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1. 发明申请

US20100272692A1 ANTICANCER COMPOSITION COMPRISING PLANT STEM CELL LINE DERIVED FROM TAXUS CAMBIUM OR PROCAMBIUM 审中-公开
标题翻译：包含从TAXUS CAMBIUM或PROCAMBIUM衍生的植物干细胞系的抗体组合物
公开(公告)号：US20100272692A1
公开(公告)日：2010-10-28
申请号：US12682574
申请日：2008-10-10
申请人： Joong Hyun Park , Min Jung Lim , Il Seok Oh , Dae Hee Lee , Jung Chang Lee , Eun Kyong Lee , Young Woo Jin
发明人： Joong Hyun Park , Min Jung Lim , Il Seok Oh , Dae Hee Lee , Jung Chang Lee , Eun Kyong Lee , Young Woo Jin
IPC分类号： A61K35/00 , A61K36/13 , A61P35/00
CPC分类号： A61K36/13
摘要： The present invention relates to a composition for preventing or treating cancer, which contains, as an active ingredient, a Taxus cambium- or procambium-derived cell line; a lysate thereof; an extract thereof; or a culture medium thereof. The cell line, the lysate, the extract, and the culture medium has minimized side effects compared to the conventional therapeutic drugs, is safe to the human body, is involved directly in the growth of cancer to induce cancer cell death, and shows anticancer activity of inhibiting angiogenesis occurring in carcinogenesis. Accordingly, the cell line, the lysate, the extract and the culture medium is useful for the prevention, treatment and alleviation of cancer.
摘要翻译：本发明涉及一种用于预防或治疗癌症的组合物，其含有作为有效成分的红豆杉形成层或原生动物来源的细胞系; 其裂解物; 其提取物; 或其培养基。细胞系，裂解物，提取物和培养基与常规治疗药物相比具有最小化的副作用，对人体是安全的，直接参与癌症的生长以诱导癌细胞死亡，并且显示抗癌活性抑制致癌作用中发生的血管生成。因此，细胞系，裂解物，提取物和培养基可用于预防，治疗和缓解癌症。

2. 发明申请

US20110097310A1 ANTI-AGING OR ANTIOXIDANT COMPOSITION CONTAINING PLANT STEM CELL LINE DERIVED FROM CAMBIUM OF PANAX GINSENG 审中-公开
标题翻译：含有PANAX GINSENG CAMBIUM的植物干细胞系的抗衰老或抗氧化剂组合物
公开(公告)号：US20110097310A1
公开(公告)日：2011-04-28
申请号：US12997858
申请日：2009-06-12
申请人： Mi Ok Jang , Min Jung Lim , Il Seok Oh , Dae Hee Lee , Eun Kyong Lee , Young Woo Jin
发明人： Mi Ok Jang , Min Jung Lim , Il Seok Oh , Dae Hee Lee , Eun Kyong Lee , Young Woo Jin
IPC分类号： A61K36/25 , C12N5/04 , A61P17/00
CPC分类号： A61K8/97 , A61K2800/522 , A61Q19/004 , A61Q19/08
摘要： The present invention relates to an anti-aging or antioxidant composition which contains, as an active ingredient, a plant stem cell line derived from the cambium of Panax ginseng, including wild ginseng and ginseng, or an extract thereof, a lysate thereof and a culture thereof. The composition has minimized side effects compared to existing anti-aging agents and antioxidants, and thus is safe for the skin. Also, the composition of the present invention shows an antioxidant effect of inhibiting reactive oxygen species caused by exposure to UV radiation that is the major cause of skin aging, and it can effectively reduce or inhibit aging-related factors. Thus, the composition is useful for the prevention and inhibition of aging.
摘要翻译：本发明涉及一种抗老化或抗氧化剂组合物，其含有源自人参人参和人参的形成层的植物干细胞系作为活性成分，或其提取物，其裂解物和培养物其中。与现有的抗老化剂和抗氧化剂相比，该组合物具有最小的副作用，因此对于皮肤是安全的。此外，本发明的组合物显示出由于暴露于作为皮肤老化的主要原因的紫外线辐射引起的活性氧的抑制作用，并且可以有效地降低或抑制与老化有关的因素。因此，该组合物可用于预防和抑制老化。

