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1. 发明授权

US07972330B2 Methods and apparatus for closing a layered tissue defect 有权
标题翻译：闭合层状组织缺损的方法和装置
公开(公告)号：US07972330B2
公开(公告)日：2011-07-05
申请号：US11613415
申请日：2006-12-20
申请人： Jose Alejandro , Mark E. Deem , Erik Engelson , Dominique Filloux , Dan Francis , Hanson Gifford , Kenneth Horne , Uday N. Kumar , William Malecki , Miriam H. Taimisto , Venkata Vegesna
发明人： Jose Alejandro , Mark E. Deem , Erik Engelson , Dominique Filloux , Dan Francis , Hanson Gifford , Kenneth Horne , Uday N. Kumar , William Malecki , Miriam H. Taimisto , Venkata Vegesna
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B17/2202 , A61B18/02 , A61B18/08 , A61B18/18 , A61B18/20 , A61B2017/00575 , A61B2018/00083 , A61B2018/00214 , A61B2018/00351 , A61B2018/00619 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61B2018/00898 , A61B2018/1407 , A61B2018/143 , A61B2018/144 , A61B2018/1467 , A61B2090/3782 , A61B2090/3929
摘要： Methods and apparatus for treatment of layered tissue defects such as a patent foramen ovale provide for applying energy to tissues adjacent to the PFO with a closure device that substantially closes the PFO. Apparatus generally includes an elongate flexible member having a proximal end and a distal end and an energy transmission member deployable from the elongate flexible member. The energy transmission member applies energy to the layered tissue defect at a first position and a second position adjacent to the first position so as to substantially close the layered tissue defect along at least a portion of the defect. Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating, direct heat energy, cryogenic or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.
摘要翻译：用于治疗层状组织缺陷（例如卵孔卵孔专利）的方法和装置提供了使用基本上封闭PFO的闭合装置向PFO附近的组织施加能量。设备通常包括细长的柔性构件，其具有近端和远端以及能够从细长柔性构件展开的能量传递构件。能量传递部件在与第一位置相邻的第一位置和第二位置处向层状组织缺损施加能量，以沿着缺损的至少一部分基本上封闭层状组织缺损。应用能量可以是单极性或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热，直接热能，低温等。通过基于本发明的基于能量的方法的PFO闭合可以有助于预防中风，治疗偏头痛，并且可能治疗或预防其它医疗状况。

2. 发明授权

US08021362B2 Methods and apparatus for closing a layered tissue defect 有权
标题翻译：闭合层状组织缺损的方法和装置
公开(公告)号：US08021362B2
公开(公告)日：2011-09-20
申请号：US11613422
申请日：2006-12-20
申请人： Mark E. Deem , Erik Engelson , Dominique Filloux , Dan Francis , Hanson Gifford , Kenneth Horne , Uday N. Kumar , William Malecki , Miriam H. Taimisto
发明人： Mark E. Deem , Erik Engelson , Dominique Filloux , Dan Francis , Hanson Gifford , Kenneth Horne , Uday N. Kumar , William Malecki , Miriam H. Taimisto
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00575 , A61B2017/00867 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00619 , A61B2018/0063 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2018/1472 , A61B2090/3614 , C08L2201/12
摘要： Methods and apparatus for treatment of layered tissue defects having a majority of the surfaces of the defect layers in contact generally involve use of a catheter having at least one energy transmission member at its distal end. The distal end of the apparatus also typically has a force applying member which can apply a force to the tissue defect. Often this force is a lateral force or vacuum which helps the tissue to appose itself. An exemplary method of closing a patent foramen ovale (PFO) involves positioning a closure device between layers of the PFO. Energy is then applied to the layered tissue defect with the closure device so as to substantially close the tissue defect. The energy is often monopolar or bipolar radiofrequency energy. A force may also be applied by the closure device to the layered tissue defect so as to bring the layered tissue defect together.
摘要翻译：用于治疗具有接触缺陷层的大部分表面的层状组织缺陷的方法和装置通常涉及在其远端使用具有至少一个能量传递构件的导管。该装置的远端通常还具有可施加力到组织缺损的施力部件。这种力通常是侧向力或真空，有助于组织自身。闭合卵孔卵泡（PFO）的示例性方法涉及将闭合装置定位在PFO的层之间。然后用闭合装置将能量施加到层状组织缺陷，以便基本上封闭组织缺损。能量通常是单极或双极射频能量。还可以通过闭合装置将力施加到层状组织缺陷，以使层状组织缺陷在一起。

