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1. 发明申请

US20050143452A1 Dihydrobenzofuranyl alkanamine derivatives and methods for using same 失效
标题翻译：二氢苯并呋喃基烷胺衍生物及其使用方法
公开(公告)号：US20050143452A1
公开(公告)日：2005-06-30
申请号：US10970714
申请日：2004-10-21
申请人： Jonathan Gross , Marla Williams , Gary Stack , Hong Gao , Dahui Zhou
发明人： Jonathan Gross , Marla Williams , Gary Stack , Hong Gao , Dahui Zhou
IPC分类号： C07D307/81 , A61K31/343 , C07D307/78
CPC分类号： C07D307/81
摘要： Compounds of Formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译：提供式1化合物或其药学上可接受的盐：其是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。

2. 发明申请

US20050261347A1 Dihydrobenzofuranyl alkanamine derivatives and methods for using same 审中-公开
标题翻译：二氢苯并呋喃基烷胺衍生物及其使用方法
公开(公告)号：US20050261347A1
公开(公告)日：2005-11-24
申请号：US11113170
申请日：2005-04-22
申请人： Jonathan Gross , Marla Williams , Gary Stack , Hong Gao , Dahui Zhou
发明人： Jonathan Gross , Marla Williams , Gary Stack , Hong Gao , Dahui Zhou
IPC分类号： C07D307/81 , A61K31/4433 , A61K31/343 , A61K31/381 , C07D45/02 , C07D49/02
CPC分类号： C07D405/04 , C07D307/81 , C07D407/04 , C07D409/04
摘要： Compounds of formula 2 or pharmaceutically acceptable salts thereof are provided: wherein each of R1a, R2a, R3a, Ar, y, and m are as defined herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, are used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译：提供式2化合物或其药学上可接受的盐：其中R 1a，R 2a，R 3a，Ar，y和 m如本文所定义，其是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。化合物和含有这些化合物的组合物用于治疗各种中枢神经系统疾病如精神分裂症。

3. 发明申请

US20060241172A1 Benzodioxane and benzodioxolane derivatives and uses thereof 审中-公开
标题翻译：苯并二恶烷和苯并二氧杂环戊烷衍生物及其用途
公开(公告)号：US20060241172A1
公开(公告)日：2006-10-26
申请号：US11409466
申请日：2006-04-21
申请人： Dahui Zhou , Gary Stack , Jonathan Gross , Hong Gao
发明人： Dahui Zhou , Gary Stack , Jonathan Gross , Hong Gao
IPC分类号： A61K31/36 , C07D319/14
CPC分类号： C07D319/20 , C07D317/46 , C07D409/04
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, y, n, m, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译：提供式I化合物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4， y，n，m和Ar定义如下，并且在本文的类别和亚类中描述，其是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。

4. 发明申请

US20060258714A1 Chromane and chromene derivatives and uses thereof 失效
标题翻译：色原和色烯衍生物及其用途
公开(公告)号：US20060258714A1
公开(公告)日：2006-11-16
申请号：US11409467
申请日：2006-04-21
申请人： Gavin Heffernan , Gary Stack , Jonathan Gross , Dahui Zhou , Hong Gao
发明人： Gavin Heffernan , Gary Stack , Jonathan Gross , Dahui Zhou , Hong Gao
IPC分类号： A61K31/4433 , A61K31/381 , A61K31/353
CPC分类号： C07D311/04 , C07D311/20 , C07D311/58 , C07D313/08 , C07D401/04 , C07D405/04
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译：提供式I化合物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4， y，m，n和Ar如上所定义，并且在本文的类别和亚类中描述，它们是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。

5. 发明申请

US20060247276A1 Benzofuranyl alkanamine derivatives and uses thereof 失效
标题翻译：苯并呋喃基烷胺衍生物及其用途
公开(公告)号：US20060247276A1
公开(公告)日：2006-11-02
申请号：US11408319
申请日：2006-04-21
申请人： Jonathan Gross , Gary Stack , Dahui Zhou , Hong Gao
发明人： Jonathan Gross , Gary Stack , Dahui Zhou , Hong Gao
IPC分类号： A61K31/4433 , A61K31/381 , A61K31/343 , C07D409/02 , C07D405/02
CPC分类号： C07D307/81
摘要： Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R1′, R2, R3, R4, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译：提供式I化合物或其药学上可接受的盐：其中R 1，R 1，R 2，R 2，R 2， 3，R 4，n和Ar如上所定义，并在本文的类别和亚类中描述，它们是脑5-羟色胺受体的2C亚型的激动剂或部分激动剂。化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。

6. 发明申请

US20050004157A1 Quinoline 3-amino chroman derivatives 失效
标题翻译：喹啉-3-氨基苯并二氢吡喃衍生物
公开(公告)号：US20050004157A1
公开(公告)日：2005-01-06
申请号：US10835128
申请日：2004-04-29
申请人： Nicole Hatzenbuhler , Dahui Zhou , Gary Stack , Jonathan Gross
发明人： Nicole Hatzenbuhler , Dahui Zhou , Gary Stack , Jonathan Gross
IPC分类号： A61P25/24 , C07D491/04 , C07D491/02 , A61K31/4741
CPC分类号： C07D491/04
摘要： Quinoline 3-amino chroman derivatives and compositions containing such compounds are disclosed. Methods for using the quinoline 3-amino chroman derivatives and compositions containing such compounds in the treatment of serotonin disorders are disclosed. Also disclosed are processes for preparing quinoline 3-amino chroman derivatives.
摘要翻译：公开了喹啉-3-氨基苯并二氢吡喃衍生物和含有这些化合物的组合物。公开了使用喹啉3-氨基苯并二氢吡喃衍生物和含有这些化合物的组合物治疗血清素紊乱的方法。还公开了制备喹啉3-氨基苯并二氢吡喃衍生物的方法。