3. 发明申请

US20120189660A1 Composition for Preventing or Treating Liver Diseases, Containing Plant Stem Cell Lines Derived from the Cambium of Panax Ginseng Including Mountain Ginseng or Ginseng as Active Ingredient 审中-公开
标题翻译：用于预防或治疗肝病的组合物，含有人参或人参作为活性成分的人参合成植物干细胞系
公开(公告)号：US20120189660A1
公开(公告)日：2012-07-26
申请号：US13058949
申请日：2009-08-14
申请人： Young Woo Jin , Eun Kyong Lee , Min Jung Lim
发明人： Young Woo Jin , Eun Kyong Lee , Min Jung Lim
IPC分类号： A61K36/258 , A61P31/14 , A61P1/16 , A61P37/04 , C12N5/04
CPC分类号： A61K36/258 , A01H4/005 , A23L33/105 , A61K36/25 , C12N5/04
摘要： The present invention relates to a composition for preventing or treating liver diseases, which contains, as an active ingredient, any one or more of a homogeneous cell line derived from the cambium of Panax ginseng, including wild ginseng or ginseng, a lysate thereof, an extract thereof and a culture medium thereof. The homogeneous cell line according to the present invention, a lysate thereof, an extract thereof and a culture medium thereof have minimized side effects compared to existing agents for treating liver diseases, and thus are safe for the human body. Also, they can increase the levels of s-antibody (HBsAb) and e-antibody (HBeAb) against hepatitis virus and inhibit the proliferation of hepatitis virus, and thus they are useful for the prevention and treatment of liver diseases. In addition, they have the effect of lowering the levels of liver injury, and thus are useful as a functional food for improving liver function.
摘要翻译：本发明涉及一种预防或治疗肝病的组合物，其含有源自人参的人参或人参的形成层的均质细胞系中的任何一种或多种作为活性成分，其裂解物，提取物及其培养基。根据本发明的均相细胞系，其裂解物，其提取物和培养基与现有用于治疗肝脏疾病的药剂相比具有最小的副作用，因此对人体是安全的。此外，它们可以增加针对肝炎病毒的s-抗体（HBsAb）和e-抗体（HBeAb）的水平，并抑制肝炎病毒的增殖，从而可用于预防和治疗肝脏疾病。此外，它们具有降低肝损伤水平的作用，因此可用作改善肝功能的功能性食物。

4. 发明授权

US08617621B2 Composition for enhancing immunity containing plant stem cell line derived from cambium of Panax ginseng including wild ginseng or ginseng as an active ingredient 有权
标题翻译：用于增强免疫力的组合物，其含有来源于人参的形态层的植物干细胞系，包括野山参或人参作为活性成分
公开(公告)号：US08617621B2
公开(公告)日：2013-12-31
申请号：US13202868
申请日：2010-02-23
申请人： Min Jung Lim , Young Woo Jin , Eun Kyong Lee
发明人： Min Jung Lim , Young Woo Jin , Eun Kyong Lee
IPC分类号： A61K36/00 , A61K36/25 , A61K39/00 , A61K45/00 , C12N5/00
CPC分类号： A61K36/258 , A01H4/005 , A23L33/105 , A23V2002/00 , C12N5/04 , A23V2200/324 , A23V2250/2124
摘要： The present invention relates to a composition for enhancing immunity, comprising one or more of the following: a homogenous cell line, and a lysate, an extract and a culture medium thereof as an active ingredient. The homogenous cell line, the lysate, the extract and the culture thereof according to the present invention, which are derived from a natural product, minimize adverse side effects of prior immune enhancing agents and safe for the human body. Further, they effectively increase the activity of NK cells responsible for innate immunity, as well as increase the proliferation rate of lymph node cells when the cells were re-exposed to an antigen in a specific immune reaction to enhance acquired immunity, and thus are useful as an immune enhancing agent. In particular, the homogenous cell line, the lysate, the extract, and the culture thereof according to the present invention also effectively increase the number of hone marrow cells, thus are not only used as an adjuvant in an immune reaction, but also used in the prevention and treatment of anemia through hematopoiesis.
摘要翻译：本发明涉及一种用于增强免疫力的组合物，其包含以下一种或多种：均质细胞系，其裂解物，提取物和培养基作为活性成分。衍生自天然产物的根据本发明的均质细胞系，裂解物，提取物及其培养物使先前的免疫增强剂的不良副作用最小化并且对人体而言是安全的。此外，它们有效地增加负责先天免疫的NK细胞的活性，并且当细胞在特异性免疫反应中再次暴露于抗原以增强获得性免疫时增加淋巴结细胞的增殖率，因此是有用的作为免疫增强剂。特别是根据本发明的均质细胞系，裂解物，提取物及其培养物也有效地增加了骨髓细胞的数量，因此不仅用作免疫反应中的佐剂，而且还用于通过造血预防和治疗贫血。

