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1. 发明授权

US07927824B2 Complex of a chaperone with β-amyloid and methods employing this complex 有权
标题翻译：伴侣与复合体的复合物 - 淀粉样蛋白和使用该复合物的方法
公开(公告)号：US07927824B2
公开(公告)日：2011-04-19
申请号：US11231065
申请日：2005-09-19
申请人： Jordan L. Holtzman
发明人： Jordan L. Holtzman
IPC分类号： G01N33/532 , G01N33/533 , G01N33/68
CPC分类号： C07K14/4711 , A61K38/00 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： A chaperone protein Q2 and β-amyloid can form a complex. This complex can be detected in a biological sample, such as, for example, tissues or fluids from a mammal. Q2 levels can also be detected in a biological sample. A method for determining the Q2 level in a biological sample and comparing that level to a normal Q2 level can be used to detect, screen, diagnose, or otherwise determine a person's susceptibility to Alzheimer's disease such as, for example, the presence or absence of Alzheimer's disease, of symptoms of this disease, of factors leading to or associated with this disease, of likelihood of developing this disease, and the like. In one embodiment, a decline in Q2 level correlates to an increased likelihood of developing Alzheimer's disease. In another embodiment, a decline in Q2 level correlates to an increase in β-amyloid aggregation. The method may further include screening for an apolipoprotein E genotype, which is associated with Alzheimer's disease.
摘要翻译：分子伴侣蛋白质Q2和β-淀粉样蛋白可以形成复合物。该复合物可以在生物样品中检测，例如来自哺乳动物的组织或液体。也可以在生物样品中检测到Q2水平。用于确定生物样品中Q2水平并将该水平与正常Q2水平进行比较的方法可用于检测，筛选，诊断或以其他方式确定个体对阿尔茨海默病的易感性，例如存在或不存在阿尔茨海默病，该疾病的症状，导致或与该疾病相关的因素，发生该疾病的可能性等。在一个实施方案中，Q2水平的下降与发生阿尔茨海默氏病的可能性增加相关。在另一个实施方案中，Q2水平的下降与淀粉样蛋白聚集的增加相关。该方法还可以包括筛选与阿尔茨海默病有关的载脂蛋白E基因型。

2. 发明申请

US20150177227A1 CELLULAR AND ANIMAL MODELS FOR SCREENING THERAPEUTIC AGENTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于筛选治疗阿尔茨海默病的治疗药物的细胞和动物模型
公开(公告)号：US20150177227A1
公开(公告)日：2015-06-25
申请号：US14414650
申请日：2013-07-15
申请人： Jordan L. HOLTZMAN
发明人： Jordan L. Holtzman
IPC分类号： G01N33/50 , C12N9/10
CPC分类号： G01N33/5073 , C07K2319/60 , C12N9/1048 , G01N33/5023 , G01N33/5058 , G01N33/5088 , G01N33/6896 , G01N2500/10 , G01N2800/2821
摘要： Constructs, models, and methods to assay candidate therapeutic agents to treat Alzheimer's disease are described herein.
摘要翻译：本文描述了用于测定候选治疗剂治疗阿尔茨海默病的构建体，模型和方法。

3. 发明授权

US08211658B2 Complex of a chaperone with β-amyloid and methods employing this complex 有权
标题翻译：伴侣与复合体的复合物 - 淀粉样蛋白和使用该复合物的方法
公开(公告)号：US08211658B2
公开(公告)日：2012-07-03
申请号：US13089940
申请日：2011-04-19
申请人： Jordan L. Holtzman
发明人： Jordan L. Holtzman
IPC分类号： G01N33/68 , A61K35/30
CPC分类号： C07K14/4711 , A61K38/00 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： A chaperone protein Q2 and β-amyloid can form a complex. This complex can be detected in a biological sample, such as, for example, tissues or fluids from a mammal. Q2 levels can also be detected in a biological sample. A method for determining the Q2 level in a biological sample and comparing that level to a normal Q2 level can be used to detect, screen, diagnose, or otherwise determine a person's susceptibility to Alzheimer's disease such as, for example, the presence or absence of Alzheimer's disease, of symptoms of this disease, of factors leading to or associated with this disease, of likelihood of developing this disease, and the like. In one embodiment, a decline in Q2 level correlates to an increased likelihood of developing Alzheimer's disease. In another embodiment, a decline in Q2 level correlates to an increase in β-amyloid aggregation. The method may further include screening for an apolipoprotein E genotype, which is associated with Alzheimer's disease.
摘要翻译：分子伴侣蛋白质Q2和β-淀粉样蛋白可以形成复合物。该复合物可以在生物样品中检测，例如来自哺乳动物的组织或液体。也可以在生物样品中检测到Q2水平。用于确定生物样品中Q2水平并将该水平与正常Q2水平进行比较的方法可用于检测，筛选，诊断或以其他方式确定个体对阿尔茨海默病的易感性，例如存在或不存在阿尔茨海默病，该疾病的症状，导致或与该疾病相关的因素，发生该疾病的可能性等。在一个实施方案中，Q2水平的下降与发生阿尔茨海默氏病的可能性增加相关。在另一个实施方案中，Q2水平的下降与淀粉样蛋白聚集的增加相关。该方法还可以包括筛选与阿尔茨海默病有关的载脂蛋白E基因型。

