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1. 发明授权

US06238351B1 Method for compensating for non-metabolic changes in respiratory or blood gas profile parameters 有权
标题翻译：补偿呼吸或血气剖面参数中非代谢变化的方法
公开(公告)号：US06238351B1
公开(公告)日：2001-05-29
申请号：US09150136
申请日：1998-09-09
申请人： Joseph A. Orr , Michael B. Jaffe , Kai Kück , Dinesh G. Haryadi
发明人： Joseph A. Orr , Michael B. Jaffe , Kai Kück , Dinesh G. Haryadi
IPC分类号： A61B508
CPC分类号： A61B5/0836 , A61B5/029 , A61B5/087 , G01N33/49 , G01N33/497
摘要： A method of compensating for non-metabolic changes in respiratory or blood gas parameters including generating a compensatory signal based on the magnitude of the non-metabolic change and the amount of time elapsed since the onset of the non-metabolic change. The method of the present invention is useful for compensating for non-metabolic changes in non-invasive carbon dioxide elimination measurements and, particularly, when carbon dioxide elimination is employed to determine cardiac output on a non-invasive, continuous basis.
摘要翻译：补偿呼吸或血液气体参数中的非代谢变化的方法，包括基于非代谢变化的大小和自非代谢变化开始以来经过的时间量产生补偿信号。本发明的方法可用于补偿非侵入性二氧化碳消除测量中的非代谢变化，特别是当采用二氧化碳消除来确定非侵入性连续的心输出量时。

2. 发明授权

US06258038B1 Methods of non-invasively estimating intrapulmonary shunt fraction and measuring cardiac output 有权
$Methods of non-invasively estimating intrapulmonary shunt fraction and measuring cardiac output$
标题翻译：非侵入性评估肺内分流分数和测量心输出量的方法
公开(公告)号：US06258038B1
公开(公告)日：2001-07-10
申请号：US09465059
申请日：1999-12-16
申请人： Dinesh G. Haryadi , Joseph A. Orr , Kai Kück , Michael B. Jaffe
发明人： Dinesh G. Haryadi , Joseph A. Orr , Kai Kück , Michael B. Jaffe
IPC分类号： A61B502
CPC分类号： A61B5/14551 , A61B5/029 , A61B5/083 , A61B5/0836
摘要： A method of non-invasively estimating the intrapulmonary shunt in a patient. The method includes non-invasively measuring respiratory flow, respiratory carbon dioxide content, and arterial blood oxygen content. A re-breathing process is employed to facilitate an estimate of the patient's pulmonary capillary blood flow. Any inaccuracies of the arterial blood oxygen content are corrected to provide a substantially accurate arterial blood oxygen content measurement. The respiratory flow, carbon dioxide content and arterial blood oxygen content measurements, and the pulmonary capillary blood flow estimate are employed to estimate an intrapulmonary shunt of the patient. The invention also includes a method of determining the total cardiac output of the patient which considers the estimated intrapulmonary shunt.
摘要翻译：一种非侵入性估计患者肺内分流的方法。该方法包括非侵入性地测量呼吸流量，呼吸二氧化碳含量和动脉血氧含量。采用呼吸过程来促进对患者肺毛细血管血流的估计。校正动脉血氧含量的任何不准确性，以提供基本上精确的动脉血氧含量测量。使用呼吸流量，二氧化碳含量和动脉血氧含量测量以及肺毛细血管血流估计来估计患者的肺内分流。本发明还包括确定考虑到估计的肺内分流的患者的总心输出量的方法。

