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1. 发明授权

US07324845B2 Assessment of sleep quality and sleep disordered breathing based on cardiopulmonary coupling 有权
标题翻译：基于心肺耦合评估睡眠质量和睡眠呼吸障碍
公开(公告)号：US07324845B2
公开(公告)日：2008-01-29
申请号：US10846945
申请日：2004-05-17
申请人： Joseph E. Mietus , Chung-Kang Peng , Robert J. Thomas , Ary L. Goldberger
发明人： Joseph E. Mietus , Chung-Kang Peng , Robert J. Thomas , Ary L. Goldberger
IPC分类号： A61B5/04
CPC分类号： A61B5/0456 , A61B5/0205 , A61B5/0476 , A61B5/0496 , A61B5/0816 , A61B5/4815 , A61B5/4818 , A61B5/7257 , A61B5/7278
摘要： An assessment of sleep quality and sleep disordered breathing is determined from the cardiopulmonary coupling between two physiological data series. In an embodiment, an R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal (NN) interval series. The amplitude variations in the QRS complex are used to extract to a surrogate respiration signal (i.e., ECG-derived respiration (EDR)) that is associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross power. Using the appropriate thresholds for the coherent cross power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined.
摘要翻译：睡眠质量和睡眠呼吸紊乱的评估是从两个生理数据序列之间的心肺耦合确定的。在一个实施例中，从心电图（ECG）信号导出R-R间期序列。提取R-R间隔序列中的正常搏动以产生正常到正常（NN）间隔序列。 QRS复合物中的幅度变化用于提取与NN间期序列相关联的替代呼吸信号（即，ECG导出的呼吸（EDR））。纠正这两个系列以消除异常值，并重新采样。在多个相干窗口上计算两个重采样信号的交叉光谱功率和相干性。对于每个相干窗口，使用相干和交叉光谱功率的乘积来计算相干交叉功率。使用相关交叉功率的适当阈值，确定在CAP，非CAP和唤醒和/或REM中花费的睡眠比例。

2. 发明授权

US07734334B2 Assessment of sleep quality and sleep disordered breathing based on cardiopulmonary coupling 有权
标题翻译：基于心肺耦合评估睡眠质量和睡眠呼吸障碍
公开(公告)号：US07734334B2
公开(公告)日：2010-06-08
申请号：US11178990
申请日：2005-07-12
申请人： Joseph E. Mietus , Chung-Kang Peng , Robert J. Thomas , Ary L. Goldberger
发明人： Joseph E. Mietus , Chung-Kang Peng , Robert J. Thomas , Ary L. Goldberger
IPC分类号： A61B5/04
CPC分类号： A61B5/0472 , A61B5/0205 , A61B5/021 , A61B5/0456 , A61B5/0476 , A61B5/0496 , A61B5/0816 , A61B5/087 , A61B5/0878 , A61B5/4812 , A61B5/4815 , A61B5/4818 , A61B5/7257 , A61B5/7278 , A61B8/06 , G16H50/20 , Y02A90/26
摘要： An assessment of sleep quality and sleep disordered breathing is determined from cardiopulmonary coupling between two physiological data series. An R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal interval series. The amplitude variations in the QRS complex are used to extract a surrogate respiration signal (i.e., ECG-derived respiration) associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross-power. Using the appropriate thresholds for the coherent cross-power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined. Coherent cross-power can be applied to differentiate obstructive from non-obstructive disease, and admixtures of the same.
摘要翻译：通过两个生理数据序列之间的心肺耦合来确定睡眠质量和睡眠呼吸紊乱的评估。从心电图（ECG）信号导出R-R间期序列。提取R-R间隔序列的正常搏动以产生正常到正常的间隔序列。 QRS复合体的振幅变化用于提取与NN间隔序列相关联的替代呼吸信号（即ECG导出的呼吸）。纠正这两个系列以消除异常值，并重新采样。在多个相干窗口上计算两个重采样信号的交叉光谱功率和相干性。对于每个相干窗口，使用相干和交叉光谱功率的乘积来计算相干交叉功率。使用相干交叉功率的适当阈值，确定在CAP，非CAP和唤醒和/或REM中花费的睡眠比例。相干交叉功能可以应用于区分阻塞性和非阻塞性疾病，以及它们的混合物。

3. 发明申请

US20100069762A1 System And Method For Assessing Sleep Quality 有权
标题翻译：用于评估睡眠质量的系统和方法
公开(公告)号：US20100069762A1
公开(公告)日：2010-03-18
申请号：US12570163
申请日：2009-09-30
申请人： Joseph E. Mietus , Chung-Kang Peng , Robert J. Thomas , Ary L. Goldberger
发明人： Joseph E. Mietus , Chung-Kang Peng , Robert J. Thomas , Ary L. Goldberger
IPC分类号： A61B5/0205
CPC分类号： A61B5/0472 , A61B5/0205 , A61B5/021 , A61B5/0456 , A61B5/0476 , A61B5/0496 , A61B5/0816 , A61B5/087 , A61B5/0878 , A61B5/4812 , A61B5/4815 , A61B5/4818 , A61B5/7257 , A61B5/7278 , A61B8/06 , G16H50/20 , Y02A90/26
摘要： An assessment of sleep quality and sleep disordered breathing is determined from cardiopulmonary coupling between two physiological data series. An R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal interval series. The amplitude variations in the QRS complex are used to extract a surrogate respiration signal (i.e., ECG-derived respiration) associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross-power. Using the appropriate thresholds for the coherent cross-power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined. Coherent cross-power can be applied to differentiate obstructive from non-obstructive disease, and admixtures of the same.
摘要翻译：通过两个生理数据序列之间的心肺耦合来确定睡眠质量和睡眠呼吸紊乱的评估。从心电图（ECG）信号导出R-R间期序列。提取R-R间隔序列的正常搏动以产生正常到正常的间隔序列。 QRS复合体的振幅变化用于提取与NN间隔序列相关联的替代呼吸信号（即ECG导出的呼吸）。纠正这两个系列以消除异常值，并重新采样。在多个相干窗口上计算两个重采样信号的交叉光谱功率和相干性。对于每个相干窗口，使用相干和交叉光谱功率的乘积来计算相干交叉功率。使用相干交叉功率的适当阈值，确定在CAP，非CAP和唤醒和/或REM中花费的睡眠比例。相干交叉功能可以应用于区分阻塞性和非阻塞性疾病，以及它们的混合物。