3. 发明授权

US08109274B2 Methods and electrode apparatus to achieve a closure of a layered tissue defect 有权
标题翻译：实现层状组织缺损闭合的方法和电极装置
公开(公告)号：US08109274B2
公开(公告)日：2012-02-07
申请号：US11403052
申请日：2006-04-11
申请人： Kenneth Horne , Jose Alejandro , Erik Engelson , Dominique Filloux , Dan Francis , Lucia Kim , Uday N. Kumar , Doug Sutton , Miriam H. Taimisto , Andy Uchida
发明人： Kenneth Horne , Jose Alejandro , Erik Engelson , Dominique Filloux , Dan Francis , Lucia Kim , Uday N. Kumar , Doug Sutton , Miriam H. Taimisto , Andy Uchida
IPC分类号： A61B19/00
CPC分类号： A61B17/0057 , A61B18/1492 , A61B2017/00504 , A61B2017/00557 , A61B2017/00561 , A61B2017/00575 , A61B2017/22069 , A61B2018/00351 , A61B2018/0063 , A61B2018/1407 , A61B2090/061 , A61M25/0069 , A61M25/10 , A61M2025/105 , A61M2025/1052 , A61M2025/1054
摘要： Methods for treating anatomic tissue defects such as a patent foramen ovale generally involve positioning a distal end of a catheter device at the site of the defect, exposing a housing and energy transmission member from the distal end of the catheter, engaging the housing with tissues at the site of the defect, applying suction or other approximating tool to the tissue via the housing to bring the tissue together, and applying energy to the tissue with the energy transmission member or to deliver a clip or fixation device to substantially close the defect. Apparatus generally include a catheter body, a housing extending from a distal end of the catheter body for engaging tissue at the site of the defect, and further adapted to house a fusing or fixation device such as an energy transmission member adjacent a distal end of the housing, or a clip or fixation delivery element.
摘要翻译：用于治疗解剖组织缺陷的方法，例如卵孔卵孔通常涉及将导管装置的远端定位在缺损部位，使外壳和能量传递构件从导管的远端露出，使壳体与组织接合通过外壳向组织施加吸力或其它近似工具以将组织带到一起，以及用能量传递构件向组织施加能量，或者输送夹子或固定装置以基本上封闭缺陷。装置通常包括导管主体，从导管主体的远端延伸的壳体，用于接合缺损位置处的组织，并且还适于容纳定影或固定装置，例如邻近于所述导管主体的远端的能量传递构件外壳，或夹子或固定传递元件。

4. 发明申请

US20120215123A1 NON-INVASIVE CARDIAC MONITOR AND METHODS OF USING CONTINUOUSLY RECORDED CARDIAC DATA 审中-公开
标题翻译：非侵入性心脏监护仪及使用持续记录心脏数据的方法
公开(公告)号：US20120215123A1
公开(公告)日：2012-08-23
申请号：US13407389
申请日：2012-02-28
申请人： Uday N. Kumar , Kit Yee Au-Yeung , John Warren White , Joseph A. Knight
发明人： Uday N. Kumar , Kit Yee Au-Yeung , John Warren White , Joseph A. Knight
IPC分类号： A61B5/0432
CPC分类号： A61B5/02438 , A61B5/0006 , A61B5/0408 , A61B5/0432 , A61B5/04325 , A61B5/411 , A61B5/6833 , A61B2560/0412 , A61B2560/0468 , G16H10/60 , G16H15/00 , G16H40/63
摘要： Embodiments of the invention provide methods of obtaining continuous cardiac information from a mammal. First, attach a self-contained, wearable, portable continuous cardiac monitor to the mammal to create a chamber containing electrodes used to detect cardiac signals from the mammal. Next, continuously detect without analyzing the cardiac signals from the mammal for at least 24 hours. Next, store information related to substantially all detected cardiac signals in the cardiac monitor.
摘要翻译：本发明的实施方案提供从哺乳动物获得连续心脏信息的方法。首先，向哺乳动物附上一个独立的，可携带的便携式连续心脏监测器，以产生含有用于检测来自哺乳动物的心脏信号的电极的腔室。接下来，连续检测不分析来自哺乳动物的心脏信号至少24小时。接下来，将与心脏监视器中基本上所有检测到的心脏信号相关的信息存储。

