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1. 发明授权

US06599921B2 Non-steroidal estrogen receptor ligands 有权
公开(公告)号：US06599921B2
公开(公告)日：2003-07-29
申请号：US09934254
申请日：2001-08-21
申请人： Jonathan Martin Schmidt , Julie Mercure , Jeffry Lawrence Lowell , Stefan Kwiatkowski , Krzysztof Pupek , Shuguang Zhu , John Whelan , Natalie Lazarowych
发明人： Jonathan Martin Schmidt , Julie Mercure , Jeffry Lawrence Lowell , Stefan Kwiatkowski , Krzysztof Pupek , Shuguang Zhu , John Whelan , Natalie Lazarowych
IPC分类号： A61K31445
CPC分类号： C07D295/088 , C07D311/80
摘要： Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor related disease states. The compounds specified are tetra-cyclic derivatives and have been shown to be antiproliferative against human estrogen-dependent cancer cells and to have good binding affinity for the estrogen receptor.

2. 发明授权

US06632835B2 Dibenzo[c]chromen-6-one derivatives as anti-cancer agents 失效
标题翻译：二苯并[c]色烯-6-酮衍生物作为抗癌剂
公开(公告)号：US06632835B2
公开(公告)日：2003-10-14
申请号：US09934086
申请日：2001-08-21
申请人： Jonathan Martin Schmidt , Peter Redden , Julie Mercure , Shuguang Zhu , John Whelan , Natalie Lazarowych
发明人： Jonathan Martin Schmidt , Peter Redden , Julie Mercure , Shuguang Zhu , John Whelan , Natalie Lazarowych
IPC分类号： A61K3135
CPC分类号： C07D407/04 , Y10S977/911 , Y10S977/912
摘要： Molecules demonstrating anti-proliferative effects against epithelial cancer cell lines and endothelial cells and methods of synthesis are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of cancer through either anti-angiogenesis or other anti-cancer mechanisms. The compounds specified are 6H-dibenzo[b,d]pyran-6-one derivatives and have been shown to be antiproliferative against human endothelial cells.
摘要翻译：揭示了证明对上皮癌细胞系和内皮细胞的抗增殖作用的分子和合成方法。该分子旨在用于通过抗血管生成或其它抗癌机制治疗癌症的治疗制剂。所指定的化合物是6H-二苯并[b，d]吡喃-6-酮衍生物，已被证明是对人内皮细胞具有抗增殖作用。

3. 发明授权

US06232591B1 Light detection device 有权
标题翻译：光检测装置
公开(公告)号：US06232591B1
公开(公告)日：2001-05-15
申请号：US09308606
申请日：1999-07-29
申请人： John Whelan , Graham Henry Stout
发明人： John Whelan , Graham Henry Stout
IPC分类号： H01J4014
CPC分类号： H01L23/576 , G01J1/44 , H01L2924/0002 , H01L2924/3011 , H01L2924/00
摘要： A light detection device has a biasing transistor (1) arranged to provide a bias current and a reverse biased transistor. The reverse biased transistor has a drain terminal (6) coupled via a high impedance resistor (4) to the supply voltage. Incident visible light is detected by a voltage drop at the drain electrode.
摘要翻译：光检测装置具有设置成提供偏置电流的偏置晶体管（1）和反向偏置晶体管。反向偏置晶体管具有经由高阻抗电阻（4）耦合到电源电压的漏极端子（6）。入射可见光通过漏电极处的电压降检测。

4. 发明申请

US20140032592A1 LOCATING RELEVANT DIFFERENTIATORS WITHIN AN ASSOCIATIVE MEMORY 有权
标题翻译：在相关记忆中定位相关的差异化因子
公开(公告)号：US20140032592A1
公开(公告)日：2014-01-30
申请号：US13560437
申请日：2012-07-27
申请人： John Whelan , Jaime Antonio Flores, JR.
发明人： John Whelan , Jaime Antonio Flores, JR.
IPC分类号： G06F17/30
CPC分类号： G06F17/30533 , G06F17/30554
摘要： A system including an associative memory comprising a plurality of data and a plurality of associations among the plurality of data. The plurality of data is collected into associated groups. The associative memory is configured to be queried based on at least indirect relationships among the plurality of data. The system also includes an input device in communication with the associative memory. The input device is configured to receive a query to compare entities in the associative memory. The system also includes a coordinator in communication with the associative memory. The coordinator is configured to compare the entities to identify a similar attribute value among the entities. The coordinator is further configured to identify a differentiator among the entities.
摘要翻译：一种包括在多个数据中包括多个数据和多个关联的关联存储器的系统。多个数据被收集到相关联的组中。所述关联存储器被配置为基于所述多个数据中的至少间接关系进行查询。该系统还包括与关联存储器通信的输入设备。输入设备被配置为接收查询以比较关联存储器中的实体。该系统还包括与关联存储器通信的协调器。协调器被配置为比较实体以在实体之间标识类似的属性值。协调器还被配置为识别实体之间的微分器。

