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1. 发明申请

US20130252924A1 Compounds and Methods for Treating Pain 审中-公开
标题翻译：化合物和治疗疼痛的方法
公开(公告)号：US20130252924A1
公开(公告)日：2013-09-26
申请号：US13884920
申请日：2011-11-11
申请人： Josef Penninger , Graham Gregory Neely , Shane McManus , Henrik Nilsson
发明人： Josef Penninger , Graham Gregory Neely , Shane McManus , Henrik Nilsson
IPC分类号： A61K31/675 , A61K31/496 , A61K31/50 , A61K31/435 , A61K31/506 , A61K31/277
CPC分类号： A61K31/675 , A61K31/00 , A61K31/192 , A61K31/277 , A61K31/4155 , A61K31/4164 , A61K31/435 , A61K31/44 , A61K31/496 , A61K31/50 , A61K31/506 , A61K31/517
摘要： The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.
摘要翻译：本发明涉及治疗疼痛和相关疾病的新疗法，以及用于所述疗法的药物化合物。

2. 发明申请

US20130030007A1 Obesity Small Molecules 审中-公开
标题翻译：肥胖小分子
公开(公告)号：US20130030007A1
公开(公告)日：2013-01-31
申请号：US13520961
申请日：2011-01-07
申请人： Josef Penninger , Andrew Pospisilik , Shane McManus
发明人： Josef Penninger , Andrew Pospisilik , Shane McManus
IPC分类号： A61K31/496 , A61P3/04 , A61K31/517
CPC分类号： A61K31/427
摘要： The present invention relates to new therapies to treat obesity and related diseases, as well as for reducing triglyceride levels and body weight.
摘要翻译：本发明涉及治疗肥胖症和相关疾病以及降低甘油三酯水平和体重的新疗法。

3. 发明授权

US10143747B2 Breast cancer therapeutics 有权
公开(公告)号：US10143747B2
公开(公告)日：2018-12-04
申请号：US13825655
申请日：2011-09-22
申请人： Josef Penninger , Daniel Schramek
发明人： Josef Penninger , Daniel Schramek
IPC分类号： A61K39/395 , A61K31/57 , A61K38/18 , A61K31/565 , A61K31/713 , A61K39/00
摘要： The present invention relates to a method of treating or preventing cancer in a subject comprising administering a therapeutically effective amount of a RANKL inhibitor to said patient.

4. 发明申请

US20130316374A1 BREAST CANCER DIAGNOSTICS 审中-公开
标题翻译：乳腺癌诊断
公开(公告)号：US20130316374A1
公开(公告)日：2013-11-28
申请号：US13825502
申请日：2011-09-22
申请人： Josef Penninger , Daniel Schramek , Georg Schett , Martin Widschwendter , Ian J. Jacobs , Usha Menon
发明人： Josef Penninger , Daniel Schramek , Georg Schett , Martin Widschwendter , Ian J. Jacobs , Usha Menon
IPC分类号： G01N33/68
CPC分类号： G01N33/57415 , G01N33/6893 , G01N2333/70575 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to methods and means for detecting cancer or of predicting a patient developing cancer or of determining the rate of progression of cancer in a patient suffering from cancer, comprising determining RANKL activity and/or the amount of OPG in a sample of said patient.
摘要翻译：本发明涉及用于检测癌症或预测患有癌症的患者或确定患有癌症的患者的癌症进展速率的方法和手段，包括确定所述癌症的样品中的RANKL活性和/或OPG的量患者。