5. 发明申请

US20090149902A1 IMPLANTED CARDIAC DEVICE FOR DEFIBRILLATION 失效
标题翻译：用于定位的植入式心脏装置
公开(公告)号：US20090149902A1
公开(公告)日：2009-06-11
申请号：US12281260
申请日：2007-03-01
申请人： Uday N. Kumar , John Warren White , Joseph Allen Knight , Kit Yee Au-Yeung
发明人： Uday N. Kumar , John Warren White , Joseph Allen Knight , Kit Yee Au-Yeung
IPC分类号： A61N1/39 , A61N1/362
CPC分类号： A61N1/37 , A61N1/0587 , A61N1/375 , A61N1/3756 , A61N1/3962 , A61N1/3968
摘要： An implantable medical device for delivering electrical cardiac therapy includes a first implantable housing containing a battery. There is also a second implantable housing separate from the first implantable housing and containing at least one of: electronic circuitry adapted to evaluate and initiate electrical cardiac therapy, a storage capacitor and an electrode structure comprising a sensing electrode, a pacing electrode and a therapy electrode. The electronic circuit, the storage capacitor or the electrode structure are electrically connected to the battery. Alternatively, there is an implantable medical device for delivering electrical cardiac therapy having an implantable structure containing the following electrically connected components: a battery, electronic circuitry adapted to evaluate and initiate electrical cardiac therapy, a storage capacitor and an electrode structure comprising a sensing electrode, a pacing electrode and a therapy electrode. A method of providing electrical cardiac therapy is also provided.
摘要翻译：用于递送电心脏治疗的可植入医疗装置包括容纳电池的第一可植入壳体。还存在与第一可植入壳体分离的第二可植入壳体并且包含以下中的至少一个：适于评估和启动电心脏治疗的电子电路，存储电容器和包括感测电极，起搏电极和治疗电极的电极结构。电子电路，存储电容器或电极结构电连接到电池。或者，存在用于递送具有包含以下电连接部件的可植入结构的电心电疗法的可植入医疗装置：电池，适于评估和启动电心脏治疗的电子电路，存储电容器和包括感测电极的电极结构，起搏电极和治疗电极。还提供了提供电心脏治疗的方法。

6. 发明申请

US20120310070A1 DEVICE FEATURES AND DESIGN ELEMENTS FOR LONG-TERM ADHESION 有权
标题翻译：长期粘合的设备特点和设计要素
公开(公告)号：US20120310070A1
公开(公告)日：2012-12-06
申请号：US13563546
申请日：2012-07-31
申请人： Uday N. Kumar , Peter H. Livingston , Mark J. Day , Shena H. Park , William F. Willis , William H. Righter , Timothy J. Bahney
发明人： Uday N. Kumar , Peter H. Livingston , Mark J. Day , Shena H. Park , William F. Willis , William H. Righter , Timothy J. Bahney
IPC分类号： A61B5/0408
CPC分类号： A61B5/6832 , A61B5/0408 , A61B5/04085 , A61B5/04087 , A61B5/0478 , A61B5/6833 , A61B2560/0406 , A61B2560/0468 , Y10T156/10
摘要： An electronic device for long-term adhesion to a mammal includes a housing with an electronic component. The electronic device may include a first wing and a second wing, each being integrally formed with the housing. An electrode is positioned on a bottom surface of each of the wings, the electrodes electrically connected to the electronic component. An adhesive layer is provided for adhesion to a surface of the mammal. The adhesive layer may cover a portion of the bottom surfaces of the wings but generally does not cover the electrode or a bottom surface of the housing. A method of applying an electronic device to a mammal includes removing first and second adhesive covers from first and second wings of the electronic device to expose an electrode and an adhesive coated on a bottom surface of each wing.
摘要翻译：用于长期粘附到哺乳动物的电子设备包括具有电子部件的壳体。电子设备可以包括第一翼和第二翼，每个翼与壳体整体形成。电极位于每个翼的底表面上，电极电连接到电子部件。提供粘合层用于粘附到哺乳动物的表面。粘合剂层可以覆盖翼的底表面的一部分，但是通常不覆盖电极或壳体的底表面。将电子设备施加到哺乳动物的方法包括从电子设备的第一和第二翼部移除第一和第二粘合剂覆盖物，以暴露电极和涂覆在每个翼的底表面上的粘合剂。