5. 发明授权

US08246834B2 High pressure flash chromatography 有权
标题翻译：高压快速色谱法
公开(公告)号：US08246834B2
公开(公告)日：2012-08-21
申请号：US13014204
申请日：2011-01-26
申请人： Lalit Chordia , Harbaksh Sidhu , Todd Palcic , John Whelan
发明人： Lalit Chordia , Harbaksh Sidhu , Todd Palcic , John Whelan
IPC分类号： B01D15/08
CPC分类号： B01D15/165 , B01D15/20
摘要： A method for separating a sample using high pressure flash chromatography is provided. The method comprises the steps of: i) providing a pressurized vessel containing an adsorption material; ii) pressurizing a compressible fluid, optionally containing a cosolvent, to create a mobile phase; iii) premixing the sample with the mobile phase or optionally placing the sample in the pressurized vessel; iv) eluting the mobile phase through the pressurized vessel, to obtain a separated sample; v) heating the mobile phase containing the separated sample after the mobile phase exits the pressurized vessel to remove the compressible fluid; and iv) collecting the separated sample. The pressurized vessel contains an adsorption material having a particle size of 10-100 microns, and the pressure of the adsorption vessel is held at 50-350 bar during elution. Also provided is an apparatus for carrying out the above method.
摘要翻译：提供了使用高压快速色谱法分离样品的方法。该方法包括以下步骤：i）提供含有吸附材料的加压容器; ii）对可压缩流体（任选地含有助溶剂）加压以产生流动相; iii）用流动相预先混合样品或任选地将样品置于加压容器中; iv）通过加压容器洗脱流动相，得到分离的样品; v）在流动相离开加压容器之后加热含有分离的样品的流动相以除去可压缩流体; 和iv）收集分离的样品。加压容器含有粒度为10-100微米的吸附材料，并且在洗脱期间吸附容器的压力保持在50-350巴。还提供了一种用于执行上述方法的装置。

6. 发明申请

US20080053908A1 High pressure flash chromatography 审中-公开
标题翻译：高压快速色谱法
公开(公告)号：US20080053908A1
公开(公告)日：2008-03-06
申请号：US11899059
申请日：2007-09-04
申请人： Lalit Chordia , Harbaksh Sidhu , Todd Palcic , John Whelan
发明人： Lalit Chordia , Harbaksh Sidhu , Todd Palcic , John Whelan
IPC分类号： B01D15/08
CPC分类号： B01D15/165 , B01D15/20 , G01N30/34 , B01D15/40
摘要： A method for separating a sample using high pressure flash chromatography is provided. The method comprises the steps of: i) providing a pressurized vessel containing an adsorption material; ii) pressurizing a compressible fluid, optionally containing a cosolvent, to create a mobile phase; iii) premixing the sample with the mobile phase or optionally placing the sample in the pressurized vessel; iv) eluting the mobile phase through the pressurized vessel, to obtain a separated sample; v) heating the mobile phase containing the separated sample after the mobile phase exits the pressurized vessel to remove the compressible fluid; and iv) collecting the separated sample. The pressurized vessel contains an adsorption material having a particle size of 10-100 microns, and the pressure of the adsorption vessel is held at 50-350 bar during elution. Also provided is an apparatus for carrying out the above method.
摘要翻译：提供了使用高压快速色谱法分离样品的方法。该方法包括以下步骤：i）提供含有吸附材料的加压容器; ii）对可压缩流体（任选地含有助溶剂）加压以产生流动相; iii）用流动相预先混合样品或任选地将样品置于加压容器中; iv）通过加压容器洗脱流动相，得到分离的样品; v）在流动相离开加压容器之后加热含有分离的样品的流动相以除去可压缩流体; 和iv）收集分离的样品。加压容器含有粒度为10-100微米的吸附材料，并且在洗脱期间吸附容器的压力保持在50-350巴。还提供了一种用于执行上述方法的装置。

7. 发明申请

US20070276031A1 Process for Purifying (-)- 9-Trans-Tetrahydrocannabinol 有权
标题翻译：纯化（ - ） - 9-反式四氢大麻酚的方法
公开(公告)号：US20070276031A1
公开(公告)日：2007-11-29
申请号：US10584122
申请日：2004-12-17
申请人： Fiona Geiser , John Keenan , Ronald Rossi , Albert Sanchez , John Whelan
发明人： Fiona Geiser , John Keenan , Ronald Rossi , Albert Sanchez , John Whelan
IPC分类号： A61K31/352 , A61P43/00 , G01N30/00
CPC分类号： C07D311/80
摘要： A process for separating (−)-Δ9-trans-tetrahydrocannabinol from a mixture of cannabinoids is disclosed. The process comprises at least one chromatographic step wherein a mobile phase passes trough a stationary phase. The stationary phase comprises a derivatised polysaccharide and the mobile phase comprises carbon dioxide.
摘要翻译：公开了从大麻素混合物中分离出（ - ） - 三差反式四氢大麻酚的方法。该方法包括至少一个色谱步骤，其中流动相通过固定相。固定相包含衍生的多糖，流动相包含二氧化碳。

