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1. 发明授权

US09135397B2 System and method for enabling therapeutic delivery of aerosolized medicament to a plurality of subjects to be monitored 有权
标题翻译：用于使雾化药物能够治疗性递送至待监测的多个受治疗者的系统和方法
公开(公告)号：US09135397B2
公开(公告)日：2015-09-15
申请号：US13384791
申请日：2010-07-12
申请人： Jonathan S. H. Denyer , Michael James Robbert Leppard , Ian Philip Rabbetts , Anthony Dyche
发明人： Jonathan S. H. Denyer , Michael James Robbert Leppard , Ian Philip Rabbetts , Anthony Dyche
IPC分类号： A61M16/10 , G06F19/00
CPC分类号： G06F19/3418 , G06F19/00
摘要： A server is configured to be communicatively linked with drug delivery devices used by a plurality of different subjects to receive aerosolized medicament as part of a therapy regime. The server provides a user with a user interface that enables the user to access therapy information related to the therapy of a plurality of different subjects. This may facilitate the monitoring of therapy received by the plurality of subjects.
摘要翻译：服务器被配置为与由多个不同主体使用的药物递送装置通信地链接，以接收作为治疗方案的一部分的雾化药物。服务器为用户提供使用户能够访问与多个不同主题的治疗有关的治疗信息的用户界面。这可以有助于监测由多个受试者接受的治疗。

2. 发明申请

US20120143073A1 SYSTEM AND METHOD OF REMOTELY MONITORING AND/OR MANAGING THE TREATMENT OF A PLURALITY OF SUBJECTS WITH AEROSOLIZED MEDICAMENT 审中-公开
标题翻译：远程监测和/或管理用放射化药物处理多个物种的系统和方法
公开(公告)号：US20120143073A1
公开(公告)日：2012-06-07
申请号：US13390215
申请日：2010-07-13
申请人： Jonathan S. H. Denyer , Anthony Dyche , Ivan Richard Prince
发明人： Jonathan S. H. Denyer , Anthony Dyche , Ivan Richard Prince
IPC分类号： A61B5/091 , A61M11/00
CPC分类号： A61M11/00 , A61B5/0002 , A61B5/0871 , A61B5/091 , A61B5/743 , A61B5/744 , A61B5/746 , A61M15/009 , A61M2016/0039 , A61M2202/064 , A61M2205/18 , A61M2205/3561 , A61M2205/3584 , A61M2205/502 , G06F19/00 , G06F19/3462
摘要： Therapy regimes of a plurality of subjects are remotely monitored and/or managed, wherein the therapy regimes include reception of aerosolized medicament. This enables users such as medical care providers, researchers, clinic administrators, and/or other users to monitor and/or manage the therapy regimes of the plurality of subjects through a centralized access point. This reduces physical requirements of proximity for the users and/or the subjects, alleviates the administrative the burden placed on the users to manage and/or monitor individual therapy regimes, and/or provides other enhancements over convention systems.
摘要翻译：远程监测和/或管理多个受试者的治疗方案，其中治疗方案包括雾化药物的接收。这使得诸如医疗保健提供者，研究人员，诊所管理员和/或其他用户之类的用户能够通过集中接入点监视和/或管理多个受试者的治疗方案。这减少了用户和/或对象的接近度的物理需求，减轻了管理对用户管理和/或监视单独的治疗方案的负担，和/或提供了比常规系统更多的增强。

3. 发明授权

US10130779B2 System and method of remotely monitoring and/or managing the treatment of a plurality of subjects with aerosolized medicament 有权
公开(公告)号：US10130779B2
公开(公告)日：2018-11-20
申请号：US13390215
申请日：2010-07-13
申请人： Jonathan S. H. Denyer , Anthony Dyche , Ivan Richard Prince
发明人： Jonathan S. H. Denyer , Anthony Dyche , Ivan Richard Prince
IPC分类号： A61B5/08 , A61M11/00 , A61B5/087 , A61M15/00 , G06F19/00 , A61B5/00 , A61B5/091 , A61M16/00
摘要： Therapy regimes of a plurality of subjects are remotely monitored and/or managed, wherein the therapy regimes include reception of aerosolized medicament. This enables users such as medical care providers, researchers, clinic administrators, and/or other users to monitor and/or manage the therapy regimes of the plurality of subjects through a centralized access point. This reduces physical requirements of proximity for the users and/or the subjects, alleviates the administrative the burden placed on the users to manage and/or monitor individual therapy regimes, and/or provides other enhancements over convention systems.