5. 发明申请

US20120039918A1 Composition for Enhancing Immunity Containing Plant Stem Cell Line Derived from Cambium of Panax Ginseng Including Wild Ginseng or Ginseng as an Active Ingredient 有权
标题翻译：含有人参或人参作为活性成分的人参成膜植物干细胞系免疫的组合物
公开(公告)号：US20120039918A1
公开(公告)日：2012-02-16
申请号：US13202868
申请日：2010-02-23
申请人： Min Jung Lim , Young Woo Jin , Eun Kyong Lee
发明人： Min Jung Lim , Young Woo Jin , Eun Kyong Lee
IPC分类号： A61K36/258 , A61P37/04 , A61P7/06 , C12N5/04
CPC分类号： A61K36/258 , A01H4/005 , A23L33/105 , A23V2002/00 , C12N5/04 , A23V2200/324 , A23V2250/2124
摘要： The present invention relates to a composition for enhancing immunity, comprising one or more of the following: a homogenous cell line, and a lysate, an extract and a culture medium thereof as an active ingredient. The homogenous cell line, the lysate, the extract and the culture thereof according to the present invention, which are derived from a natural product, minimize adverse side effects of prior immune enhancing agents and safe for the human body. Further, they effectively increase the activity of NK cells responsible for innate immunity, as well as increase the proliferation rate of lymph node cells when the cells were re-exposed to an antigen in a specific immune reaction to enhance acquired immunity, and thus are useful as an immune enhancing agent. In particular, the homogenous cell line, the lysate, the extract, and the culture thereof according to the present invention also effectively increase the number of hone marrow cells, thus are not only used as an adjuvant in an immune reaction, but also used in the prevention and treatment of anemia through hematopoiesis.
摘要翻译：本发明涉及一种用于增强免疫力的组合物，其包含以下一种或多种：均质细胞系，其裂解物，提取物和培养基作为活性成分。衍生自天然产物的根据本发明的均质细胞系，裂解物，提取物及其培养物使先前的免疫增强剂的不良副作用最小化并且对人体而言是安全的。此外，它们有效地增加负责先天免疫的NK细胞的活性，并且当细胞在特异性免疫反应中再次暴露于抗原以增强获得性免疫时增加淋巴结细胞的增殖速率，因此是有用的作为免疫增强剂。特别是根据本发明的均质细胞系，裂解物，提取物及其培养物也有效地增加了骨髓细胞的数量，因此不仅用作免疫反应中的佐剂，而且还用于通过造血预防和治疗贫血。

