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1. 发明授权

US4751324A Benzoyl alanine compounds and their use as corrosion inhibitors 失效
标题翻译：苯甲酰丙氨酸化合物及其作为缓蚀剂的用途
公开(公告)号：US4751324A
公开(公告)日：1988-06-14
申请号：US874255
申请日：1986-06-13
申请人： Josef Penninger , Karl H. Schmid , Juergen Geke
发明人： Josef Penninger , Karl H. Schmid , Juergen Geke
IPC分类号： C07C67/00 , C07C227/00 , C07C229/36 , C23F11/14 , C07C101/34
CPC分类号： C23F11/144
摘要： Benzoyl alanines having the formula: ##STR1## in which the symbols R.sup.1 and R.sup.2 (a) both represent hydrogen or(b) both represent a straight-chain or branched chain alkyl residue having from 1 to about 6 carbon atoms, or(c) R.sup.1 represents hydrogen and R.sup.2 represents a straight-chain or branched chain alkyl residue having from 1 to about 6 carbon atoms and in which the symbol R.sup.3 represents a C(CH.sub.3).sub.m (CH.sub.2 OH).sub.3-m moiety wherein the symbol m represents an integer of from 0 to 3and alkali metal and ammonium salts thereof, are disclosed.The compounds are useful as corrosion-inhibitors for metals in aqueous systems.
摘要翻译：或者（c）具有1至约6个碳原子的直链或支链烷基，或（c）具有下列结构式的苯甲酰基丙氨酸：其中符号R1和R2（a）均代表氢或（b） R1表示氢，R2表示具有1至约6个碳原子的直链或支链烷基，其中符号R3表示C（CH3）m（CH2OH）3-m部分，其中符号m表示整数为0至3，以及其碱金属和铵盐。该化合物可用作水性体系中金属的腐蚀抑制剂。

2. 发明授权

US4686084A Benzoyl alanines and their use as corrosion inhibitors 失效
标题翻译：苯甲酰丙氨酸及其用作腐蚀抑制剂
公开(公告)号：US4686084A
公开(公告)日：1987-08-11
申请号：US713123
申请日：1985-03-18
申请人： Juergen Geke , Josef Penninger
发明人： Juergen Geke , Josef Penninger
IPC分类号： C07D295/14 , C07C67/00 , C07C227/00 , C07C229/36 , C07D295/145 , C10M133/06 , C10M173/00 , C10N10/02 , C10N30/12 , C11D3/30 , C23F11/14 , C23F11/12
CPC分类号： C07D295/145 , C23F11/14 , C23F11/149
摘要： Benzoyl alanines of the formula ##STR1## in which R.sup.1 and R.sup.2 can be the same or different and represent hydrogen or an alkyl radical containing from 1 to 12 carbon atoms and R.sup.3 and R.sup.4 can be the same or different and represent hydrogen, an unbranched or branched alkyl radical containing from 1 to 10 carbon atoms, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or alkylaminoalkyl radicals containing from 1 to 3 carbon atoms in the alkyl radicals and wherein R.sup.3 and R.sup.4 together can be the --CH.sub.2 CH.sub.2 --O--CH.sub.2 CH.sub.2 -- group or the --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- group which form with the nitrogen atom the morpholino or the piperidino ring, respectively; with the proviso that(a) when R.sup.1 is hydrogen or methyl and R.sup.2 and R.sup.3 are hydrogen, R.sup.4 cannot represent hydroxyethyl or carboxymethyl, and(b) when R.sup.1 is hydrogen or methyl and R.sup.2 is hydrogen R.sup.3 and R.sup.4 cannot both represent hydroxyethyl, and(c) when R.sup.1 and R.sup.2 are both hydrogen, R.sup.3 and R.sup.4 together cannot be a --CH.sub.2 CH.sub.2 --O--CH.sub.2 CH.sub.2 -- or a --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- group;and alkali metal ammonium salts thereof with ammonia, mono-, di- and triethanolamine are useful as corrosion inhibitors in aqueous solutions.
摘要翻译：其中R 1和R 2可以相同或不同并且表示氢或含有1至12个碳原子的烷基和R 3和R 4的式（I）的苯甲酰基丙氨酸可以相同或不同，表示氢，含有1至10个碳原子的非支链或支链烷基，在烷基中含有1至3个碳原子的羟基烷基，烷氧基烷基，羧基烷基或烷基氨基烷基，其中R3和R4一起可以是-CH2CH2-O-CH2CH2-基团或与氮原子分别形成吗啉代或哌啶子基的-CH 2 CH 2 CH 2 CH 2 CH 2基; 条件是（a）当R1是氢或甲基，R2和R3是氢时，R4不能代表羟乙基或羧甲基，和（b）当R1是氢或甲基，R2是氢时R3和R4不能都表示羟乙基，和（c）当R 1和R 2均为氢时，R 3和R 4一起不能是-CH 2 CH 2 -O-CH 2 CH 2 - 或-CH 2 CH 2 CH 2 CH 2 CH 2 - 基; 其与氨，单 - ，二 - 和三乙醇胺的碱金属铵盐可用作水溶液中的腐蚀抑制剂。