4. 发明授权

US08607786B2 Inhalation method and apparatus 有权
标题翻译：吸入方法和装置
公开(公告)号：US08607786B2
公开(公告)日：2013-12-17
申请号：US10535867
申请日：2003-11-20
申请人： Jonathan S. H. Denyer , Ivan R. Prince , Anthony Dyche
发明人： Jonathan S. H. Denyer , Ivan R. Prince , Anthony Dyche
IPC分类号： A61M16/00 , A61M15/00 , B05D7/14 , B65D83/06
CPC分类号： A61M15/00 , A61M15/0085 , A61M2016/0039 , A61M2205/50 , A61M2205/581 , A61M2205/582
摘要： A drug delivery apparatus of the type which releases a drug in aerosolized form into the inhaled airstream of a person, programmed to release the drug in a pulse which ends a pre-set time before the person is expected to stop inhaling. In doing so, a minimum residence time within the lungs is created, and drug treatment time can be reduced. A corresponding method of controlling a drug delivery apparatus comprises the step of controlling the apparatus to release the drug in aerosolized form into the inhaled airstream of a person in a pulse which ends a pre-set time before the person is expected to stop inhaling.
摘要翻译：一种将药物以雾化形式释放到人的吸入气流中的药物递送装置，其被编程为在人预期停止吸入之前结束预设时间的脉冲中释放药物。在这样做时，产生肺内最小停留时间，并且可以减少药物治疗时间。控制药物递送装置的相应方法包括以下步骤：控制该装置以将气雾剂形式的药物释放到患者预期停止吸入之前结束预设时间的人的吸入气流中。

5. 发明授权

US08261738B2 Apparatus and method for maintaining consistency for aerosol drug delivery treatments 有权
标题翻译：用于保持气溶胶药物递送处理的一致性的装置和方法
公开(公告)号：US08261738B2
公开(公告)日：2012-09-11
申请号：US12175486
申请日：2008-07-18
申请人： Jonathan S. H. Denyer , Ivan R. Prince , Anthony Dyche
发明人： Jonathan S. H. Denyer , Ivan R. Prince , Anthony Dyche
IPC分类号： A61M15/00
CPC分类号： A61M11/005 , A61M15/0085 , A61M2016/0039 , A61M2202/0468 , A61M2205/502 , A61M2205/52 , A61M2230/40 , A61M2230/005
摘要： An aerosol drug delivery apparatus is provided. The apparatus may include a reservoir constructed to contain a predetermined dose of a liquid drug, an aerosol generator in communication with the reservoir, and a power source arranged to deliver power to the aerosol generator in order to produce an aerosolized form of the dose that can be administered to a patient. The apparatus may maintain consistent aerosol drug delivery treatments, for example, by way of a breath measuring mechanism that monitors the patient's breathing pattern during the administration of the dose and a controller configured to vary the power level at which the power source during the administration of the dose based on the monitored breathing pattern.
摘要翻译：提供了一种气溶胶药物输送装置。该装置可以包括构造成容纳预定剂量的液体药物的储存器，与储存器连通的气溶胶发生器，以及布置成将动力输送到气溶胶发生器以产生雾化形式的剂量的电源，该剂量可以给予患者。该装置可以保持一致的气溶胶药物递送处理，例如通过呼吸测量机构，其在施用剂量期间监测患者的呼吸模式，以及控制器，其被配置为改变在给药期间电源的功率水平基于监测呼吸模式的剂量。

6. 发明授权

US08608090B2 Nebulizer metering chamber 有权
公开(公告)号：US08608090B2
公开(公告)日：2013-12-17
申请号：US10185365
申请日：2002-06-26
申请人： Jonathan S. H. Denyer , Anthony Dyche
发明人： Jonathan S. H. Denyer , Anthony Dyche
IPC分类号： B05B1/08
CPC分类号： A61M11/00 , A61M11/005 , A61M15/0065 , A61M15/0085 , A61M15/02 , A61M2205/3386
摘要： A nebulizer includes nebulization device for nebulizing a substance and a reservoir having a metering chamber arranged so as to feed a substance to be nebulized to the nebulization device and a second chamber arranged to hold and retain any of this substance in excess of the volume held in the metering chamber.