7. 发明申请

US20070191417A1 QUINOLINE 3-AMINO CHROMAN DERIVATIVES 审中-公开
标题翻译：喹啉3-氨基铬衍生物
公开(公告)号：US20070191417A1
公开(公告)日：2007-08-16
申请号：US11738692
申请日：2007-04-23
申请人： Nicole Hatzenbuhler , Dahui Zhou , Gary Stack , Jonathan Gross
发明人： Nicole Hatzenbuhler , Dahui Zhou , Gary Stack , Jonathan Gross
IPC分类号： A61K31/44
CPC分类号： C07D491/04
摘要： Quinoline 3-amino chroman derivatives and compositions containing such compounds are disclosed. Methods for using the quinoline 3-amino chroman derivatives and compositions containing such compounds in the treatment of serotonin disorders are disclosed. Also disclosed are processes for preparing quinoline 3-amino chroman derivatives.
摘要翻译：公开了喹啉-3-氨基苯并二氢吡喃衍生物和含有这些化合物的组合物。公开了使用喹啉3-氨基苯并二氢吡喃衍生物和含有这些化合物的组合物治疗血清素紊乱的方法。还公开了制备喹啉3-氨基苯并二氢吡喃衍生物的方法。

8. 发明申请

US20050124692A1 Dihydrobenzofuranyl alkanamines and methods for using same as cns agents 失效
标题翻译：二氢苯并呋喃基链烷胺及其与cns试剂一起使用的方法
公开(公告)号：US20050124692A1
公开(公告)日：2005-06-09
申请号：US10970103
申请日：2004-10-21
申请人： Jonathan Gross , Gary Stack , Hong Gao
发明人： Jonathan Gross , Gary Stack , Hong Gao
IPC分类号： C07D307/00 , C07D307/92 , C07D307/93 , A61K31/343
CPC分类号： C07D307/00 , C07D307/92 , C07D307/93
摘要： Compounds of formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists and partial agonists of the 2c subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
摘要翻译：提供式1化合物或其药学上可接受的盐：其是脑5-羟色胺受体的2c亚型的激动剂和部分激动剂。化合物和含有这些化合物的组合物可用于治疗各种中枢神经系统疾病如精神分裂症。

9. 发明申请

US20060246551A1 Dihydrobenzofuran derivatives and uses thereof 失效
标题翻译：二氢苯并呋喃衍生物及其用途
公开(公告)号：US20060246551A1
公开(公告)日：2006-11-02
申请号：US11408653
申请日：2006-04-21
申请人： Gary Stack , Jonathan Gross
发明人： Gary Stack , Jonathan Gross
IPC分类号： C12P19/12
CPC分类号： C07D307/81 , C12P17/04 , C12P17/14
摘要： Compounds of formula I are provided: wherein each of R1, R2, y, m, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of melatoninergic receptors. The compounds, and compositions containing the compounds, can be used to treat melatoninergic disorders.
摘要翻译：提供了式I化合物：其中R 1，R 2，Y，m，n和Ar各自如本文中的类别和亚类所定义和描述，它们是褪黑激素受体的激动剂或部分激动剂。化合物和含有这些化合物的组合物可用于治疗褪黑激素障碍。

10. 发明申请

US20070225013A1 Method and apparatus for managing an active set 审中-公开
标题翻译：用于管理活动集的方法和装置
公开(公告)号：US20070225013A1
公开(公告)日：2007-09-27
申请号：US11390613
申请日：2006-03-27
申请人： Mark Pflum , Jonathan Gross
发明人： Mark Pflum , Jonathan Gross
IPC分类号： H04Q7/20
CPC分类号： H04W36/30 , H04W36/18
摘要： A method and apparatus of managing an active set of a mobile station in a soft-handoff environment includes for a reverse link, comparing a reverse link quality metric to a reverse link quality threshold, where the reverse link is associated with a base station in the active set, and determining an aggregate reverse link quality metric corresponding to at least one base station that is a member of the active set but is not under consideration to be dropped from the active set. If the reverse link quality metric is below the reverse link quality threshold for a time period, the aggregate reverse link quality metric is compared to an aggregate reverse link quality threshold, and if the aggregate reverse link quality metric compares favorably to the aggregate reverse link quality threshold, the base station is removed from the active set.
摘要翻译：在软切换环境中管理移动台的有源集合的方法和装置包括：用于反向链路，将反向链路质量度量与反向链路质量阈值进行比较，其中反向链路与基站在并且确定对应于作为所述活动集的成员但不被考虑从所述活动集丢弃的至少一个基站的聚合反向链路质量度量。如果反向链路质量度量在一段时间内低于反向链路质量阈值，则将聚合反向链路质量度量与聚合反向链路质量阈值进行比较，并且如果聚合反向链路质量度量与聚合反向链路质量相比有利阈值，基站从活动集中移除。

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