DATA 有权
标题翻译：在资源利用数据中基于时间的导航
公开(公告)号：US20130152051A1
公开(公告)日：2013-06-13
申请号：US13324444
申请日：2011-12-13
申请人： James Rapp , Daniel Griffing , Alexander Dadiomov , Matthew Jacobs , Hazim Shafi , Ryan Nowak , Ben Nesson , Drake A. Campbell , Mayank Agarwal , Paulo Cesar Sales Janotti , Xinhua Ji , George Essex Englebeck , Vikram Bapat
发明人： James Rapp , Daniel Griffing , Alexander Dadiomov , Matthew Jacobs , Hazim Shafi , Ryan Nowak , Ben Nesson , Drake A. Campbell , Mayank Agarwal , Paulo Cesar Sales Janotti , Xinhua Ji , George Essex Englebeck , Vikram Bapat
IPC分类号： G06F11/36
CPC分类号： G06F11/3664 , G06F11/3017 , G06F11/323 , G06F11/3409
摘要： The present invention extends to methods, systems, and computer program products for time-based navigation within resource utilization data. A computer system is configured to present resource utilization data representing performance of computer resources. The resource utilization data is displayed on a diagnostic data trace during the execution of the application. The user can select a desired time range and the resource utilization data within the time range will be displayed at other traces. The diagnostic data trace is still presented so that the user can understand the relation between the selected time range and the overall time length. Further, the user can modify the selected time range by change the extents of the selected time range using resizing tool. The resource utilization data within the modified selected time range, similarly, is also displayed along with the diagnostic data trace.
摘要翻译：本发明扩展到资源利用数据内的时间导航的方法，系统和计算机程序产品。计算机系统被配置为呈现表示计算机资源的性能的资源利用率数据。在执行应用程序期间，资源利用率数据显示在诊断数据跟踪上。用户可以选择期望的时间范围，并且时间范围内的资源利用率数据将显示在其他轨迹上。仍然呈现诊断数据跟踪，以便用户可以了解所选时间范围与总时间长度之间的关系。此外，用户可以通过使用调整大小工具来改变所选择的时间范围的范围来修改所选择的时间范围。修改的选定时间范围内的资源利用率数据也与诊断数据跟踪一起显示。

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