5. 发明申请

US20090162426A1 Use of a Compound with RANKL Activity 审中-公开
标题翻译：使用具有RANKL活性的化合物
公开(公告)号：US20090162426A1
公开(公告)日：2009-06-25
申请号：US12300074
申请日：2007-05-08
申请人： Josef Penninger , Karin Loser , Stefan Beissert
发明人： Josef Penninger , Karin Loser , Stefan Beissert
IPC分类号： A61K9/127 , A61K38/17 , A61K38/20 , C07K14/52
CPC分类号： A61K38/2006 , A61K31/00 , A61K38/191 , A61K38/20 , A61K38/204 , A61K2300/00
摘要： The present invention relates to the use of a compound with receptor activator of nuclear factor-kB ligand (RANKL) activity for the manufacture of a topical pharmaceutical formulation for the modulation of local or systemic Treg numbers and the treatment or the prevention of skin-associated or systemic diseases.
摘要翻译：本发明涉及具有核因子-kB配体（RANKL）活性受体激活剂的化合物在制备用于调节局部或全身Treg数量的局部药物制剂中的用途，以及治疗或预防与皮肤有关的或全身性疾病。

6. 发明申请

US20060035806A1 Increase in the water absorption capacity of textiles 审中-公开
标题翻译：增加纺织品的吸水能力
公开(公告)号：US20060035806A1
公开(公告)日：2006-02-16
申请号：US11201343
申请日：2005-08-10
申请人： Josef Penninger
发明人： Josef Penninger
IPC分类号： C11D3/22
CPC分类号： C11D3/225 , C11D3/0026 , C11D3/0036 , C11D17/0039 , D06M15/09 , D06M2200/00
摘要： The water absorption capacity of textiles is increased by contacting a textile material with a soil release-capable alkylated or hydroxyalkylated cellulose derivative comprising on average from 0.5 to 2.5 alkyl groups and from 0.02 to 0.5 hydroxyalkyl groups per anhydroglycose monomer unit. The cellulose derivative can be used by itself or in a laundry detergent composition in a washing step or is a post washing step. The cellulose derivative is particularly effective on synthetic fibers.
摘要翻译：纺织品的吸水能力通过使织物材料与平均0.5至2.5个烷基平均含有脱离力的烷基化或羟烷基化纤维素衍生物和每个脱水糖苷单体单元0.02至0.5个羟基烷基接触来增加。纤维素衍生物可以在洗涤步骤中本身或衣物洗涤剂组合物中使用或者是后洗涤步骤。纤维素衍生物在合成纤维上特别有效。

7. 发明授权

US5880083A Liquid bleach-containing formulation for washing or cleaning 失效
标题翻译：含有液体漂白剂的用于洗涤或清洗的配方
公开(公告)号：US5880083A
公开(公告)日：1999-03-09
申请号：US776682
申请日：1997-02-14
申请人： Hans-Josef Beaujean , Christian Block , Rainer Hofmann , Dieter Legel , Rudolf Lind , Josef Penninger , Bernd Richter , Reiner Schackmann , Karl Schwadtke
发明人： Hans-Josef Beaujean , Christian Block , Rainer Hofmann , Dieter Legel , Rudolf Lind , Josef Penninger , Bernd Richter , Reiner Schackmann , Karl Schwadtke
IPC分类号： C11D1/83 , C11D3/39 , C11D3/395 , C11D9/42 , C11D10/04 , C11D17/00 , C11D17/08 , C11D7/18 , C11D7/54
CPC分类号： C11D3/3947 , C11D17/0004
摘要： A substantially non-aqueous, free-flowing, storable liquid washing or cleaning formulation comprising:A) from more than 20 to less than 78% by weight of at least one nonionic surfactant;B) from 0.1 to 25% by weight of at least one anionic surfactant;C) from 1 to less than 20% by weight of at least one water-soluble builder; andD) from more than 20 to 35% by weight of at least one bleaching agent.
摘要翻译： PCT No.PCT / EP95 / 03124 Sec。 371日期1997年2月14日 102（e）日期1997年2月14日PCT提交1995年8月7日PCT公布。公开号WO96 / 05284 日期1996年2月22日一种基本上非水的，自由流动的，可储存的液体洗涤或清洁制剂，其包含：A）至少一种非离子表面活性剂的重量百分比以上至少于78％ B）0.1至25重量％的至少一种阴离子表面活性剂; C）1至少于20重量％的至少一种水溶性助洗剂; 和D）至少一种漂白剂的20至35重量％。

