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1. 发明申请

US20050054109A1 Pressurized oxygen for evaluation of molding compound stability in semiconductor packaging 有权
标题翻译：加压氧气用于评估半导体封装中的化合物稳定性
公开(公告)号：US20050054109A1
公开(公告)日：2005-03-10
申请号：US10658859
申请日：2003-09-09
申请人： Joseph Comeau , Adele Mahoney , Jason Ritter , Gerald Seilla , Charles Wilson
发明人： Joseph Comeau , Adele Mahoney , Jason Ritter , Gerald Seilla , Charles Wilson
IPC分类号： G01M99/00 , G01N27/20 , G01N33/00
CPC分类号： G01N27/205 , Y10T436/16 , Y10T436/20
摘要： A test environment and an associated method of testing and analyzing a semiconductor package material containing a molding compound, for stability in a sustained oxygen environment. Test samples are exposed to a pressurized gas containing oxygen, under elevated temperature below the glass transition temperature of the molding compound. Control samples are exposed to a pressurized inert gas under similar or more severe conditions of gas pressure, temperature, and humidity. At least one characteristic common to the test samples and the control samples is measured. A determination is made as to whether there exists at least one significant difference between the at least one measured characteristic of the test samples and the control samples.
摘要翻译：用于测试和分析含有模塑料的半导体封装材料的测试环境和相关方法，用于在持续的氧气环境中稳定。在低于模塑料的玻璃化转变温度的高温下，将测试样品暴露于含氧气的加压气体中。在气体压力，温度和湿度的类似或更严格的条件下，对照样品暴露于加压惰性气体。测量样品和对照样品的至少一个特征。确定测试样品的至少一个测量特征与对照样品之间是否存在至少一个显着差异。

2. 发明申请

US20080006079A1 PRESSURIZED OXYGEN FOR EVALUATION OF MOLDING COMPOUND STABILITY IN SEMICONDUCTOR PACKAGING 失效
标题翻译：用于评估半导体封装中模塑复合稳定性的加压氧化
公开(公告)号：US20080006079A1
公开(公告)日：2008-01-10
申请号：US11861369
申请日：2007-09-26
申请人： Joseph Comeau , Adele Mahoney , Jason Ritter , Gerald Scilla , Charles Wilson
发明人： Joseph Comeau , Adele Mahoney , Jason Ritter , Gerald Scilla , Charles Wilson
IPC分类号： G01M19/00
CPC分类号： G01N27/205 , Y10T436/16 , Y10T436/20
摘要： A test environment and an associated method of testing and analyzing a semiconductor package material containing a molding compound, for stability in a sustained oxygen environment. Test samples are exposed to a pressurized gas containing oxygen, under elevated temperature below the glass transition temperature of the molding compound. Control samples are exposed to a pressurized inert gas under similar or more severe conditions of gas pressure, temperature, and humidity. At least one characteristic common to the test samples and the control samples is measured. A determination is made as to whether there exists at least one significant difference between the at least one measured characteristic of the test samples and the control samples.
摘要翻译：用于测试和分析含有模塑料的半导体封装材料的测试环境和相关方法，用于在持续的氧气环境中稳定。在低于模塑料的玻璃化转变温度的高温下，将测试样品暴露于含氧气的加压气体中。在气体压力，温度和湿度的类似或更严格的条件下，对照样品暴露于加压惰性气体。测量样品和对照样品的至少一个特征。确定测试样品的至少一个测量特征与对照样品之间是否存在至少一个显着差异。

3. 发明授权

US08853376B2 Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics 有权
标题翻译：稳定的适体与血小板衍生生长因子及其作为肿瘤学治疗的用途
公开(公告)号：US08853376B2
公开(公告)日：2014-10-07
申请号：US13235222
申请日：2011-09-16
申请人： Dilara McCauley , John L. Diener , Charles Wilson , Thomas Greene McCauley
发明人： Dilara McCauley , John L. Diener , Charles Wilson , Thomas Greene McCauley
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C12N15/115 , A61K31/4745 , A61K31/7088 , A61K45/06 , A61K47/60 , C12N2310/16 , C12N2310/335 , C12N2310/351 , C12N2310/353 , C12N2320/30 , C12N2320/31
摘要： Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
摘要翻译：提供材料和方法用于生产和使用适合于能够以极大的亲和力和特异性结合PDGF，PDGF同种型，PDGF受体，VEGF和VEGF受体或其任何组合的肿瘤学治疗剂的适体。本发明的组合物特别可用于实体瘤治疗，并且可以单独使用或与已知的细胞毒剂组合用于治疗实体瘤。还公开了具有一个或多个CpG基序嵌入其中或附着于其上的适体。