3. 发明授权

US06217524B1 Method of continuously, non-invasively monitoring pulmonary capillary blood flow and cardiac output 有权
标题翻译：方法连续，非侵入性地监测肺毛细血管血流量和心输出量
公开(公告)号：US06217524B1
公开(公告)日：2001-04-17
申请号：US09150446
申请日：1998-09-09
申请人： Joseph A. Orr , Michael B. Jaffe , Kai Kück , Dinesh G. Haryadi
发明人： Joseph A. Orr , Michael B. Jaffe , Kai Kück , Dinesh G. Haryadi
IPC分类号： A61B502
CPC分类号： A61B5/0836 , A61M16/021 , A61M2016/0036 , A61M2016/103
摘要： A method of continuously, non-invasively determining the cardiac output of a patient. The method includes intermittently measuring the cardiac output, the volume of carbon dioxide exhaled by the patient per breath, and determining the arterial-venous gradient of the patient or a similar substantially constant value by dividing the volume of carbon dioxide exhaled by the measured cardiac output. The arterial-venous gradient or similar substantially constant value may then be employed to determine the cardiac output of the patient on a breath-by-breath basis. The carbon dioxide elimination, which is non-invasively measured as the volume of carbon dioxide exhaled by the patient per breath, is divided by the arterial-venous gradient or the substantially constant value to determine the cardiac output. The method may also include generating a signal to compensate for any non-metabolic changes in the carbon dioxide elimination, arterial-venous gradient, or other respiratory or blood gas profile measurements that may be caused by a change in ventilation or breathing of the patient. The compensatory signal may be employed to modify one or more of the respiratory or blood gas profile measurements in order to facilitate the accurate determination of cardiac output during or after changes in ventilation or breathing.
摘要翻译：一种连续，非侵入性地确定患者的心输出量的方法。该方法包括间歇地测量心输出量，每次呼吸患者呼出的二氧化碳的体积，以及通过将所测量的心输出量呼出的二氧化碳的体积除以来确定患者的动脉 - 静脉梯度或类似的基本上恒定的值。然后可以采用动脉 - 静脉梯度或类似的基本上恒定的值来确定患者在呼吸基础上的心输出量。二氧化碳消除，其被非侵入性地测量为每个呼吸患者呼出的二氧化碳的体积，除以动脉 - 静脉梯度或基本上恒定的值以确定心输出量。该方法还可以包括产生信号以补偿二氧化碳消除，动脉 - 静脉梯度或可能由患者的通气或呼吸改变引起的其它呼吸或血气分布测量中的任何非代谢变化。补偿信号可以用于修改呼吸或血气剖面测量中的一个或多个，以便于在通气或呼吸改变期间或之后准确确定心输出量。

4. 发明授权

US06241681B1 Methods of measuring cardiac output using a non-invasively estimated intrapulmonary shunt fraction 有权
$Methods of measuring cardiac output using a non-invasively estimated intrapulmonary shunt fraction$
标题翻译：使用非侵入性估计的肺内分流部分测量心输出量的方法
公开(公告)号：US06241681B1
公开(公告)日：2001-06-05
申请号：US09464589
申请日：1999-12-16
申请人： Dinesh G. Haryadi , Joseph A. Orr , Kai Kück , Michael B. Jaffe
发明人： Dinesh G. Haryadi , Joseph A. Orr , Kai Kück , Michael B. Jaffe
IPC分类号： A61B502
CPC分类号： A61B5/14551 , A61B5/029 , A61B5/083 , A61B5/0836
摘要： A method of non-invasively estimating the intrapulmonary shunt in a patient. The method includes non-invasively measuring respiratory flow, respiratory carbon dioxide content, and arterial blood oxygen content. A re-breathing process is employed to facilitate an estimate of the patient's pulmonary capillary blood flow. Any inaccuracies of the arterial blood oxygen content are corrected to provide a substantially accurate arterial blood oxygen content measurement. The respiratory flow, carbon dioxide content and arterial blood oxygen content measurements, and the pulmonary capillary blood flow estimate are employed to estimate an intrapulmonary shunt of the patient. The invention also includes a method of determining the total cardiac output of the patient which considers the estimated intrapulmonary shunt.
摘要翻译：一种非侵入性估计患者肺内分流的方法。该方法包括非侵入性地测量呼吸流量，呼吸二氧化碳含量和动脉血氧含量。采用呼吸过程来促进对患者肺毛细血管血流的估计。校正动脉血氧含量的任何不准确性，以提供基本上精确的动脉血氧含量测量。使用呼吸流量，二氧化碳含量和动脉血氧含量测量以及肺毛细血管血流量估计来估计患者的肺内分流。本发明还包括确定考虑到估计的肺内分流的患者的总心输出量的方法。

5. 发明授权

US06200271B1 Bi-directional partial re-breathing method 有权
标题翻译：双向局部再呼吸法
公开(公告)号：US06200271B1
公开(公告)日：2001-03-13
申请号：US09150135
申请日：1998-09-09
申请人： Kai Kück , Joseph A. Orr , Michael B. Jaffe , Dinesh G. Haryadi
发明人： Kai Kück , Joseph A. Orr , Michael B. Jaffe , Dinesh G. Haryadi
IPC分类号： A61B508
CPC分类号： A61B5/083 , A61B5/029
摘要： A re-breathing method for determining pulmonary capillary blood flow that accounts for changes in the carbon dioxide content of a patient. The carbon dioxide elimination and partial pressure of end tidal carbon dioxide of the patient are measured prior to re-breathing, during re-breathing, and after re-breathing. A rate of change of carbon dioxide content of the venous blood of the patient is then calculated. The rate of change is then employed in calculating the pulmonary capillary blood flow of the patient.
摘要翻译：用于确定肺毛细血管血流量的再呼吸方法，其考虑到患者的二氧化碳含量的变化。在再次呼吸，再呼吸之前和再次呼吸之后，测量患者的二氧化碳消除和结束潮气二氧化碳的分压。然后计算患者静脉血二氧化碳含量的变化率。然后在计算患者的肺毛细血管血流量时采用变化率。