6. 发明授权

US09585923B2 Antioxidant, anti-inflammatory or anti-aging composition containing taxus cambium- or procambium-derived cell line as active ingredient 有权
标题翻译：抗氧化剂，抗炎或抗衰老组合物，其含有形成层或原生殖细胞源的细胞系作为活性成分
公开(公告)号：US09585923B2
公开(公告)日：2017-03-07
申请号：US12992810
申请日：2009-05-14
申请人： Dae Hee Lee , Eun Kyong Lee , Eun Mi So , Young Woo Jin
发明人： Dae Hee Lee , Eun Kyong Lee , Eun Mi So , Young Woo Jin
IPC分类号： A61K36/00 , A61K36/13 , A61K8/97 , A61Q19/02 , A61Q19/08
CPC分类号： A61K36/13 , A61K8/97 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to an antioxidant, anti-inflammatory or anti-aging composition containing any one or more of a Taxus cambium- or procambium-derived cell line, an extract thereof, a lysate thereof and a culture medium thereof. The composition according to the present invention has minimized side effects compared to existing antioxidants and anti-inflammatory agents, is involved in intracellular metabolism to reduce intracellular reactive oxygen species, and reduces and induces aging-related signals. Thus, the composition of the preset invention is useful for preventing and delaying aging. In addition, the composition of the present invention has the effect of inhibiting melanogenesis, and thus is useful as a whitening cosmetic composition.
摘要翻译：本发明涉及一种抗氧化剂，抗炎或抗衰老组合物，其中含有一种或多种紫杉形成层或原生动物来源的细胞系，其提取物，其裂解物及其培养基。根据本发明的组合物与现有抗氧化剂和抗炎剂相比具有最小化的副作用，涉及细胞内代谢以减少细胞内活性氧，并减少并诱导老化相关信号。因此，本发明的组合物可用于防止和延缓老化。此外，本发明的组合物具有抑制黑素生成的作用，因此可用作美白化妆品组合物。

7. 发明申请

US20110117039A1 ANTIOXIDANT, ANTI-INFLAMMATORY OR ANTI-AGING COMPOSITION CONTAINING TAXUS CAMBIUM- OR PROCAMBIUM-DERIVED CELL LINE AS ACTIVE INGREDIENT 有权
标题翻译：抗氧化剂，含有紫杉醇或衍生细胞细胞系作为活性成分的抗炎剂或抗生素组合物
公开(公告)号：US20110117039A1
公开(公告)日：2011-05-19
申请号：US12992810
申请日：2009-05-14
申请人： Dae Hee Lee , Eun Kyong Lee , Eun Mi So , Young Woo Jin
发明人： Dae Hee Lee , Eun Kyong Lee , Eun Mi So , Young Woo Jin
IPC分类号： A61K8/97 , A61K36/13 , C12N5/04 , C12N5/02 , A61P29/00 , A61P39/06 , A61Q19/02 , A61Q19/08
CPC分类号： A61K36/13 , A61K8/97 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to an antioxidant, anti-inflammatory or anti-aging composition containing any one or more of a Taxus cambium- or procambium-derived cell line, an extract thereof, a lysate thereof and a culture medium thereof. The composition according to the present invention has minimized side effects compared to existing antioxidants and anti-inflammatory agents, is involved in intracellular metabolism to reduce intracellular reactive oxygen species, and reduces and induces aging-related signals. Thus, the composition of the preset invention is useful for preventing and delaying aging. In addition, the composition of the present invention has the effect of inhibiting melanogenesis, and thus is useful as a whitening cosmetic composition.
摘要翻译：本发明涉及一种抗氧化剂，抗炎或抗衰老组合物，其中含有一种或多种紫杉形成层或原生动物来源的细胞系，其提取物，其裂解物及其培养基。根据本发明的组合物与现有抗氧化剂和抗炎剂相比具有最小化的副作用，涉及细胞内代谢以减少细胞内活性氧，并减少并诱导老化相关信号。因此，本发明的组合物可用于防止和延缓老化。此外，本发明的组合物具有抑制黑素生成的作用，因此可用作美白化妆品组合物。

8. 发明申请

US20130137178A1 Plant Stem Cell Line Derived from Cambium of Herbaceous Plant with Storage Root and Method for Isolating the Same 审中-公开
标题翻译：植物干细胞系源自草本植物与存根的形成和分离方法
公开(公告)号：US20130137178A1
公开(公告)日：2013-05-30
申请号：US13551207
申请日：2012-07-17
申请人： Mi Ok Jang , Eun Kyong Lee , Young Woo Jin
发明人： Mi Ok Jang , Eun Kyong Lee , Young Woo Jin
IPC分类号： C12N5/04
CPC分类号： C12N5/04
摘要： The present invention relates to a cell line derived from the cambium of an herbaceous plant having a storage root and a method for isolating the same. More specifically, relates to a cambium-derived homogeneous cell line having the ability to divide, which is obtained from the cambium-containing storage tissue of an herbaceous plant having a storage root without a separate dedifferentiation process, and to a method for isolating the same. The cell line derived from the cambium of an herbaceous plant having a storage root has an active division ability and is homogeneous. Also, it is stable during culture, because it has not undergone a dedifferentiation process. Thus, through the optimization of proliferation thereof, the cell line can be allowed to proliferate in a large amount within a short time.
摘要翻译：本发明涉及源自具有贮藏根的草本植物的形成层的细胞系及其分离方法。更具体地说，涉及具有分割能力的形成层的均质细胞系，其具有不具有分离去分化方法的具有储存根的草本植物的含有形成层的存储组织，以及其分离方法。源自具有储存根的草本植物的形成层的细胞系具有活性分裂能力并且是均匀的。此外，它在培养期间是稳定的，因为它没有经历去分化过程。因此，通过优化其增殖，可以在短时间内允许细胞系大量增殖。