7. 发明授权

US08244335B2 Non-invasive cardiac monitor and methods of using continuously recorded cardiac data 有权
标题翻译：非侵入性心脏监测器和使用连续记录的心脏数据的方法
公开(公告)号：US08244335B2
公开(公告)日：2012-08-14
申请号：US11703335
申请日：2007-02-06
申请人： Uday N. Kumar , Joseph A. Knight , Kit Yee Au-Yeung , John Warren White
发明人： Uday N. Kumar , Joseph A. Knight , Kit Yee Au-Yeung , John Warren White
IPC分类号： A61B5/0432
CPC分类号： A61B5/02438 , A61B5/0006 , A61B5/0408 , A61B5/0432 , A61B5/04325 , A61B5/411 , A61B5/6833 , A61B2560/0412 , A61B2560/0468 , G06F19/00 , G16H10/60 , G16H15/00 , G16H40/63
摘要： Embodiments of the present invention provide a method of analyzing cardiac information by collecting a plurality of self-contained, wearable, portable cardiac monitors each of the cardiac monitors electronically storing at least 24 hours of continuously detected and unanalyzed cardiac signals from a mammal. Next, retrieving cardiac information stored in each of the plurality of self-contained portable cardiac monitors. Next, forwarding retrieved cardiac information.
摘要翻译：本发明的实施例提供了一种通过收集多个独立的，可穿戴的便携式心脏监测器来分析心脏信息的方法，每个心脏监测器电子地存储来自哺乳动物的至少24小时的连续检测和未分析的心脏信号。接下来，检索存储在多个独立式便携式心脏监测器中的每一个中的心脏信息。接下来，转发所检索的心脏信息。

8. 发明授权

US08150502B2 Non-invasive cardiac monitor and methods of using continuously recorded cardiac data 有权
标题翻译：非侵入性心脏监测器和使用连续记录的心脏数据的方法
公开(公告)号：US08150502B2
公开(公告)日：2012-04-03
申请号：US11703428
申请日：2007-02-06
申请人： Uday N. Kumar , Kit Yee Au-Yeung , John Warren White , Joseph A. Knight
发明人： Uday N. Kumar , Kit Yee Au-Yeung , John Warren White , Joseph A. Knight
IPC分类号： A61B5/0432
CPC分类号： A61B5/02438 , A61B5/0006 , A61B5/0408 , A61B5/0432 , A61B5/04325 , A61B5/411 , A61B5/6833 , A61B2560/0412 , A61B2560/0468 , G06F19/00 , G16H10/60 , G16H15/00 , G16H40/63
摘要： Embodiments of the invention provide methods of obtaining continuous cardiac information from a mammal. First, attach a self-contained, wearable, portable continuous cardiac monitor to the mammal to create a chamber containing electrodes used to detect cardiac signals from the mammal. Next, continuously detect without analyzing the cardiac signals from the mammal for at least 24 hours. Next, store information related to substantially all detected cardiac signals in the cardiac monitor.
摘要翻译：本发明的实施方案提供从哺乳动物获得连续心脏信息的方法。首先，向哺乳动物附上一个独立的，可携带的便携式连续心脏监测器，以产生含有用于检测来自哺乳动物的心脏信号的电极的腔室。接下来，连续检测不分析来自哺乳动物的心脏信号至少24小时。接下来，在心脏监视器中存储与基本上所有检测到的心脏信号相关的信息。