7. 发明授权

US08875697B2 Drug delivery apparatus and method 有权
标题翻译：药物输送装置及方法
公开(公告)号：US08875697B2
公开(公告)日：2014-11-04
申请号：US12176582
申请日：2008-07-21
申请人： Jonathan S. H. Denyer , Ivan R. Prince , Ian Rabbetts
发明人： Jonathan S. H. Denyer , Ivan R. Prince , Ian Rabbetts
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00 , B05B17/06 , B05D7/14 , B65D83/06
CPC分类号： A61M15/00 , A61M15/002 , A61M15/0021 , A61M15/0085 , A61M2016/0036 , A61M2202/04 , A61M2205/502
摘要： A drug delivery apparatus includes a mouthpiece portion having an internal conduit for delivering an aerosol including the drug to the patient. The internal conduit has an inlet end and a mouthpiece end that is structured to be received in the patient's mouth. The mouthpiece portion is structured to operate at a substantially fixed inhalation flow rate when the patient inhales through the mouthpiece end. The apparatus further includes an aerosol generator for generating the aerosol from a drug supply and injecting the aerosol into a first region within the mouthpiece portion located between an outlet of the aerosol generator and the inlet end of the conduit. The mouthpiece portion also includes a flow accelerating mechanism that causes a localized flow rate at the first region to be greater than the inhalation flow rate. A method is also provided that increases the local flow rate within the mouthpiece portion.
摘要翻译：药物输送装置包括具有用于将包括药物的气溶胶输送给患者的内部导管的接口部分。内部导管具有入口端和接口端，其被构造成容纳在患者口中。接口部分构造成当患者通过接口端吸入时以基本上固定的吸入流速操作。该装置还包括气溶胶发生器，其用于从药物供应产生气溶胶并将气雾剂喷射到位于气溶胶发生器的出口与导管的入口端之间的接口部分内的第一区域中。接口部分还包括使第一区域的局部流量大于吸入流量的流动加速机构。还提供了增加接口部分内局部流速的方法。

8. 发明授权

US07748382B2 Inhalation method and apparatus 有权
标题翻译：吸入方法和装置
公开(公告)号：US07748382B2
公开(公告)日：2010-07-06
申请号：US10535597
申请日：2003-11-20
申请人： Jonathan S. H. Denyer , Ivan R. Prince
发明人： Jonathan S. H. Denyer , Ivan R. Prince
IPC分类号： F16K31/02
CPC分类号： A61M15/0085 , A61M15/002 , A61M2016/0021 , A61M2205/3375 , A61M2205/3386 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/587
摘要： Signals may be generated in a drug delivering apparatus through which a person inhales to generate a inhaled airstream to signal to the person to cease inhalation after a pre-set period of time has elapsed from detection of the commencement breathing by that person. The pre-set period of time for subsequent inhalations is adjusted depending on the time the person takes to stop inhaling after being signalled.
摘要翻译：信号可以在药物递送装置中产生，通过该药物输送装置吸入人造成吸入气流，以在从该人的开始呼吸的检测经过预设时间后停止吸入。随后吸入的预设时间段根据人员在发出信号后停止吸气的时间进行调整。

9. 发明授权

US08371299B2 Ventilator aerosol delivery 有权
标题翻译：呼吸机气雾剂输送
公开(公告)号：US08371299B2
公开(公告)日：2013-02-12
申请号：US12100487
申请日：2008-04-10
申请人： Jonathan S. H. Denyer , Ivan R. Prince
发明人： Jonathan S. H. Denyer , Ivan R. Prince
IPC分类号： A62B7/00
CPC分类号： A61M16/14 , A61M11/005 , A61M2016/0027 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2230/202 , A61M2230/205 , A61M2230/42 , A61M2230/46
摘要： The delivery of a medicament to a mechanically ventilated patient may include the steps of delivering a respiratory maneuver to such a patient, monitoring the physiological effects of the respiratory maneuver on such patient, automatically establishing an adjustment to the respiratory maneuver in response to the monitored physiological effects, and delivering the adjusted respiratory maneuver to such a patient.
摘要翻译：将药物递送到机械通气的患者可以包括以下步骤：向这样的患者输送呼吸机动，监测对该患者的呼吸机动的生理作用，响应于监测的生理学自动建立对呼吸机动的调节效果，并将调整后的呼吸运动递送给这样的患者。

10. 发明申请

US20080257337A1 Ventilator Aerosol Delivery 有权
标题翻译：呼吸机气雾剂送货
公开(公告)号：US20080257337A1
公开(公告)日：2008-10-23
申请号：US12100487
申请日：2008-04-10
申请人： Jonathan S. H. Denyer , Ivan R. Prince
发明人： Jonathan S. H. Denyer , Ivan R. Prince
IPC分类号： A61M16/10 , A61M11/00 , A61B5/091
CPC分类号： A61M16/14 , A61M11/005 , A61M2016/0027 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2230/202 , A61M2230/205 , A61M2230/42 , A61M2230/46
摘要： A method for delivering a medicament to a mechanically ventilated patient receiving a flow of breathing gas comprises delivering a respiratory maneuver to such a patient, monitoring the physiological effects of the respiratory maneuver on such patient, automatically establishing an optimized respiratory maneuver in response to the monitored physiological effects, and delivering the optimized respiratory maneuver to such a patient. A system for delivering an aerosolized medicament to a ventilated patient is also provided.
摘要翻译：将药物递送到接受呼吸气体流动的机械通气患者的方法包括向这样的患者输送呼吸机动，监测对该患者的呼吸机动的生理作用，响应所监视的自动建立最佳呼吸机动生理效应，并将优化的呼吸机动力递送给这样的患者。还提供了一种用于将气雾化药物递送到通气患者的系统。

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