8. 发明授权

US08785362B2 Triazine derivative dye transfer inhibitors, washing products containing the same and uses therefor 有权
标题翻译：三嗪衍生物染料转移抑制剂，含有相同用途的洗涤产品
公开(公告)号：US08785362B2
公开(公告)日：2014-07-22
申请号：US13430769
申请日：2012-03-27
申请人： Josef Penninger , Birgit Glüsen
发明人： Josef Penninger , Birgit Glüsen
IPC分类号： C11D3/00
CPC分类号： C11D3/349 , C11D3/0021
摘要： Washing products comprising a dye transfer inhibitor selected from triazine derivatives of the general formulae T(NH—Ar(SO3Na)a)bHalc (I), X(NH-T(NH—Ar(SO3Na)a)eHalf)2 (II), X(NH-T(NH—Ar(SO3Na)d—NH-T(NH—Ar(SO3Na)a)Hal)Hal)7 (III) and combinations thereof, wherein T represents a 1,3,5-triazinyl; each Ar independently represents a naphthalene or benzene; X represents a divalent hydrocarbyl selected from linear or branched C1-20 hydrocarbon groups optionally including one or more —N(H)— carbon chain interruptions, stilbene and biphenyl groups which may optionally be mono- or poly-SO3Na-substituted; each Hal independently represents a halogen selected chlorine, bromine, and iodine; each of a and d independently represents 1, 2 or 3; b and c each represent 1 or 2 such that b+c=3; e represents 1 or 2 and f represents 0 or 1 such that e+f=2; and wherein the triazinyl substituents are located at the 2, 4 and 6 positions of the 1,3,5-triazinyl.
摘要翻译：洗涤产物，其包含选自通式T（NH-Ar（SO 3 Na）a）b Halc（I），X（NH-T（NH-Ar（SO 3 Na）a）eHalf）2（II）的三嗪衍生物的染料转移抑制剂，X（NH-T（NH-Ar（SO 3 Na）d -NH-T（NH-Ar（SO 3 Na）a）Hal）Hal）7（III）及其组合，其中T表示1,3,5-三嗪基 ; 每个Ar独立地表示萘或苯; X表示选自直链或支链C 1-20烃基的二价烃基，任选地包括一个或多个-N（H） - 碳链中断，二苯乙烯和联苯基团，其可任选地被单或多SO 3 N 3取代; 每个Hal独立地表示卤素选择的氯，溴和碘; a和d各自独立地表示1,2或3; b和c各自表示1或2，使得b + c = 3; e表示1或2，f表示0或1，使e + f = 2; 并且其中三嗪基取代基位于1,3,5-三嗪基的2,4和6位。