6. 发明授权

US6042550A Methods of non-invasively estimating intrapulmonary shunt fraction and measuring cardiac output 有权
$Methods of non-invasively estimating intrapulmonary shunt fraction and measuring cardiac output$
标题翻译：非侵入性评估肺内分流分数和测量心输出量的方法
公开(公告)号：US6042550A
公开(公告)日：2000-03-28
申请号：US150450
申请日：1998-09-09
申请人： Dinesh G. Haryadi , Joseph A. Orr , Kai Kuck , Michael B. Jaffe
发明人： Dinesh G. Haryadi , Joseph A. Orr , Kai Kuck , Michael B. Jaffe
IPC分类号： A61B5/00 , A61B5/029 , A61B5/083 , A61B5/02
CPC分类号： A61B5/14551 , A61B5/0836 , A61B5/029 , A61B5/083
摘要： A method of non-invasively estimating the intrapulmonary shunt in a patient. The method includes non-invasively measuring respiratory flow, respiratory carbon dioxide content, and arterial blood oxygen content. A re-breathing process is employed to facilitate an estimate of the patient's pulmonary capillary blood flow. Any inaccuracies of the arterial blood oxygen content are corrected to provide a substantially accurate arterial blood oxygen content measurement. The respiratory flow and carbon dioxide content and arterial blood oxygen content measurements, and the pulmonary capillary blood flow estimate are employed to estimate an intrapulmonary shunt of the patient. The invention also includes a method of determining the total cardiac output of the patient which considers the estimated intrapulmonary shunt.
摘要翻译：一种非侵入性估计患者肺内分流的方法。该方法包括非侵入性地测量呼吸流量，呼吸二氧化碳含量和动脉血氧含量。采用呼吸过程来促进对患者肺毛细血管血流的估计。校正动脉血氧含量的任何不准确性，以提供基本上精确的动脉血氧含量测量。使用呼吸流量和二氧化碳含量和动脉血氧含量测量以及肺毛细血管血流估计来估计患者的肺内分流。本发明还包括确定考虑到估计的肺内分流的患者的总心输出量的方法。

7. 发明授权

US6059732A ISO-volumetric method of measuring carbon dioxide elimination 有权
标题翻译：测量二氧化碳消除的ISO容积法
公开(公告)号：US6059732A
公开(公告)日：2000-05-09
申请号：US150447
申请日：1998-09-09
申请人： Joseph A. Orr , Michael B. Jaffe , Kai Kuck , Dinesh G. Haryadi
发明人： Joseph A. Orr , Michael B. Jaffe , Kai Kuck , Dinesh G. Haryadi
IPC分类号： A61B5/083 , A61B5/08
CPC分类号： A61B5/083
摘要： A method of calculating the carbon dioxide elimination of a patient that includes counteracting any inaccuracy or inconsistency in respiratory flow measurements that may be caused by "noise", such as is attributable to respiratory circuit leaks, signal drift, a non-unity respiratory quotient, or another respiratory flow error-inducing factor. The method includes monitoring the respiratory flow and carbon dioxide of the patient during at least a portion of both inspiration and expiration; calculating an inspiratory tidal volume, an inspiratory volume averaged carbon dioxide fraction, an expiratory tidal volume, and an expiratory volume averaged carbon dioxide fraction; and selecting a tidal volume to replace at least one of the inspiratory tidal volume and the expiratory tidal volume. The carbon dioxide elimination of the patient is then calculated with the select tidal volume, the inspiratory volume averaged carbon dioxide fraction, and the expiratory volume averaged carbon dioxide fraction.
摘要翻译：一种计算患者二氧化碳消除的方法，其包括抵消由“噪音”引起的呼吸流量测量的任何不精确或不一致性，例如归因于呼吸电路泄漏，信号漂移，非统一呼吸商，或另一种呼吸道流量误差因子。该方法包括在吸气和呼气的至少一部分期间监测患者的呼吸流量和二氧化碳; 计算吸气潮气量，吸气体积平均二氧化碳分数，呼气潮气量和呼气量平均二氧化碳分数; 以及选择潮气量以代替吸气潮气量和呼气潮气量中的至少一个。然后用选择的潮气量，吸气体积平均二氧化碳分数和呼气量平均二氧化碳分数计算患者的二氧化碳消除。

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