3. 发明授权

US4909987A Aroylcarboxylic acid corrosion inhibitors 失效
标题翻译：芳酰基羧酸腐蚀抑制剂
公开(公告)号：US4909987A
公开(公告)日：1990-03-20
申请号：US241797
申请日：1988-09-06
申请人： Josef Penninger , Juergen Geke
发明人： Josef Penninger , Juergen Geke
IPC分类号： C23F11/12
CPC分类号： C23F11/126
摘要： Alkali and/or salts of compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 independently are H or C.sub.1-6 -alkyl and R.sub.3 is CH.dbd.CH, (CH.sub.2).sub.2 or (CH.sub.2).sub.3, are used as metal corrosion inhibitors in aqueous systems.
摘要翻译：碱式和/或下式化合物的盐：其中R 1和R 2独立地为H或C 1-6 - 烷基且R 3为CH = CH，（CH 2）2或（CH 2）3）用作金属腐蚀抑制剂在水系统中。

4. 发明授权

US10143747B2 Breast cancer therapeutics 有权
公开(公告)号：US10143747B2
公开(公告)日：2018-12-04
申请号：US13825655
申请日：2011-09-22
申请人： Josef Penninger , Daniel Schramek
发明人： Josef Penninger , Daniel Schramek
IPC分类号： A61K39/395 , A61K31/57 , A61K38/18 , A61K31/565 , A61K31/713 , A61K39/00
摘要： The present invention relates to a method of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of a RANKL inhibitor to said patient.

5. 发明申请

US20130316374A1 BREAST CANCER DIAGNOSTICS 审中-公开
标题翻译：乳腺癌诊断
公开(公告)号：US20130316374A1
公开(公告)日：2013-11-28
申请号：US13825502
申请日：2011-09-22
申请人： Josef Penninger , Daniel Schramek , Georg Schett , Martin Widschwendter , Ian J. Jacobs , Usha Menon
发明人： Josef Penninger , Daniel Schramek , Georg Schett , Martin Widschwendter , Ian J. Jacobs , Usha Menon
IPC分类号： G01N33/68
CPC分类号： G01N33/57415 , G01N33/6893 , G01N2333/70575 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to methods and means for detecting cancer or of predicting a patient developing cancer or of determining the rate of progression of cancer in a patient suffering from cancer, comprising determining RANKL activity and/or the amount of OPG in a sample of said patient.
摘要翻译：本发明涉及用于检测癌症或预测患有癌症的患者或确定患有癌症的患者的癌症进展速率的方法和手段，包括确定所述癌症的样品中的RANKL活性和/或OPG的量患者。