9. 发明申请

US20110279963A1 DEVICE FEATURES AND DESIGN ELEMENTS FOR LONG-TERM ADHESION 有权
标题翻译：长期粘合的设备特点和设计要素
公开(公告)号：US20110279963A1
公开(公告)日：2011-11-17
申请号：US13106750
申请日：2011-05-12
申请人： Uday N. Kumar , Peter H. Livingston , Mark J. Day , Shena H. Park , William F. Willis , William H. Righter
发明人： Uday N. Kumar , Peter H. Livingston , Mark J. Day , Shena H. Park , William F. Willis , William H. Righter
IPC分类号： G06F1/16 , B31B1/62 , H05K7/00
CPC分类号： A61B5/6832 , A61B5/0408 , A61B5/04085 , A61B5/04087 , A61B5/0478 , A61B5/6833 , A61B2560/0406 , A61B2560/0468 , Y10T156/10
摘要： An electronic device for long-term adhesion to a mammal includes a housing with an electronic component. There is a first wing and a second wing, each being integrally formed with the housing. An electrode is positioned on a bottom surface of each of the wings, the electrodes electrically connected to the electronic component. An adhesive layer is provided for adhesion to a surface of the mammal. The adhesive layer is coated on a portion of the bottom surfaces of the wings. The adhesive layer is not coated on the electrode or on a bottom surface of the housing. A method of applying an electronic device to a mammal includes removing a first adhesive cover from a first wing of the electronic device to expose an electrode and an adhesive coated on a bottom surface of the first wing. There is a step of placing the exposed electrode into contact with the mammal by adhering the adhesive coated bottom of the first wing to the mammal. There is a step of removing a second adhesive cover from the second wing of the electronic device to expose an adhesive coated on a bottom surface of the second wing and another exposed electrode. There is a step of placing the another exposed electrode into contact with the mammal by adhering the adhesive coated bottom of the second wing to the mammal. After performing the removing and the placing steps, the housing is unattached to the mammal, but is held in position on the mammal using the adhesive coated bottoms of the first and the second wings.
摘要翻译：用于长期粘附到哺乳动物的电子设备包括具有电子部件的壳体。存在第一翼和第二翼，每个翼与壳体一体形成。电极位于每个翼的底表面上，电极电连接到电子部件。提供粘合层用于粘附到哺乳动物的表面。粘合剂层涂覆在翼的底表面的一部分上。粘合剂层未涂覆在电极或壳体的底表面上。将电子设备应用于哺乳动物的方法包括从电子设备的第一翼移除第一粘合剂盖以暴露涂覆在第一翼的底表面上的电极和粘合剂。通过将第一翼的粘合剂涂覆的底部粘附到哺乳动物，存在将暴露的电极与哺乳动物接触的步骤。从电子设备的第二翼移除第二粘合剂盖以暴露涂覆在第二翼的底表面上的粘合剂和另一暴露的电极的步骤。通过将第二翼的粘合剂涂覆的底部粘附到哺乳动物，存在将另一暴露的电极与哺乳动物接触的步骤。在执行去除和放置步骤之后，壳体不附着于哺乳动物，而是使用第一和第二翼的粘合剂涂覆的底部在哺乳动物上保持就位。

10. 发明授权

US08160682B2 Non-invasive cardiac monitor and methods of using continuously recorded cardiac data 有权
标题翻译：非侵入性心脏监测器和使用连续记录的心脏数据的方法
公开(公告)号：US08160682B2
公开(公告)日：2012-04-17
申请号：US11703311
申请日：2007-02-06
申请人： Uday N. Kumar , Joseph A. Knight , Kit Yee Au-Yeung , John Warren White
发明人： Uday N. Kumar , Joseph A. Knight , Kit Yee Au-Yeung , John Warren White
IPC分类号： A61B5/0432
CPC分类号： A61B5/02438 , A61B5/0006 , A61B5/0408 , A61B5/0432 , A61B5/04325 , A61B5/411 , A61B5/6833 , A61B2560/0412 , A61B2560/0468 , G06F19/00 , G16H10/60 , G16H15/00 , G16H40/63
摘要： One embodiment of the invention is a cardiac monitor having a housing; a plurality of electrodes within and extending from the housing; a state machine within the housing configured to digitialize and store in memory signals from the plurality of electrodes; a sealing surface and an adhesive on the sealing surface configured to form a watertight perimeter around the plurality of electrodes when the housing is affixed to a mammal. Another embodiment of the invention provides a continuous cardiac monitor having a housing; a surface on the housing adapted to be sealably engaged to a mammal; an adhesive on the surface that is adapted to remain affixed to the mammal for at least 7 days; at least two electrodes within the housing positioned to detect a cardiac information of the mammal while the surface is sealably engaged to the mammal; an electronic memory within the housing wherein, the electronic memory is sized to store at least 24 hours of continuous cardiac information; and wiring within the housing connecting the electronic memory to the electrodes.
摘要翻译：本发明的一个实施例是具有外壳的心脏监护仪; 在所述壳体内并从所述壳体延伸的多个电极; 所述壳体内的状态机被配置为对来自所述多个电极的存储器信号进行数字化和存储; 所述密封表面和所述密封表面上的粘合剂被构造成当所述壳体固定到哺乳动物时在所述多个电极周围形成水密周界。本发明的另一个实施例提供一种具有壳体的连续心脏监测器; 适于与哺乳动物密封地接合的壳体上的表面; 表面上的粘合剂适于保持固定在哺乳动物上至少7天; 所述壳体内的至少两个电极定位成在所述表面与所述哺乳动物密封地接合时检测哺乳动物的心脏信息; 所述壳体内的电子存储器，其中，所述电子存储器的尺寸设置为存储至少24小时的连续心脏信息; 以及在将电子存储器连接到电极的壳体内的布线。

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