9. 发明授权

US08263541B2 Triazine derivative dye transfer inhibitors, washing products containing the same and uses therefor 有权
标题翻译：三嗪衍生物染料转移抑制剂，含有相同用途的洗涤产品
公开(公告)号：US08263541B2
公开(公告)日：2012-09-11
申请号：US12064107
申请日：2006-08-05
申请人： Josef Penninger , Birgit Gluesen
发明人： Josef Penninger , Birgit Gluesen
IPC分类号： C11D3/37 , C11D7/18 , C11D3/00 , D06L1/04
CPC分类号： C11D3/349 , C11D3/0021
摘要： Washing products which comprise a dye transfer inhibitor selected from the group consisting of triazine derivatives of the general formulae I, II, III and combinations thereof: T(NH—Ar(SO3Na)a)bHalc (I) X(NH-T(NH—Ar(SO3Na)a)eHalf)2 (II) X(NH-T(NH—Ar(SO3Na)d—NH-T(NH—Ar(SO3Na)a)Hal)Hal)2 (III) wherein T represents a 1,3,5-triazinyl residue; each Ar independently represents a naphthalene or benzene moiety; X represents a divalent hydrocarbyl moiety selected from the group consisting of linear or branched C1-20 hydrocarbon groups which may optionally include one or more —N(H)— carbon chain interruptions, stilbene groups and biphenyl groups which may optionally be mono- or poly-SO3Na-substituted; each Hal independently represents a halogen selected from the group consisting of chlorine, bromine, and iodine; each of a and d independently represents 1, 2 or 3; b and c each represent 1 or 2 such that b+c=3; e represents 1 or 2 and f represents 0 or 1 such that e+f=2; and wherein the triazinyl residue substituents are located at the 2, 4 and 6 positions of the 1,3,5-triazinyl residue.
摘要翻译：包含选自通式I，II，III的三嗪衍生物及其组合的染料转移抑制剂的洗涤产品：T（NH-Ar（SO 3 Na）a）b氢化（I）X（NH-T（NH -Ar（SO3Na）a）eHalf）2（II）X（NH-T（NH-Ar（SO3Na）d-NH-T（NH-Ar（SO3Na）a）Hal）Hal）2（III）其中T表示 1,3,5-三嗪基残基; 每个Ar独立地表示萘或苯部分; X表示选自直链或支链C 1-20烃基的二价烃基部分，其可以任选地包括一个或多个-N（H） - 碳链中断，二苯乙烯基团和联苯基团，其可任选地是单或多 -SO 3 Na-取代的每个Hal独立地表示选自氯，溴和碘的卤素; a和d各自独立地表示1,2或3; b和c各自表示1或2，使得b + c = 3; e表示1或2，f表示0或1，使e + f = 2; 并且其中三嗪基残基取代基位于1,3,5-三嗪基残基的2,4和6位。

10. 发明申请

US20090069210A1 COLOUR-PROTECTING LAUNDRY DETERGENT COMPOSITION 有权
标题翻译：彩色保护洗衣洗涤剂组合物
公开(公告)号：US20090069210A1
公开(公告)日：2009-03-12
申请号：US12282610
申请日：2007-02-08
申请人： Josef Penninger , Birgit Glusen
发明人： Josef Penninger , Birgit Glusen
IPC分类号： C11D3/28
CPC分类号： C11D3/28 , C11D3/0021
摘要： Detergent compositions comprising a color transfer inhibitor and optionally surfactant(s), the color transfer inhibitor comprising one or more compounds selected from the group consisting of triazine derivatives corresponding to general formulae I and II: T(NH—Ar(CO2M)a)bHalc (I) X—NH—CH2CH2—(NY—CH2CH2—)nNH—X (II) wherein T represents a 1,3,5-triazinyl group; Ar represents a phenyl group; each M independently represents a substituent selected from the group consisting of H, Na, Li, and K; each Hal independently represents a halogen selected from the group consisting of Cl, Br, and I; each a independently represents 1, 2 or 3; b and c each represent 1 or 2 wherein b+c=3; each X represents a T(NH—Ar(CO2M)a)bHalc−1 group; each Y independently represents H or X; and n represents a number of 0 to 50, and uses therefor in washing and treating dyed and/or undyed textiles.
摘要翻译：包含颜色转移抑制剂和任选的表面活性剂的洗涤剂组合物，所述颜色转移抑制剂包含一种或多种选自对应于通式I和II的三嗪衍生物的化合物：<？in-line-formula description =“In “公式”end =“lead”？> T（NH-Ar（CO2M）a）bHalc（I）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in -line-formula description =“In-line Formulas”end =“lead”？X-NH-CH2CH2-（NY-CH2CH2-）nNH-X（II）<？in-line-formula description =“In-line 式“end =”tail“？>其中T表示1,3,5-三嗪基; Ar表示苯基; 每个M独立地表示选自H，Na，Li和K的取代基; 每个Hal独立地表示选自Cl，Br和I的卤素; 每个独立地代表1,2或3; b和c各自表示1或2，其中b + c = 3; 每个X表示T（NH-Ar（CO 2 M）a）b Halc-1基团; 每个Y独立地表示H或X; n表示0〜50的数，用于洗涤和/或未染色染色纺织品。

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