4. 发明申请

US20110256569A1 COMPLEX OF A CHAPERONE WITH BETA-AMYLOID AND METHODS EMPLOYING THIS COMPLEX 有权
标题翻译：具有β-淀粉样的CHAPERONE的复合物和使用该复合物的方法
公开(公告)号：US20110256569A1
公开(公告)日：2011-10-20
申请号：US13089940
申请日：2011-04-19
申请人： Jordan L. Holtzman
发明人： Jordan L. Holtzman
IPC分类号： C12Q1/26
CPC分类号： C07K14/4711 , A61K38/00 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： A chaperone protein Q2 and β-amyloid can form a complex. This complex can be detected in a biological sample, such as, for example, tissues or fluids from a mammal. Q2 levels can also be detected in a biological sample. A method for determining the Q2 level in a biological sample and comparing that level to a normal Q2 level can be used to detect, screen, diagnose, or otherwise determine a person's susceptibility to Alzheimer's disease such as, for example, the presence or absence of Alzheimer's disease, of symptoms of this disease, of factors leading to or associated with this disease, of likelihood of developing this disease, and the like. In one embodiment, a decline in Q2 level correlates to an increased likelihood of developing Alzheimer's disease. In another embodiment, a decline in Q2 level correlates to an increase in βamyloid aggregation. The method may further include screening for an apolipoprotein E genotype, which is associated with Alzheimer's disease.
摘要翻译：分子伴侣蛋白质Q2和β-淀粉样蛋白可以形成复合物。该复合物可以在生物样品中检测，例如来自哺乳动物的组织或液体。也可以在生物样品中检测到Q2水平。用于确定生物样品中Q2水平并将该水平与正常Q2水平进行比较的方法可用于检测，筛选，诊断或以其他方式确定个体对阿尔茨海默病的易感性，例如存在或不存在阿尔茨海默病，该疾病的症状，导致或与该疾病相关的因素，发生该疾病的可能性等。在一个实施方案中，Q2水平的下降与发生阿尔茨海默氏病的可能性增加相关。在另一个实施方案中，Q2水平的下降与淀粉样蛋白聚集的增加相关。该方法还可以包括筛选与阿尔茨海默病有关的载脂蛋白E基因型。

5. 发明授权

US06972318B1 Complex of a chaperone protein with amyloid 有权
标题翻译：伴侣蛋白与淀粉样蛋白的复合物
公开(公告)号：US06972318B1
公开(公告)日：2005-12-06
申请号：US09830749
申请日：1999-10-29
申请人： Jordan L. Holtzman
发明人： Jordan L. Holtzman
IPC分类号： G01N33/53 , A61K38/00 , A61P25/28 , C07K14/47 , C07K16/46 , C07K19/00 , G01N33/68 , C07K14/435
CPC分类号： C07K14/4711 , A61K38/00 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： A chaperone protein Q2 and β-amyloid can form a complex. This complex can be detected in a biological sample, such as, for example, tissues or fluids from a mammal. Q2 levels can also be detected in a biological sample. A method for detecting the Q2 level is a biological sample and comparing that level to a normal Q2 level can be used to detect, screen, diagnose, or otherwise determine a person's susceptibility to Alzheimer's disease such as, for example, the presence or absence of Alzheimer's disease, of symptoms of this disease, of factors leading to or associated with this disease, of likelihood of developing this disease, and the like. In one embodiment, a decline in Q2 level correlates to an increased likelihood for developing Alzheimer's disease. In another embodiment, a decline in Q2 level correlates to an increase in β-amyloid aggregation. The method may further include screening for an apolipoprotein E genetype, which is associated with Alzheimer's disease.
摘要翻译：伴侣蛋白Q2和β-淀粉样蛋白可以形成复合物。该复合物可以在生物样品中检测，例如来自哺乳动物的组织或液体。也可以在生物样品中检测到Q2水平。用于检测Q2水平的方法是生物样品，并且将该水平与正常的Q2水平进行比较可用于检测，筛选，诊断或以其他方式确定人对阿尔茨海默病的易感性，例如，存在或不存在阿尔茨海默病，该疾病的症状，导致或与该疾病相关的因素，发生该疾病的可能性等。在一个实施方案中，Q2水平的下降与增加发生阿尔茨海默氏病的可能性相关。在另一个实施方案中，Q2水平的下降与β-淀粉样蛋白聚集的增加相关。该方法还可以包括筛选与阿尔茨海默氏病有关的载脂蛋白E基因型。

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