4. 发明申请

US20130153396A1 Purification of a fluid for example water after fracturing 审中-公开
$Purification of a fluid for example water after fracturing$
标题翻译：压裂后液体例如水的净化
公开(公告)号：US20130153396A1
公开(公告)日：2013-06-20
申请号：US13326990
申请日：2011-12-15
申请人： Charles Wilson
发明人： Charles Wilson
IPC分类号： B01D3/10
CPC分类号： B01D21/2461 , B01D1/222 , B01D5/006 , B01D2221/04 , C02F1/048
摘要： An apparatus for treating frac water may include a vacuum container to support a vacuum, a heating device to heat the vacuum container, a spiral auger to rotate to separate the frac water being positioned within the vacuum container, a condenser to condense the water vapor to liquid water, a second vacuum chamber to receive the liquid water and a storage container to store the liquid water.
摘要翻译：用于处理压裂水的装置可以包括用于支撑真空的真空容器，用于加热真空容器的加热装置，旋转螺旋钻以分离位于真空容器内的压裂水，冷凝器将水蒸汽冷凝至液体水，第二真空室以接收液态水和存储容器以储存液态水。

5. 发明申请

US20130113259A1 ADJUSTMENT MECHANISM 审中-公开
标题翻译：调整机制
公开(公告)号：US20130113259A1
公开(公告)日：2013-05-09
申请号：US13810190
申请日：2011-07-08
申请人： Charles Wilson
发明人： Charles Wilson
IPC分类号： A47C7/40 , A47C7/54
CPC分类号： A47C7/40 , A47C7/54 , A47C17/12
摘要： An adjustment mechanism (20) for an article of furniture includes a support structure (22) securable to a seat base of the article of furniture. A carrier (24) is displaceably arranged relative to the support structure (22), the carrier (24) being configured to mount a component (12) of the article of furniture. A link assembly (26) interconnects the support structure (22) and the carrier (24). The link assembly (26) comprises at least one linkage mechanism (52) which causes initial, substantially linear motion of the carrier (24) relative to the support structure (22) to become substantially rotary motion as the carrier (24) moves from a first position to a second position relative to the seat base of the article of furniture.
摘要翻译：用于家具的调节机构（20）包括可固定到家具制品的座椅底座的支撑结构（22）。载体（24）相对于支撑结构（22）可置换地布置，载体（24）构造成安装家具制品的部件（12）。连杆组件（26）将支撑结构（22）和载体（24）互连。连杆组件（26）包括至少一个连杆机构（52），当至少一个联动机构（52）从托架（24）移动时，托架（24）相对于支撑结构（22）初始的基本线性运动将变得基本上旋转运动第一位置相对于家具的座椅底座到达第二位置。

6. 发明申请

US20070009476A1 Multivalent aptamer therapeutics with improved pharmacodynamic properties and methods of making and using the same 审中-公开
标题翻译：具有改善的药效学性质的多价适体治疗剂及其制备和使用方法
公开(公告)号：US20070009476A1
公开(公告)日：2007-01-11
申请号：US11482671
申请日：2006-07-06
申请人： Charles Wilson , David Epstein , Jeffrey Kurz , Markus Kurz
发明人： Charles Wilson , David Epstein , Jeffrey Kurz , Markus Kurz
IPC分类号： A61K38/22 , A61K31/785 , C08G63/91
CPC分类号： C12N15/115 , C07H21/04 , C12N2310/16 , C12N2310/3183
摘要： Materials and methods are provided for producing aptamer therapeutics having improved pharmacokinetic and pharmacodymanic properties, as well as increased target valency. The aptamers produced by the methods of the invention are useful as therapeutics for treating disease.
摘要翻译：提供材料和方法用于生产具有改善的药代动力学和药效学性质的适配剂治疗剂以及提高的目标化合价。通过本发明的方法产生的适体可用作治疗疾病的治疗剂。

7. 发明申请

US20060018871A1 Aptamer therapeutics useful in the treatment of complement-related disorders 有权
公开(公告)号：US20060018871A1
公开(公告)日：2006-01-26
申请号：US11058134
申请日：2005-02-14
申请人： Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
发明人： Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
IPC分类号： A61K48/00 , C12Q1/68
CPC分类号： C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.