6. 发明申请

US20130030007A1 Obesity Small Molecules 审中-公开
标题翻译：肥胖小分子
公开(公告)号：US20130030007A1
公开(公告)日：2013-01-31
申请号：US13520961
申请日：2011-01-07
申请人： Josef Penninger , Andrew Pospisilik , Shane McManus
发明人： Josef Penninger , Andrew Pospisilik , Shane McManus
IPC分类号： A61K31/496 , A61P3/04 , A61K31/517
CPC分类号： A61K31/427
摘要： The present invention relates to new therapies to treat obesity and related diseases, as well as for reducing triglyceride levels and body weight.
摘要翻译：本发明涉及治疗肥胖症和相关疾病以及降低甘油三酯水平和体重的新疗法。

7. 发明申请

US20090162426A1 Use of a Compound with RANKL Activity 审中-公开
标题翻译：使用具有RANKL活性的化合物
公开(公告)号：US20090162426A1
公开(公告)日：2009-06-25
申请号：US12300074
申请日：2007-05-08
申请人： Josef Penninger , Karin Loser , Stefan Beissert
发明人： Josef Penninger , Karin Loser , Stefan Beissert
IPC分类号： A61K9/127 , A61K38/17 , A61K38/20 , C07K14/52
CPC分类号： A61K38/2006 , A61K31/00 , A61K38/191 , A61K38/20 , A61K38/204 , A61K2300/00
摘要： The present invention relates to the use of a compound with receptor activator of nuclear factor-kB ligand (RANKL) activity for the manufacture of a topical pharmaceutical formulation for the modulation of local or systemic Treg numbers and the treatment or the prevention of skin-associated or systemic diseases.
摘要翻译：本发明涉及具有核因子-kB配体（RANKL）活性受体激活剂的化合物在制备用于调节局部或全身Treg数量的局部药物制剂中的用途，以及治疗或预防与皮肤有关的或全身性疾病。

8. 发明申请

US20060035806A1 Increase in the water absorption capacity of textiles 审中-公开
标题翻译：增加纺织品的吸水能力
公开(公告)号：US20060035806A1
公开(公告)日：2006-02-16
申请号：US11201343
申请日：2005-08-10
申请人： Josef Penninger
发明人： Josef Penninger
IPC分类号： C11D3/22
CPC分类号： C11D3/225 , C11D3/0026 , C11D3/0036 , C11D17/0039 , D06M15/09 , D06M2200/00
摘要： The water absorption capacity of textiles is increased by contacting a textile material with a soil release-capable alkylated or hydroxyalkylated cellulose derivative comprising on average from 0.5 to 2.5 alkyl groups and from 0.02 to 0.5 hydroxyalkyl groups per anhydroglycose monomer unit. The cellulose derivative can be used by itself or in a laundry detergent composition in a washing step or is a post washing step. The cellulose derivative is particularly effective on synthetic fibers.
摘要翻译：纺织品的吸水能力通过使织物材料与平均0.5至2.5个烷基平均含有脱离力的烷基化或羟烷基化纤维素衍生物和每个脱水糖苷单体单元0.02至0.5个羟基烷基接触来增加。纤维素衍生物可以在洗涤步骤中本身或衣物洗涤剂组合物中使用或者是后洗涤步骤。纤维素衍生物在合成纤维上特别有效。