8. 发明授权

US09659110B2 Associative memory technology for analysis of requests for proposal 有权
公开(公告)号：US09659110B2
公开(公告)日：2017-05-23
申请号：US13277771
申请日：2011-10-20
申请人： William G. Arnold , Brian Warn , John Whelan , Jaime Antonio Flores, Jr.
发明人： William G. Arnold , Brian Warn , John Whelan , Jaime Antonio Flores, Jr.
IPC分类号： G06F7/00 , G06F17/30 , G06Q10/10 , G06Q30/06
CPC分类号： G06F17/30982 , G06F17/30312 , G06F17/30598 , G06Q10/10 , G06Q30/0611
摘要： A system for analyzing a request for proposal. The system includes an associative memory including a plurality of data having a plurality of associations. The system also includes an input device in communication with the associative memory. The input device is configured to provide the request for proposal to the associative memory in a format understandable to the associative memory. The associative memory is configured to digest the request for proposal to be included within the plurality of data, wherein a digested request for proposal is formed. The system also includes an analyzer in communication with the associative memory. The associative memory is configured to analyze the digested request for proposal by receiving a query comprising one or more terms, creating relationships among the plurality of data in the associative memory based on the query, and returning an output that includes requirements or other attributes presented in the digested request for proposal based on the query.

9. 发明授权

US08935282B2 Locating relevant differentiators within an associative memory 有权
标题翻译：在关联记忆中查找相关的区分符
公开(公告)号：US08935282B2
公开(公告)日：2015-01-13
申请号：US13560437
申请日：2012-07-27
申请人： John Whelan , Jaime Antonio Flores, Jr.
发明人： John Whelan , Jaime Antonio Flores, Jr.
IPC分类号： G06F17/30
CPC分类号： G06F17/30533 , G06F17/30554
摘要： A system including an associative memory comprising a plurality of data and a plurality of associations among the plurality of data. The plurality of data is collected into associated groups. The associative memory is configured to be queried based on at least indirect relationships among the plurality of data. The system also includes an input device in communication with the associative memory. The input device is configured to receive a query to compare entities in the associative memory. The system also includes a coordinator in communication with the associative memory. The coordinator is configured to compare the entities to identify a similar attribute value among the entities. The coordinator is further configured to identify a differentiator among the entities.
摘要翻译：一种包括在多个数据中包括多个数据和多个关联的关联存储器的系统。多个数据被收集到相关联的组中。所述关联存储器被配置为基于所述多个数据中的至少间接关系进行查询。该系统还包括与关联存储器通信的输入设备。输入设备被配置为接收查询以比较关联存储器中的实体。该系统还包括与关联存储器通信的协调器。协调器被配置为比较实体以在实体之间标识类似的属性值。协调器还被配置为识别实体之间的微分器。

10. 发明申请

US20130054476A1 SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR PARCEL ASSESSMENT 审中-公开
标题翻译：系统，方法和计算机程序产品用于PARCEL评估
公开(公告)号：US20130054476A1
公开(公告)日：2013-02-28
申请号：US13215936
申请日：2011-08-23
申请人： John Whelan
发明人： John Whelan
IPC分类号： G06Q40/00
CPC分类号： G06Q50/16 , G06Q30/02
摘要： A system, method and computer program product are provided in order to determine the value of a parcel based upon a number of different attributes and keywords relating to a number of features of the parcel. In the context of a system, a receiver module is configured to receive one or more attributes of the first parcel and one or more keywords of the first parcel. Each keyword may include a category type and a corresponding value. The system may also include an associative memory configured to compare the one or more attributes and one or more keywords of the first parcel with attributes and keywords, respectively, of a plurality of other parcels in order to determine a plurality of similar parcels. Further, the system may include an assessment module configured to determine the value of the first parcel based upon the prices of the plurality of similar parcels.
摘要翻译：提供了一种系统，方法和计算机程序产品，以便基于与包裹的多个特征相关的不同属性和关键词的数量来确定包裹的价值。在系统的上下文中，接收器模块被配置为接收第一包裹的一个或多个属性和第一包裹的一个或多个关键字。每个关键字可以包括类别类型和对应的值。该系统还可以包括被配置为将第一包裹中的一个或多个属性与一个或多个关键词分别与多个其他包裹的属性和关键字进行比较以便确定多个相似包裹的关联存储器。此外，系统可以包括评估模块，其被配置为基于多个相似包裹的价格来确定第一包裹的价值。

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