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1. 发明申请

US20050204304A1 User interface elements of a sheet set manager for a graphics program 审中-公开
标题翻译：用于图形程序的工作表管理器的用户界面元素
公开(公告)号：US20050204304A1
公开(公告)日：2005-09-15
申请号：US10800877
申请日：2004-03-15
申请人： Jose Garcia , John Ford , Jay Behr , Qun Lu , Thomas Stoeckel , Karen Mason
发明人： Jose Garcia , John Ford , Jay Behr , Qun Lu , Thomas Stoeckel , Karen Mason
IPC分类号： G06F15/00 , G06F17/00
CPC分类号： G06F3/0481 , G06T11/00
摘要： A Sheet Set Manager for a computer-implemented graphics program allows drawings to be organized logically as a Sheet Set comprising a collection of Sheets and Subsets of Sheets, wherein each Sheet comprises a drawing, layout or view. The Sheet Set Manager is a graphical user interface for displaying, accessing and managing the Sheet Sets, Subsets and Sheets, as well as editing components of the Sheet Sets, Subsets and Sheets.
摘要翻译：用于计算机实现的图形程序的纸张集管理器允许将图纸逻辑地组织为包括纸张和纸张组合的纸张集合，其中每个纸张包括图纸，布局或视图。工作表管理器是用于显示，访问和管理工作表集，子集和工作表的图形用户界面，以及编辑工作表集，子集和工作表的组件。

2. 发明申请

US20050203662A1 Sheet set manager for a graphics program 审中-公开
标题翻译：图形程序的工作表管理器
公开(公告)号：US20050203662A1
公开(公告)日：2005-09-15
申请号：US10800477
申请日：2004-03-15
申请人： Jose Garcia , John Ford , Jay Behr , Jules Brenner , Randy Kintzley , Stefanos Makris , Qun Lu , Khanh-Truong Vo-Vu , Christopher Miller
发明人： Jose Garcia , John Ford , Jay Behr , Jules Brenner , Randy Kintzley , Stefanos Makris , Qun Lu , Khanh-Truong Vo-Vu , Christopher Miller
IPC分类号： G06F19/00
CPC分类号： G06F17/50 , G06T19/00 , G06T2200/24
摘要： A Sheet Set Manager for a computer-implemented graphics program allows drawings to be organized logically as a Sheet Set comprising a collection of Sheets and Subsets of Sheets, wherein each Sheet comprises a drawing, layout or view. The Sheet Set Manager is a graphical user interface for displaying, accessing and managing the Sheet Sets, Subsets and Sheets, as well as editing components of the Sheet Sets, Subsets and Sheets.
摘要翻译：用于计算机实现的图形程序的纸张集管理器允许将图纸逻辑地组织为包括纸张和纸张组合的纸张集合，其中每个纸张包括图纸，布局或视图。工作表管理器是用于显示，访问和管理工作表集，子集和工作表的图形用户界面，以及编辑工作表集，子集和工作表的组件。

3. 发明申请

US20050204303A1 Transmittal and archive tool in a sheet set manager for a graphics program 审中-公开
标题翻译：在图形程序的工作表管理器中传送和归档工具
公开(公告)号：US20050204303A1
公开(公告)日：2005-09-15
申请号：US10800584
申请日：2004-03-15
申请人： Jose Garcia , Karen Mason , Qun Lu , Stefanos Makris
发明人： Jose Garcia , Karen Mason , Qun Lu , Stefanos Makris
IPC分类号： G06F3/00
CPC分类号： G06F3/0483 , G06F3/0482
摘要： A Sheet Set Manager for a computer-implemented graphics program allows drawings to be organized logically as a Sheet Set comprising a collection of Sheets and Subsets of Sheets, wherein each Sheet comprises a drawing, layout or view. The Sheet Set Manager is a graphical user interface for displaying, accessing and managing the Sheet Sets, Subsets and Sheets, as well as editing components of the Sheet Sets, Subsets and Sheets.
摘要翻译：用于计算机实现的图形程序的纸张集管理器允许将图纸逻辑地组织为包括纸张和纸张组合的纸张集合，其中每个纸张包括图纸，布局或视图。工作表管理器是用于显示，访问和管理工作表集，子集和工作表的图形用户界面，以及编辑工作表集，子集和工作表的组件。