4. 发明授权

US08401626B2 System and method for assessing sleep quality 有权
标题翻译：睡眠质量评估系统和方法
公开(公告)号：US08401626B2
公开(公告)日：2013-03-19
申请号：US12570163
申请日：2009-09-30
申请人： Joseph E. Mietus , Chung-Kang Peng , Robert Joseph Thomas , Ary L. Goldberger
发明人： Joseph E. Mietus , Chung-Kang Peng , Robert Joseph Thomas , Ary L. Goldberger
IPC分类号： A61B5/08 , A61B5/04
CPC分类号： A61B5/0472 , A61B5/0205 , A61B5/021 , A61B5/0456 , A61B5/0476 , A61B5/0496 , A61B5/0816 , A61B5/087 , A61B5/0878 , A61B5/4812 , A61B5/4815 , A61B5/4818 , A61B5/7257 , A61B5/7278 , A61B8/06 , G16H50/20 , Y02A90/26
摘要： An assessment of sleep quality and sleep disordered breathing is determined from cardiopulmonary coupling between two physiological data series. An R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal interval series. The amplitude variations in the QRS complex are used to extract a surrogate respiration signal (i.e., ECG-derived respiration) associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross-power. Using the appropriate thresholds for the coherent cross-power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined. Coherent cross-power can be applied to differentiate obstructive from non-obstructive disease, and admixtures of the same.
摘要翻译：通过两个生理数据序列之间的心肺耦合来确定睡眠质量和睡眠呼吸紊乱的评估。从心电图（ECG）信号导出R-R间期序列。提取R-R间隔序列的正常搏动以产生正常到正常的间隔序列。 QRS复合体的振幅变化用于提取与NN间隔序列相关联的替代呼吸信号（即ECG导出的呼吸）。纠正这两个系列以消除异常值，并重新采样。在多个相干窗口上计算两个重采样信号的交叉光谱功率和相干性。对于每个相干窗口，使用相干和交叉光谱功率的乘积来计算相干交叉功率。使用相干交叉功率的适当阈值，确定在CAP，非CAP和唤醒和/或REM中花费的睡眠比例。相干交叉功能可以应用于区分阻塞性和非阻塞性疾病，以及它们的混合物。

5. 发明授权

US08403848B2 Assessment of sleep quality and sleep disordered breathing based on cardiopulmonary coupling 有权
标题翻译：基于心肺耦合评估睡眠质量和睡眠呼吸障碍
公开(公告)号：US08403848B2
公开(公告)日：2013-03-26
申请号：US12018768
申请日：2008-01-23
申请人： Joseph E. Mietus , Chung-Kang Peng , Robert Joseph Thomas , Ary L. Goldberger
发明人： Joseph E. Mietus , Chung-Kang Peng , Robert Joseph Thomas , Ary L. Goldberger
IPC分类号： A61B5/00 , A61B5/08 , A61B5/04
CPC分类号： A61B5/0456 , A61B5/0205 , A61B5/0476 , A61B5/0496 , A61B5/0816 , A61B5/4815 , A61B5/4818 , A61B5/7257 , A61B5/7278
摘要： An assessment of sleep quality and sleep disordered breathing is determined from the cardiopulmonary coupling between two physiological data series. In an embodiment, an R-R interval series is derived from an electrocardiogram (ECG) signal. The normal beats from the R-R interval series are extracted to produce a normal-to-normal (NN) interval series. The amplitude variations in the QRS complex are used to extract to a surrogate respiration signal (i.e., ECG-derived respiration (EDR)) that is associated with the NN interval series. The two series are corrected to remove outliers, and resampled. The cross-spectral power and coherence of the two resampled signals are calculated over a plurality of coherence windows. For each coherence window, the product of the coherence and cross-spectral power is used to calculate coherent cross power. Using the appropriate thresholds for the coherent cross power, the proportion of sleep spent in CAP, non-CAP, and wake and/or REM are determined.
摘要翻译：睡眠质量和睡眠呼吸紊乱的评估是从两个生理数据序列之间的心肺耦合确定的。在一个实施例中，从心电图（ECG）信号导出R-R间期序列。提取R-R间隔序列中的正常搏动以产生正常到正常（NN）间隔序列。 QRS复合物中的幅度变化用于提取与NN间期序列相关联的替代呼吸信号（即，ECG导出的呼吸（EDR））。纠正这两个系列以消除异常值，并重新采样。在多个相干窗口上计算两个重采样信号的交叉光谱功率和相干性。对于每个相干窗口，使用相干和交叉光谱功率的乘积来计算相干交叉功率。使用相关交叉功率的适当阈值，确定在CAP，非CAP和唤醒和/或REM中花费的睡眠比例。

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