9. 发明授权

US5880083A Liquid bleach-containing formulation for washing or cleaning 失效
标题翻译：含有液体漂白剂的用于洗涤或清洗的配方
公开(公告)号：US5880083A
公开(公告)日：1999-03-09
申请号：US776682
申请日：1997-02-14
申请人： Hans-Josef Beaujean , Christian Block , Rainer Hofmann , Dieter Legel , Rudolf Lind , Josef Penninger , Bernd Richter , Reiner Schackmann , Karl Schwadtke
发明人： Hans-Josef Beaujean , Christian Block , Rainer Hofmann , Dieter Legel , Rudolf Lind , Josef Penninger , Bernd Richter , Reiner Schackmann , Karl Schwadtke
IPC分类号： C11D1/83 , C11D3/39 , C11D3/395 , C11D9/42 , C11D10/04 , C11D17/00 , C11D17/08 , C11D7/18 , C11D7/54
CPC分类号： C11D3/3947 , C11D17/0004
摘要： A substantially non-aqueous, free-flowing, storable liquid washing or cleaning formulation comprising:A) from more than 20 to less than 78% by weight of at least one nonionic surfactant;B) from 0.1 to 25% by weight of at least one anionic surfactant;C) from 1 to less than 20% by weight of at least one water-soluble builder; andD) from more than 20 to 35% by weight of at least one bleaching agent.
摘要翻译： PCT No.PCT / EP95 / 03124 Sec。 371日期1997年2月14日 102（e）日期1997年2月14日PCT提交1995年8月7日PCT公布。公开号WO96 / 05284 日期1996年2月22日一种基本上非水的，自由流动的，可储存的液体洗涤或清洁制剂，其包含：A）至少一种非离子表面活性剂的重量百分比以上至少于78％ B）0.1至25重量％的至少一种阴离子表面活性剂; C）1至少于20重量％的至少一种水溶性助洗剂; 和D）至少一种漂白剂的20至35重量％。

10. 发明授权

US08785362B2 Triazine derivative dye transfer inhibitors, washing products containing the same and uses therefor 有权
标题翻译：三嗪衍生物染料转移抑制剂，含有相同用途的洗涤产品
公开(公告)号：US08785362B2
公开(公告)日：2014-07-22
申请号：US13430769
申请日：2012-03-27
申请人： Josef Penninger , Birgit Glüsen
发明人： Josef Penninger , Birgit Glüsen
IPC分类号： C11D3/00
CPC分类号： C11D3/349 , C11D3/0021
摘要： Washing products comprising a dye transfer inhibitor selected from triazine derivatives of the general formulae T(NH—Ar(SO3Na)a)bHalc (I), X(NH-T(NH—Ar(SO3Na)a)eHalf)2 (II), X(NH-T(NH—Ar(SO3Na)d—NH-T(NH—Ar(SO3Na)a)Hal)Hal)7 (III) and combinations thereof, wherein T represents a 1,3,5-triazinyl; each Ar independently represents a naphthalene or benzene; X represents a divalent hydrocarbyl selected from linear or branched C1-20 hydrocarbon groups optionally including one or more —N(H)— carbon chain interruptions, stilbene and biphenyl groups which may optionally be mono- or poly-SO3Na-substituted; each Hal independently represents a halogen selected chlorine, bromine, and iodine; each of a and d independently represents 1, 2 or 3; b and c each represent 1 or 2 such that b+c=3; e represents 1 or 2 and f represents 0 or 1 such that e+f=2; and wherein the triazinyl substituents are located at the 2, 4 and 6 positions of the 1,3,5-triazinyl.
摘要翻译：洗涤产物，其包含选自通式T（NH-Ar（SO 3 Na）a）b Halc（I），X（NH-T（NH-Ar（SO 3 Na）a）eHalf）2（II）的三嗪衍生物的染料转移抑制剂，X（NH-T（NH-Ar（SO 3 Na）d -NH-T（NH-Ar（SO 3 Na）a）Hal）Hal）7（III）及其组合，其中T表示1,3,5-三嗪基 ; 每个Ar独立地表示萘或苯; X表示选自直链或支链C 1-20烃基的二价烃基，任选地包括一个或多个-N（H） - 碳链中断，二苯乙烯和联苯基团，其可任选地被单或多SO 3 N 3取代; 每个Hal独立地表示卤素选择的氯，溴和碘; a和d各自独立地表示1,2或3; b和c各自表示1或2，使得b + c = 3; e表示1或2，f表示0或1，使e + f = 2; 并且其中三嗪基取代基位于1,3,5-三嗪基的2,4和6位。

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