4. 发明授权

US11439608B2 Roles of modulators of intersectin-CDC42 signaling in Alzheimer's disease 有权
公开(公告)号：US11439608B2
公开(公告)日：2022-09-13
申请号：US16141849
申请日：2018-09-25
申请人： Qun Lu
发明人： Qun Lu , Byron Aguilar , Yi Zhu , Yan-Hua Chen
IPC分类号： A61K31/18 , A61K31/166 , A61K31/343 , A61K31/505 , A61P25/28
摘要： Methods of treating Alzheimer's disease and other neurodegenerative and/or neurocognitive and/or neurodevelopmental diseases are described. The methods comprise the administration of compounds that modulate an activity of cell division control protein 42 (Cdc42), such as the interaction between Cdc42 and intersectin (ITSN). Exemplary modulator compounds include thioureas, disulfonamides of fused aromatic systems (e.g., benzofuran), and acyl hydrazones, among others. Some of the modulator compounds act as activators of Cdc42, while others act as inhibitors. In some cases, the modulator compound has dual functionality and the ability of the modulator compound to act as an inhibitor or activator depends on whether or not Cdc42 is already activated in a particular disease stage or biological environment by an upstream activating signal of Cdc42.

5. 发明授权

US10085991B2 Formulation inhibiting effects of low acid environment 有权
公开(公告)号：US10085991B2
公开(公告)日：2018-10-02
申请号：US15532721
申请日：2015-12-01
申请人： Merck Sharp & Dohme Corp. , Lei Zhu , Yvonne Cegielnik , Qun Lu
发明人： Lei Zhu , Yvonne Cegielnik , Qun Lu
IPC分类号： A61K31/52 , A61K9/00 , A61K47/26 , A61K47/02 , A61K47/20 , A61K47/12 , A61K47/32 , A61K9/10 , A61K47/38
摘要： The present invention is directed to formulations comprising PVP polymer, a dispersion of a compound of Formula I (API), and citric acid, which formulations mitigate the effects of coadministering the compound of Formula I with a proton pump inhibitor compound.

6. 发明授权

US08932824B2 Method of detecting cancer using delta-catenin 有权
标题翻译：使用δ-连环蛋白检测癌症的方法
公开(公告)号：US08932824B2
公开(公告)日：2015-01-13
申请号：US13251481
申请日：2011-10-03
申请人： Qun Lu , Yan-hua Chen
发明人： Qun Lu , Yan-hua Chen
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , C12Q1/6886 , G01N33/574 , G01N33/57434
摘要： The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence or absence of delta-catenin in said sample, or increased levels of delta-catenin in said sample as compared to a normal or control subject. The presence of delta-catenin in said sample, or increased levels of delta-catenin in said sample, indicating said subject is afflicted with or at least at risk of developing cancer.
摘要翻译：本发明提供了用于检测或筛选受试者中癌症存在的方法。该方法包括从所述受试者获得，提供或收集组织或流体样品（例如尿液样品），然后确定所述样品中δ-连环蛋白的存在或不存在，或所述样品中δ-连环蛋白的增加水平为与正常或对照对象相比。所述样品中δ-连环蛋白的存在或所述样品中δ-连环蛋白的水平升高，表明所述受试者患有或至少具有发展为癌症的风险。

7. 发明授权

US5933343A Multi-deck power converter module 失效
标题翻译：多层电源转换器模块
公开(公告)号：US5933343A
公开(公告)日：1999-08-03
申请号：US158221
申请日：1998-09-22
申请人： Qun Lu , Paul E. Grandmont , Shih-Chang Liu
发明人： Qun Lu , Paul E. Grandmont , Shih-Chang Liu
IPC分类号： H02M3/00 , H05K1/14 , H02M1/00
CPC分类号： H05K1/144 , H02M3/00 , H02M7/003
摘要： A multi-deck power converter module assembly for connection with a substrate (e.g., a host board) having connection regions disposed on its surface includes a second circuit board positioned over a first circuit board, the second circuit board having apertures extending from an upper surface to a lower surface of the second circuit board. At least two rail members are positioned over the second circuit board, each rail member having a first and a second plurality of holes. A pair of spacers are disposed between the first and second circuit boards, each spacer extending through one of the apertures of the second circuit board and received within one of the first plurality of holes of one of the rail members. Terminal pins are attached to the first circuit board, at least one terminal pin extending through the second circuit board and a corresponding one of the second plurality of holes for connection to one of the connection regions on the substrate. Each of the second plurality of holes is sized to allow the rail members to be slidably positioned over the terminal pins during assembly of the power converter module.
摘要翻译：用于与具有设置在其表面上的连接区域的基板（例如，主板）连接的多层电力转换器模块组件包括位于第一电路板上的第二电路板，第二电路板具有从上表面到第二电路板的下表面。至少两个轨道构件定位在第二电路板上方，每个轨道构件具有第一和第二多个孔。一对间隔件设置在第一和第二电路板之间，每个间隔件延伸穿过第二电路板的一个孔并被接纳在一个轨道构件的第一多个孔中的一个孔内。端子销附接到第一电路板，延伸穿过第二电路板的至少一个端子引脚和用于连接到基板上的一个连接区域的第二多个孔中的相应一个。第二多个孔中的每一个的尺寸被设计成允许轨道构件在组装功率转换器模块期间可滑动地定位在端子销上方。