9. 发明申请

US20100255585A1 PLANT STEM CELL LINE DERIVED FROM QUIESCENT CENTER AND METHOD FOR ISOLATING THE SAME 审中-公开
标题翻译：从QUIESCENT中心衍生的植物干细胞系及其分离方法
公开(公告)号：US20100255585A1
公开(公告)日：2010-10-07
申请号：US12679263
申请日：2008-09-22
申请人： Young-Mi Yu , Eun Kyong Lee , Sun Mi Hong , Young Woo Jin
发明人： Young-Mi Yu , Eun Kyong Lee , Sun Mi Hong , Young Woo Jin
IPC分类号： C12N5/04 , C12N5/02
CPC分类号： C12N5/04
摘要： The present invention relates to a cell line derived from the quiescent center of a plant and a method for isolating the same, more specifically, relates to a quiescent center-derived homogeneous cell line of single-cell origin, which is obtained from the quiescent center of a plant without needing a separate de-differentiation process, and a method for isolating the same.
摘要翻译：本发明涉及从植物的静止中心衍生的细胞系及其分离方法，更具体地涉及从静止中心获得的单细胞来源的静态中心衍生的均质细胞系的植物，而不需要单独的去分化过程，以及用于分离其的方法。

10. 发明授权

US08247230B2 Plant stem cell line derived from cambium of herbaceous plant with storage root and method for isolating the same 有权
标题翻译：源自草本植物形成层的植物干细胞系与储存根和分离相同的方法
公开(公告)号：US08247230B2
公开(公告)日：2012-08-21
申请号：US12679269
申请日：2008-09-22
申请人： Mi Ok Jang , Eun Kyong Lee , Young Woo Jin
发明人： Mi Ok Jang , Eun Kyong Lee , Young Woo Jin
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/04
摘要： The present invention relates to a cell line derived from the cambium of an herbaceous plant having a storage root and a method for isolating the same. More specifically, relates to a cambium-derived homogeneous cell line having the ability to divide, which is obtained from the cambium-containing storage tissue of an herbaceous plant having a storage root without a separate dedifferentiation process, and to a method for isolating the same. The cell line derived from the cambium of an herbaceous plant having a storage root has active division ability and is homogeneous. Also, it is stable during culture, because it has not undergone a dedifferentiation process. Thus, through the optimization of proliferation thereof, the cell line can be allowed to proliferate in a large amount within a short time. Accordingly, the cell line derived from the cambium of an herbaceous plant having a storage root makes it possible to produce large amounts of useful plants which are difficult to cultivate outdoor due to various problems associated with the period of cultivation, the selection of cultivation land, cultivation cost and the like.
摘要翻译：本发明涉及源自具有贮藏根的草本植物的形成层的细胞系及其分离方法。更具体地说，涉及具有分割能力的形成层的均质细胞系，其是从没有分离去分化方法的具有储存根的草本植物的含有形成层的储存组织获得的，以及其分离方法。源自具有储存根的草本植物的形成层的细胞系具有活性分裂能力并且是均匀的。此外，它在培养期间是稳定的，因为它没有经历去分化过程。因此，通过优化其增殖，可以在短时间内允许细胞系大量增殖。因此，从具有储藏根的草本植物的形成层衍生的细胞系，由于与栽培期间，种植面积的选择有关的各种问题，可能产生大量难以栽培的有用植物，栽培成本等。

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