8. 发明申请

US20050189774A1 Long-handled tool with plastic molded-over handle 失效
标题翻译：长柄工具，带塑料成型手柄
公开(公告)号：US20050189774A1
公开(公告)日：2005-09-01
申请号：US11067262
申请日：2005-02-25
申请人： Brian Conaway , Thomas Parker , Charles Wilson
发明人： Brian Conaway , Thomas Parker , Charles Wilson
IPC分类号： A01B1/02 , A01B1/22
CPC分类号： A01B1/02
摘要： A long-handled shovel includes a head having a blade and a socket and an elongate handle member partially extending into the socket of the head. The handle member is a tube. A rod partially extends into the handle member and partially extends into the socket to provide resilient flexing between the head and the handle member when prying forces are applied thereto. A collar encircles the socket to limit outward expansion of the socket. A continuous outer layer of plastic material is molded over the entire length of the handle member and at least partially molded over the socket and the collar. The outer layer provides added strength by extending over the joint between the handle member and the socket.
摘要翻译：长柄铲包括具有刀片和插座的头部和部分延伸到头部的插座中的细长手柄部件。手柄构件是管。杆部分地延伸到把手构件中并且部分地延伸到插座中以在将刺痛力施加到头部和手柄构件之间时提供弹性挠曲。套环环绕插座以限制插座的向外扩张。在手柄构件的整个长度上模制连续的塑料材料外层，并且至少部分地模制在插座和套环上。外层通过在手柄构件和插座之间的接头上延伸而提供附加的强度。

9. 发明授权

US06423310B1 Biological coating with a protective and curative effect for the control of postharvest decay 失效
标题翻译：生物涂层具有保护和治疗效果，用于控制收获后腐烂
公开(公告)号：US06423310B1
公开(公告)日：2002-07-23
申请号：US09324524
申请日：1999-06-02
申请人： Charles Wilson , Ahmed El Ghaouth
发明人： Charles Wilson , Ahmed El Ghaouth
IPC分类号： A01N6304
CPC分类号： A23L3/3526 , A01N43/16 , A23B7/154 , A23B7/155 , A23B7/157 , A23B7/16 , A23L3/3472 , A01N2300/00
摘要： Novel methods and compositions are provided for the biocontrol of plant diseases by use of a biological coating that confers both a protective and a curative effect for the control of postharvest decay. The coating includes chitosan salts, an antagonistic microorganism, and a cation. A composition of chitosan salts, CaCl2 and yeast is effective. The combined fungicidal activities of the chitosan salts and the antagonistic microorganism make the compositions of the present invention superior to previous coatings. When applied to the surface of a harvested plant commodity, the compositions both prevent and cure postharvest decay.
摘要翻译：提供了新的方法和组合物，用于通过使用生物涂层对植物病害进行生物防治，其赋予对收获后衰变的控制的保护作用和治疗效果。涂层包括壳聚糖盐，拮抗微生物和阳离子。壳聚糖盐，CaCl2和酵母的组成是有效的。壳聚糖盐和拮抗微生物的组合杀真菌活性使得本发明的组合物优于先前的涂层。当施用于收获的植物商品的表面时，组合物既预防和治愈收获后的腐烂。

10. 发明授权

US5688670A Self-modifying RNA molecules and methods of making 失效
标题翻译：自我修饰的RNA分子及其制备方法
公开(公告)号：US5688670A
公开(公告)日：1997-11-18
申请号：US299498
申请日：1994-09-01
申请人： Jack W. Szostak , Jon R. Lorsch , Charles Wilson
发明人： Jack W. Szostak , Jon R. Lorsch , Charles Wilson
IPC分类号： C12N9/00 , C07H21/02 , C12N15/113 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/111 , C12N2310/12
摘要： The invention concerns a method for creating, identifying, and isolating ribozymes capable of binding a selected ligand and catalyzing a reaction involving the selected ligand. The method entails sequential selections for ligand binding molecules and catalytic molecules. The invention also includes novel ribozymes produced by these methods.
摘要翻译：本发明涉及用于产生，鉴定和分离能够结合所选配体并催化涉及所选择的配体的反应的核酶的方法。该方法需要顺序选择配体结合分子和催化分子。本发明还包括通过这些方法产生的新型核酶。

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