8. 发明授权

US5781093A Planar transformer 失效
公开(公告)号：US5781093A
公开(公告)日：1998-07-14
申请号：US693878
申请日：1996-08-05
申请人： Paul E. Grandmont , Qun Lu , Fei Ma
发明人： Paul E. Grandmont , Qun Lu , Fei Ma
IPC分类号： H01F17/00 , H01F27/28 , H01F41/04 , H01F5/00
CPC分类号： H01F27/2804 , H01F17/0006 , H01F41/041
摘要： A planar winding assembly includes first and second windings, each winding having an axis and a pair of insulative sheet layers, laminated together, with at least one of each of the pairs of insulative sheets having a hole. Each winding further includes a metal strip conductor that is wound about the axis of its winding and is sealed between the laminated insulative sheet layers. The metal strip conductor has a portion projecting into the hole. The metal strip conductor of the first winding is electrically connected to the metal strip conductor of the second winding through the holes of the insulative sheets.

9. 发明公开

US20230165815A1 ROLES OF MODULATORS OF INTERSECTIN-CDC42 SIGNALING IN ALZHEIMER?S DISEASE 审中-公开
公开(公告)号：US20230165815A1
公开(公告)日：2023-06-01
申请号：US17942657
申请日：2022-09-12
申请人： Qun Lu
发明人： Qun Lu , Yan-Hua Chen , Yi Zhu , Byron Aguilar
IPC分类号： A61K31/18 , A61K31/166 , A61P25/28 , A61K31/505 , A61K31/343
CPC分类号： A61K31/18 , A61K31/166 , A61K31/343 , A61K31/505 , A61P25/28
摘要： Methods of treating Alzheimer’s disease and other neurodegenerative and/or neurocognitive and/or neurodevelopmental diseases are described. The methods comprise the administration of compounds that modulate an activity of cell division control protein 42 (Cdc42), such as the interaction between Cdc42 and intersectin (ITSN). Exemplary modulator compounds include thioureas, disulfonamides of fused aromatic systems (e.g., benzofuran), and acyl hydrazones, among others. Some of the modulator compounds act as activators of Cdc42, while others act as inhibitors. In some cases, the modulator compound has dual functionality and the ability of the modulator compound to act as an inhibitor or activator depends on whether or not Cdc42 is already activated in a particular disease stage or biological environment by an upstream activating signal of Cdc42.

10. 发明申请

US20140194451A1 Cdc42 Inhibitor and Uses Thereof 审中-公开
标题翻译： Cdc42抑制剂及其用途
公开(公告)号：US20140194451A1
公开(公告)日：2014-07-10
申请号：US14087662
申请日：2013-11-22
申请人： Qun Lu , Huchen Zhou , Yanhua Chen , Amy Friesland
发明人： Qun Lu , Huchen Zhou , Yanhua Chen , Amy Friesland
IPC分类号： C07D239/42 , C07C335/12
CPC分类号： C07D239/42 , C07C335/12 , C07D239/69
摘要： Compounds which inhibit the small G protein Rho GTPase cell division cycle protein Cdc42 are provided. Morphological analyses of filopodia, western blots of Ccd42 phosphorylation, and effects on cellular wound healing and on growth cone formation all demonstrate that the described compounds are able to inhibit all tested Cdc42-mediated processes. The compounds effectively inhibit, the effects of Cdc42 and effectively inhibit Cdc42-related cellular functions involving actin, such as Golgi organization and cell movement. Furthermore, the described Cdc42 inhibitor compounds may be provided as a medicament for the treatment of various conditions.
摘要翻译：提供抑制小G蛋白Rho GTPase细胞分裂周期蛋白Cdc42的化合物。丝状伪足，Ccd42磷酸化的蛋白质印迹以及对细胞伤口愈合和对生长锥形成的影响的形态学分析都证明所述化合物能够抑制所有测试的Cdc42介导的过程。这些化合物有效抑制Cdc42的作用，并有效抑制涉及肌动蛋白的Cdc42相关细胞功能，如高尔基体组织和细胞运动。此外，所述Cdc42抑制剂化合物可以作为治疗各种病症的药物提供。

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